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公开(公告)号：US20060193861A1
公开(公告)日：2006-08-31
申请号：US11416310
申请日：2006-05-03
申请人： Reiner Gentz , Reinhard Ebner , Guo-Liang Yu , Steven Ruben , Jian Ni , Ping Feng
发明人： Reiner Gentz , Reinhard Ebner , Guo-Liang Yu , Steven Ruben , Jian Ni , Ping Feng
CPC分类号： A61K48/005 , A61K38/00 , A61K48/0058 , C07K14/4703 , C07K14/70578 , C07K14/7151 , C07K2319/00 , C07K2319/30 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158
摘要： The present invention relates to novel Tumor Necrosis Factor Receptor proteins. In particular, isolated nucleic acid molecules are provided encoding the human TNFR-6α & -6β proteins. TNFR-6α & -6β polypeptides and antibodies that bind TNFR-6α & -6β polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TNFR-6α & -6β activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译： 本发明涉及新型肿瘤坏死因子受体蛋白。 特别地，提供编码人TNFR-6α和-6β蛋白的分离的核酸分子。 还提供TNFR-6α和-6β多肽和结合TNFR-6α和-6β多肽的抗体，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及鉴定TNFR-6α和-6β活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。
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公开(公告)号：US20060234285A1
公开(公告)日：2006-10-19
申请号：US11419656
申请日：2006-05-22
申请人： Reiner Gentz , Guo-Liang Yu , Jian Ni , Reinhard Ebner , Ping Feng , Steven Ruben
发明人： Reiner Gentz , Guo-Liang Yu , Jian Ni , Reinhard Ebner , Ping Feng , Steven Ruben
IPC分类号： C12Q1/68 , G01N33/574 , A61K38/17 , C07H21/04 , C12P21/06 , C07K14/715
CPC分类号： G01N33/57488 , A61K38/00 , C07K14/70578 , C07K14/7151
摘要： The present invention relates to novel Tumor Necrosis Factor Receptor proteins. In particular, isolated nucleic acid molecules are provided encoding the human TNFR-6α & -6β proteins. TNFR-6α & -6β polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TNFR-6α & -6β activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译： 本发明涉及新型肿瘤坏死因子受体蛋白。 特别地，提供编码人TNFR-6α和-6β蛋白的分离的核酸分子。 还提供了TNFR-6α和-6β多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及鉴定TNFR-6α和-6β活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。
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公开(公告)号：US20050214844A1
公开(公告)日：2005-09-29
申请号：US11111953
申请日：2005-04-22
申请人： Paul Moore , Yanggu Shi , Craig Rosen , Steven Ruben , David Lafleur , Henrik Olsen , Reinhard Ebner , Laurie Brewer , Paul Young , John Greene , Ann Ferrie , Guo-Liang Yu , Jian Ni , Ping Feng
发明人： Paul Moore , Yanggu Shi , Craig Rosen , Steven Ruben , David Lafleur , Henrik Olsen , Reinhard Ebner , Laurie Brewer , Paul Young , John Greene , Ann Ferrie , Guo-Liang Yu , Jian Ni , Ping Feng
IPC分类号： G01N33/53 , A61K38/00 , A61K48/00 , A61P43/00 , C07H21/02 , C07H21/04 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/00 , C12N5/04 , C12N5/06 , C12N5/10 , C12N5/16 , C12N9/00 , C12N15/00 , C12N15/09 , C12N15/10 , C12N15/11 , C12N15/12 , C12P21/02 , C12P21/04 , C12P21/06 , C12Q1/68 , G01N33/566
CPC分类号： C07K14/47
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。
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公开(公告)号：US20060084082A1
公开(公告)日：2006-04-20
申请号：US11144947
申请日：2005-06-06
申请人： Steven Ruben , Craig Rosen , Daniel Soppet , Kenneth Carter , Daniel Bednarik , Gregory Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul Young , John Greene , Ann Ferrie , D. Duan , Jing-Shan Hu , Kimberly Florence , Henrik Olsen , Carrie Fischer , Reinhard Ebner , Laurie Brewer , Paul Moore , Yanggu Shi , David LaFleur , Yi Li , ZhiZhen Zeng , Hla Kyaw
发明人： Steven Ruben , Craig Rosen , Daniel Soppet , Kenneth Carter , Daniel Bednarik , Gregory Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul Young , John Greene , Ann Ferrie , D. Duan , Jing-Shan Hu , Kimberly Florence , Henrik Olsen , Carrie Fischer , Reinhard Ebner , Laurie Brewer , Paul Moore , Yanggu Shi , David LaFleur , Yi Li , ZhiZhen Zeng , Hla Kyaw
CPC分类号： C07K14/4748 , A61K38/00 , C07K14/47 , G01N33/566 , G01N2800/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
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公开(公告)号：US20070238664A1
公开(公告)日：2007-10-11
申请号：US11751886
申请日：2007-05-22
申请人： Steven Ruben , Craig Rosen , Carrie Fischer , Daniel Soppet , Kenneth Carter , Daniel Bednarik , Gregory Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul Young , John Greene , Ann Ferrie , Roxanne Duan , Jing-Shan Hu , Kimberly Florence , Henrik Olsen , Reinhard Ebner , Laurie Brewer , Yanggu Shi
