摘要:
Compounds having the formula or a pharmaceutically acceptable salt thereof wherein R1 is (a) hydrogen, (b) loweralkyl, (c) alkenyl, (d) alkoxy, (e) thioalkoxy, (f) halo, (g) haloalkyl, (h) aryl-L2—, and (i) heterocyclic-L2—; R2 is selected from (a) (b) —C(O)NH—CH(R14)—C(O)OR15, (d) —C(O)NH—CH(R14)—C(O)NHSO2R16, (e) —C(O)NH—CH(R14)-tetrazolyl, (f) —C(O)NH-heterocyclic, and (g) —C(O)NH—CH(R14)—C(O)NR17R18; R3 is substituted or unsubstituted heterocyclic or aryl, substituted or unsubstituted cycloalkyl or cycloalkenyl, and —P(W)RR3RR3′; R4 is hydrogen, lower alkyl, haloalkyl, halogen, aryl, arylakyl, heterocyclic, or (heterocyclic)alkyl; L1 is absent or is selected from (a) —L4—N(R5)—L5—, (b) —L4—O—L5—, (c) —L4—S(O)n—L5—(d) —L4—L6—C(W)—N(R5)—L5—, (e) —L4—L6—S(O)m—N(R5)—L5—, (f) —L4—N(R5)—C(W)—L7—L5—, (g) —L4—N(R5)—S(O)p—L7—L5—, (h) optionally substituted alkylene, (i) optionally substituted alkenylene, (j) optionally substituted alkynylene (k) a covalent bond, (l) and (m) are inhibitors of protein isoprenyl transferases. Also disclosed are protein isoprenyl transferase inhibiting compositions and a method of inhibiting protein isoprenyl transferases.
摘要翻译:具有式的化合物或其药学上可接受的盐,其中R 1是(a)氢,(b)低级烷基,(c)烯基,(d)烷氧基,(e)硫代烷氧基,(f)卤素,(g)卤代烷基,(h) 芳基-L2-和(i)杂环-L2-; R 2选自(a)(b)-C(O)NH-CH(R 14)-C(O)OR 15,(d)-C(O)NH-CH(R 14)-C(O)NHSO 2 R 16 e)-C(O)NH-CH(R14) - 四唑基,(f)-C(O)NH-杂环基和(g)-C(O)NH-CH(R14)-C(O)NR17R18; R 3是取代或未取代的杂环或芳基,取代或未取代的环烷基或环烯基,和-P(W)RR 3 R R 3'; R4是氢,低级烷基,卤代烷基,卤素,芳基,芳基烷基,杂环或(杂环)烷基; (a)-L4-N(R5)-L5-,(b)-L4-O-L5-,(c)-L4-S(O)n-L5-(d) - L4-L6-C(W)-N(R5)-L5-,(e)-L4-L6-S(O)mN(R5)-L5-,(f)-L4-N(R5)-C W)-L7-L5-,(g)-L4-N(R5)-S(O)p-L7-L5-,(h)任选取代的亚烷基,(i)任选取代的亚烯基,(j)任选取代的亚炔基 (k)共价键,(1)和(m)是蛋白质异戊二烯基转移酶的抑制剂。 还公开了蛋白质异戊二烯转移酶抑制组合物和抑制蛋白质异戊二烯转移酶的方法。
摘要:
Compounds having the formula or a pharmaceutically acceptable salt thereof wherein R1 is (a) hydrogen, (b) loweralkyl, (c) alkenyl, (d) alkoxy, (e) thioalkoxy, (f) halo, (g) haloalkyl, (h) aryl-L2—, and (i) heterocyclic-L2—; R2 is selected from (b) —C(O)NH—CH(R14)—C(O)OR15, (d) —C(O)NH—CH(R14)—C(O)NHSO2R16, (e) —C(O)NH—CH(R14)-tetrazolyl, (f) —C(O)NH-heterocyclic, and (g) —C(O)NH—CH(R14)—C(O)NR17R18; R3 is heterocyclic, aryl, substituted or unsubstituted cycloalkyl; R4 is hydrogen, lower alkyl, haloalkyl, halogen, aryl, arylakyl, heterocyclic, or (heterocyclic)alkyl; L1 is absent or is selected from (a) —L4—N(R5)—L5—, (b) —L4—O—L5—, (c) —L4—S(O)n—L5— (d) —L4—L6—C(W)—N(R5)—L5—, (e) —L4—L6—S(O)m—N(R5)—L5 —, (f) —L4—N(R5)—C(W)—L7—L5 —, (g) —L4—N(R5)—S(O)p—L7—L5—, (h) optionally substituted alkylene, (i) optionally substituted alkenylene, and (j) optionally substituted alkynylene are inhibitors of protein isoprenyl transferases. Also disclosed are protein isoprenyl transferase inhibiting compositions and a method of inhibiting protein isoprenyl transferases.
摘要:
A Metal-Oxide-Semiconductor Field Effect Transistor (MOSFET) is disclosed. The MOSFET includes a substrate, a well region formed in the substrate, a shallow channel layer, a channel, a gate oxide layer, a gate region, a source region, and a drain region. The shallow channel layer is formed on a portion of the well region and includes a first shallow channel region and a second shallow channel region. The channel is arranged between the first shallow channel region and the second shallow channel region and connects the first shallow channel region and the second shallow channel region. Further, the gate oxide layer is formed on a portion of the well region between the first shallow channel region and the second shallow channel region and includes a first gate oxide region and a second gate oxide region arranged on different sides of the channel. The gate region is formed on the channel and the gate oxide layer; the source region is formed in the first shallow channel region and vertically extends into the well region under the first shallow channel region; and the drain region is formed in the second shallow channel region and vertically extends into the well region under the second shallow channel region.
