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公开(公告)号：US20050215775A1
公开(公告)日：2005-09-29
申请号：US10979111
申请日：2004-11-02
申请人： Steven Ruben , Craig Rosen , Carrie Fischer , Daniel Soppet , Kenneth Carter , Daniel Bednarik , Gregory Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul Young , John Greene , Ann Ferrie , D. Duan , Jing-Shan Hu , Kimberly Florence , Henrik Olsen , Reinhard Ebner , Laurie Brewer , Yanggu Shi
发明人： Steven Ruben , Craig Rosen , Carrie Fischer , Daniel Soppet , Kenneth Carter , Daniel Bednarik , Gregory Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul Young , John Greene , Ann Ferrie , D. Duan , Jing-Shan Hu , Kimberly Florence , Henrik Olsen , Reinhard Ebner , Laurie Brewer , Yanggu Shi
CPC分类号： C07K14/47 , Y10T436/143333
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
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公开(公告)号：US20050208602A1
公开(公告)日：2005-09-22
申请号：US10773236
申请日：2004-02-09
申请人： Craig Rosen , Kevin Baker , Charles Birse , Gil Choi , Michele Fiscella , George Komatsoulis , Paul Moore , Jian Ni , Henrik Olsen , Steven Ruben , Ping Wei , D. Roxanne Duan , Yanggu Shi
发明人： Craig Rosen , Kevin Baker , Charles Birse , Gil Choi , Michele Fiscella , George Komatsoulis , Paul Moore , Jian Ni , Henrik Olsen , Steven Ruben , Ping Wei , D. Roxanne Duan , Yanggu Shi
IPC分类号： A61K38/00 , A61K38/17 , G01N33/53 , G01N33/537 , G01N33/543 , G01N33/68
CPC分类号： G01N33/68 , A61K38/00 , G01N33/5005 , G01N33/5008 , G01N33/502 , G01N33/6845
摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating diseases, disorders, and/or conditions related to said human secreted proteins. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
摘要翻译： 本发明涉及人分泌多肽和编码所述多肽的分离的核酸分子，其可用于诊断和治疗与所述人分泌蛋白相关的疾病，病症和/或病症。 结合这些多肽的抗体也包括在本发明中。 本发明还包括载体，宿主细胞，以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。 本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。
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公开(公告)号：US20080020969A1
公开(公告)日：2008-01-24
申请号：US11780874
申请日：2007-07-20
申请人： David LaFleur , Daniel Soppet , Henrik Olsen , Steven Ruben , Jian Ni , Craig Rosen , Laurie Brewer , Roxanne Duan , Reinhard Ebner
发明人： David LaFleur , Daniel Soppet , Henrik Olsen , Steven Ruben , Jian Ni , Craig Rosen , Laurie Brewer , Roxanne Duan , Reinhard Ebner
IPC分类号： A61K38/00 , A61K48/00 , C07H21/00 , C07K14/00 , C12N15/00 , C12N15/87 , C12N5/06 , C12P21/04 , G01N33/53
摘要： The present invention relates to 36 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译： 本发明涉及36种新型人分泌蛋白和含有编码这种蛋白质的基因的编码区的分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。
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公开(公告)号：US20070190612A1
公开(公告)日：2007-08-16
申请号：US11738671
申请日：2007-04-23
申请人： Jian Ni , Steven Ruben , Craig Rosen , Reinhard Ebner , Kimberly Florence , Paul Young , Charles Birse , Kenneth Carter , George Komatsoulis
发明人： Jian Ni , Steven Ruben , Craig Rosen , Reinhard Ebner , Kimberly Florence , Paul Young , Charles Birse , Kenneth Carter , George Komatsoulis
CPC分类号： C07K14/47 , A01K2217/075 , A61K38/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US20070154912A1
公开(公告)日：2007-07-05
申请号：US11566261
申请日：2006-12-04
申请人： Paul Young , John Greene , Ann Ferrie , Steven Ruben , Craig Rosen , Roxanne Duan , Jing-Shan Hu , Kimberly Florence , Henrik Olsen , Reinhard Ebner , Laurie Brewer , Paul Moore , Yanggu Shi , David LaFleur , Jian Ni
发明人： Paul Young , John Greene , Ann Ferrie , Steven Ruben , Craig Rosen , Roxanne Duan , Jing-Shan Hu , Kimberly Florence , Henrik Olsen , Reinhard Ebner , Laurie Brewer , Paul Moore , Yanggu Shi , David LaFleur , Jian Ni
CPC分类号： C12Q1/6883 , A61K38/00 , C07K14/47 , G01N33/6893
摘要： The present invention relates to 87 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译： 本发明涉及87种新的人分泌蛋白和含有编码这种蛋白质的基因的编码区的分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。
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公开(公告)号：US20060234285A1
