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公开(公告)号：US20190134420A1
公开(公告)日：2019-05-09
申请号：US15808122
申请日：2017-11-09
Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
Inventor： Hariklia Deligianni , Ko-Tao Lee , Ning Li , Devendra Sadana , Roy R. Yu
Abstract: Technical solutions are described for implementing an optogenetics treatment using a probe and probe controller are described. A probe controller controls a probe to perform the method that includes emitting, by a light source of the probe, the probe is embeddable in a tissue, a light wave to interact with a corresponding chemical in one or more cells in the tissue. The method further includes capturing, by a sensor of the probe, a spectroscopy of the light wave interacting with the corresponding chemical. The method further includes sending, by the probe, the spectroscopy to an analysis system. The method further includes receiving, by the probe, from the analysis system, adjusted parameters for the light source, and adjusting, by a controller of the probe, settings of the light source according to the received adjusted parameters to emit a different light wave to interact with the corresponding chemical.
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公开(公告)号：US20180340204A1
公开(公告)日：2018-11-29
申请号：US15810356
申请日：2017-11-13
Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
Inventor： Steven J. Holmes , Emily R. Kinser , Qinghuang Lin , Nathan P. Marchack , Roy R. Yu
IPC: C12Q1/00 , C12Q1/26 , G01N27/327
Abstract: A biosensor includes an array of electrically conductive nanorods formed on a substrate. The nanorods each includes a nanoscale porous coating formed on a surface of the nanorods from silicon dioxide layers. An enzyme coating is bound to the porous coating.
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公开(公告)号：US20180340203A1
公开(公告)日：2018-11-29
申请号：US15602332
申请日：2017-05-23
Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
Inventor： Steven J. Holmes , Emily R. Kinser , Qinghuang Lin , Nathan P. Marchack , Roy R. Yu
IPC: C12Q1/00 , C12Q1/26 , G01N27/327
Abstract: A biosensor includes an array of electrically conductive nanorods formed on a substrate. The nanorods each includes a nanoscale porous coating formed on a surface of the nanorods from silicon dioxide layers. An enzyme coating is bound to the porous coating.
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公开(公告)号：US20180272048A1
公开(公告)日：2018-09-27
申请号：US15927443
申请日：2018-03-21
Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
Inventor： Stacey M. Gifford , Huan Hu , Emily R. Kinser , Roy R. Yu , Sufi Zafar
Abstract: Aspects include methods of fabricating antibacterial surfaces for medical implant devices including patterning a photoresist layer on a silicon substrate and etching the silicon to generate a plurality of nanopillars. Aspects also include removing the photoresist layer from the structure and coating the plurality of nanopillars with a biocompatible film. Aspects also include a system for preventing bacterial infection associated with medical implants including a thin silicon film including a plurality of nanopillars.
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公开(公告)号：US20180272047A1
公开(公告)日：2018-09-27
申请号：US15927428
申请日：2018-03-21
Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
Inventor： Stacey M. Gifford , Huan Hu , Emily R. Kinser , Roy R. Yu , Sufi Zafar
CPC classification number: A61L31/16 , A61L27/06 , A61L27/306 , A61L27/34 , A61L27/50 , A61L31/06 , A61L31/088 , A61L31/10 , A61L2300/406 , A61L2300/606 , A61L2400/12 , A61L2400/18 , A61L2420/02 , A61L2420/08 , B81B2203/0361 , B81B2207/056 , B81C1/00206 , B82B3/0019 , B82B3/0033
Abstract: Aspects include methods of fabricating antibacterial surfaces for medical implant devices including patterning a photoresist layer on a silicon substrate and etching the silicon to generate a plurality of nanopillars. Aspects also include removing the photoresist layer from the structure and coating the plurality of nanopillars with a biocompatible film. Aspects also include a system for preventing bacterial infection associated with medical implants including a thin silicon film including a plurality of nanopillars.
