Abstract:
A 3-phenylthiomethylstyrene derivative having the general formula (1): ##STR1## or salt thereof with a base, when X is hydroxyl group, R.sup.1 is hydrogen atom or R.sup.2 is hydrogen atom, a process for preparing the 3-phenylthiomethylstyrene derivative (1), and an antiallergic agent and a tyrosinekinase inhibiting agent containing the 3-phenylthiomethylstyrene derivative (1) as an effective component. The compound (1) of the present invention is a useful intermediate for preparing various organic compounds, and has excellent antiallergic and tyrosinekinase inhibiting activities.
Abstract:
A triple-layer electrode structure or a multilayer interconnecting structure of a semiconductor device comprising a contact (a lower conductive) layer of aluminum or its alloy which comes into contact with a silicon substrate, a barrier layer of refractory metal nitride (e.g. titanium nitride) and refractory metal (e.g., tungsten), and a (upper) conductive layer of aluminum or its alloy. The TiN-W barrier layer prevents overdissolution of silicon into aluminum in spite of heat-treatment at a relatively elevated temperature. The barrier layer is formed by sintering a mixture of refractory metal nitride powder and refractory metal powder to form a target which is sputter deposited on the contact layer in an atomsphere excluding gaseous nitrogen.
Abstract:
The disclosed permanent magnet has a coercive force of larger than 500 Oe, a residual magnetic flux density of larger than 5 kG, and a maximum energy product of larger than 2 MGOe, and it consisting essentially of 48.about.66.9 Atm % of iron, 33.about.47 Atm % of platinum, and 0.1.about.10 Atm % of niobium. It includes a crystal structure of an incomplete single .gamma..sub.1 phase of a face-centered tetragonal system due to either the composition thereof or heat treatment applied thereto. The permanent magnet is made by heating an alloy of the above main composition at 900.degree..about.400.degree. for one minute to ten hours and quenching the alloy at a high speed of faster than 30.degree. C./minute but slower than 2,000.degree. C./sec.
Abstract:
The present invention relates to .beta.-lactam compound having the formula (I): ##STR1## wherein R.sup.1 is a trialkylsilyl group, dimethyl-1,1,2-trimethylpropylsilyl group, acetyl group, benzyloxycarbonyl group, O-nitrobenzyloxycarbonyl group, p-nitrobenzyloxycarbonyl group or t-butyl group, R.sup.2, R.sup.3 and R.sup.4 are a member selected from the group consisting of a lower alkyl group having 1 to 6 carbon atoms, phenyl group and an aralkyl group and a process for preparing the compound which comprises reacting enolsilylethers having the formula (III): ##STR2## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as above, with chlorosulfonylisocyanate and then reducing the obtained product. The .beta.-lactam compound of the present invention is a useful intermediate for preparing carbapenem .beta.-lactam compound.
Abstract:
A process for preparing N-[1(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanyl-L-proline, which comprises reacting N-carboxyanhydride of N-[1(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine with L-proline in the presence of a base. According to the process, enalapril can be prepared economically, easily and effectively.
Abstract:
A process for preparing the optically active oxazolidinone derivative [(S)-I] by utilizing microorganisms or enzymes having a stereoselective esterase activity capable of asymmetrically hydrolyzing the racemates of the acyloxyoxazolidinone derivative [(R,S)-II], by separating the unreacted compound [(S)-II] from the hydrolyzed compound [(R)-I] and by hydrolyzing the compound [(S)-II]. The compounds are useful as intermediates for preparing optically active .beta.-adrenergic blocking agents.
Abstract:
The disclosed permanent magnet consists of an iron-palladium alloy consisting of 25 to 40 atomic % of palladium, and the remainder of iron with less than 0.5 atomic % of impurities or an iron-palladium-silver alloy consisting of 19.5 atomic % of palladium, 0.1 to 27.5 atomic % of silver and the remainder of iron with less than 0.5 atomic % of impurities and having a crystalline structure with fine dispersion of .alpha.+.gamma..sub.1 phase in a matrix, so that the permanent magnet has a coercive force of higher than 500 Oe, a residual magnetic flux density of larger than 6 kG, and a maximum energy product of larger than 2 MG.Oe. The disclosed method of producing the aforementioned permanent magnet comprises steps of homogenizing solid solution treatment at a temperature depending on the specific alloy composition, cooling, and tempering at a suitable temperature so as to generate the aforementioned crystalline structure.
Abstract:
A process is disclosed in which an optically active monoalkyl ester of .beta.-(S)-aminoglutaric acid is prepared by subjecting a dialkyl ester of .beta.-protected aminoglutaric acid to the action of a culture broth, cells, or treated cells of a microorganism capable of stereoselectively hydrolyzing only one of the ester groups in the above-mentioned dialkyl ester to produce an optically active monoalkyl ester of .beta.-protected (S)-aminoglutaric acid, and then removing the amino-protecting group from the product. An optically active monoalkyl ester of .beta.-(S)-aminoglutaric acid is useful as a starting material for synthesizing .beta.-lactam antibiotics of carbapenem type such as thienamycin.
Abstract:
A process is disclosed wherein an optically active .beta.-mercaptoalkanoic acid represented by formula (I): ##STR1## wherein R.sub.1 is lower alkyl having from 1 to 4 carbon atoms, is prepared by(1) reacting an optically active .beta.-hydroxyalkanoic acid represented by formula (II): ##STR2## wherein R.sub.1 is the same as defined above, with a halogenating reagent to prepare an optically active .beta.-haloalkanoyl halide represented by formula (III): ##STR3## wherein X is halogen and R.sub.1 is the same as defined above; (2) reacting the .beta.-haloalkanoyl halide with water or an aqueous alkaline solution to prepare an optically active .beta.-haloalkanoic acid represented by formula (IV): ##STR4## wherein X and R.sub.1 are each the same as defined above, or a salt thereof, respectively; and(3) reacting the .beta.-haloalkanoic acid or the salt thereof with a reagent capable of converting the halogen into the thiol group, the configuration of the compound (II), (III), and (IV) being retained throughout the process to prepare the compound represented by formula (I). The product of the present invention is useful as an intermediate for preparation of an antihypertensive agent such as N-(3-mercapto-2-D-methylpropanoyl)-L-proline.
Abstract:
A finisher 100 includes a pair of bundle discharge rollers 130, a lower stack tray 137, and a width-direction aligning portion 200. The width-direction aligning portion includes a pair of aligning members 1 and a driving motor. The aligning member includes a pair of first aligning members 91 that is rotatably supported while being movable in the sheet width direction orthogonal to the discharge direction and a pair of second aligning members 92. The driving motor rotates the pair of first aligning members and moves the pair of first aligning members in the width direction. When the pair of first aligning members rotates and one of the pair of second aligning members abuts on the sheet, the pair of second aligning members forms opposite surfaces in which the sheet can be aligned in the width direction, and the pair of first aligning members align the sheet by the opposite surfaces.