Abstract:
A system includes a knot tying device for tying a filament in a knot around an article and a filament delivery device from which is drawn the filament. The filament delivery device may be in the form of a cartridge having a housing sized and arranged to be releasably attached to the knot tying device where the housing has an opening through which pre-cut or loosely coupled lengths of the filament can be drawn. The knot tying device includes a shuttle attachable to the filament where the shuttle is caused to be moved during a knot tying process around an article to be tied and a device for at least pulling the filament away from the article at appropriate times during the knot tying process.
Abstract:
Cephalad and caudal vertebral facet joint prostheses and methods of use are provided. The prostheses provide an artificial facet joint structure including an artificial articular configuration unlike the preexisting articular configuration. The radii and material stress values of the prostheses are configured to sustain contact stress. The cephalad prosthesis provides for posterior-anterior adjustment. Both prostheses permit lateral adjustment and adjustment to accommodate interpedicle distance. Further, the prostheses may be customized to provide a pre-defined lordotic angle and a pre-defined pedicle entry angle.
Abstract:
Cephalad and caudal vertebral facet joint prostheses and methods of use are provided. The prostheses provide an artificial facet joint structure including an artificial articular configuration unlike the preexisting articular configuration. The radii and material stress values of the prostheses are configured to sustain contact stress. The cephalad prosthesis provides for posterior-anterior adjustment. Both prostheses permit lateral adjustment and adjustment to accommodate interpedicle distance. Further, the prostheses may be customized to provide a pre-defined lordotic angle and a pre-defined pedicle entry angle.
Abstract:
A method and apparatus for reducing the emissions and improving the performance of an internal combustion engine (40). An input air stream is separated into an oxygen-enriched air stream and a nitrogen-enriched air stream. The nitrogen-enriched air stream is received by a holding chamber (35). The oxygen-enriched air and a combustible fuel are provided to a combustion chamber (45) of the internal combustion engine (40) and a combustion process is initiated. After a predefined time delay, a volume of nitrogen-enriched air is provided from the holding chamber (35) to the combustion chamber (45) to be used during the rest of the combustion process.
Abstract:
Compounds of formula (I) and their use in therapy, particularly for the treatment of a disorder mediated by CB1 receptors such as obesity: Formula (I) wherein: R1 and R2 are independently selected from aryl; and R3 is hydrogen or alkyl; or a pharmaceutically acceptable salt or prodrug thereof, wherein at least one of R1 and R2 has a non-hydrogen substituent in the ortho-position(s) thereof relative to the point of attachment to the [—CH-0-] group.
Abstract:
This invention relates to the field of balloon catheters and more particularly to catheter balloons having controlled failure mechanisms for the prevention of catastrophic failure of the balloon during overpressure conditions.
Abstract:
A process of removing trace levels of metallic impurities from resist or photoresist component solutions and obtaining a purer resist or resist component solution without isolating the resist or resist component as a solid by treating the resist or resist component solution with an aqueous solution of a water soluble oxidizer, such as hydrogen peroxide, then with an acidic aqueous solution, and then allowing organic and aqueous phases to form with said aqueous phase containing metallic impurities extracted from said organic phase and the organic phase containing said resist or resist component solution with reduced amount of trace metal impurities, and separating the two phases.
Abstract:
A system of metalization in an integrated polymer microsystem. A flexible polymer substrate is provided and conductive ink is applied to the substrate. In one embodiment the flexible polymer substrate is silicone. In another embodiment the flexible polymer substrate comprises poly(dimethylsiloxane).
Abstract:
A chemical compound of formula (I) wherein R1 and R2 are independently selected from hydrogen and alkyl; R3 is alkyl; R4 and R5 are selected from hydrogen and alkyl; R6 and R7 are independently selected from hydrogen, halogen, hydroxyl, alkyl, aryl, amino, alkylamino, dialkylamino, alkoxy, aryloxy, alkylthio, alkylsulfoxyl, nitro, carbonitrile, carbo-alkoxy, carbo-aryloxy and carboxyl; and A is a 5- or 6-membered ring optionally containing one or more heteroatoms wherein the atoms of the ring A, other than the unsaturated carbon atoms of the phenyl ring to which the ring A is fused, are saturated or unsaturated, and pharmaceutically acceptable salts, addition compounds and prodrugs thereof; and the use thereof in therapy, particularly as an agonist or antagonist of a 5HT receptor, particularly a 5HT2C receptor, for instance in the treatment of disorders of the central nervous system; damage to the central nervous system; cardiovascular disorders; gastrointestinal disorders; diabetes insipidus, and sleep apnea, and particularly for the treatment of obesity.
Abstract translation:式(I)的化合物,其中R 1和R 2各自独立地选自氢和烷基; R 3是烷基; R 4和R 5选自氢和烷基; R 6和R 7独立地选自氢,卤素,羟基,烷基,芳基,氨基,烷基氨基,二烷基氨基,烷氧基,芳氧基,烷硫基,烷基亚砜基,硝基,腈 ,碳 - 烷氧基,碳 - 芳氧基和羧基; 并且A是任选地含有一个或多个杂原子的5-或6-元环,其中除了环A稠合的苯环的不饱和碳原子之外的环A的原子是饱和或不饱和的, 可接受的盐,加成化合物和前药; 以及其在治疗中的用途,特别是作为5HT受体,特别是5HT 2C受体的激动剂或拮抗剂,例如用于治疗中枢神经系统疾病; 损害中枢神经系统; 心血管疾病; 胃肠道疾病; 尿崩症和睡眠呼吸暂停,特别是用于治疗肥胖。
Abstract:
A new anti tip safety attachment for ambulatory aids that provides the stability needed to help keep ambulatory aids from being inadvertently pushed or tipped over. The Support Arm is universal and comes in a pair with each set being comprised of a 2 piece leg clamp molded from non toxic polymer plastic, 4 steel screws and a support arm made of approximately 1″ anodized aluminum tubing with a rubber stopper on the end. The 2 piece leg clamps attach to the ambulatory aid with the support arm facing out and down with the rubber stopper at least 1″ from the walking surface. There is no need to engage The Support Arm once secured and it will fold with the ambulatory aid.