-
公开(公告)号:US20120283201A1
公开(公告)日:2012-11-08
申请号:US13547870
申请日:2012-07-12
申请人: Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Y. Ismail , Todd Bowser , Jimmy Dumornay , Glen Rennie , Gui Liu , Darrell J. Koza , Paul Sheahan , Karen Stapleton , Paul Hawkins , Beena Bhalie , Atul K. Verma , Laura Honeyman , Tadeusz Warchol , David Messersmith
发明人: Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Y. Ismail , Todd Bowser , Jimmy Dumornay , Glen Rennie , Gui Liu , Darrell J. Koza , Paul Sheahan , Karen Stapleton , Paul Hawkins , Beena Bhalie , Atul K. Verma , Laura Honeyman , Tadeusz Warchol , David Messersmith
IPC分类号: A61K31/65 , C07C275/40 , C07C271/30 , C07D307/81 , C07D333/24 , C07D317/60 , C07F9/40 , A61K31/662 , C07C311/21 , C07C255/60 , C07F7/10 , A61K31/695 , C07D295/155 , C07C275/54 , C07C335/20 , C07C311/05 , C07D213/56 , C07C279/18 , C07H15/203 , A61K31/7034 , A61P31/04 , A61P35/00 , C07D213/64 , C07C237/26
CPC分类号: A61K31/65 , C07C237/26 , C07C255/59 , C07C271/22 , C07C271/28 , C07C271/30 , C07C271/58 , C07C275/30 , C07C275/34 , C07C275/38 , C07C275/40 , C07C275/42 , C07C275/50 , C07C275/54 , C07C311/06 , C07C311/21 , C07C333/08 , C07C335/22 , C07C381/10 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2603/46 , C07D295/155 , C07F9/4006 , C07F9/4056 , Y02A50/473 , Y02A50/481
摘要: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译: 本发明至少部分地涉及新的9-取代的米诺环素化合物。 这些米诺环素化合物可用于治疗多种四环素化合物反应状态,例如细菌感染和肿瘤,以及其他已知的米诺环素和四环素化合物的一般应用,例如阻断四环素外排和调节基因表达。
-
公开(公告)号:US20090325908A1
公开(公告)日:2009-12-31
申请号:US12351405
申请日:2009-01-09
申请人: Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Y. Ismail , Todd Bowser , Jimmy Dumornay , Glen Rennie , Gui Liu , Darrell J. Koza , Paul Sheahan , Karen Stapleton , Paul Hawkins , Beena Bhatia , Atul K. Verma , Laura Honeyman , Tadeusz Warchol , David Messersmith
发明人: Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Y. Ismail , Todd Bowser , Jimmy Dumornay , Glen Rennie , Gui Liu , Darrell J. Koza , Paul Sheahan , Karen Stapleton , Paul Hawkins , Beena Bhatia , Atul K. Verma , Laura Honeyman , Tadeusz Warchol , David Messersmith
IPC分类号: A61K31/65 , C07C237/26
CPC分类号: A61K31/65 , C07C237/26 , C07C255/59 , C07C271/22 , C07C271/28 , C07C271/30 , C07C271/58 , C07C275/30 , C07C275/34 , C07C275/38 , C07C275/40 , C07C275/42 , C07C275/50 , C07C275/54 , C07C311/06 , C07C311/21 , C07C333/08 , C07C335/22 , C07C381/10 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2603/46 , C07D295/155 , C07F9/4006 , C07F9/4056 , Y02A50/473 , Y02A50/481
摘要: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译: 本发明至少部分地涉及新的9-取代的米诺环素化合物。 这些米诺环素化合物可用于治疗多种四环素化合物反应状态,例如细菌感染和肿瘤,以及其他已知的米诺环素和四环素化合物的一般应用,例如阻断四环素外排和调节基因表达。
-
公开(公告)号:US08048867B2
公开(公告)日:2011-11-01
申请号:US10839023
申请日:2004-05-04
申请人: Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Y. Ismail , Todd Bowser , Jimmy Dumornay , Glen Rennie , Gui Liu , Darrell J. Koza , Paul Sheahan , Karen Stapleton , Paul Hawkins , Beena Bhatia , Atul K. Verma , Laura McIntyre , Tadeusz Warchol , David Messersmith
发明人: Mark L. Nelson , Roger Frechette , Peter Viski , Mohamed Y. Ismail , Todd Bowser , Jimmy Dumornay , Glen Rennie , Gui Liu , Darrell J. Koza , Paul Sheahan , Karen Stapleton , Paul Hawkins , Beena Bhatia , Atul K. Verma , Laura McIntyre , Tadeusz Warchol , David Messersmith
