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公开(公告)号：US08722059B2
公开(公告)日：2014-05-13
申请号：US13214110
申请日：2011-08-19
Applicant: Erich Hoffman , Hong Jin , Bin Lu , Greg Duke , George Kemble
Inventor： Erich Hoffman , Hong Jin , Bin Lu , Greg Duke , George Kemble
IPC: A61K39/145 , C12N7/00 , C12N7/04
CPC classification number: A61K39/145 , A61K2039/5254 , C07K14/005 , C12N7/00 , C12N15/85 , C12N15/86 , C12N15/87 , C12N2760/16122 , C12N2760/16143 , C12N2760/16162 , C12N2760/16222 , C12N2760/16243 , C12N2760/16262
Abstract: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided.
Abstract translation: 提供了用于在细胞培养中生产适合作为重组流感疫苗的流感病毒的载体和方法。 提供了用于多质粒流感病毒表达系统的双向表达载体。
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公开(公告)号：US08574591B2
公开(公告)日：2013-11-05
申请号：US13296933
申请日：2011-11-15
Applicant: Erich Hoffmann , Hong Jin , George Kemble , Zhongying Chen
Inventor： Erich Hoffmann , Hong Jin , George Kemble , Zhongying Chen
IPC: A61K39/145 , A61K39/00 , A61K39/12 , C12P21/04
CPC classification number: C12N15/86 , A61K2039/5254 , C07K14/005 , C12N7/00 , C12N15/85 , C12N2760/16122 , C12N2760/16134 , C12N2760/16143 , C12N2760/16162 , C12N2760/16222 , C12N2760/16234 , C12N2760/16243 , C12N2760/16262 , C12N2840/20
Abstract: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. A method of producing a cold adapted (ca) influenza virus that replicates efficiently at, e.g., 25° C. (and immunogenic compositions comprising the same) is also provided.
Abstract translation: 提供了用于在细胞培养中生产适合作为重组流感疫苗的流感病毒的载体和方法。 提供了用于多质粒流感病毒表达系统的双向表达载体。 另外，本发明提供了生产能够在含胚鸡蛋和/或细胞（例如Vero和/或MDCK）中复制的流感病毒的方法，并进一步提供具有增强的复制特征的流感病毒。 还提供了生产在例如25℃下有效复制的冷适应（ca）流感病毒的方法（和包含其的免疫原性组合物）。
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33.发明授权Non-noble metal based catalyst and fuel cell including the non-noble metal based catalyst 有权非贵金属类催化剂和包含非贵金属类催化剂的燃料电池公开(公告)号：US08466084B2
公开(公告)日：2013-06-18
申请号：US12708687
申请日：2010-02-19
Applicant: Duckyoung Yoo , Gang Liu , Huamin Zhang , Hong Jin , Ting Xu , Yuanwei Ma , Hexiang Zhong
Inventor： Duckyoung Yoo , Gang Liu , Huamin Zhang , Hong Jin , Ting Xu , Yuanwei Ma , Hexiang Zhong
IPC: B01J23/00
CPC classification number: H01M4/90 , H01M4/9083 , H01M2008/1095
Abstract: A non-noble metal based catalyst includes a compound represented by Formula 1: ZraMbOxNy [Formula 1] where M is at least one element selected from Group 4 elements through Group 12 elements, a is a number in the range of about 1 to about 8, b is a number in the range of 1 to 8, x is a number in the range of about 0.2 to about 32, and y is a number in the range of about 0.2 to about 16. A fuel cell electrode and fuel cell may be formed using the non-noble metal based catalyst.
Abstract translation: 非贵金属基催化剂包括由式1表示的化合物：ZraMbO x N y [式1]其中M是选自第4族元素至第12族元素中的至少一种元素，a为约1至约8的数 ，b为1〜8的数，x为约0.2〜约32的数，y为约0.2〜约16的数。燃料电池电极和燃料电池可以 使用非贵金属类催化剂形成。
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公开(公告)号：US20130014431A1
公开(公告)日：2013-01-17
申请号：US13476564
申请日：2012-05-21
Applicant: Hong Jin , Cory B. Phillips , Daren E. Daugaard , Kristi A. Fjare , Robert A. Levine
Inventor： Hong Jin , Cory B. Phillips , Daren E. Daugaard , Kristi A. Fjare , Robert A. Levine
IPC: C10L1/14
CPC classification number: C10L1/02 , C10G2300/1014 , C10G2300/202 , C10G2300/302 , C10L1/04 , Y02P30/20
Abstract: A fuel composition and the process of making the fuel composition are described. More specifically, a novel biomass derived low sulfur bunker fuels composition and the method of making thereof. Embodiment of the invention discloses a novel low sulfur bunker fuels composition derived from blending various bio-oil with other heavy residual fuel oils and distillates where final sulfur content and carbon intensity is controlled by the ratio of bio-oil to other heavy residual fuel oils and distillates. Embodiment of the invention also discloses a process of making a novel biomass derived low sulfur bunker fuels by blending various bio-oil with other heavy residual fuel oils and distillates.