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Patent Agency Ranking
公开(公告)号：US09995686B2
公开(公告)日：2018-06-12
申请号：US15177829
申请日：2016-06-09
Applicant: International Business Machines Corporation
Inventor： Emily R. Kinser , Roy R. Yu
CPC classification number: G01N21/658 , G01J3/02 , G01J3/18 , G01J3/44 , G01N21/65
Abstract: Surface enhanced Raman spectroscopy is employed to obtain chemical data with respect to cells while electrophysiological data relating to cell membranes is obtained using the patch clamp technique. A SERS-facilitating assembly is coupled to a micropipette and is used in conjunction with a monochromatic light source for generating scattered light. Surface enhanced Raman spectroscopy is employed to obtain the chemical data. Electrophysiological data is obtained using the same micropipette to perform the patch clamp technique.
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37.发明申请公开(公告)号：US20180103848A1
公开(公告)日：2018-04-19
申请号：US15293267
申请日：2016-10-13
Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
Inventor： Emily R. Kinser , John U. Knickerbocker , Roy R. Yu
IPC: A61B5/00
Abstract: Surface enhanced Raman spectroscopy is employed to obtain chemical data with respect to body tissue and cells. The chemical environments of stimulation implants and drug-delivery catheters are spectroscopically monitored in real time using an implantable probe. The probe includes a surface enhancer that facilitates surface enhanced Raman spectroscopy in opposing relation to an array of optical fibers. Light emitted by the optical fibers can be employed for chemical detection and/or tissue stimulation. Wavelength and optical power are selected based on whether the probe is employed for such detection or stimulation. Fabrication of a probe assembly that enables surface enhanced Raman spectroscopy is further disclosed.
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38.发明申请公开(公告)号：US20180103847A1
公开(公告)日：2018-04-19
申请号：US15293261
申请日：2016-10-13
Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
Inventor： Emily R. Kinser , John U. Knickerbocker , Roy R. Yu
IPC: A61B5/00
CPC classification number: A61B5/0075 , A61B5/0084 , A61B2560/0443
Abstract: Surface enhanced Raman spectroscopy is employed to obtain chemical data with respect to body tissue and cells. The chemical environments of stimulation implants and drug-delivery catheters are spectroscopically monitored in real time using an implantable probe. The probe includes a surface enhancer that facilitates surface enhanced Raman spectroscopy in opposing relation to an array of optical fibers. Light emitted by the optical fibers can be employed for chemical detection and/or tissue stimulation. Wavelength and optical power are selected based on whether the probe is employed for such detection or stimulation.
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公开(公告)号：US20170190127A1
公开(公告)日：2017-07-06
申请号：US15131411
申请日：2016-04-18
Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
Inventor： Emily R. Kinser , John U. Knickerbocker , Roy R. Yu
IPC: B29D11/00
CPC classification number: G02C7/083 , B29D11/00028 , B29D11/00807 , B29D11/00826 , G02C7/04
Abstract: Methods of forming a lens include forming components on a lower substrate. The components are sealed on the lower substrate with a sealing layer. An upper substrate is formed over the sealing layer. The lower substrate is polished to a lower lens curvature.
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40.发明授权Volumetric integrated circuit and volumetric integrated circuit manufacturing method 有权体积集成电路和体积集成电路制造方法公开(公告)号：US09583410B2
公开(公告)日：2017-02-28
申请号：US14221477
申请日：2014-03-21
Applicant: International Business Machines Corporation
Inventor： Daniel C. Edelstein , Michael A. Gaynes , Thomas M. Shaw , Bucknell C. Webb , Roy R. Yu
CPC classification number: H01L23/293 , H01L23/291 , H01L23/3171 , H01L23/3192 , H01L2224/11
Abstract: A volumetric integrated circuit manufacturing method is provided. The method includes assembling a slab element of elongate chips, exposing a wiring layer between adjacent elongate chips of the slab element, metallizing a surface of the slab element at and around the exposed wiring layer to form a metallized surface electrically coupled to the wiring layer and passivating the metallized surface to hermetically seal the metallized surface.
Abstract translation: 提供了体积集成电路制造方法。 该方法包括组装细长芯片的平板元件，暴露板坯元件的相邻细长芯片之间的布线层，将暴露的布线层周围和周围的平板元件的表面金属化以形成电耦合到布线层的金属化表面，以及 钝化金属化表面以气密地密封金属化表面。
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