IPC分类号: A61K31/59 , C07C401/00
CPC分类号: A61K31/65 , C07C237/26 , C07C255/59 , C07C271/22 , C07C271/28 , C07C271/30 , C07C271/58 , C07C275/30 , C07C275/34 , C07C275/38 , C07C275/40 , C07C275/42 , C07C275/50 , C07C275/54 , C07C311/06 , C07C311/21 , C07C333/08 , C07C335/22 , C07C381/10 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2603/46 , C07D295/155 , C07F9/4006 , C07F9/4056 , Y02A50/473 , Y02A50/481
摘要: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译: 本发明至少部分地涉及新的9-取代的米诺环素化合物。 这些米诺环素化合物可用于治疗多种四环素化合物反应状态,例如细菌感染和肿瘤,以及其他已知的米诺环素和四环素化合物的一般应用,例如阻断四环素外排和调节基因表达。
-
公开(公告)号:US07595309B2
公开(公告)日:2009-09-29
申请号:US10853635
申请日:2004-05-24
申请人: Mark L. Nelson , Roger Frechette , Peter Viski , Beena Bhatia , David Messersmith , Mohamed Y. Ismail , Todd Bowser , Laura McIntyre , Darrell J. Koza , Glen Rennie , Paul Sheahan , Paul Hawkins , Atul K. Verma , Tadeusz Warchol , Upul Bandarage
发明人: Mark L. Nelson , Roger Frechette , Peter Viski , Beena Bhatia , David Messersmith , Mohamed Y. Ismail , Todd Bowser , Laura McIntyre , Darrell J. Koza , Glen Rennie , Paul Sheahan , Paul Hawkins , Atul K. Verma , Tadeusz Warchol , Upul Bandarage
IPC分类号: A61K31/65 , C07C43/00 , C07D221/18
CPC分类号: C07D213/64 , C07C237/26 , C07C251/24 , C07C251/48 , C07C271/22 , C07C271/28 , C07C271/58 , C07C275/24 , C07C311/06 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2603/46 , C07D207/22 , C07D213/50 , C07D213/56 , C07D239/36 , C07D261/18 , C07D277/30 , C07D277/42 , C07D295/096 , C07D295/135 , C07D295/155 , C07D307/54 , C07D307/68 , C07D307/79 , C07D317/60 , C07D333/24 , C07D333/28 , C07D333/60 , C07F9/2475
摘要: The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译: 本发明至少部分地涉及新的7-取代四环素化合物。 这些四环素化合物可用于治疗多种四环素化合物反应状态,例如细菌感染和肿瘤,以及其他已知的米诺环素和四环素化合物的一般应用,例如阻断四环素外排和调节基因表达。
-
公开(公告)号:US07326696B2
公开(公告)日:2008-02-05
申请号:US10737361
申请日:2003-12-15
申请人: Mark L. Nelson , Kwasi Ohemeng , Roger Frechette , Paul Abato , Victor Amoo , Haregewein Assefa , Joel Berniac , Beena Bhatia , Todd Bowser , Jackson Chen , Laura Honeyman , Mohamed Y. Ismail , Oak Kim , Rachid Mechiche , N. Laxma Reddy , Atul K. Verma , Peter Viski , Tadeusz Warchol , Ivan Yanachkov
发明人: Mark L. Nelson , Kwasi Ohemeng , Roger Frechette , Paul Abato , Victor Amoo , Haregewein Assefa , Joel Berniac , Beena Bhatia , Todd Bowser , Jackson Chen , Laura Honeyman , Mohamed Y. Ismail , Oak Kim , Rachid Mechiche , N. Laxma Reddy , Atul K. Verma , Peter Viski , Tadeusz Warchol , Ivan Yanachkov
CPC分类号: C07D207/404 , C07C237/26 , C07C239/20 , C07C255/58 , C07C271/22 , C07C275/34 , C07C323/60 , C07C335/12 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/46 , C07D207/16 , C07D207/20 , C07D207/335 , C07D209/44 , C07D211/58 , C07D211/70 , C07D213/20 , C07D213/64 , C07D213/82 , C07D213/89 , C07D231/12 , C07D261/10 , C07D261/14 , C07D261/18 , C07D277/42 , C07D277/56 , C07D295/116 , C07D295/155 , C07D295/215 , C07D307/52 , C07D307/54 , C07D317/66 , C07D335/02
摘要: Aminomethyl substituted tetracycline compounds, pharmaceutical compositions, and methods of use thereof are discussed.
