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41 条记录 (耗时 0.042 秒)

    Compositions and Methods for Inhibiting Expression of TGF-BETA Receptor Genes
    31.
    发明申请
    Compositions and Methods for Inhibiting Expression of TGF-BETA Receptor Genes 审中-公开
    抑制TGF-β受体基因表达的组合物和方法

    公开(公告)号：US20110119781A1

    公开(公告)日：2011-05-19

    申请号：US13054111

    申请日：2009-07-08

    申请人： Birgit Bramlage ,  Markus Hossbach ,  Pamela Tan ,  Hans-Peter Vamlocher

    发明人： Birgit Bramlage ,  Markus Hossbach ,  Pamela Tan ,  Hans-Peter Vamlocher

    IPC分类号： A01K67/027 ,  C07H21/02 ,  C12N5/10

    CPC分类号： C12N15/1138 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3521

    摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a TGF-beta receptor type I gene, comprising an antisense strand having a nucleotide sequence which is less than 30 nucleotides in length and which is substantially complementary to at least a part of a TGF-beta receptor type I gene. The invention also relates to a pharmaceutical composition comprising the dsRNA or nucleic acid molecules or vectors encoding the same together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of a TGF-beta receptor type I gene using said pharmaceutical composition; and methods for inhibiting the expression of a TGF-beta receptor type I gene in a cell.

    摘要翻译： 本发明涉及用于抑制TGF-β受体I型基因表达的双链核糖核酸（dsRNA），其包含具有长度小于30个核苷酸的核苷酸序列的反义链，并且其与 至少一部分TGF-β受体I型基因。 本发明还涉及包含dsRNA或核酸分子的药物组合物或其编码与其药学上可接受的载体的载体; 使用所述药物组合物治疗由TGF-β受体I型基因表达引起的疾病的方法; 以及用于抑制细胞中TGF-β受体I型基因表达的方法。

    Compositions and methods for inhibiting expression of a gene from the JC virus
    32.
    发明授权
    Compositions and methods for inhibiting expression of a gene from the JC virus 失效
    用于抑制基因从JC病毒表达的组合物和方法

    公开(公告)号：US07691824B2

    公开(公告)日：2010-04-06

    申请号：US11741205

    申请日：2007-04-27

    申请人： Pamela Tan ,  Dinah Sah ,  Birgit Bramlage

    发明人： Pamela Tan ,  Dinah Sah ,  Birgit Bramlage

    IPC分类号： A61K31/70 ,  C07H21/04 ,  C12N21/00 ,  C12N15/00 ,  C12N5/00

    CPC分类号： C12N15/1131 ,  A61K48/005 ,  C07H21/02 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3521

    摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the JC Virus (JC virus genome), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of a gene from the JC Virus. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by JC virus expression and the expression of a gene from the JC Virus using the pharmaceutical composition; and methods for inhibiting the expression of a gene from the JC Virus in a cell.

    摘要翻译： 本发明涉及用于抑制来自JC病毒（JC病毒基因组）的基因表达的双链核糖核酸（dsRNA），其包含长度小于30个核苷酸的核苷酸序列的反义链，通常为19- 长度为25个核苷酸，并且其与来自JC病毒的基因的至少一部分基本互补。 本发明还涉及包含dsRNA与药学上可接受的载体的药物组合物; 用于治疗由JC病毒表达引起的疾病的方法和使用该药物组合物从JC病毒中表达基因的方法; 以及用于抑制细胞中来自JC病毒的基因表达的方法。

    COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF A GENE FROM THE JC VIRUS
    33.
    发明申请
    COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF A GENE FROM THE JC VIRUS 失效
    用于抑制来自JC病毒的基因表达的组合物和方法

    公开(公告)号：US20120022141A1

    公开(公告)日：2012-01-26

    申请号：US13252414

    申请日：2011-10-04

    申请人： Pamela Tan ,  Dinah Sah ,  Birgit Bramlage

    发明人： Pamela Tan ,  Dinah Sah ,  Birgit Bramlage

    IPC分类号： A61K31/713 ,  C12N5/071 ,  A61P31/20 ,  C12N15/113 ,  C12N5/10 ,  C07H21/02 ,  C12N15/63

    CPC分类号： C12N15/1131 ,  A61K48/005 ,  C07H21/02 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3521

    摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the JC Virus (JC virus genome), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of a gene from the JC Virus. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by JC virus expression and the expression of a gene from the JC Virus using the pharmaceutical composition; and methods for inhibiting the expression of a gene from the JC Virus in a cell.

