公开(公告)号：US06919461B2

公开(公告)日：2005-07-19

申请号：US10291158

申请日：2002-11-08

申请人： Siegfried Heinz Reich ,  Ted Michael Bleckman ,  Susan Elizabeth Kephart ,  William Henry Romines ,  Michael B. Wallace

发明人： Siegfried Heinz Reich ,  Ted Michael Bleckman ,  Susan Elizabeth Kephart ,  William Henry Romines ,  Michael B. Wallace

IPC分类号： B22D11/10 ,  A61K31/416 ,  A61K31/4184 ,  A61K31/4375 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/5377 ,  A61P9/00 ,  A61P35/00 ,  A61P43/00 ,  B22D41/50 ,  B22D41/56 ,  C07D231/56 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D471/04 ,  C07D521/00

CPC分类号： C07D249/08 ,  B22D41/56 ,  C07D231/12 ,  C07D231/56 ,  C07D233/56 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D471/04 ,  C07F7/1804

摘要： Indazole compounds that modulate and/or inhibit cell proliferation, such as the activity of protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating, e.g., kinases-dependent diseases to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.

摘要翻译： 描述了调节和/或抑制细胞增殖的吲唑化合物，例如蛋白激酶的活性。 这些化合物和含有它们的药物组合物能够介导例如激酶依赖性疾病以调节和/或抑制不期望的细胞增殖。 本发明还涉及含有这些化合物的药物组合物的治疗或预防用途，以及治疗癌症以及与不想要的血管发生和/或细胞增殖相关的其它疾病状态的方法，例如糖尿病性视网膜病变，新生血管性青光眼，类风湿性关节炎 和牛皮癣，通过施用有效量的这种化合物。

公开(公告)号：US06720346B2

公开(公告)日：2004-04-13

申请号：US10190219

申请日：2002-07-05

申请人： Shao Song Chu ,  Larry Andrew Alegria ,  Ted Michael Bleckman ,  Wesley Kwan Mung Chong ,  Rohit K. Duvadie ,  Lin Li ,  Siegfried Heinz Reich ,  William Henry Romines, III ,  Michael B. Wallace ,  Yi Yang

发明人： Shao Song Chu ,  Larry Andrew Alegria ,  Ted Michael Bleckman ,  Wesley Kwan Mung Chong ,  Rohit K. Duvadie ,  Lin Li ,  Siegfried Heinz Reich ,  William Henry Romines, III ,  Michael B. Wallace ,  Yi Yang

IPC分类号： A61K31425

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D277/42 ,  C07D417/12 ,  C07D491/10

摘要： Aminothiazole compounds with mono-/di-substituted benzamide are represented by the Formula (I), and their pharmaceutically acceptable salts, pharmaceutically acceptable prodrugs, pharmaceutically active metabolites, and pharmaceutically acceptable salts of said metabolites are described. These agents modulate and/or inhibit the cell proliferation and activity of protein kinases and are useful as pharmaceuticals for treating malignancies and other disorders.

摘要翻译： 描述了具有单 - 二取代苯甲酰胺的氨基噻唑化合物由式（I）表示，并且描述了其药学上可接受的盐，药学上可接受的前药，药学活性代谢物和所述代谢物的药学上可接受的盐。这些试剂调节和/或抑制 蛋白激酶的细胞增殖和活性，并且可用作治疗恶性肿瘤和其它疾病的药物。

公开(公告)号：US08288536B2

公开(公告)日：2012-10-16

申请号：US12755301

申请日：2010-04-06

申请人： Qing Dong ,  David J. Hosfield ,  Bheema R. Paraselli ,  Nicholas Scorah ,  Jeffrey A. Stafford ,  Michael B. Wallace ,  Zhiyuan Zhang

发明人： Qing Dong ,  David J. Hosfield ,  Bheema R. Paraselli ,  Nicholas Scorah ,  Jeffrey A. Stafford ,  Michael B. Wallace ,  Zhiyuan Zhang

IPC分类号： C07D487/04 ,  A61K31/517 ,  A61P19/02

CPC分类号： C07D487/04

摘要： Compounds, pharmaceutical compositions and kits are provided for use with kinases that comprise a compound selected from the group consisting of: wherein the variables are as defined herein.

摘要翻译： 化合物，药物组合物和试剂盒提供用于包含选自以下的化合物的激酶：其中变量如本文所定义。

公开(公告)号：US20110034865A1

公开(公告)日：2011-02-10

申请号：US12835397

申请日：2010-07-13

申请人： Michael B. Wallace

发明人： Michael B. Wallace

IPC分类号： A61M1/00 ,  A61M25/14

CPC分类号： A61M25/0122 ,  A61M3/0216 ,  A61M3/022 ,  A61M3/0233 ,  A61M3/0283 ,  A61M25/0032 ,  A61M25/007 ,  A61M2025/0034 ,  A61M2210/1064

摘要： A colonic lavage catheter includes a head attached at an end of a suction tube and having both rearward and lateral fluid discharge openings. A pair of tubes extend along the suction tube with their ends attached to the head to place the rearward and lateral fluid discharge openings in fluid communication with a source of pressurized fluid. The suction tube includes a plurality of suction orifices through the outer wall along its length proximate the catheter head. A cleaning process may be performed by inserting the catheter head into the colon and then discharging fluid through the rearward openings to advance the catheter. At points along the colon, pressurized fluid may be discharged through the lateral discharge openings to lavage the adjacent walls of the colon, with suction being applied to draw the dislodged material into the suction tube through the suction orifices.