Abstract translation: 描述燃料组合物和制备燃料组合物的方法。 更具体地说，一种新型生物质衍生的低硫燃料燃料组合物及其制备方法。 本发明的实施例公开了一种新型的低硫燃料燃料组合物，其衍生自将各种生物油与其它重质残余燃料油和馏出物混合，其中最终硫含量和碳强度由生物油与其它重质残余燃料油的比例控制， 馏出物 本发明的实施方案还公开了通过将各种生物油与其它重质残余燃料油和馏出物混合来制备新型生物质衍生的低硫燃料燃料的方法。
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公开(公告)号：US20120308602A1
公开(公告)日：2012-12-06
申请号：US13488700
申请日：2012-06-05
Applicant: Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant , David Kirkwood Clarke , Peter Palese
Inventor： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant , David Kirkwood Clarke , Peter Palese
IPC: A61K39/155 , A61P31/14 , C12N7/04 , A61P37/04
CPC classification number: C07K14/005 , A61K39/00 , A61K2039/51 , A61K2039/5254 , A61K2039/5256 , C12N7/00 , C12N15/86 , C12N2760/16022 , C12N2760/18522 , C12N2760/18543 , C12N2760/18561 , C12N2840/20
Abstract: The present invention relates to genetically engineered recombinant respiratory syncytial viruses and viral vectors which contain deletions of various viral accessory gene(s) either singly or in combination. In accordance with the present invention, the recombinant respiratory syncytial viral vectors and viruses are engineered to contain complete deletions of the M2-2, NS1, NS2, or SH viral accessory genes or various combinations thereof. In addition, the present invention relates to the attenuation of respiratory syncytial virus by mutagenisis of the M2-1 gene.
Abstract translation: 本发明涉及遗传工程重组呼吸道合胞病毒和病毒载体，其含有单独或组合的各种病毒辅助基因的缺失。 根据本发明，重组呼吸道合胞病毒载体和病毒被工程化以含有M2-2，NS1，NS2或SH病毒附属基因或其各种组合的完全缺失。 此外，本发明涉及通过M2-1基因的诱变来减轻呼吸道合胞病毒。
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Patent Agency Ranking
36.发明申请公开(公告)号：US20100062532A1
公开(公告)日：2010-03-11
申请号：US12552018
申请日：2009-09-01
CPC classification number: C12N7/00 , A61K39/12 , A61K39/145 , C07K14/005 , C12N2760/16121 , C12N2760/16122 , C12N2760/16134
Abstract: In certain aspects, the present invention provides methods for increasing the replication capacity of influenza viruses in hens' eggs and/or cell culture, recombinant and/or reassortant influenza viruses with increased replication capacity, and immunogenic and vaccine compositions comprising such recombinant and/or reassortant influenza viruses. In other aspects, the invention further provides nucleic acids encoding influenza genes associated with increased replication capacity, expression vectors comprising the nucleic acids of the invention, methods for making influenza viruses with increased replication capacity, and kits useful for practice of the methods.
Abstract translation: 在某些方面，本发明提供了增加在具有增加的复制能力的母鸡卵和/或细胞培养物，重组和/或重配流感病毒中的流感病毒的复制能力的方法，以及包含这种重组和/或 重配流感病毒。 在其它方面，本发明还提供编码与增加的复制能力相关的流感基因的核酸，包含本发明的核酸的表达载体，具有增加的复制能力的制备流感病毒的方法，以及可用于实施该方法的试剂盒。
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公开(公告)号：US20100028377A1
公开(公告)日：2010-02-04
申请号：US12434781
申请日：2009-05-04
Applicant: Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant , David Kirkwood Clarke , Peter Palese
Inventor： Hong Jin , Roderick Tang , Shengqiang Li , Martin Bryant , David Kirkwood Clarke , Peter Palese
IPC: A61K39/155 , C12N7/00 , C12N15/11 , A61K35/76
CPC classification number: C07K14/005 , A61K39/00 , A61K2039/51 , A61K2039/5254 , A61K2039/5256 , C12N7/00 , C12N15/86 , C12N2760/16022 , C12N2760/18522 , C12N2760/18543 , C12N2760/18561 , C12N2840/20
Abstract: The present invention relates to genetically engineered recombinant respiratory syncytial viruses and viral vectors which contain deletions of various viral accessory gene(s) either singly or in combination. In accordance with the present invention, the recombinant respiratory syncytial viral vectors and viruses are engineered to contain complete deletions of the M2-2, NS1, NS2, or SH viral accessory genes or various combinations thereof. In addition, the present invention relates to the attenuation of respiratory syncytial virus by mutagenisis of the M2-1 gene.
