-
31.Transdiscal administration of specific inhibitors of pro-inflammatory cytokines 有权
标题翻译: 跨时间给药促炎细胞因子的特异性抑制剂公开(公告)号:US08728523B2
公开(公告)日:2014-05-20
申请号:US12291378
申请日:2008-11-07
申请人: Mohamed Attawia , Thomas M. DiMauro , Hassan Serhan , Sudhakar Kadiyala , David Urbahns , Scott Bruder
发明人: Mohamed Attawia , Thomas M. DiMauro , Hassan Serhan , Sudhakar Kadiyala , David Urbahns , Scott Bruder
IPC分类号: A61K45/00 , A61K39/395
CPC分类号: A61K35/28 , A61B5/055 , A61B17/7061 , A61K9/0012 , A61K9/0019 , A61K9/0085 , A61K35/32 , A61K38/17 , A61K38/1793 , A61K38/18 , A61K38/1841 , A61K38/1875 , A61K38/20 , A61K38/363 , A61K38/4833 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K47/34 , C12Y304/21005 , G01N33/6869 , G01N2333/54
摘要: The present invention relates to injecting a high specificity cytokine antagonist into a diseased intervertebral disc.
摘要翻译: 本发明涉及将高特异性细胞因子拮抗剂注射到患病的椎间盘中。
-
32.Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints 有权
标题翻译: 将高特异性细胞因子抑制剂的跨荚膜施用于矫形关节公开(公告)号:US08361467B2
公开(公告)日:2013-01-29
申请号:US10630227
申请日:2003-07-30
申请人: Thomas M. DiMauro , Mohamed Attawia , Hassan Serhan , Martin A. Reynolds , Melissa Grace , Sudhakar Kadiyala , David Urbahns , Scott Bruder , Gregory Collins , Laura J. Brown , Jeff Geesin , Pamela L. Plouhar , Catherine Smith , John Siekierka
发明人: Thomas M. DiMauro , Mohamed Attawia , Hassan Serhan , Martin A. Reynolds , Melissa Grace , Sudhakar Kadiyala , David Urbahns , Scott Bruder , Gregory Collins , Laura J. Brown , Jeff Geesin , Pamela L. Plouhar , Catherine Smith , John Siekierka
IPC分类号: A61K39/395 , A61K39/00 , A61K38/18
CPC分类号: A61K38/30 , A61K31/198 , A61K31/436 , A61K38/1816 , A61K2039/505
摘要: The present invention relates to trans-capsularly administering into a diseased joint a high specificity antagonist selected from the group consisting of: i) an inhibitor of a pro-inflammatory interleukin; ii) an inhibitor of TNF-α synthesis; iii) an inhibitor of membrane-bound TNF-α; iv) an inhibitor of a natural receptor of TNF-α; v) an inhibitor of NO synthase, vi) an inhibitor of PLA2 enzyme; vii) an anti-proliferative agent; viii) an anti-oxidant; ix) an apoptosis inhibitor selected from the group consisting of EPO mimetic peptides, EPO mimetibodies, IGF-I, IGF-II, and caspase inhibitors, and x) an inhibitor of MMPs; and xi) an inhibitor of p38 kinase.
摘要翻译: 本发明涉及向患病关节中透射施用高特异性拮抗剂,所述高特异性拮抗剂选自:i)促炎白细胞介素的抑制剂; ii)TNF-α合成抑制剂; iii)膜结合TNF-α的抑制剂; iv)TNF-α的天然受体的抑制剂; v)NO合酶抑制剂,vi)PLA2酶抑制剂; vii)抗增殖剂; viii)抗氧化剂; ix)选自EPO模拟肽,EPO模拟物,IGF-I,IGF-II和胱天蛋白酶抑制剂的细胞凋亡抑制剂,和x)MMP的抑制剂; 和xi)p38激酶的抑制剂。
-
公开(公告)号:US20110022130A1
公开(公告)日:2011-01-27
申请号:US12822788
申请日:2010-06-24
IPC分类号: A61N5/06
CPC分类号: A61N5/0603 , A61N2005/0607 , A61N2005/0644 , A61N2005/0659
摘要: A method of treating disease in which intranasal red light devices are used to shine red light upon the brain structures in the basal prefrontal cortex.
