公开(公告)号：US20150246354A1

公开(公告)日：2015-09-03

申请号：US14667615

申请日：2015-03-24

Applicant: Massachusetts Institute of Technology

Inventor： Rohit Nandkumar Karnik ,  Seungpyo Hong ,  Ying Mei ,  Daniel Griffith Anderson ,  Jeffrey Michael Karp ,  Robert S. Langer ,  Suman Bose

IPC: B01L3/00 ,  C12M3/06 ,  C12M1/00

CPC classification number: C12N5/0068 ,  B01L3/502715 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0877 ,  B01L2300/16 ,  C12M23/16 ,  C12M47/02 ,  C12N5/0062 ,  C12N2501/58 ,  C12N2501/585 ,  C12N2533/50 ,  C12N2533/52 ,  C12N2535/10

Abstract: The present invention provides systems for cell separation based on cell rolling on surfaces along edges of regions coated with cell adhesion molecules. A variety of designs of coated regions and edges are disclosed.

Abstract translation: 本发明提供了基于在细胞粘附分子包被的区域的边缘上的表面上的细胞滚动的细胞分离系统。 公开了涂覆区域和边缘的各种设计。

公开(公告)号：US20140322309A1

公开(公告)日：2014-10-30

申请号：US14364028

申请日：2012-12-15

Applicant: Massachusetts Institute of Technology

Inventor： Arturo Jose Vegas ,  Kathryn Ann Whitehead ,  Daniel Griffith Anderson ,  Robert S. Langer ,  Joseph R. Dorkin

IPC: A61K47/34 ,  A61K31/713 ,  C08G12/34 ,  A61K39/00 ,  C12N15/113 ,  C08G12/06 ,  A61K33/00 ,  A61K38/16

CPC classification number: A61K47/34 ,  A61K9/1271 ,  A61K9/5146 ,  A61K31/713 ,  A61K33/00 ,  A61K38/16 ,  A61K39/00 ,  C08G12/06 ,  C08G12/34 ,  C08G73/00 ,  C08L79/00 ,  C12N15/113

Abstract: α-Aminoamidine polymers and methods of preparing a-aminoamidine polymers by reacting by reacting one or more amines with one or more isocyanides and one or more aldehydes are described. Methods of preparing a-aminoamidine polymers from commercially available starting materials are also provided, wherein the starting materials are racemic or stereochemically pure. a-Aminoamidine polymers or salt forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems and for other purposes as well such as, for example, coatings, additives, excipients, plastics, and materials, etc. Given the amino moiety of these α-aminoamidine polymers, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive α-aminoamidine polymers and polynucleotides can be prepared. The inventive α-aminoamidine polymers may also be used in preparing microparticles for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.

Abstract translation: α-氨基脒聚合物和通过使一种或多种胺与一种或多种异氰化物和一种或多种醛反应而制备α-氨基脒聚合物的方法。 还提供了从市售的原料制备α-氨基脒聚合物的方法，其中原料是外消旋或立体化学纯的。 α-氨基脒聚合物或其盐形式优选是可生物降解和生物相容的，并且可以用于各种药物递送系统和用于其它目的，例如涂料，添加剂，赋形剂，塑料和材料等。给定 这些α-氨基脒聚合物的氨基部分特别适用于递送多核苷酸。 可以制备含有本发明α-氨基脒聚合物和多核苷酸的复合物，胶束，脂质体或颗粒。 本发明的α-氨基脒聚合物也可用于制备用于药物递送的微粒。 考虑到缓冲其周围环境的pH值，它们特别适用于提供不稳定剂。

公开(公告)号：US20250049714A1

公开(公告)日：2025-02-13

申请号：US18717095

申请日：2022-12-08

Applicant: Massachusetts Institute of Technology

Inventor： Daniel Griffith Anderson ,  Luke Hyunsik Rhym ,  Bowen Li ,  Akiva Gordon ,  Manan Rajith Singh ,  Jacob Witten

IPC: A61K9/127 ,  A61K9/00 ,  A61K9/16 ,  A61K9/51 ,  A61K31/7105 ,  A61K31/711 ,  C07C229/12 ,  C07C229/16 ,  C07D207/06 ,  C07D213/38 ,  C07D255/02 ,  C07D295/13 ,  C12N15/88

Abstract: Provided herein are compounds, such as compounds of Formula (I), and pharmaceutically acceptable salts, hydrates, solvates, polymorphs, co-crystals, tautomers, stereoisomers, and isotopically labeled derivatives thereof, and compositions, methods, uses, and kits thereof. The compounds provided herein are lipids useful for delivery of polynucleotides, such as mRNA, for the treatment and/or prevention of various diseases and conditions (e.g., genetic disease, proliferative disease, hematological disease, neurological disease, liver disease, spleen disease, lung disease, painful condition, psychiatric disorder, musculoskeletal disease, a metabolic disorder, inflammatory disease, or autoimmune disease).