Abstract translation: 本发明涉及遗传工程重组呼吸道合胞病毒和病毒载体，其含有单独或组合的各种病毒辅助基因的缺失。 根据本发明，重组呼吸道合胞病毒载体和病毒被工程化以含有M2-2，NS1，NS2或SH病毒附属基因或其各种组合的完全缺失。 此外，本发明涉及通过M2-1基因的诱变来减轻呼吸道合胞病毒。
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公开(公告)号：US20090117150A1
公开(公告)日：2009-05-07
申请号：US12241229
申请日：2008-09-30
Applicant: Hong Jin , Robert Brazas , Bin Lu
Inventor： Hong Jin , Robert Brazas , Bin Lu
CPC classification number: C12N7/045 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/543 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2760/18522 , C12N2760/18534 , C12N2760/18543 , C12N2760/18561 , C12N2800/40 , G01N33/56983 , G01N2469/20 , G01N2500/00
Abstract: The present invention provides recombinant respiratory syncytial viruses that have an attenuated phenotype and that comprise one or more mutations in the viral P, M2-1 and/or M2-2 proteins, as well as live attenuated vaccines comprising such viruses and nucleic acids encoding such viruses. Recombinant RSV P, M2-1 and M2-2 proteins are described. Methods of producing attenuated recombinant RSV, and methods of quantitating neutralizing antibodies that utilize recombinant viruses of family Paramyxoviridae, are also provided.
Abstract translation: 本发明提供具有减毒表型并且包含病毒P，M2-1和/或M2-2蛋白中的一个或多个突变的重组呼吸道合胞病毒，以及包含这样的病毒和编码这种病毒的核酸的活减毒疫苗 病毒 描述了重组RSV P，M2-1和M2-2蛋白。 还提供了产生减毒重组RSV的方法，以及定量利用副粘病毒科重组病毒的中和抗体的方法。
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公开(公告)号：US20120288521A1
公开(公告)日：2012-11-15
申请号：US13296933
申请日：2011-11-15
Applicant: Erich Hoffmann , Hong Jin , George Kemble , Zhongying Chen
Inventor： Erich Hoffmann , Hong Jin , George Kemble , Zhongying Chen
IPC: A61K39/145 , A61P31/16 , A61P37/04 , C12N7/01 , C12N15/74
CPC classification number: C12N15/86 , A61K2039/5254 , C07K14/005 , C12N7/00 , C12N15/85 , C12N2760/16122 , C12N2760/16134 , C12N2760/16143 , C12N2760/16162 , C12N2760/16222 , C12N2760/16234 , C12N2760/16243 , C12N2760/16262 , C12N2840/20
Abstract: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. A method of producing a cold adapted (ca) influenza virus that replicates efficiently at, e.g., 25° C. (and immunogenic compositions comprising the same) is also provided.
Abstract translation: 提供了用于在细胞培养中生产适合作为重组流感疫苗的流感病毒的载体和方法。 提供了用于多质粒流感病毒表达系统的双向表达载体。 另外，本发明提供了生产能够在含胚鸡蛋和/或细胞（例如Vero和/或MDCK）中复制的流感病毒的方法，并进一步提供具有增强的复制特征的流感病毒。 还提供了生产在例如25℃下有效复制的冷适应（ca）流感病毒的方法（和包含其的免疫原性组合物）。
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公开(公告)号：US20120020997A1
公开(公告)日：2012-01-26
申请号：US13214110
申请日：2011-08-19
Applicant: Erich Hoffman , Hong Jin , Bin Lu , Greg Duke , George Kemble
Inventor： Erich Hoffman , Hong Jin , Bin Lu , Greg Duke , George Kemble
IPC: A61K39/145 , C12N7/04 , C12N7/00 , C07K14/11 , C40B40/08 , C12N5/00 , C12N7/01 , C07H21/04 , C12N7/02 , C12N15/86
CPC classification number: A61K39/145 , A61K2039/5254 , C07K14/005 , C12N7/00 , C12N15/85 , C12N15/86 , C12N15/87 , C12N2760/16122 , C12N2760/16143 , C12N2760/16162 , C12N2760/16222 , C12N2760/16243 , C12N2760/16262
Abstract: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided.
Abstract translation: 提供了用于在细胞培养中生产适合作为重组流感疫苗的流感病毒的载体和方法。 提供了用于多质粒流感病毒表达系统的双向表达载体。
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