公开(公告)号：US20190105425A1

公开(公告)日：2019-04-11

申请号：US16155763

申请日：2018-10-09

Applicant: MicroVention, Inc.

Inventor： Gregory M. Cruise ,  Xinping Wu ,  Matthew J. Fitz ,  Yue Wu

IPC: A61L24/00

Abstract: Liquid embolic preparations and medical treatment methods of using those preparations are described. In some embodiments, the preparations or solutions can transition from a liquid to a solid for use in the embolization. The preparations can include biocompatible polymers with covalently bound radioactive iodine isotopes.

公开(公告)号：US10226258B2

公开(公告)日：2019-03-12

申请号：US15635046

申请日：2017-06-27

Applicant: MicroVention, Inc.

Inventor： Gregory M. Cruise ,  Michael J. Constant ,  Terrance Tran

IPC: A61B17/12 ,  A61L31/00 ,  A61L31/02 ,  A61L31/04 ,  A61L31/06 ,  A61L31/14 ,  C08L71/02

Abstract: Devices for the occlusion of body cavities, such as the embolization of vascular aneurysms and the like, and methods for making and using such devices. The devices may be comprised of novel expansile materials, novel infrastructure design, or both. The devices provided are very flexible and enable deployment with reduced or no damage to bodily tissues, conduits, cavities, etceteras.

公开(公告)号：US10155064B2

公开(公告)日：2018-12-18

申请号：US15878294

申请日：2018-01-23

Applicant: MicroVention, Inc.

Inventor： Gregory M. Cruise ,  Steve Plotkin ,  Xinping Wu

IPC: C08F220/38 ,  C08F220/56 ,  C08F222/10 ,  C08F222/38 ,  C08F222/40 ,  A61K9/00 ,  A61K9/16 ,  A61L24/06 ,  A61L24/00

Abstract: Embolic particles are described. The particles are reaction products of a prepolymer solution including at least one polyether macromer and an appropriate monomer.

公开(公告)号：US09907880B2

公开(公告)日：2018-03-06

申请号：US15081648

申请日：2016-03-25

Applicant: MicroVention, Inc.

Inventor： Gregory M. Cruise ,  Steve Plotkin ,  Xinping Wu

IPC: C08F222/38 ,  A61L24/06 ,  A61L24/00

CPC classification number: A61L24/06 ,  A61L24/001 ,  A61L2430/36 ,  C08F222/385 ,  C08L33/08 ,  C08L33/10 ,  C08L33/26

Abstract: Embolic particles are described comprising a treated polymer particle. The particles are reaction products of a prepolymer solution including at least one polyether macromer and an appropriate monomer. The treated polymer particles can have a first diameter that is smaller than a second diameter, wherein the second diameter is achieved when the treated polymer particle is subjected to a physiological condition. Methods of making and using these polymer particles are also described.

公开(公告)号：US20170290593A1

公开(公告)日：2017-10-12

申请号：US15635046

申请日：2017-06-27

Applicant: MicroVention, Inc.

Inventor： Gregory M. Cruise ,  Michael J. Constant ,  Terrance Tran

IPC: A61B17/12 ,  A61L31/02 ,  A61L31/04 ,  A61L31/14 ,  A61L31/06

CPC classification number: A61B17/1219 ,  A61B17/12113 ,  A61B17/1214 ,  A61B17/12145 ,  A61B17/12154 ,  A61B17/12168 ,  A61L31/00 ,  A61L31/022 ,  A61L31/041 ,  A61L31/048 ,  A61L31/06 ,  A61L31/14 ,  A61L31/145 ,  A61L31/146 ,  A61L2400/04 ,  C08L71/02

Abstract: Devices for the occlusion of body cavities, such as the embolization of vascular aneurysms and the like, and methods for making and using such devices. The devices may be comprised of novel expansile materials, novel infrastructure design, or both. The devices provided are very flexible and enable deployment with reduced or no damage to bodily tissues, conduits, cavities, etceteras.

公开(公告)号：US20170216484A1

公开(公告)日：2017-08-03

申请号：US15491864

申请日：2017-04-19

Applicant: MicroVention, Inc.

Inventor： Gregory M. Cruise ,  Michael J. Constant ,  Edward Michael Keeley ,  Rob Greene ,  Clayton Harris

IPC: A61L24/06 ,  A61K49/12 ,  A61L24/00 ,  A61K49/04

CPC classification number: A61L24/06 ,  A61K49/0442 ,  A61K49/12 ,  A61L24/001 ,  A61L24/0015 ,  A61L2300/44 ,  A61L2400/06 ,  A61L2430/36 ,  C08L33/08 ,  C08L33/26

Abstract: Polymeric compositions are described comprising a biocompatible polymer including a biodegradable linkage to a visualization agent and a non-physiological pH solution; wherein the biocompatible polymer is soluble in the non-physiological pH solution and insoluble at a physiological pH. Methods of forming the solutions and polymers are disclosed as well as methods of therapeutic use.

