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公开(公告)号：US08492365B2
公开(公告)日：2013-07-23
申请号：US12481368
申请日：2009-06-09
申请人： Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Ismail , Todd Bowser , Beena Bhatia , David Messersmith , Laura McIntyre , Darrell Koza , Glen Rennie , Paul Sheahan , Paul Hawkins , Atul Verma , Tadeusz Warchol , Upul Bandarage
发明人： Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Ismail , Todd Bowser , Beena Bhatia , David Messersmith , Laura McIntyre , Darrell Koza , Glen Rennie , Paul Sheahan , Paul Hawkins , Atul Verma , Tadeusz Warchol , Upul Bandarage
IPC分类号： A61K31/65 , A61K31/42 , A61K31/426 , A61K31/4402 , A61K31/505 , A61K31/5375 , C07C237/26 , C07D239/26 , C07D295/104 , C07D261/08 , C07D277/42
CPC分类号： C07D213/64 , C07C237/26 , C07C251/24 , C07C251/48 , C07C271/22 , C07C271/28 , C07C271/58 , C07C275/24 , C07C311/06 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2603/46 , C07D207/22 , C07D213/50 , C07D213/56 , C07D239/36 , C07D261/18 , C07D277/30 , C07D277/42 , C07D295/096 , C07D295/135 , C07D295/155 , C07D307/54 , C07D307/68 , C07D307/79 , C07D317/60 , C07D333/24 , C07D333/28 , C07D333/60 , C07F9/2475
摘要： The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
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公开(公告)号：US20090306022A1
公开(公告)日：2009-12-10
申请号：US12481368
申请日：2009-06-09
申请人： Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Ismail , Todd Bowser , Beena Bhatia , David Messersmith , Laura McIntyre , Darrell Koza , Glen Rennie , Paul Sheahan , Paul Hawkins , Atul Verma , Tadeusz Warchol , Upul Bandarage
发明人： Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Ismail , Todd Bowser , Beena Bhatia , David Messersmith , Laura McIntyre , Darrell Koza , Glen Rennie , Paul Sheahan , Paul Hawkins , Atul Verma , Tadeusz Warchol , Upul Bandarage
IPC分类号： A61K31/65 , C07C237/26 , C07D277/38 , C07D333/24 , C07D213/56 , C07D307/54 , C07D239/52 , C07D413/06 , C07D239/34
CPC分类号： C07D213/64 , C07C237/26 , C07C251/24 , C07C251/48 , C07C271/22 , C07C271/28 , C07C271/58 , C07C275/24 , C07C311/06 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2603/46 , C07D207/22 , C07D213/50 , C07D213/56 , C07D239/36 , C07D261/18 , C07D277/30 , C07D277/42 , C07D295/096 , C07D295/135 , C07D295/155 , C07D307/54 , C07D307/68 , C07D307/79 , C07D317/60 , C07D333/24 , C07D333/28 , C07D333/60 , C07F9/2475
摘要： The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译： 本发明至少部分地涉及新的7-取代四环素化合物。 这些四环素化合物可用于治疗多种四环素化合物反应状态，例如细菌感染和肿瘤，以及其他已知的米诺环素和四环素化合物的一般应用，例如阻断四环素外排和调节基因表达。
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公开(公告)号：US20050038002A1
公开(公告)日：2005-02-17
申请号：US10740961
申请日：2003-12-18
申请人： Mark Nelson , Kwasi Ohemeng , Roger Frechette , Paul Abato , Victor Amoo , Upul Bandarage , Joel Berniac , Beena Bhatia , Jackson Chen , Mohamed Ismail , Oak Kim , Laura Honeyman , Rachid Mechiche , Andre Pearson , Laxma Nagavelli , Paul Sheahan , Atul Verma , Peter Viski , Tadeusz Warchol
发明人： Mark Nelson , Kwasi Ohemeng , Roger Frechette , Paul Abato , Victor Amoo , Upul Bandarage , Joel Berniac , Beena Bhatia , Jackson Chen , Mohamed Ismail , Oak Kim , Laura Honeyman , Rachid Mechiche , Andre Pearson , Laxma Nagavelli , Paul Sheahan , Atul Verma , Peter Viski , Tadeusz Warchol