摘要翻译: 讨论了氨基甲基取代的四环素化合物,药物组合物及其使用方法。
-
公开(公告)号:US20110086822A1
公开(公告)日:2011-04-14
申请号:US12901196
申请日:2010-10-08
申请人: Mark L. Nelson , Kwasi Ohemeng , Roger Frechette , Paul Abato , Victor Amoo , Upul Bandarage , Joel Berniac , Beena Bhatia , Jackson Chen , Mohamed Y. Ismail , Oak Kim , Laura Honeyman , Rachid Mechiche , Andre Pearson , Laxma Reddy Nagavelli , Paul Sheahan , Atul K. Verma , Peter Viski , Tadeusz Warchol
发明人: Mark L. Nelson , Kwasi Ohemeng , Roger Frechette , Paul Abato , Victor Amoo , Upul Bandarage , Joel Berniac , Beena Bhatia , Jackson Chen , Mohamed Y. Ismail , Oak Kim , Laura Honeyman , Rachid Mechiche , Andre Pearson , Laxma Reddy Nagavelli , Paul Sheahan , Atul K. Verma , Peter Viski , Tadeusz Warchol
IPC分类号: A61K31/65 , C07C237/26 , C07D307/02 , C07D493/00 , C07D211/00 , C07D405/06 , C07D265/30 , A61P31/04
CPC分类号: C07D307/52 , C07C237/26 , C07C239/18 , C07C251/08 , C07C251/48 , C07C255/25 , C07C255/43 , C07C255/58 , C07C255/59 , C07C271/28 , C07C271/44 , C07C275/34 , C07C279/18 , C07C281/14 , C07C309/61 , C07C311/19 , C07C311/21 , C07C317/48 , C07C323/32 , C07C323/60 , C07C2603/46 , C07D207/16 , C07D211/58 , C07D213/30 , C07D213/61 , C07D213/65 , C07D213/75 , C07D239/26 , C07D239/30 , C07D239/42 , C07D261/10 , C07D261/18 , C07D295/108 , C07D295/155 , C07D295/215 , C07D307/28 , C07D307/68 , C07D317/54 , C07D401/04
摘要: The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译: 本发明至少部分地涉及新的取代的四环素化合物。 这些四环素化合物可用于治疗多种四环素化合物反应状态,例如细菌感染和肿瘤,以及其他已知的米诺环素和四环素化合物的一般应用,例如阻断四环素外排和调节基因表达。
-
公开(公告)号:US20100305072A1
公开(公告)日:2010-12-02
申请号:US11963540
申请日:2007-12-21
申请人: Oak K. Kim , Mark L. Nelson , Paul Abato , Haregewein Assefa , Joel Bernaiac , Mohamed Y. Ismail , Todd Bowser , Mark Grier , Beena Bhatia , Atul K. Verma , Laura Honeyman , Jingwen Pan
发明人: Oak K. Kim , Mark L. Nelson , Paul Abato , Haregewein Assefa , Joel Bernaiac , Mohamed Y. Ismail , Todd Bowser , Mark Grier , Beena Bhatia , Atul K. Verma , Laura Honeyman , Jingwen Pan
IPC分类号: A61K31/65 , C07C237/26 , C07D211/34 , C07D265/30 , A61P31/00
CPC分类号: C07C237/26 , C07C2603/46 , C07D207/20 , C07D207/50 , C07D211/14 , C07D231/12 , C07D239/20 , C07D239/26 , C07D241/12 , C07D261/02 , C07D261/04 , C07D263/32 , C07D265/02 , C07D265/30 , C07D295/13 , C07D307/52
摘要: The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms.
摘要翻译: 本发明至少部分地涉及新的取代的四环素化合物。 这些四环素化合物可用于治疗许多四环素化合物反应状态,如细菌感染和赘生物。
-
8.