公开(公告)号：US09486221B2

公开(公告)日：2016-11-08

申请号：US13899357

申请日：2013-05-21

Applicant: MicroVention, Inc.

Inventor： Gregory M. Cruise ,  Michael J. Constant ,  Edward Michael Keeley ,  Terrance T. Tran

IPC: A61B17/12 ,  A61L27/16 ,  A61L27/18 ,  A61L27/56 ,  A61L31/04 ,  A61L31/06 ,  A61L31/14 ,  A61L31/18

CPC classification number: A61B17/12113 ,  A61B17/12181 ,  A61B90/39 ,  A61B2017/00004 ,  A61B2017/1205 ,  A61B2090/3966 ,  A61K49/0404 ,  A61L24/001 ,  A61L24/0031 ,  A61L24/046 ,  A61L27/16 ,  A61L27/18 ,  A61L27/56 ,  A61L31/048 ,  A61L31/06 ,  A61L31/146 ,  A61L31/18 ,  A61L2430/36 ,  C08L39/06 ,  C08L71/02

Abstract: Described herein are apparatus, compositions, systems and associated methods to occlude structures and malformations with radiopaque hydrogel filaments with delayed controlled rates of expansion permitting the repositioning of the device once inside the structure or malformation. Further described is a device for implantation in an animal comprising a difunctional, low molecular weight ethylenically unsaturated shapeable macromer; an ethylenically unsaturated monomer; and a radiopaque element, wherein said device contains no support members. Methods of forming such devices are also disclosed.

公开(公告)号：US20160311990A1

公开(公告)日：2016-10-27

申请号：US15199633

申请日：2016-06-30

Applicant: MicroVention, Inc.

Inventor： Gregory M. Cruise ,  Gloria Hincapie ,  Clayton Harris ,  Yue Wu

IPC: C08J5/18 ,  A61L31/14 ,  A61K47/32 ,  A61L31/04

CPC classification number: C08J5/18 ,  A61K9/0024 ,  A61K47/32 ,  A61L31/048 ,  A61L31/148 ,  A61L31/16 ,  C08F120/56 ,  C08F220/56 ,  C08F222/1006 ,  C08F222/385 ,  C08J2333/14 ,  C08J2333/26 ,  Y10T428/21

Abstract: Biodegradable, cross-linked polymer films and methods of making the same are described. The polymer films can be used for preventing adhesions following surgery and/or delivering therapeutic agents.

公开(公告)号：US20150283306A1

公开(公告)日：2015-10-08

申请号：US14678525

申请日：2015-04-03

Applicant: MicroVention, Inc.

Inventor： Michael Constant ,  Edward Michael Keeley ,  Joshua Garretson ,  Gregory M. Cruise ,  Wendy Graczyk

IPC: A61L31/04 ,  A61L31/14

CPC classification number: A61L31/048 ,  A61L31/145 ,  A61L31/18 ,  A61L2300/102 ,  A61L2430/36 ,  C08L33/26 ,  C08L33/10

Abstract: Described herein are apparatus, compositions, systems and methods for occluding vascular structures and vascular malformations with radiopaque hydrogel filaments. The filaments can contain no support members and can be CT and MR compatible. Methods of forming such filaments are also disclosed.

Abstract translation: 本文描述的是用不透射线水凝胶细丝阻塞血管结构和血管畸形的装置，组合物，系统和方法。 长丝不能含有支撑构件，可以兼容CT和MR。 还公开了形成这种细丝的方法。

公开(公告)号：US20150190553A1

公开(公告)日：2015-07-09

申请号：US14661995

申请日：2015-03-18

Applicant: MicroVention, Inc.

Inventor： Michael Constant ,  Edward Michael Keeley ,  Joshua Garretson ,  Gregory M. Cruise

IPC: A61L31/04 ,  A61L31/14

CPC classification number: A61L31/048 ,  A61K9/0019 ,  A61K9/0024 ,  A61K47/30 ,  A61K47/34 ,  A61K49/0404 ,  A61K49/126 ,  A61K51/1213 ,  A61L31/145 ,  A61L31/18 ,  A61L2430/36 ,  Y10T428/298 ,  C08L33/26

Abstract: Described herein are apparatus, compositions, systems and methods for occluding vascular structures and vascular malformations with radiopaque hydrogel filaments. The filaments can contain no support members and can be CT and MR compatible. Methods of forming such filaments are also disclosed.