公开(公告)日：2006-10-19
申请号：US11419656
申请日：2006-05-22
申请人： Reiner Gentz , Guo-Liang Yu , Jian Ni , Reinhard Ebner , Ping Feng , Steven Ruben
发明人： Reiner Gentz , Guo-Liang Yu , Jian Ni , Reinhard Ebner , Ping Feng , Steven Ruben
IPC分类号： C12Q1/68 , G01N33/574 , A61K38/17 , C07H21/04 , C12P21/06 , C07K14/715
CPC分类号： G01N33/57488 , A61K38/00 , C07K14/70578 , C07K14/7151
摘要： The present invention relates to novel Tumor Necrosis Factor Receptor proteins. In particular, isolated nucleic acid molecules are provided encoding the human TNFR-6α & -6β proteins. TNFR-6α & -6β polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TNFR-6α & -6β activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译： 本发明涉及新型肿瘤坏死因子受体蛋白。 特别地，提供编码人TNFR-6α和-6β蛋白的分离的核酸分子。 还提供了TNFR-6α和-6β多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及鉴定TNFR-6α和-6β活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。
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公开(公告)号：US20060223077A1
公开(公告)日：2006-10-05
申请号：US11229770
申请日：2005-09-20
申请人： Jian Ni , Reinhard Ebner , David LaFleur , Paul Moore , Henrik Olsen , Craig Rosen , Steven Ruben , Daniel Soppet , Paul Young , Yanggu Shi , Kimberly Florence , Ying-Fei Wei , Charles Florence , Jing-Shan Hu , Yi Li , Hla Kyaw , Carrie Fischer , Ann Ferrie , Ping Fan , Ping Feng , Gregory Endress , Patrick Dillon , Kenneth Carter , Laurie Brewer , Guo-Liang Yu , Zhizhen Zeng , John Greene
发明人： Jian Ni , Reinhard Ebner , David LaFleur , Paul Moore , Henrik Olsen , Craig Rosen , Steven Ruben , Daniel Soppet , Paul Young , Yanggu Shi , Kimberly Florence , Ying-Fei Wei , Charles Florence , Jing-Shan Hu , Yi Li , Hla Kyaw , Carrie Fischer , Ann Ferrie , Ping Fan , Ping Feng , Gregory Endress , Patrick Dillon , Kenneth Carter , Laurie Brewer , Guo-Liang Yu , Zhizhen Zeng , John Greene
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
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公开(公告)号：US20060160126A1
公开(公告)日：2006-07-20
申请号：US11375414
申请日：2006-03-15
申请人： Steven Ruben , Daniel Soppet , Reinhard Ebner , Henrik Olsen , Paul Young , John Greene , Ann Ferrie , Guo-Liang Yu , Jian Ni , Craig Rosen , Laurie Brewer , Fouad Janat , Charles Birse
发明人： Steven Ruben , Daniel Soppet , Reinhard Ebner , Henrik Olsen , Paul Young , John Greene , Ann Ferrie , Guo-Liang Yu , Jian Ni , Craig Rosen , Laurie Brewer , Fouad Janat , Charles Birse
CPC分类号： C07K14/47 , C12Q1/6883
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
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公开(公告)号：US20060147454A1
公开(公告)日：2006-07-06
申请号：US11357337
申请日：2006-02-21
申请人： Jian Ni , Steven Ruben
发明人： Jian Ni , Steven Ruben
IPC分类号： A61K39/395 , C12Q1/68 , C07H21/04 , C12P21/06 , C12N9/64
CPC分类号： C12N9/6424 , A61K38/00 , C07K14/8121 , C07K2319/00 , C12N2799/026
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
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公开(公告)号：US20060045878A1
公开(公告)日：2006-03-02
申请号：US11048774
申请日：2005-02-03
申请人： Jian Ni , Reiner Gentz , Steven Ruben , Y. Shi
发明人： Jian Ni , Reiner Gentz , Steven Ruben , Y. Shi
IPC分类号： C07H21/04 , A61K39/395 , C07K16/44 , C12N5/06
CPC分类号： C07K14/81 , A61K38/00 , A61K48/00 , C07K14/8132 , C07K2319/00 , Y02A50/463
摘要： The present invention relates to a novel member of the plasminogen activator inhibitor protein family. In particular, isolated nucleic acid molecules are provided encoding the pancreas-derived plasminogen activator inhibitor protein. Pancreas-derived plasminogen activator inhibitor polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to methods for treating physiologic and pathologic disease conditions and diagnostic methods for detecting pathologic disorders.
摘要翻译： 本发明涉及纤溶酶原激活物抑制剂蛋白家族的新成员。 特别地，提供编码胰腺衍生的纤溶酶原激活物抑制蛋白的分离的核酸分子。 还提供了胰腺来源的纤溶酶原激活物抑制剂多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于治疗生理和病理疾病状况的方法以及用于检测病理学疾病的诊断方法。
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