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48 条记录 (耗时 0.028 秒)

    Demineralized bone matrix compositions and methods
    32.
    发明授权
    Demineralized bone matrix compositions and methods 有权
    脱矿质骨基质组成及方法

    公开(公告)号：US08435566B2

    公开(公告)日：2013-05-07

    申请号：US13526987

    申请日：2012-06-19

    申请人： Keyvan Behnam ,  Guobao Wei ,  James A. Beisser

    发明人： Keyvan Behnam ,  Guobao Wei ,  James A. Beisser

    IPC分类号： A61K9/10 ,  A61K35/32

    CPC分类号： A61L27/3608 ,  A61L27/3683 ,  A61L27/50 ,  A61L27/54 ,  A61L2300/414

    摘要： Bone matrix compositions and, more specifically, demineralized bone matrix (DBM) having increased osteoinductive capacity and methods for its production are provided. Specifically, DBM derived from cortical bone from the periosteal layer of bone are provided. Compositions comprising a disproportionate amount of DBM prepared from bone derived from the periosteal and/or middle layer of bone are provided. Preparations of and methods of use of periosteal DBM compositions are disclosed.

    摘要翻译： 提供骨基质组合物，更具体地说，具有增强的骨诱导能力的去矿物质骨基质（DBM）及其生产方法。 具体地，提供了从骨的骨膜层衍生自皮质骨的DBM。 提供了包含由来自骨膜和/或中间骨层的骨制备的不相称量的DBM的组合物。 公开了骨膜DBM组合物的制备和使用方法。

    MODIFICATION OF REACTIVITY OF BONE CONSTRUCTS
    35.
    发明申请
    MODIFICATION OF REACTIVITY OF BONE CONSTRUCTS 有权
    骨骼结构的反应性修改

    公开(公告)号：US20130195805A1

    公开(公告)日：2013-08-01

    申请号：US13361339

    申请日：2012-01-30

    申请人： Guobao Wei ,  Susan J. Drapeau

    发明人： Guobao Wei ,  Susan J. Drapeau

    IPC分类号： A61K35/32 ,  A61P19/00 ,  A61K35/28 ,  A61K35/12 ,  A61K38/46

    CPC分类号： A61K35/28 ,  A61K35/32 ,  A61L27/3608 ,  A61L27/3683 ,  A61L27/3821 ,  A61L27/3834 ,  A61L27/50 ,  A61L2300/414 ,  A61L2430/02

    摘要： A method of enhancing the binding of growth factors and cell cultures to a demineralized allograft bone material which includes applying ex vivo an effective quantity of an ionic force change agent to at least a portion of the surface of a demineralized allograft bone material to produce a binding-sensitized demineralized allograft bone material and implanting the binding-sensitized demineralized allograft bone material into a host bone. The ionic force change agent may include at least one of enzymes, pressure, chemicals, heat, sheer force, oxygen plasma, supercritical nitrogen, supercritical carbon, supercritical water or a combination thereof. A molecule, a cell culture, or a combination thereof is administered to the binding-sensitized demineralized allograft bone material.

    摘要翻译： 增强生长因子和细胞培养物与软化的同种异体移植骨材料的结合的方法，其包括向体内施用有效量的离子力变化剂至少部分脱矿质的同种异体移植骨材料的表面以产生结合 敏化的脱矿质同种异体移植骨材料并将结合致敏的脱矿质同种异体移植骨材料植入宿主骨中。 离子力变化剂可以包括酶，压力，化学物质，热量，剪切力，氧等离子体，超临界氮，超临界碳，超临界水或其组合中的至少一种。 将一种分子，细胞培养物或其组合施用于结合致敏的脱矿质同种异体移植骨材料。

    BONE DELIVERY SYSTEM
    36.
    发明申请
    BONE DELIVERY SYSTEM 有权
    骨输送系统

    公开(公告)号：US20130190891A1

    公开(公告)日：2013-07-25

    申请号：US13355064

    申请日：2012-01-20

    申请人： Susan J. Drapeau ,  Guobao Wei

    发明人： Susan J. Drapeau ,  Guobao Wei

    IPC分类号： A61F2/28

    CPC分类号： A61F2/28 ,  A61F2002/2835 ,  A61F2002/30062 ,  A61F2002/30075 ,  A61F2002/30462 ,  A61F2002/30467 ,  A61F2002/30588 ,  A61F2002/30677 ,  A61F2002/30909 ,  A61F2002/3096

    摘要： A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be formed of polymers for providing extended shelf life and/or increased moisture and radiation resistance, and may include a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust the release of the substance. In various embodiments, the covering may be formed of a biocompatible material and is suitable for a variety of procedure specific uses.

