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公开(公告)号：US20090306022A1
公开(公告)日：2009-12-10
申请号：US12481368
申请日：2009-06-09
申请人： Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Ismail , Todd Bowser , Beena Bhatia , David Messersmith , Laura McIntyre , Darrell Koza , Glen Rennie , Paul Sheahan , Paul Hawkins , Atul Verma , Tadeusz Warchol , Upul Bandarage
发明人： Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Ismail , Todd Bowser , Beena Bhatia , David Messersmith , Laura McIntyre , Darrell Koza , Glen Rennie , Paul Sheahan , Paul Hawkins , Atul Verma , Tadeusz Warchol , Upul Bandarage
IPC分类号： A61K31/65 , C07C237/26 , C07D277/38 , C07D333/24 , C07D213/56 , C07D307/54 , C07D239/52 , C07D413/06 , C07D239/34
CPC分类号： C07D213/64 , C07C237/26 , C07C251/24 , C07C251/48 , C07C271/22 , C07C271/28 , C07C271/58 , C07C275/24 , C07C311/06 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2603/46 , C07D207/22 , C07D213/50 , C07D213/56 , C07D239/36 , C07D261/18 , C07D277/30 , C07D277/42 , C07D295/096 , C07D295/135 , C07D295/155 , C07D307/54 , C07D307/68 , C07D307/79 , C07D317/60 , C07D333/24 , C07D333/28 , C07D333/60 , C07F9/2475
摘要： The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译： 本发明至少部分地涉及新的7-取代四环素化合物。 这些四环素化合物可用于治疗多种四环素化合物反应状态，例如细菌感染和肿瘤，以及其他已知的米诺环素和四环素化合物的一般应用，例如阻断四环素外排和调节基因表达。
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公开(公告)号：US20110081316A1
公开(公告)日：2011-04-07
申请号：US12896042
申请日：2010-10-01
IPC分类号： A61K31/4439 , C07D401/06 , C07D401/14 , C07D403/10 , A61K31/498 , A61K31/4709 , A61P37/00 , A61P29/00 , A61P25/00 , A61K38/21 , A61K39/395 , C12N9/99
CPC分类号： C07D401/08 , C07D401/14 , C07D403/08
摘要： The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作PI3K抑制剂，特别是PI3Kγ的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US20100316605A1
公开(公告)日：2010-12-16
申请号：US12796825
申请日：2010-06-09
IPC分类号： A61K38/21 , C07D417/14 , A61K31/4439 , C07D401/14 , A61K31/444 , C07D277/44 , A61K31/426 , A61K31/397 , A61K31/4545 , C07D241/42 , A61K31/498 , C07D215/12 , A61K31/4709 , C07D471/04 , A61K31/4375 , C07D413/14 , A61K31/5377 , A61K39/395 , A61P9/10 , A61P25/00 , A61P29/00 , A61P37/02 , C12N9/99
CPC分类号： C07D417/06
摘要： The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作PI3K抑制剂，特别是PI3Kγ的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US20090325908A1
公开(公告)日：2009-12-31
申请号：US12351405
申请日：2009-01-09
申请人： Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Y. Ismail , Todd Bowser , Jimmy Dumornay , Glen Rennie , Gui Liu , Darrell J. Koza , Paul Sheahan , Karen Stapleton , Paul Hawkins , Beena Bhatia , Atul K. Verma , Laura Honeyman , Tadeusz Warchol , David Messersmith
发明人： Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Y. Ismail , Todd Bowser , Jimmy Dumornay , Glen Rennie , Gui Liu , Darrell J. Koza , Paul Sheahan , Karen Stapleton , Paul Hawkins , Beena Bhatia , Atul K. Verma , Laura Honeyman , Tadeusz Warchol , David Messersmith
IPC分类号： A61K31/65 , C07C237/26
CPC分类号： A61K31/65 , C07C237/26 , C07C255/59 , C07C271/22 , C07C271/28 , C07C271/30 , C07C271/58 , C07C275/30 , C07C275/34 , C07C275/38 , C07C275/40 , C07C275/42 , C07C275/50 , C07C275/54 , C07C311/06 , C07C311/21 , C07C333/08 , C07C335/22 , C07C381/10 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2603/46 , C07D295/155 , C07F9/4006 , C07F9/4056 , Y02A50/473 , Y02A50/481
摘要： The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译： 本发明至少部分地涉及新的9-取代的米诺环素化合物。 这些米诺环素化合物可用于治疗多种四环素化合物反应状态，例如细菌感染和肿瘤，以及其他已知的米诺环素和四环素化合物的一般应用，例如阻断四环素外排和调节基因表达。