摘要:
A method for manufacturing compatible vertical double diffused metal oxide semiconductor (VDMOS) transistor and lateral double diffused metal oxide semiconductor (LDMOS) transistor includes: providing a substrate having an LDMOS transistor region and a VDMOS transistor region; forming an N-buried region in the substrate; forming an epitaxial layer on the N-buried layer region; forming isolation regions in the LDMOS transistor region and the VDMOS transistor region; forming a drift region in the LDMOS transistor region; forming gates in the LDMOS transistor region and the VDMOS transistor region; forming PBODY regions in the LDMOS transistor region and the VDMOS transistor region; forming an N-type GRADE region in the LDMOS transistor region; forming an NSINK region in the VDMOS transistor region, where the NSINK region is in contact with the N-buried layer region; forming sources and drains in the LDMOS transistor region and the VDMOS transistor region; and forming a P+ region in the LDMOS transistor region, where the P+ region is in contact with the source.
摘要:
Methods and apparatuses for parallel decoding and data processing of Turbo codes are provided. The method includes: a codeword dividing step for dividing a whole codeword into Q sub-blocks to form a plurality of boundaries between adjacent sub-blocks of the Q sub-blocks so as to decode the Q sub-blocks, wherein the decoding process comprises P times of decoding iterations, and wherein Q is a positive integer and Q>1 and P is a positive integer and P>1; and a boundary moving step for moving at least one position of the boundaries formed in a pth decoding iteration by an offset Δ before performing a (p+n)th decoding iteration, wherein p is a positive integer and 1≦p
摘要翻译:提供Turbo码并行解码和数据处理的方法和装置。 该方法包括:码字分割步骤,用于将整个码字划分为Q个子块,以在Q个子块的相邻子块之间形成多个边界,以对Q个子块进行解码,其中解码过程包括 P次解码迭代,其中Q是正整数,Q> 1,P是正整数,P> 1; 以及边界移动步骤,用于在执行第(p + n)个解码迭代之前将形成在第p解码迭代中的边界的至少一个位置移动偏移量Δt,其中p是正整数,1 <= p
摘要:
A method is provided for manufacturing a double-gate structure. The method includes providing a substrate and forming a first gate region on a surface of the substrate using a first gate layer. The method also includes forming a second gate layer on the surface of the substrate, wherein the second gate layer covers the first gate region, forming an etch-stop layer on the second gate layer, and forming a silicide layer on the etch-stop layer. The method also includes forming a second gate region, different from the first gate region, containing the second gate layer and the silicide layer without the etch-stop layer. Further, the etch-stop layer is arranged between the second gate layer and the silicide layer to facilitate even etching of the second gate layer around the first gate region.
摘要:
A method for manufacturing a bipolar transistor includes forming a first epitaxial layer on a semiconductor substrate, forming a second epitaxial layer on the first epitaxial layer, forming an oxide layer on the second epitaxial layer, etching the oxide layer to form an opening in which the second epitaxial layer is exposed, and forming a third epitaxial layer in the opening. The first and third epitaxial layers have a first-type conductivity, and the second epitaxial layer has a second-type conductivity.
摘要:
A method for manufacturing compatible vertical double diffused metal oxide semiconductor (VDMOS) transistor and lateral double diffused metal oxide semiconductor (LDMOS) transistor includes: providing a substrate having an LDMOS transistor region and a VDMOS transistor region; forming an N-buried region in the substrate; forming an epitaxial layer on the N-buried layer region; forming isolation regions in the LDMOS transistor region and the VDMOS transistor region; forming a drift region in the LDMOS transistor region; forming gates in the LDMOS transistor region and the VDMOS transistor region; forming PBODY regions in the LDMOS transistor region and the VDMOS transistor region; forming an N-type GRADE region in the LDMOS transistor region; forming an NSINK region in the VDMOS transistor region, where the NSINK region is in contact with the N-buried layer region; forming sources and drains in the LDMOS transistor region and the VDMOS transistor region; and forming a P+ region in the LDMOS transistor region, where the P+ region is in contact with the source.
摘要:
A method for fabricating trench DMOS transistor includes: forming an oxide layer and a barrier layer with photolithography layout sequentially on a semiconductor substrate; etching the oxide layer and the semiconductor substrate with the barrier layer as a mask to form a trench; forming a gate oxide layer on the inner wall of the trench; forming a polysilicon layer on the barrier layer, filling up the trench; etching back the polysilicon layer with the barrier layer mask to remove the polysilicon layer on the barrier layer to form a trench gate; removing the barrier layer and the oxide layer; implanting ions into the semiconductor substrate on both sides of the trench gate to form a diffusion layer; coating a photoresist layer on the diffusion layer and defining a source/drain layout thereon; implanting ions into the diffusion layer based on the source/drain layout with the photoresist layer mask to form the source/drain; forming sidewalls on both the sides of the trench gate after removing the photoresist layer; and forming a metal silicide layer on the diffusion layer and the trench gate. Effective result of the present invention is achieved with lower cost and improved efficiency of fabrication.