IPC分类号： C07D295/20 , A61K31/65 , A61P31/04 , A61P43/00 , C07C237/26 , C07C239/18 , C07C245/20 , C07C251/08 , C07C251/48 , C07C255/25 , C07C255/43 , C07C255/58 , C07C255/59 , C07C271/28 , C07C271/44 , C07C275/34 , C07C279/18 , C07C281/14 , C07C309/61 , C07C311/06 , C07C311/19 , C07C311/21 , C07C317/48 , C07C323/32 , C07C323/60 , C07D207/16 , C07D211/58 , C07D213/30 , C07D213/61 , C07D213/65 , C07D213/75 , C07D239/26 , C07D239/30 , C07D239/42 , C07D261/10 , C07D261/18 , C07D295/108 , C07D295/155 , C07D295/215 , C07D307/28 , C07D307/52 , C07D307/54 , C07D307/68 , C07D317/54 , C07D317/60 , C07D401/04 , C07F7/10
CPC分类号： C07D307/52 , C07C237/26 , C07C239/18 , C07C251/08 , C07C251/48 , C07C255/25 , C07C255/43 , C07C255/58 , C07C255/59 , C07C271/28 , C07C271/44 , C07C275/34 , C07C279/18 , C07C281/14 , C07C309/61 , C07C311/19 , C07C311/21 , C07C317/48 , C07C323/32 , C07C323/60 , C07C2603/46 , C07D207/16 , C07D211/58 , C07D213/30 , C07D213/61 , C07D213/65 , C07D213/75 , C07D239/26 , C07D239/30 , C07D239/42 , C07D261/10 , C07D261/18 , C07D295/108 , C07D295/155 , C07D295/215 , C07D307/28 , C07D307/68 , C07D317/54 , C07D401/04
摘要： The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译： 本发明至少部分地涉及新的取代的四环素化合物。 这些四环素化合物可用于治疗多种四环素化合物反应状态，例如细菌感染和肿瘤，以及其他已知的米诺环素和四环素化合物的一般应用，例如阻断四环素外排和调节基因表达。
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公开(公告)号：US20100160263A1
公开(公告)日：2010-06-24
申请号：US12617111
申请日：2009-11-12
申请人： Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Ismail , Todd Bowser , Laura McIntyre , Beena Bhatia , Paul Hawkins , Laxma Reddy Nagavelli , Karen Stepleton , Tad Warchol , Paul Sheahan
发明人： Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Ismail , Todd Bowser , Laura McIntyre , Beena Bhatia , Paul Hawkins , Laxma Reddy Nagavelli , Karen Stepleton , Tad Warchol , Paul Sheahan
IPC分类号： A61K31/65 , C07C237/26 , C07D403/10 , C07D213/30 , C07D215/14 , A61P31/00
CPC分类号： C07C237/26 , B32B37/0007 , B32B37/003 , B32B37/1284 , C07C2601/14 , C07C2601/16 , C07C2603/46 , C07D209/48 , C07D213/82 , C07D215/14 , C07D307/24 , C07D317/60
摘要： The present invention pertains to novel 7,9-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译： 本发明涉及新的7,9-取代的四环素化合物。 这些四环素化合物可用于治疗多种四环素化合物反应状态，例如细菌感染和肿瘤，以及其他已知的米诺环素和四环素化合物的一般应用，例如阻断四环素外排和调节基因表达。
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公开(公告)号：US06683068B2
公开(公告)日：2004-01-27
申请号：US09895797
申请日：2001-06-29
申请人： Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Ismail , Todd Bowser , Laura McIntyre , Beena Bhatia , Paul Hawkins , Laxma Reddy , Karen Stapleton , Tad Warchol , Paul Sheahan
发明人： Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Ismail , Todd Bowser , Laura McIntyre , Beena Bhatia , Paul Hawkins , Laxma Reddy , Karen Stapleton , Tad Warchol , Paul Sheahan
IPC分类号： A61K3165
CPC分类号： C07C237/26 , B32B37/0007 , B32B37/003 , B32B37/1284 , C07C2601/14 , C07C2601/16 , C07C2603/46 , C07D209/48 , C07D213/82 , C07D215/14 , C07D307/24 , C07D317/60
摘要： The present invention pertains to novel 7,9-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译： 本发明涉及新的7,9-取代的四环素化合物。 这些四环素化合物可用于治疗多种四环素化合物反应状态，例如细菌感染和肿瘤，以及其他已知的米诺环素和四环素化合物的一般应用，例如阻断四环素外排和调节基因表达。
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公开(公告)号：US20050026875A1
公开(公告)日：2005-02-03
申请号：US10737361
申请日：2003-12-15
申请人： Mark Nelson , Kwasi Ohemeng , Roger Frechette , Paul Abato , Victor Amoo , Haregewein Assefa , Joel Berniac , Beena Bhatia , Todd Bowser , Jackson Chen , Laura Honeyman , Mohamed Ismail , Oak Kim , Rachid Mechiche , N. Reddy , Atul Verma , Peter Viski , Tadeusz Warchol , Ivan Yanachkov