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35.发明申请LNG SYSTEM EMPLOYING STACKED VERTICAL HEAT EXCHANGERS TO PROVIDE LIQUID REFLUX STREAM 有权液化天然气系统采用堆叠垂直热交换器提供液体反射流公开(公告)号：US20080022716A1
公开(公告)日：2008-01-31
申请号：US11869824
申请日：2007-10-10
申请人： Anthony Eaton , David Messersmith , Ed Bailey
发明人： Anthony Eaton , David Messersmith , Ed Bailey
IPC分类号： F25J1/00
CPC分类号： F28F5/00 , F25J1/0022 , F25J1/004 , F25J1/0052 , F25J1/0085 , F25J1/0087 , F25J1/021 , F25J1/0258 , F25J1/0274 , F25J3/0209 , F25J3/0233 , F25J3/0238 , F25J5/002 , F25J5/005 , F25J2200/02 , F25J2200/04 , F25J2200/70 , F25J2200/76 , F25J2205/02 , F25J2210/06 , F25J2250/02 , F25J2250/10 , F25J2270/12 , F25J2270/60 , F25J2290/40 , F25J2290/80 , Y10S62/903
摘要： An improved apparatus and method for providing reflux to a refluxed heavies removal column of a LNG facility. The system withdraws a fraction of a predominately methane refrigerant from a methane refrigeration cycle of the LNG facility. The withdrawn methane refrigerant is then cooled in an auxiliary heat exchange system by indirect heat exchange with a refrigerant that is also used to cool the natural gas feed stream upstream of the heavies removal column. The resulting cooled predominately methane steam is then employed as reflux to the heavies removal column.
摘要翻译： 一种改进的装置和方法，用于向LNG设备的回流重质除去塔提供回流。 该系统从LNG设施的甲烷制冷循环中提取了主要甲烷制冷剂的一部分。 然后将所抽出的甲烷制冷剂在辅助热交换系统中通过与还用于冷却重质拆除塔上游天然气进料流的制冷剂进行间接热交换来冷却。 然后将所得冷却的主要甲烷蒸汽用作回流至重质除去塔。
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36.发明授权LNG system employing optimized heat exchangers to provide liquid reflux stream 有权LNG系统采用优化的热交换器提供液体回流公开(公告)号：US07310971B2
公开(公告)日：2007-12-25
申请号：US10972795
申请日：2004-10-25
IPC分类号： F25J1/00
CPC分类号： F28F5/00 , F25J1/0022 , F25J1/004 , F25J1/0052 , F25J1/0085 , F25J1/0087 , F25J1/021 , F25J1/0258 , F25J1/0274 , F25J3/0209 , F25J3/0233 , F25J3/0238 , F25J5/002 , F25J5/005 , F25J2200/02 , F25J2200/04 , F25J2200/70 , F25J2200/76 , F25J2205/02 , F25J2210/06 , F25J2250/02 , F25J2250/10 , F25J2270/12 , F25J2270/60 , F25J2290/40 , F25J2290/80 , Y10S62/903
摘要： An improved apparatus and method for providing reflux to a refluxed heavies removal column of a LNG facility. The apparatus comprises stacked vertical core-in-kettle heat exchangers and an economizer disposed between the heat exchangers. The reflux stream originates from the methane-rich refrigerant of the methane refrigeration cycle. The liquid reflux stream generated by cooling the methane-rich stream in the vertical heat exchangers via indirect heat exchange with an upstream refrigerant.
摘要翻译： 一种改进的装置和方法，用于向LNG设备的回流重质除去塔提供回流。 该装置包括堆叠的垂直锅炉内热交换器和设置在热交换器之间的节能器。 回流物流来自甲烷制冷循环的富含甲烷的制冷剂。 通过经由与上游制冷剂的间接热交换将垂直热交换器中的富甲烷流冷却而产生的液体回流物流。
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公开(公告)号：US09518570B2
公开(公告)日：2016-12-13
申请号：US13445673
申请日：2012-04-12
申请人： David Messersmith , Andrew Jaap
发明人： David Messersmith , Andrew Jaap
CPC分类号： F04B17/00 , F04B49/065 , H02K15/125 , H02P29/62 , H02P2207/01
摘要： A motor controller includes a motor winding heater function. The motor controller applies a predefined current to one or more of the motor windings without the use of additional dedicated motor winding heater devices. The motor controller serves to control the operation of the motor, while the motor windings serve both as a heater at times and to produce torque at times.
