公开(公告)号：US06998236B2

公开(公告)日：2006-02-14

申请号：US10212917

申请日：2002-08-05

申请人： Wei Shao ,  Junquan Xu ,  Wan-Li Xing ,  Jing Cheng

发明人： Wei Shao ,  Junquan Xu ,  Wan-Li Xing ,  Jing Cheng

IPC分类号： C12Q1/68 ,  C12M1/36 ,  G01N31/22

CPC分类号： B01L3/50851 ,  B01J19/0046 ,  B01J2219/00315 ,  B01J2219/00351 ,  B01J2219/00495 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00529 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00608 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00659 ,  B01J2219/00662 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/0074 ,  B01J2219/00743 ,  B01L3/502 ,  B01L7/00 ,  B01L9/52 ,  B81B7/04 ,  C40B40/06 ,  C40B60/14 ,  G01N33/54373 ,  G01N35/00029 ,  G01N2035/00158 ,  Y10S977/924

摘要： This invention relates generally to the field of microarray technology. In particular, the invention provides an integrated microarray device, which device comprises a substrate comprising a plurality of distinct microlocations and a plurality of microarray chips, wherein the number of said microlocations equals to or is more than the number of said microarray chips. In preferred embodiments, the devices also comprises a temperature controller at some or all of the microlocations. The use of the integrated microarray devices for detecting interactions among various moieties in various fields, such as clinical diagnostics, drug discovery, environmental monitoring and forensic analysis, etc., are further provided.

公开(公告)号：US06703203B2

公开(公告)日：2004-03-09

申请号：US09898271

申请日：2001-07-02

申请人： Wei Shao ,  Junquan Xu ,  Wan-Li Xing ,  Jing Cheng

发明人： Wei Shao ,  Junquan Xu ,  Wan-Li Xing ,  Jing Cheng

IPC分类号： C12Q168

CPC分类号： B01L3/50851 ,  B01J19/0046 ,  B01J2219/00315 ,  B01J2219/00351 ,  B01J2219/00495 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00529 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00608 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00659 ,  B01J2219/00662 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/0074 ,  B01J2219/00743 ,  B01L3/502 ,  B01L7/00 ,  B01L9/52 ,  B81B7/04 ,  C40B40/06 ,  C40B60/14 ,  G01N33/54373 ,  G01N35/00029 ,  G01N2035/00158 ,  Y10S977/924

摘要： This invention relates generally to the field of microarray technology. In particular, the invention provides an integrated microarray device, which device comprises a substrate comprising a plurality of distinct microlocations and a plurality of microarray chips, wherein the number of said microlocations equals to or is more than the number of said microarray chips. In preferred embodiments, the devices also comprises a temperature controller at some or all of the microlocations. The use of the integrated microarray devices for detecting interactions among various moieties in various fields, such as clinical diagnostics, drug discovery, environmental monitoring and forensic analysis, etc., are further provided.

摘要翻译： 本发明一般涉及微阵列技术领域。 特别地，本发明提供了一种集成微阵列装置，该装置包括包含多个不同微位置和多个微阵列芯片的基板，其中所述微位置的数量等于或大于所述微阵列芯片的数量。 在优选实施例中，装置还包括位于微位置的部分或全部的温度控制器。 还提供了使用集成的微阵列装置来检测各个领域的各个部分之间的相互作用，诸如临床诊断，药物发现，环境监测和法医分析等。

公开(公告)号：US06806050B2

公开(公告)日：2004-10-19

申请号：US09955343

申请日：2001-09-18

申请人： Yuxiang Zhou ,  Litian Liu ,  Ken Chen ,  Depu Chen ,  Jia Wang ,  Zewen Liu ,  Zhimin Tan ,  Junquan Xu ,  Xiaoshan Zhu ,  Xuezhong He ,  Wenzhang Xie ,  Zhiming Li ,  Xiumel Liu

发明人： Yuxiang Zhou ,  Litian Liu ,  Ken Chen ,  Depu Chen ,  Jia Wang ,  Zewen Liu ,  Zhimin Tan ,  Junquan Xu ,  Xiaoshan Zhu ,  Xuezhong He ,  Wenzhang Xie ,  Zhiming Li ,  Xiumel Liu

IPC分类号： G01N33543

CPC分类号： B01L3/502761 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00468 ,  B01J2219/005 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00614 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00639 ,  B01J2219/00648 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00722 ,  B01L3/5025 ,  B01L2200/0647 ,  B01L2200/0668 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0877 ,  B01L2300/089 ,  B01L2400/043 ,  C40B40/06 ,  C40B60/14 ,  G01N35/0098 ,  Y10S436/806

摘要： This invention provides electromagnetic chips and electromagnetic biochips having arrays of individually addressable micro-electromagnetic units, as well as methods of utilizing these chips for directed manipulation of micro-particles and micro-structures such as biomolecules and chemical reagents. An electromagnetic biochip comprises an individually addressable micro-electromagnetic unit chip with ligand molecules immobilized on its surface. By controlling the electromagnetic field at each unit of the array and combining this control with magnetic modification of biomolecules, these chips can be used for directed manipulation, synthesis and release of biomolecules in order to increase sensitivity of biochemical or chemical analysis and reduce assay time. Other advantages with these chips include minimized damages to biological molecules and increased reproducibility of assay results.

摘要翻译： 本发明提供具有独立寻址的微电磁单元阵列的电磁芯片和电磁生物芯片，以及利用这些芯片来定向操纵微粒和微结构如生物分子和化学试剂的方法。 电磁生物芯片包括具有固定在其表面上的配体分子的单独可寻址的微电磁单元芯片。 通过控制阵列的每个单元的电磁场并将该控制与生物分子的磁性修饰相组合，这些芯片可用于生物分子的定向操作，合成和释放，以提高生物化学或化学分析的灵敏度并减少测定时间。 这些芯片的其他优点包括对生物分子的最小化损害和提高测定结果的再现性。