公开(公告)号：US11608412B2

公开(公告)日：2023-03-21

申请号：US16663585

申请日：2019-10-25

Applicant: Massachusetts Institute of Technology

Inventor： James C. Kaczmarek ,  Daniel Griffith Anderson ,  Luke Hyunsik Rhym ,  Kevin John Kauffman ,  Asha Kumari Patel

IPC: C08G63/685 ,  A61K47/59 ,  A61K47/54 ,  A61K47/28 ,  C08G63/56 ,  A61K31/7105

Abstract: The present disclosure relates to improvements in the selection and formulation of PBAE polymers using a design of experiment approach, in which statistical methods are used to limit possible experimental conditions. The present disclosure relates to improved PBAE polymers and formulations.

公开(公告)号：US20220054642A1

公开(公告)日：2022-02-24

申请号：US17517111

申请日：2021-11-02

Applicant: Massachusetts Institute of Technology

Inventor： Matthew J. Webber ,  Eric Andrew Appel ,  Robert S. Langer ,  Daniel Griffith Anderson

IPC: A61K47/54 ,  A61K47/60 ,  A61K47/34 ,  C07K14/62 ,  C07D519/00 ,  C07K14/605 ,  A61K47/68 ,  A61K38/26 ,  A61K38/28 ,  C07K16/28

Abstract: The modification of biomolecules, small molecules, and other agents of via conjugation of excipients, tags, or labels is of great importance. For example, the modification of therapeutic agents can confer improved stability, solubility, duration of action, or pharmacological properties. Supramolecular chemistry utilizes specific, directional, reversible, non-covalent molecular recognition motifs in order to achieve organization of molecules, and can be used to complex tags to agents of interest (e.g., insulin, glucagon, antibodies). The present invention provides useful supramolecular complexes wherein an agent of interest is specifically bound to a host via non-covalent interactions, and wherein the host is conjugated to a tag. The present invention also provides methods and compounds useful in preparing supramolecular complexes, and methods of treating diseases using the supramolecular complexes.

公开(公告)号：US11191841B2

公开(公告)日：2021-12-07

申请号：US15765585

申请日：2016-10-06

Applicant: Massachusetts Institute of Technology

Inventor： Matthew J. Webber ,  Eric Andrew Appel ,  Robert S. Langer ,  Daniel Griffith Anderson

IPC: A61K47/60 ,  A61K47/34 ,  C07K14/62 ,  C07D519/00 ,  C07K14/605 ,  A61K47/54 ,  A61K47/68 ,  A61K38/26 ,  A61K38/28 ,  C07K16/28

Abstract: The modification of biomolecules, small molecules, and other agents of via conjugation of excipients, tags, or labels is of great importance. For example, the modification of therapeutic agents can confer improved stability, solubility, duration of action, or pharmacological properties. Supramolecular chemistry utilizes specific, directional, reversible, non-covalent molecular recognition motifs in order to achieve organization of molecules, and can be used to complex tags to agents of interest (e.g., insulin, glucagon, antibodies). The present invention provides useful supramolecular complexes wherein an agent of interest is specifically bound to a host via non-covalent interactions, and wherein the host is conjugated to a tag. The present invention also provides methods and compounds useful in preparing supramolecular complexes, and methods of treating diseases using the supramolecular complexes.