    摘要翻译： 本发明涉及用于抑制来自JC病毒（JC病毒基因组）的基因表达的双链核糖核酸（dsRNA），其包含长度小于30个核苷酸的核苷酸序列的反义链，通常为19- 长度为25个核苷酸，并且其与来自JC病毒的基因的至少一部分基本互补。 本发明还涉及包含dsRNA与药学上可接受的载体的药物组合物; 用于治疗由JC病毒表达引起的疾病的方法和使用该药物组合物从JC病毒中表达基因的方法; 以及用于抑制细胞中来自JC病毒的基因表达的方法。

    Compositions and methods for inhibiting expression of the MYC gene
    34.
    发明授权
    Compositions and methods for inhibiting expression of the MYC gene 有权
    用于抑制MYC基因表达的组合物和方法

    公开(公告)号：US08124752B2

    公开(公告)日：2012-02-28

    申请号：US12373039

    申请日：2007-07-09

    申请人： David Bumcrot ,  Birgit Bramlage ,  Pamela Tan

    发明人： David Bumcrot ,  Birgit Bramlage ,  Pamela Tan

    IPC分类号： C07H21/04

    CPC分类号： C12N15/1135 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/3521

    摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the MYC gene (MYC gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of the MYC gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by MYC gene expression and the expression of the MYC gene using the pharmaceutical composition.

    摘要翻译： 本发明涉及用于抑制MYC基因（MYC基因）表达的双链核糖核酸（dsRNA），其包含具有长度小于30个核苷酸的核苷酸序列的反义链，其长度通常为19-25个核苷酸 并且其与MYC基因的至少一部分基本上互补。 本发明还涉及包含dsRNA与药学上可接受的载体的药物组合物; 用于治疗由MYC基因表达引起的疾病的方法和使用该药物组合物的MYC基因的表达。

    Compositions and methods for inhibiting expression of a gene from the JC virus
    35.
    发明授权
    Compositions and methods for inhibiting expression of a gene from the JC virus 有权
    用于抑制基因从JC病毒表达的组合物和方法

    公开(公告)号：US08058257B2

    公开(公告)日：2011-11-15

    申请号：US12720465

    申请日：2010-03-09

    申请人： Pamela Tan ,  Dinah Sah ,  Birgit Bramlage

    发明人： Pamela Tan ,  Dinah Sah ,  Birgit Bramlage

    IPC分类号： A61K48/06 ,  C07H21/04 ,  C12N15/00

    CPC分类号： C12N15/1131 ,  A61K48/005 ,  C07H21/02 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3521

    摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the JC Virus (JC virus genome), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of a gene from the JC Virus. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by JC virus expression and the expression of a gene from the JC Virus using the pharmaceutical composition; and methods for inhibiting the expression of a gene from the JC Virus in a cell.

    摘要翻译： 本发明涉及用于抑制来自JC病毒（JC病毒基因组）的基因表达的双链核糖核酸（dsRNA），其包含长度小于30个核苷酸的核苷酸序列的反义链，通常为19- 长度为25个核苷酸，并且其与来自JC病毒的基因的至少一部分基本互补。 本发明还涉及包含dsRNA与药学上可接受的载体的药物组合物; 用于治疗由JC病毒表达引起的疾病的方法和使用该药物组合物从JC病毒中表达基因的方法; 以及用于抑制细胞中来自JC病毒的基因表达的方法。

    Compositions and Methods for Inhibiting Expression of the MYC Gene
    38.
    发明申请
    Compositions and Methods for Inhibiting Expression of the MYC Gene 有权
    抑制MYC基因表达的组合物和方法

    公开(公告)号：US20100016405A1

    公开(公告)日：2010-01-21

    申请号：US12373039

    申请日：2007-07-09

    申请人： David Bumcrot ,  Birgit Bramlage ,  Tan Pamela

    发明人： David Bumcrot ,  Birgit Bramlage ,  Tan Pamela

    IPC分类号： A61K31/7088 ,  C07H21/02 ,  C12N5/00 ,  C12N15/09

    CPC分类号： C12N15/1135 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/3521

    摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the MYC gene (MYC gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of the MYC gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by MYC gene expression and the expression of the MYC gene using the pharmaceutical composition.

    摘要翻译： 本发明涉及用于抑制MYC基因（MYC基因）表达的双链核糖核酸（dsRNA），其包含具有长度小于30个核苷酸的核苷酸序列的反义链，其长度通常为19-25个核苷酸 并且其与MYC基因的至少一部分基本上互补。 本发明还涉及包含dsRNA与药学上可接受的载体的药物组合物; 用于治疗由MYC基因表达引起的疾病的方法和使用该药物组合物的MYC基因的表达。