摘要翻译： 结肠灌洗导管包括附接在吸管的端部并具有向后和向外的流体排出口的头部。 一对管沿着吸管延伸，其端部附接到头部，以使后部和侧向流体排放口与加压流体源流体连通。 抽吸管包括沿其长度靠近导管头的穿过外壁的多个抽吸孔。 可以通过将导管头插入结肠，然后通过后开口排出流体以推进导管来执行清洁过程。 在结肠的点处，加压流体可以通过侧向排出口排出，以冲洗结肠的相邻壁，同时施加抽吸以通过抽吸孔将移动的物质吸入吸管中。

公开(公告)号：US20100160633A1

公开(公告)日：2010-06-24

申请号：US12706837

申请日：2010-02-17

申请人： Jason W. Brown ,  Qing Dong ,  Bheema R. Paraselli ,  Jeffrey A. Stafford ,  Xianchang Gong ,  Yan Liu ,  Nicholas Scorah ,  Michael B. Wallace

发明人： Jason W. Brown ,  Qing Dong ,  Bheema R. Paraselli ,  Jeffrey A. Stafford ,  Xianchang Gong ,  Yan Liu ,  Nicholas Scorah ,  Michael B. Wallace

IPC分类号： C07F9/06

CPC分类号： C07F9/6561 ,  C07D471/04

摘要： Compounds are provided for use with kinases that comprise a compound selected from the group consisting of: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

摘要翻译： 提供化合物用于与包含选自以下的化合物的激酶一起使用：其中变量如本文所定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。

公开(公告)号：US20090124595A1

公开(公告)日：2009-05-14

申请号：US12267353

申请日：2008-11-07

申请人： MarK Adams ,  Qing Dong ,  Toufike Kanouni ,  Stephen W. Kaldor ,  Nicholas Scorah ,  Michael B. Wallace

发明人： MarK Adams ,  Qing Dong ,  Toufike Kanouni ,  Stephen W. Kaldor ,  Nicholas Scorah ,  Michael B. Wallace

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/4375 ,  C07D513/04 ,  C07D498/04 ,  A61P35/04 ,  C12N9/99

CPC分类号： C07D471/04 ,  C07D498/04 ,  C07D513/04

摘要： Compounds of the following formula are provided for use with MEK: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

摘要翻译： 提供下式的化合物用于MEK：其中变量如本文所定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。

公开(公告)号：US20090118324A1

公开(公告)日：2009-05-07

申请号：US12050139

申请日：2008-03-17

申请人： Qing DONG ,  Toufiko Kanounl ,  Michael B. Wallace

发明人： Qing DONG ,  Toufiko Kanounl ,  Michael B. Wallace

IPC分类号： A61K31/436 ,  C07D215/20 ,  C07D471/04 ,  A61P17/06 ,  A61P35/00 ,  A61K31/47 ,  A61P9/10

CPC分类号： C07D215/56 ,  C07D215/38 ,  C07D401/12 ,  C07D471/04 ,  C07D491/052

摘要： Compounds are provided for use with MEK that comprise: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

摘要翻译： 提供了与MEK一起使用的化合物，其包含：其中变量如本文所定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。

公开(公告)号：US07235672B1

公开(公告)日：2007-06-26

申请号：US10800140

申请日：2004-03-11

申请人： Christopher L. Caster ,  Andrew J. Jennings ,  Marc E. Navre ,  Michael B. Wallace ,  Yiqin Wu

发明人： Christopher L. Caster ,  Andrew J. Jennings ,  Marc E. Navre ,  Michael B. Wallace ,  Yiqin Wu

IPC分类号： C07D493/10 ,  G01N33/532 ,  G01N33/533 ,  G01N33/534 ,  G01N33/535 ,  C12Q1/32

CPC分类号： C12Q1/32 ,  C07D493/10 ,  G01N33/531 ,  G01N33/533 ,  G01N2500/00 ,  Y10S435/81 ,  Y10S435/975

摘要： A probe, kit comprising the probe, and methods for using the probe are provided where the probe comprises: wherein DM is a detectable marker; and L is a straight or branched chain moiety providing between 1 and 20 atom separation between DM and the ring atom to which DM is attached.

摘要翻译： 提供包含探针的探针，试剂盒和使用探针的方法，其中探针包含：其中DM是可检测标记; 并且L是直链或支链部分，其提供DM与DM所连接的环原子之间的1至20原子间隔。

公开(公告)号：US06555539B2

公开(公告)日：2003-04-29

申请号：US09761656

申请日：2001-01-18

申请人： Siegfried Heinz Reich ,  Ted Michael Bleckman ,  Susan Elizabeth Kephart ,  William Henry Romines ,  Michael B. Wallace

发明人： Siegfried Heinz Reich ,  Ted Michael Bleckman ,  Susan Elizabeth Kephart ,  William Henry Romines ,  Michael B. Wallace

IPC分类号： A61K31495

CPC分类号： C07D249/08 ,  B22D41/56 ,  C07D231/12 ,  C07D231/56 ,  C07D233/56 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D471/04 ,  C07F7/1804

摘要： Indazole compounds that modulate and/or inhibit cell proliferation, such as the activity of protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating, e.g., kinases-dependent diseases to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.

公开(公告)号：US06462069B2

公开(公告)日：2002-10-08

申请号：US09835566

申请日：2001-04-17

申请人： Siegfried Heinz Reich ,  Michael B. Wallace

发明人： Siegfried Heinz Reich ,  Michael B. Wallace

IPC分类号： A61K314155

CPC分类号： C07D403/04 ,  C07D231/54 ,  C07D401/04 ,  C07D409/04

摘要： Amino-pyrazole compounds that modulate and/or inhibit the activity of protein kinases. These compounds and pharmaceutical compositions containing them are capable of mediating and/or inhibiting the activity cyclin-dependent kinases, thereby modulating and/or inhibiting unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.