公开(公告)号：US20200330501A1

公开(公告)日：2020-10-22

申请号：US16867291

申请日：2020-05-05

Applicant: Massachusetts Institute of Technology

Inventor： Yizhou Dong ,  Kevin Love ,  Robert S. Langer ,  Daniel Griffith Anderson ,  Delai Chen ,  Yi Chen ,  Arturo Jose Vegas ,  Akinleye C. Alabi ,  Yunlong Zhang

IPC: A61K31/7105 ,  C07D233/64 ,  C07D403/06 ,  C07D241/08 ,  C07C229/12 ,  C07C229/22 ,  C07C229/26 ,  C07D487/06 ,  C07D207/16 ,  C07D209/20 ,  C07C271/22 ,  C07C229/36 ,  C07C237/08 ,  C07C237/12 ,  C12N15/88 ,  C12N15/87 ,  C07C229/24 ,  C07C279/14 ,  C07C323/58 ,  C07D209/24 ,  C07D265/32 ,  C07D413/06 ,  C07D487/04 ,  C12Q1/02 ,  G01N33/15 ,  A61K31/711 ,  A61K47/22

Abstract: Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R′, R1, R2, R3, R4, R5, R8, Z, W, Y, and Z are as defined herein.

公开(公告)号：US10736966B2

公开(公告)日：2020-08-11

申请号：US14825127

申请日：2015-08-12

Applicant: Massachusetts Institute of Technology

Inventor： Yizhou Dong ,  Joseph R. Dorkin ,  Robert S. Langer ,  Daniel Griffith Anderson

IPC: A61K38/18 ,  A61K9/127 ,  C08G69/48 ,  C08G69/50 ,  A61K47/48 ,  C08G73/00 ,  C08L79/00 ,  A61K47/60 ,  A61K47/69 ,  A61K47/54 ,  A61K47/59 ,  A61K48/00 ,  C12N15/113

Abstract: The present disclosure provides brush-poly(glycoamidoamine)-lipids (PGALs) (e.g., polymers of any one of Formulae (I)-(IV)) and methods of preparing the PGALs. A described PGAL may include poly(glycoamidoamine)-derived moieties (e.g., such as which may assist the PGAL and/or a complex of the PGAL and an agent to pass through cell membranes or be taken up by cells. Also provided are compositions including a described PGAL and an agent (e.g., polynucleotide, small molecule, peptide, or protein). The present disclosure also provides methods, kits, and uses that include or involve the PGALs or compositions for delivering an agent to a subject, tissue, or cell and/or for treating and/or preventing in a subject a range of diseases, such as genetic diseases, proliferative diseases, hematological diseases, neurological diseases, immunological diseases, gastrointestinal diseases, respiratory diseases, painful conditions, psychiatric disorders, musculoskeletal diseases, genitourinary diseases, and metabolic disorders

公开(公告)号：US10695444B2

公开(公告)日：2020-06-30

申请号：US16268902

申请日：2019-02-06

Applicant: Massachusetts Institute of Technology

Inventor： Daniel Griffith Anderson ,  Joseph R. Dorkin ,  Owen Shea Fenton ,  Kevin John Kauffman ,  Rebecca L. McClellan

IPC: A61K48/00 ,  C07D241/08 ,  A61K47/54 ,  A61K38/18

Abstract: Provided herein are compounds of Formula (I), and salts thereof, wherein each instance of RL is independently optionally substituted C6-C40 alkenyl. Further provided are compositions comprising a compound of Formula (I) and an agent. Further provided are methods and kits using the compositions for delivering an agent to a subject or cell and for treating and/or preventing a range of diseases. Further provided are methods of preparing compounds of Formula (I) and precursors thereof.

公开(公告)号：US10682374B2

公开(公告)日：2020-06-16

申请号：US16126897

申请日：2018-09-10

Applicant: Massachusetts Institute of Technology

Inventor： Yizhou Dong ,  Kevin Thomas Love ,  Robert S. Langer ,  Daniel Griffith Anderson ,  Delai Chen ,  Yi Chen ,  Arturo Jose Vegas ,  Akinleye C. Alabi ,  Yunlong Zhang

IPC: A61K31/7105 ,  C07D233/64 ,  C07D403/06 ,  C07D241/08 ,  C07C229/12 ,  C07C229/22 ,  C07C229/26 ,  C07D487/06 ,  C07D207/16 ,  C07D209/20 ,  C07C271/22 ,  C07C229/36 ,  C07C237/08 ,  C07C237/12 ,  C12N15/88 ,  C12N15/87 ,  C07C229/24 ,  C07C279/14 ,  C07C323/58 ,  C07D209/24 ,  C07D265/32 ,  C07D413/06 ,  C07D487/04 ,  C12Q1/02 ,  G01N33/15 ,  A61K31/711 ,  A61K47/22

Abstract: Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R′, R1, R2, R3, R4, R5, R8, Z, W, Y, and Z are as defined herein.