发明人： Mark Nelson , Kwasi Ohemeng , Roger Frechette , Paul Abato , Victor Amoo , Haregewein Assefa , Joel Berniac , Beena Bhatia , Todd Bowser , Jackson Chen , Laura Honeyman , Mohamed Ismail , Oak Kim , Rachid Mechiche , N. Reddy , Atul Verma , Peter Viski , Tadeusz Warchol , Ivan Yanachkov
IPC分类号： C07D295/14 , A61K31/65 , A61P1/02 , A61P1/04 , A61P1/12 , A61P1/16 , A61P3/10 , A61P9/00 , A61P9/10 , A61P9/12 , A61P9/14 , A61P11/00 , A61P13/02 , A61P13/10 , A61P15/00 , A61P15/14 , A61P17/00 , A61P17/02 , A61P17/16 , A61P19/00 , A61P19/02 , A61P19/08 , A61P19/10 , A61P21/00 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P27/02 , A61P27/16 , A61P29/00 , A61P29/02 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/06 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/06 , A61P37/08 , A61P43/00 , C07C237/26 , C07C275/34 , C07C323/60 , C07D207/06 , C07D207/16 , C07D207/20 , C07D207/327 , C07D207/335 , C07D207/40 , C07D207/404 , C07D209/44 , C07D211/58 , C07D211/70 , C07D213/20 , C07D213/56 , C07D213/74 , C07D213/82 , C07D213/89 , C07D231/12 , C07D233/36 , C07D261/10 , C07D261/14 , C07D261/18 , C07D263/22 , C07D277/14 , C07D277/20 , C07D277/42 , C07D277/56 , C07D295/18 , C07D295/20 , C07D307/54 , C07D317/66 , C07D211/06 , C07D265/30
CPC分类号： C07D207/404 , C07C237/26 , C07C239/20 , C07C255/58 , C07C271/22 , C07C275/34 , C07C323/60 , C07C335/12 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/46 , C07D207/16 , C07D207/20 , C07D207/335 , C07D209/44 , C07D211/58 , C07D211/70 , C07D213/20 , C07D213/64 , C07D213/82 , C07D213/89 , C07D231/12 , C07D261/10 , C07D261/14 , C07D261/18 , C07D277/42 , C07D277/56 , C07D295/116 , C07D295/155 , C07D295/215 , C07D307/52 , C07D307/54 , C07D317/66 , C07D335/02
摘要： Aminomethyl substituted tetracycline compounds, pharmaceutical compositions, and methods of use thereof are discussed.
摘要翻译： 讨论了氨基甲基取代的四环素化合物，药物组合物及其使用方法。
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公开(公告)号：US20080015169A1
公开(公告)日：2008-01-17
申请号：US11810336
申请日：2007-06-05
申请人： Mark Nelson , Kwasi Ohemeng , Roger Frechette , Paul Abato , Victor Amoo , Haregewein Assefa , Joel Berniac , Beena Bhatia , Todd Bowser , Jackson Chen , Laura Honeyman , Mohamed Ismail , Oak Kim , Rachid Mechiche , N. Reddy , Atul Verma , Peter Viski , Tadeusz Warchol , Ivan Yanachkov
发明人： Mark Nelson , Kwasi Ohemeng , Roger Frechette , Paul Abato , Victor Amoo , Haregewein Assefa , Joel Berniac , Beena Bhatia , Todd Bowser , Jackson Chen , Laura Honeyman , Mohamed Ismail , Oak Kim , Rachid Mechiche , N. Reddy , Atul Verma , Peter Viski , Tadeusz Warchol , Ivan Yanachkov
IPC分类号： A61K31/65 , A61K31/40 , A61K31/426 , A61P25/00 , A61P29/00 , A61P35/00 , C07D237/26 , C07D295/00 , C07D277/02 , C07D227/00 , A61P31/04 , A61P27/02 , A61P11/00 , A61K31/435
CPC分类号： C07D207/404 , C07C237/26 , C07C239/20 , C07C255/58 , C07C271/22 , C07C275/34 , C07C323/60 , C07C335/12 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/46 , C07D207/16 , C07D207/20 , C07D207/335 , C07D209/44 , C07D211/58 , C07D211/70 , C07D213/20 , C07D213/64 , C07D213/82 , C07D213/89 , C07D231/12 , C07D261/10 , C07D261/14 , C07D261/18 , C07D277/42 , C07D277/56 , C07D295/116 , C07D295/155 , C07D295/215 , C07D307/52 , C07D307/54 , C07D317/66 , C07D335/02
摘要： Aminomethyl substituted tetracycline compounds, pharmaceutical compositions, and methods of use thereof are discussed.