摘要翻译： 电机控制器包括电机绕组加热器功能。 电动机控制器将一个预定义的电流施加到一个或多个电动机绕组，而不使用附加的专用电动机绕组加热器装置。 电动机控制器用于控制电动机的操作，而电动机绕组有时用作加热器并且有时产生转矩。
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公开(公告)号：US20130271060A1
公开(公告)日：2013-10-17
申请号：US13445673
申请日：2012-04-12
申请人： David Messersmith , Andrew Jaap
发明人： David Messersmith , Andrew Jaap
IPC分类号： H02P1/24
CPC分类号： F04B17/00 , F04B49/065 , H02K15/125 , H02P29/62 , H02P2207/01
摘要： A motor controller includes a motor winding heater function. The motor controller applies a predefined current to one or more of the motor windings without the use of additional dedicated motor winding heater devices. The motor controller serves to control the operation of the motor, while the motor windings serve both as a heater at times and to produce torque at times.
摘要翻译： 电机控制器包括电机绕组加热器功能。 电动机控制器将一个预定义的电流施加到一个或多个电动机绕组，而不使用附加的专用电动机绕组加热器装置。 电动机控制器用于控制电动机的操作，而电动机绕组有时用作加热器并且有时产生转矩。
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39.发明授权LNG system employing stacked vertical heat exchangers to provide liquid reflux stream 有权LNG系统采用堆叠式立式热交换器提供液体回流公开(公告)号：US08424340B2
公开(公告)日：2013-04-23
申请号：US11869824
申请日：2007-10-10
CPC分类号： F28F5/00 , F25J1/0022 , F25J1/004 , F25J1/0052 , F25J1/0085 , F25J1/0087 , F25J1/021 , F25J1/0258 , F25J1/0274 , F25J3/0209 , F25J3/0233 , F25J3/0238 , F25J5/002 , F25J5/005 , F25J2200/02 , F25J2200/04 , F25J2200/70 , F25J2200/76 , F25J2205/02 , F25J2210/06 , F25J2250/02 , F25J2250/10 , F25J2270/12 , F25J2270/60 , F25J2290/40 , F25J2290/80 , Y10S62/903
摘要： An improved apparatus and method for providing reflux to a refluxed heavies removal column of a LNG facility. The system withdraws a fraction of a predominately methane refrigerant from a methane refrigeration cycle of the LNG facility. The withdrawn methane refrigerant is then cooled in an auxiliary heat exchange system by indirect heat exchange with a refrigerant that is also used to cool the natural gas feed stream upstream of the heavies removal column. The resulting cooled predominately methane steam is then employed as reflux to the heavies removal column.
摘要翻译： 一种改进的装置和方法，用于向LNG设备的回流重质除去塔提供回流。 该系统从LNG设施的甲烷制冷循环中提取了主要甲烷制冷剂的一部分。 然后将所抽出的甲烷制冷剂在辅助热交换系统中通过与还用于冷却重质拆除塔上游天然气进料流的制冷剂进行间接热交换来冷却。 然后将所得冷却的主要甲烷蒸汽用作回流至重质除去塔。
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公开(公告)号：US20120283201A1
公开(公告)日：2012-11-08
申请号：US13547870
申请日：2012-07-12
申请人： Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Y. Ismail , Todd Bowser , Jimmy Dumornay , Glen Rennie , Gui Liu , Darrell J. Koza , Paul Sheahan , Karen Stapleton , Paul Hawkins , Beena Bhalie , Atul K. Verma , Laura Honeyman , Tadeusz Warchol , David Messersmith
发明人： Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Y. Ismail , Todd Bowser , Jimmy Dumornay , Glen Rennie , Gui Liu , Darrell J. Koza , Paul Sheahan , Karen Stapleton , Paul Hawkins , Beena Bhalie , Atul K. Verma , Laura Honeyman , Tadeusz Warchol , David Messersmith
IPC分类号： A61K31/65 , C07C275/40 , C07C271/30 , C07D307/81 , C07D333/24 , C07D317/60 , C07F9/40 , A61K31/662 , C07C311/21 , C07C255/60 , C07F7/10 , A61K31/695 , C07D295/155 , C07C275/54 , C07C335/20 , C07C311/05 , C07D213/56 , C07C279/18 , C07H15/203 , A61K31/7034 , A61P31/04 , A61P35/00 , C07D213/64 , C07C237/26
CPC分类号： A61K31/65 , C07C237/26 , C07C255/59 , C07C271/22 , C07C271/28 , C07C271/30 , C07C271/58 , C07C275/30 , C07C275/34 , C07C275/38 , C07C275/40 , C07C275/42 , C07C275/50 , C07C275/54 , C07C311/06 , C07C311/21 , C07C333/08 , C07C335/22 , C07C381/10 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2603/46 , C07D295/155 , C07F9/4006 , C07F9/4056 , Y02A50/473 , Y02A50/481
摘要： The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译： 本发明至少部分地涉及新的9-取代的米诺环素化合物。 这些米诺环素化合物可用于治疗多种四环素化合物反应状态，例如细菌感染和肿瘤，以及其他已知的米诺环素和四环素化合物的一般应用，例如阻断四环素外排和调节基因表达。
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