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    Base-by-base ratcheting of DNA/RNA in a Y-shaped nanochannel
    32.
    发明授权
    Base-by-base ratcheting of DNA/RNA in a Y-shaped nanochannel 有权
    在Y形纳米通道中DNA / RNA的逐个碱基加工

    公开(公告)号：US09534253B2

    公开(公告)日：2017-01-03

    申请号：US14615891

    申请日：2015-02-06

    Applicant: International Business Machines Corporation

    Inventor： Binquan Luan ,  Ruhong Zhou

    IPC: C12Q1/68 ,  G01N27/447 ,  G01N27/453 ,  B82Y30/00 ,  B82Y5/00

    CPC classification number: C12Q1/6869 ,  B82Y5/00 ,  B82Y30/00 ,  G01N27/447 ,  G01N27/44791 ,  G01N27/453 ,  Y10S977/742 ,  Y10S977/781 ,  Y10S977/924

    Abstract: A mechanism is provided for ratcheting a double strand molecule. The double strand molecule is driven into a Y-channel of a membrane by a first voltage pulse. The Y-channel includes a stem and branches, and the branches are connected to the stem at a junction. The double strand molecule is slowed at the junction of the Y-channel based on the first voltage pulse being weaker than a force required to break a base pair of the double strand molecule. The double strand molecule is split into a first single strand and a second single strand by driving the double strand molecule into the junction of the Y-channel at a second voltage pulse.

    Abstract translation: 提供用于棘轮双链分子的机制。 双链分子通过第一电压脉冲被驱动到膜的Y通道中。 Y型通道包括杆和支杆，并且分支在连接处连接到杆。 基于第一电压脉冲的Y通道的连接处的双链分子比破坏双链分子的碱基对所需的力弱。 通过在第二电压脉冲下将双链分子驱动到Y通道的结中，将双链分子分成第一单链和第二单链。

    Self-formed nanometer channel at wafer scale
    38.
    发明授权
    Self-formed nanometer channel at wafer scale 有权
    硅片自制纳米通道

    公开(公告)号：US08652337B1

    公开(公告)日：2014-02-18

    申请号：US13971468

    申请日：2013-08-20

    Applicant: International Business Machines Corporation

    Inventor： Ali Afzali-Ardakani ,  Binquan Luan ,  Gustavo A. Stolovitzky ,  Chao Wang ,  Deqiang Wang

    IPC: H01B13/00

    CPC classification number: H01B13/06 ,  B82Y40/00 ,  G01N33/48721 ,  Y10S977/70

    Abstract: A mechanism is provided for fabricating nanochannels for a nanodevice. Insulating film is deposited on a substrate. A nanowire is patterned on the film. Insulating material is deposited on the nanowire and film. A first circular hole is formed in the insulating material as an inlet, over a first tip of the nanowire to expose the first tip. A second circular hole is formed as an outlet, over a second tip of the nanowire opposite the first tip to expose the second tip. A nanochannel connects the first and second holes by etching away the nanowire via an etchant in the first and the second holes. A first reservoir is attached over the first hole in connection with the nanochannel at a previous location of the first tip. A second reservoir is attached over the second hole in connection with the nanochannel at a previous location of the second tip.

    Abstract translation: 提供了一种用于制造纳米器件的纳米通道的机制。 绝缘膜沉积在基底上。 纳米线在电影上图案化。 绝缘材料沉积在纳米线和薄膜上。 在绝缘材料中形成第一圆形孔作为入口，在纳米线的第一尖端上露出第一尖端。 在与第一尖端相对的纳米线的第二尖端上方形成第二圆形孔作为出口，以露出第二尖端。 纳米通道通过第一孔和第二孔中的蚀刻剂蚀刻掉纳米线而连接第一孔和第二孔。 在第一尖端的先前位置处，与纳通道相连接的第一孔附接第一储存器。 在第二个尖端的先前位置处，与第二孔相连接的第二个贮存器连接到纳米通道上。

    COMPRESSIBLE FLUID SEPARATOR PUMP
    39.
    发明公开
    COMPRESSIBLE FLUID SEPARATOR PUMP 审中-公开

    公开(公告)号：US20230256383A1

    公开(公告)日：2023-08-17

    申请号：US17672147

    申请日：2022-02-15

    Applicant: International Business Machines Corporation

    Inventor： Bruce Gordon ELMEGREEN ,  Binquan Luan

    IPC: B01D53/22 ,  F04B1/00 ,  F04B53/00 ,  F04B53/14 ,  B01D53/02

    CPC classification number: B01D53/229 ,  F04B1/00 ,  F04B53/006 ,  F04B53/14 ,  B01D53/02 ,  B01D2053/221 ,  B01D2257/504

    Abstract: A compressible fluid separator pump includes a crankshaft, four cylinders, and four pistons. Each cylinder includes an inlet including an inlet valve for mixed fluid comprising a target component and a discharge component, a reject outlet including a reject valve for a reject fluid, and a select outlet for a select fluid, wherein each of the select outlets includes a separator member that prefers the target component over the discharge component such that the target component is at a higher concentration in the select fluid than in the mixed fluid and in the reject fluid. Each piston is connected to the crankshaft and is positioned in one of the four cylinders, and the crankshaft is configured to position two of the pistons at top dead center when the other two of the pistons are at bottom dead center.

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