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公开(公告)号：US20050026876A1
公开(公告)日：2005-02-03
申请号：US10786881
申请日：2004-02-24
申请人： Mark Nelson , Roger Frechette , Mohamed Ismail , Laura Honeyman , Todd Bowser , Beena Bhatia
发明人： Mark Nelson , Roger Frechette , Mohamed Ismail , Laura Honeyman , Todd Bowser , Beena Bhatia
IPC分类号： A61K31/65 , C07D221/22 , C07D335/06
CPC分类号： C07C237/26 , C07D317/66
摘要： The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and minocycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译： 本发明至少部分地涉及新的9-取代的米诺环素化合物。 这些米诺环素化合物可用于治疗许多四环素化合物反应状态，例如细菌感染和肿瘤，以及其他已知的米诺环素和米诺环素化合物的一般应用，例如阻断四环素外排和调节基因表达。
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公开(公告)号：US20050143352A1
公开(公告)日：2005-06-30
申请号：US10877928
申请日：2004-06-25
申请人： Mark Nelson , Kwasi Ohemeng , Paul Abato , Victor Amoo , Haregewein Assefa , Joel Berniac , Beena Bhatia , Todd Bowser , Jackson Chen , Mark Grier , Laura Honeyman , Mohamed Ismail , Oak Kim , Jude Mathews , Rachid Mechiche
发明人： Mark Nelson , Kwasi Ohemeng , Paul Abato , Victor Amoo , Haregewein Assefa , Joel Berniac , Beena Bhatia , Todd Bowser , Jackson Chen , Mark Grier , Laura Honeyman , Mohamed Ismail , Oak Kim , Jude Mathews , Rachid Mechiche
IPC分类号： C07C237/26 , C07C271/22 , C07C271/54 , C07C275/28 , C07C275/30 , A61K31/65 , C07D221/18
CPC分类号： C07C237/48 , A61K31/65 , C07C237/26 , C07C271/22 , C07C271/54 , C07C275/28 , C07C275/30 , C07C2601/02 , C07C2601/14 , C07C2601/16 , C07C2603/46 , Y02A50/411 , Y02A50/473
摘要： The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译： 本发明至少部分地涉及新的取代的四环素化合物。 这些四环素化合物可用于治疗许多四环素化合物反应状态，例如细菌感染和肿瘤，以及四环素化合物的其它已知应用，例如阻断四环素外排和调节基因表达。
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公开(公告)号：US20060166945A1
公开(公告)日：2006-07-27
申请号：US11258622
申请日：2005-10-25
申请人： Paul Abato , Haregewein Assefa , Joel Berniac , Beena Bhatia , Todd Bowser , Jackson Chen , Mark Grier , Laura Honeyman , Mohamed Ismail , Mark Nelson , Kwasi Ohemeng , Jingwen Pan
发明人： Paul Abato , Haregewein Assefa , Joel Berniac , Beena Bhatia , Todd Bowser , Jackson Chen , Mark Grier , Laura Honeyman , Mohamed Ismail , Mark Nelson , Kwasi Ohemeng , Jingwen Pan
IPC分类号： C07C237/26 , A61K31/65
CPC分类号： C07D471/04 , C07C237/26 , C07C251/48 , C07C255/59 , C07C259/10 , C07C271/18 , C07C271/22 , C07C271/24 , C07C2601/02 , C07C2603/46 , C07D207/335 , C07D207/337 , C07D211/70 , C07D213/30 , C07D213/38 , C07D213/61 , C07D213/73 , C07D213/74 , C07D213/84 , C07D231/12 , C07D233/64 , C07D239/26 , C07D239/42 , C07D241/12 , C07D261/08 , C07D263/32 , C07D277/28 , C07D277/30 , C07D295/096 , C07D295/155 , C07D295/192 , C07D307/46 , C07D307/52 , C07D307/54 , C07D309/14 , C07D333/20 , C07D333/24 , C07D333/38 , C07D403/06 , C07D405/06 , C07D405/12 , C07D413/12 , C07D487/04
摘要： The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds such as blocking tetracycline efflux and modulation of gene expression.
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