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    Nitric oxide-releasing polymers derived from modified polymers
    37.
    发明申请
    Nitric oxide-releasing polymers derived from modified polymers 审中-公开
    衍生自改性聚合物的一氧化氮释放聚合物

    公开(公告)号：US20070053952A1

    公开(公告)日：2007-03-08

    申请号：US11222142

    申请日：2005-09-07

    申请人： Mingfei Chen ,  Peiwen Cheng ,  Kishore Udipi

    发明人： Mingfei Chen ,  Peiwen Cheng ,  Kishore Udipi

    IPC分类号： A61K31/785

    CPC分类号： A61L31/16 ,  A61K31/785 ,  A61L27/54

    摘要： Modified polyimines and derivatives thereof suitable as implantable medical devices and coatings therefore are provided. Specifically, implantable medical devices and/or coatings comprise amphiphilic polymers derived from modified polyimines. The medical devices and coatings of the present invention can also be used for in situ nitric oxide release/controlled release drug delivery and are useful for treating or preventing medical conditions such as restenosis, aneurysms and vulnerable plaque.

    摘要翻译： 因此，提供了适合作为可植入医疗装置和涂层的改性聚亚胺及其衍生物。 具体地，可植入医疗装置和/或涂层包含衍生自改性聚亚胺的两亲性聚合物。 本发明的医疗装置和涂层也可用于原位一氧化氮释放/控释药物递送，并且可用于治疗或预防医疗状况如再狭窄，动脉瘤和易损斑块。

    Gradient coated stent and method of fabrication
    38.
    发明授权
    Gradient coated stent and method of fabrication 有权
    梯度涂层支架及其制造方法

    公开(公告)号：US08801692B2

    公开(公告)日：2014-08-12

    申请号：US10921735

    申请日：2004-08-18

    申请人： Peiwen Cheng ,  Patrice Tremble ,  Wenda Carlyle ,  Diane Judd ,  Kishore Udipi

    发明人： Peiwen Cheng ,  Patrice Tremble ,  Wenda Carlyle ,  Diane Judd ,  Kishore Udipi

    IPC分类号： A61M31/00 ,  A61F2/06 ,  A61L33/00

    CPC分类号： A61F2/86 ,  A61F2/0077 ,  A61F2/91 ,  A61F2/915 ,  A61F2/958 ,  A61F2002/072 ,  A61F2002/91541 ,  A61F2210/0004 ,  A61F2230/0054 ,  A61F2250/0067 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/45 ,  A61L2300/606

    摘要： The gradient coated stent 150 of the present invention provides a coated stent having a continuous coating 130 disposed on the stent elements. The continuous coating 130 includes a first coating component and a second coating component. The concentration of the first coating component varies continuously over at least part of the thickness of the continuous coating 130. The concentration of the second coating component can also vary over at least part of the thickness of the continuous coating 130. In one embodiment, the concentration of the first coating component decreases in the direction from the stent element towards the outer edge of the continuous coating 130 and the concentration of the second coating component increases in the direction from the stent element towards the outer edge of the continuous coating 130.

    摘要翻译： 本发明的梯度涂层支架150提供了涂层支架，其具有设置在支架元件上的连续涂层130。 连续涂层130包括第一涂层组分和第二涂层组分。 第一涂层组分的浓度在连续涂层130的厚度的至少一部分上连续变化。第二涂层组分的浓度也可以在连续涂层130的至少一部分厚度上变化。在一个实施方案中， 第一涂层组分的浓度在从支架元件朝向连续涂层130的外边缘的方向上减小，并且第二涂层组分的浓度在从支架元件朝向连续涂层130的外边缘的方向上增加。

    Methods for Compounding and Delivering a Therapeutic Agent to the Adventitia of a Vessel
    39.
    发明申请
    Methods for Compounding and Delivering a Therapeutic Agent to the Adventitia of a Vessel 审中-公开
    将治疗剂复合并递送至血管外膜的方法

    公开(公告)号：US20090204104A1

    公开(公告)日：2009-08-13

    申请号：US11568779

    申请日：2005-05-04

    申请人： Patrice Tremble ,  Dianne Judd ,  Kishore Udipi ,  Peiwen Cheng ,  Rangarajan Sundar ,  Kaushik A. Patel ,  Eugene Tedeschi

    发明人： Patrice Tremble ,  Dianne Judd ,  Kishore Udipi ,  Peiwen Cheng ,  Rangarajan Sundar ,  Kaushik A. Patel ,  Eugene Tedeschi

    IPC分类号： A61M25/10 ,  A61M25/06 ,  A61K9/14 ,  A61P9/02

    CPC分类号： A61M25/0084 ,  A61K9/16

    摘要： The invention provides a method of delivering a therapeutic agent to the adventitia of a vessel using a catheter-based microsyringe. A therapeutic agent is formed into microparticles, which are dispersed throughout an appropriate liquid carrier to form a therapeutic mixture. A catheter is provided that includes a microsyringe operably attached to an actuator. The microsyringe includes a hollow needle in fluid communication with a therapeutic agent delivery conduit. The catheter is introduced into a target area of a vessel. The actuator is operated to thrust the needle into a wall of the vessel. The therapeutic mixture is supplied to the therapeutic agent delivery conduit and delivered through the conduit to the needle and thereby into the adventitia of the vessel. The actuator is again operated to withdraw the needle from the wall of the vessel and to enclose it within the actuator. The catheter is then removed from the vessel.

    摘要翻译： 本发明提供了使用基于导管的微量注射器将治疗剂递送至血管外膜的方法。 将治疗剂形成为微粒，其分散在适当的液体载体中以形成治疗性混合物。 提供了一种导管，其包括可操作地附接到致动器的微量注射器。 微量注射器包括与治疗剂输送管道流体连通的中空针头。 将导管引入血管的靶区域。 致动器被操作以将针推入容器的壁中。 将治疗性混合物供应到治疗剂递送导管并通过导管输送到针，从而被输送到血管的外膜。 致动器再次被操作以将针从容器的壁中抽出并将其封闭在致动器内。 然后从血管中取出导管。