公开(公告)号:US07405235B2
公开(公告)日:2008-07-29
申请号:US10700661
申请日:2003-11-03
申请人: Stuart B. Levy , Michael N. Alekshun , Brent L. Podlogar , Kwasi Ohemeng , Atul K. Verma , Tadeusz Warchol , Beena Bhatia , Todd Bowser , Mark Grier
发明人: Stuart B. Levy , Michael N. Alekshun , Brent L. Podlogar , Kwasi Ohemeng , Atul K. Verma , Tadeusz Warchol , Beena Bhatia , Todd Bowser , Mark Grier
IPC分类号: A61K31/415 , C07D235/00
CPC分类号: A61K31/40 , A61K31/407 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/44 , A61K31/47 , A61K31/4745 , A61K31/495 , A61K31/50 , A61K31/505 , A61K31/535 , A61K31/55 , A61K31/555 , Y02A50/401 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483
摘要: Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.
摘要翻译: 提供了可用作降低微生物的抗性,毒力或生长的抗感染药物的取代的苯并咪唑化合物。 制备和使用取代的苯并咪唑化合物的方法,以及其药物制剂,例如降低抗生素抗性和抑制生物膜。
-
9.
公开(公告)号:US20090131401A1
公开(公告)日:2009-05-21
申请号:US12069723
申请日:2008-02-12
申请人: Stuart B. Levy , Michael N. Alekshun , Brent L. Podlogar , Kwasi Ohemeng , Atul K. Verma , Tadeusz Warchol , Beena Bhatia , Todd Bowser , Mark Grier
发明人: Stuart B. Levy , Michael N. Alekshun , Brent L. Podlogar , Kwasi Ohemeng , Atul K. Verma , Tadeusz Warchol , Beena Bhatia , Todd Bowser , Mark Grier
IPC分类号: A61K31/553 , C07D498/04 , C12N1/36 , C07D235/04 , C07D401/02 , A61K31/422 , C07D403/02 , A61K31/427 , A61K31/5377 , A61P31/04 , C07D267/02 , A61K31/496 , A61K31/55 , C07D403/04 , C07D417/02 , A61K31/4439 , A61K31/4184 , C07D413/02 , C07K1/00 , C11D3/28
CPC分类号: A61K31/40 , A61K31/407 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/44 , A61K31/47 , A61K31/4745 , A61K31/495 , A61K31/50 , A61K31/505 , A61K31/535 , A61K31/55 , A61K31/555 , Y02A50/401 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/483
摘要: Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.
摘要翻译: 提供了可用作降低微生物的抗性,毒力或生长的抗感染药物的取代的苯并咪唑化合物。 制备和使用取代的苯并咪唑化合物的方法,以及其药物制剂,例如降低抗生素抗性和抑制生物膜。
-
10.TETRACYCLINE COMPOUNDS FOR THE TREATMENT OF RHEUMATOID ARTHRITIS AND RELATED METHODS OF TREATMENT 审中-公开
标题翻译: 用于治疗恶性肿瘤的四环素化合物及其相关治疗方法公开(公告)号:US20100190755A1
公开(公告)日:2010-07-29
申请号:US12563923
申请日:2009-09-21
申请人: Paul Abato , Todd Bowser , Paul Higgins , Atul K. Verma , Jie Zhang-Hoover
发明人: Paul Abato , Todd Bowser , Paul Higgins , Atul K. Verma , Jie Zhang-Hoover
CPC分类号: A61K31/65 , C07C237/20 , C07C237/26 , C07C237/40 , C07C251/48 , C07C2601/02 , C07C2603/46 , C07D213/38 , C07D231/12 , C07D263/32 , C07D277/28 , C07D277/30 , C07D307/52 , C07D307/54 , C07D309/22 , C07D317/58 , Y02A50/411
摘要: The present invention pertains, at least in part, to substituted tetracycline compounds. The present invention also pertains to methods for treating rheumatoid arthritis in a subject, comprising administering to the subject a tetracycline compound of the invention.
摘要翻译: 本发明至少部分地涉及取代的四环素化合物。 本发明还涉及治疗受试者类风湿性关节炎的方法,其包括对受试者施用本发明的四环素化合物。
-
-
-
-
-
-
-
-
-