发明人： Steven Ruben , Craig Rosen , Carrie Fischer , Daniel Soppet , Kenneth Carter , Daniel Bednarik , Gregory Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul Young , John Greene , Ann Ferrie , Roxanne Duan , Jing-Shan Hu , Kimberly Florence , Henrik Olsen , Reinhard Ebner , Laurie Brewer , Yanggu Shi
IPC分类号： C07K14/47 , A61K38/00 , C07H21/04 , C12N15/63 , G01N33/53 , G01N33/48 , C07K16/00 , C07K1/00
CPC分类号： C07K14/47 , Y10T436/143333
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。
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公开(公告)号：US20050215775A1
公开(公告)日：2005-09-29
申请号：US10979111
申请日：2004-11-02
申请人： Steven Ruben , Craig Rosen , Carrie Fischer , Daniel Soppet , Kenneth Carter , Daniel Bednarik , Gregory Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul Young , John Greene , Ann Ferrie , D. Duan , Jing-Shan Hu , Kimberly Florence , Henrik Olsen , Reinhard Ebner , Laurie Brewer , Yanggu Shi
发明人： Steven Ruben , Craig Rosen , Carrie Fischer , Daniel Soppet , Kenneth Carter , Daniel Bednarik , Gregory Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul Young , John Greene , Ann Ferrie , D. Duan , Jing-Shan Hu , Kimberly Florence , Henrik Olsen , Reinhard Ebner , Laurie Brewer , Yanggu Shi
CPC分类号： C07K14/47 , Y10T436/143333
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
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公开(公告)号：US20060223077A1
公开(公告)日：2006-10-05
申请号：US11229770
申请日：2005-09-20
申请人： Jian Ni , Reinhard Ebner , David LaFleur , Paul Moore , Henrik Olsen , Craig Rosen , Steven Ruben , Daniel Soppet , Paul Young , Yanggu Shi , Kimberly Florence , Ying-Fei Wei , Charles Florence , Jing-Shan Hu , Yi Li , Hla Kyaw , Carrie Fischer , Ann Ferrie , Ping Fan , Ping Feng , Gregory Endress , Patrick Dillon , Kenneth Carter , Laurie Brewer , Guo-Liang Yu , Zhizhen Zeng , John Greene
发明人： Jian Ni , Reinhard Ebner , David LaFleur , Paul Moore , Henrik Olsen , Craig Rosen , Steven Ruben , Daniel Soppet , Paul Young , Yanggu Shi , Kimberly Florence , Ying-Fei Wei , Charles Florence , Jing-Shan Hu , Yi Li , Hla Kyaw , Carrie Fischer , Ann Ferrie , Ping Fan , Ping Feng , Gregory Endress , Patrick Dillon , Kenneth Carter , Laurie Brewer , Guo-Liang Yu , Zhizhen Zeng , John Greene
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
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公开(公告)号：US20050244845A1
公开(公告)日：2005-11-03
申请号：US10986501
申请日：2004-11-12
申请人： Steven Ruben , Daniel Soppet , Reinhard Ebner , Henrik Olsen , Paul Young , John Greene , Ann Ferrie , Guo-Liang Yu , Jian Ni , Craig Rosen , Laurie Brewer , Fouad Janat , Charles Birse
发明人： Steven Ruben , Daniel Soppet , Reinhard Ebner , Henrik Olsen , Paul Young , John Greene , Ann Ferrie , Guo-Liang Yu , Jian Ni , Craig Rosen , Laurie Brewer , Fouad Janat , Charles Birse
CPC分类号： C07K14/47 , C12Q1/6883
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US20060160126A1
公开(公告)日：2006-07-20
申请号：US11375414
申请日：2006-03-15
申请人： Steven Ruben , Daniel Soppet , Reinhard Ebner , Henrik Olsen , Paul Young , John Greene , Ann Ferrie , Guo-Liang Yu , Jian Ni , Craig Rosen , Laurie Brewer , Fouad Janat , Charles Birse
发明人： Steven Ruben , Daniel Soppet , Reinhard Ebner , Henrik Olsen , Paul Young , John Greene , Ann Ferrie , Guo-Liang Yu , Jian Ni , Craig Rosen , Laurie Brewer , Fouad Janat , Charles Birse
CPC分类号： C07K14/47 , C12Q1/6883
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
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公开(公告)号：US20060099575A9
公开(公告)日：2006-05-11
申请号：US09949925
申请日：2001-09-12
申请人： Steven Ruben , Ann Ferrie , Craig Rosen , Kimberly Florence , Kenneth Carter , Daniel Soppet , Guo-Liang Yu , Charles Florence , Paul Young , Jian Ni , Gregory Endress , Ping Feng , Fouad Janat , Charles Birse
发明人： Steven Ruben , Ann Ferrie , Craig Rosen , Kimberly Florence , Kenneth Carter , Daniel Soppet , Guo-Liang Yu , Charles Florence , Paul Young , Jian Ni , Gregory Endress , Ping Feng , Fouad Janat , Charles Birse
CPC分类号： C07K14/47
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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