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45 条记录 (耗时 0.048 秒)

    Substituted 2-carboxylindoles having pharmaceutical activity
    33.
    发明授权
    Substituted 2-carboxylindoles having pharmaceutical activity 失效
    具有药物活性的取代的2-羧基吲哚

    公开(公告)号：US5145845A

    公开(公告)日：1992-09-08

    申请号：US699875

    申请日：1991-05-14

    申请人： Graham Johnson ,  Thomas C. Malone ,  Po-Wai Yuen

    发明人： Graham Johnson ,  Thomas C. Malone ,  Po-Wai Yuen

    IPC分类号： C07D209/42 ,  C07D403/04 ,  C07D403/06

    CPC分类号： C07D403/04 ,  C07D209/42 ,  C07D403/06

    摘要： The present invention relates to novel compounds, which are derivatives of ureas, thioureas, carbamates, sulfonylureas, sulfonamides, amides, and thioamides of 2-carboxyindoles as illustrated by the formula ##STR1## The invention also relates to methods for the preparation of the novel compounds, as well as to pharmaceutical compositions or methods of use for the novel compounds. More specifically, the compounds of the present invention are useful in the treatment of neurodegenerative disorders including cerebrovascular disorders as well as in the treatment of schizophrenia or epilepsy; and as analgesics and anxiolytics.

    摘要翻译： 本发明涉及新型化合物，其是如下式所示的2-羧基吲哚的脲，硫脲，氨基甲酸酯，磺酰脲，磺酰胺，酰胺和硫代酰胺的衍生物。本发明还涉及制备该新颖物质的方法 化合物，以及用于新化合物的药物组合物或使用方法。 更具体地，本发明的化合物可用于治疗神经变性疾病，包括脑血管障碍以及治疗精神分裂症或癫痫; 并作为镇痛药和抗焦虑药。

    Therapeutic pyrazolo[3,4-b]pyridines and indazoles
    37.
    发明申请
    Therapeutic pyrazolo[3,4-b]pyridines and indazoles 失效
    治疗性吡唑并[3,4-b]吡啶和吲唑

    公开(公告)号：US20060217376A1

    公开(公告)日：2006-09-28

    申请号：US11446277

    申请日：2006-06-02

    申请人： Po-Wai Yuen

    发明人： Po-Wai Yuen

    IPC分类号： A61K31/5377 ,  C07D413/02

    CPC分类号： C07D231/56 ,  C07D401/04 ,  C07D403/12 ,  C07D413/12 ,  C07D471/04

    摘要： The present invention provides for compounds of Formula I: wherein R2, R3, R4, R5, R6, R7, X, and L have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of central nervous disorders and conditions including attention deficit hyperactivity disorder, neuropathic pain, urinary incontinence, anxiety, depression, and schizophrenia and fibromyalgia. Also provided are pharmaceutical compositions comprising one or more compounds of Formula I.

    摘要翻译： 本发明提供式I化合物：其中R 2，R 3，R 4，R 5， R 6，R 7，X和L具有说明书中定义的任何值及其药学上可接受的盐，其可用作治疗 中枢神经障碍和包括注意缺陷多动障碍，神经性疼痛，尿失禁，焦虑，抑郁和精神分裂症以及纤维肌痛的疾病。 还提供了包含一种或多种式I化合物的药物组合物。

    3-heteroarylalkyl substituted gaba analogs
    39.
    发明授权
    3-heteroarylalkyl substituted gaba analogs 失效
    3-杂芳基烷基取代的gaba类似物

    公开(公告)号：US06710190B1

    公开(公告)日：2004-03-23

    申请号：US09979344

    申请日：2001-11-21

    申请人： Po-Wai Yuen

    发明人： Po-Wai Yuen

    IPC分类号： C07D30752

    CPC分类号： C07D307/54 ,  C07D333/24

    摘要： The invention is a novel series of compounds which are useful in the treatment of epilepsy, faintness attacks, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, gastrointestinal disorders such as irritable bowel syndrome (IBS), and inflammation, especially arthritis. A pharmaceutical composition containing a compound of the invention as well as methods of preparing the compounds and novel intermediates useful in the preparation of the final compounds are included.

    摘要翻译： 本发明是可用于治疗癫痫，微弱发作，神经退行性疾病，抑郁症，焦虑症，恐慌症，疼痛，神经病理学障碍，胃肠道疾病如肠易激综合征（IBS）和炎症，特别是关节炎的新一系列化合物 。 包括含有本发明化合物的药物组合物以及制备化合物的方法和用于制备最终化合物的新中间体。