    摘要翻译： 提供了将物质或材料输送到手术部位的覆盖物。 其中提供的物质的覆盖物可以被称为递送系统。 通常，覆盖物可由用于提供延长的保质期和/或增加的耐湿和耐辐射性的聚合物形成，并且可以包括能够至少部分保留其中提供的物质的单室或多室结构，直到覆盖物被置于 手术部位。 放置时，覆盖物可以促进物质或周围材料的转移。 例如，物质可以被主动地或被动地释放到手术部位。 覆盖物可以参与，控制或以其他方式调节物质的释放。 在各种实施方案中，覆盖物可以由生物相容性材料形成，并且适用于各种程序特定用途。

    Particle-containing complex porous materials
    37.
    发明授权
    Particle-containing complex porous materials 有权
    含颗粒的复合多孔材料

    公开(公告)号：US08268344B2

    公开(公告)日：2012-09-18

    申请号：US11410480

    申请日：2006-04-25

    申请人： Peter X. Ma ,  Guobao Wei

    发明人： Peter X. Ma ,  Guobao Wei

    IPC分类号： A61K9/70

    CPC分类号： A61K9/0024 ,  A61K9/1647 ,  A61K9/1652 ,  A61K9/1658 ,  A61K9/1694 ,  A61K9/5153 ,  A61K9/5161 ,  A61K9/5169 ,  A61K9/70 ,  A61K48/0008 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/252 ,  A61L2300/258 ,  A61L2300/43 ,  A61L2300/602 ,  A61L2300/622 ,  A61L2300/624

    摘要： Porous materials and methods for forming them are disclosed. One method for immobilizing micro-particles and/or nano-particles onto internal pore surfaces and/or external pore surfaces of porous materials includes suspending the micro-particles and/or nano-particles in a liquid adapted to swell, soften, and/or deform either the porous materials and/or the particles, thereby forming a liquid-particle suspension. The method further includes adding the suspension to the porous materials; and removing the liquid, thereby forming the porous materials having the micro-particles and/or nano-particles immobilized on the internal pore surfaces and/or the external pore surfaces.

    摘要翻译： 公开了用于形成它们的多孔材料和方法。 将微粒和/或纳米颗粒固定在多孔材料的内孔表面和/或外孔表面上的一种方法包括将微粒和/或纳米颗粒悬浮在适于膨胀，软化和/或 使多孔材料和/或颗粒变形，从而形成液体 - 颗粒悬浮液。 该方法还包括将悬浮液加入到多孔材料中; 并除去液体，从而形成具有固定在内孔表面和/或外孔表面上的微粒和/或纳米颗粒的多孔材料。

    ACCELERATED SPIRIT/BEVERAGE AGING AND FLAVOR LOADING METHODS AND SYSTEMS
    40.
    发明申请
    ACCELERATED SPIRIT/BEVERAGE AGING AND FLAVOR LOADING METHODS AND SYSTEMS 审中-公开

    公开(公告)号：US20180057780A1

    公开(公告)日：2018-03-01

    申请号：US15803764

    申请日：2017-11-04

    申请人： Mark DeCaro ,  Guobao Wei

    发明人： Mark DeCaro ,  Guobao Wei

    IPC分类号： C12G3/07 ,  A23L2/56

    CPC分类号： C12G3/07 ,  A23L2/56

    摘要： Accelerated spirit/beverage aging methods and systems are disclosed. Two accelerated aging methods are provided. The first aging method is to soak selected wood fibers/chips with spirits/beverages in situ in presence of subcritical/critical/supercritical carbon dioxide. The second aging method is to process selected wood fibers/chips in subcritical/critical/supercritical carbon dioxide to obtain activated wood fibers/chips. The activated wood fibers/chips are then soaked with spirits and/or beverages. A system for spirit/beverage aging and/or wood activation is also provided. It is comprised of a carbon dioxide supply device with a pump and a filter; a subcritical/critical/supercritical carbon dioxide performance vessel with a temperature/pressure control element; a mesh cage device for holding wood fibers/chips; and a carbon dioxide separation and recycle device. In some embodiments, wood and activated wood are further impregnated with natural flavors, vitamins, minerals, antioxidants, and therapeutics in a subcritical/critical/supercritical CO2 environment. Activated wood and/or impregnated wood is then combined with spirit/beverage and soaked in ambient, vacuum, pressure, or CO2 environment to obtain an aged and flavor enriched spirit/beverage.