摘要翻译: 一种治疗疾病的方法,其中使用鼻内红光装置将红光照射在基底前额叶皮层的脑结构上。
-
公开(公告)号:US07399742B2
公开(公告)日:2008-07-15
申请号:US11018438
申请日:2004-12-21
IPC分类号: A61K38/19
CPC分类号: A61L27/54 , A61K38/1841 , A61K38/2066 , A61K38/2264 , A61K38/39 , A61K38/57 , A61L2300/252 , A61L2430/38 , A61K2300/00
摘要: This invention is directed to administering an effective amount of adiponectin into an osteolytic region for treating osteolysis.
摘要翻译: 本发明涉及将有效量的脂连蛋白施用于溶骨性溶解区域用于治疗骨质溶解。
-
公开(公告)号:US08821559B2
公开(公告)日:2014-09-02
申请号:US11214445
申请日:2005-08-29
申请人: Thomas DiMauro , Mohamed Attawia , Sean Lilienfeld , Chantal Holy , Jeffrey K Sutton , Michael Ward
发明人: Thomas DiMauro , Mohamed Attawia , Sean Lilienfeld , Chantal Holy , Jeffrey K Sutton , Michael Ward
CPC分类号: A61N5/0601 , A61N2005/063 , A61N2005/0651 , A61N2005/0659 , A61N2005/0661
摘要: An intracranial, light-emitting implant for providing therapy to a patient having Alzheimer's Disease.
摘要翻译: 一种用于向患有阿尔茨海默病的患者提供治疗的颅内发光植入物。
-
公开(公告)号:US20090157087A1
公开(公告)日:2009-06-18
申请号:US12205539
申请日:2008-09-05
申请人: Guobao Wei , Keyvan Behnam , Nanette Forsyth , John Winterbottom , James Beisser , Todd M. Boyce , Mohamed Attawia , Cristy J. Richards , Lawrence A. Shimp
发明人: Guobao Wei , Keyvan Behnam , Nanette Forsyth , John Winterbottom , James Beisser , Todd M. Boyce , Mohamed Attawia , Cristy J. Richards , Lawrence A. Shimp
CPC分类号: A61F2/2846 , A61B17/7097 , A61B17/7098 , A61F2/0095 , A61F2/28 , A61F2/4455 , A61F2/4601 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/285 , A61F2002/30588 , A61F2002/30738
摘要: A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust, the release of the substance.
摘要翻译: 提供了将物质或材料输送到手术部位的覆盖物。 其中提供的物质的覆盖物可以被称为递送系统。 通常,覆盖物可以是能够至少部分地保留其中提供的物质的单室或多隔室结构,直到将覆盖物放置在手术部位。 放置时,覆盖物可以促进物质或周围材料的转移。 例如,物质可以被主动地或被动地释放到手术部位。 覆盖物可以参与,控制或以其他方式调节物质的释放。
-
37.TRANSDISCAL ADMINISTRATION OF SPECIFIC INHIBITORS OF PRO-INFLAMMATORY CYTOKINES 有权
标题翻译: 炎性细胞因子特异性抑制剂的透析管理公开(公告)号:US20070237777A1
公开(公告)日:2007-10-11
申请号:US10456948
申请日:2003-06-06
申请人: Thomas DiMauro , Hassan Serhan , Mohamed Attawia
发明人: Thomas DiMauro , Hassan Serhan , Mohamed Attawia
IPC分类号: A61K39/395 , A61K48/00 , A61K38/18
CPC分类号: A61K35/28 , A61B5/055 , A61B17/7061 , A61K9/0012 , A61K9/0019 , A61K9/0085 , A61K35/32 , A61K38/17 , A61K38/1793 , A61K38/18 , A61K38/1841 , A61K38/1875 , A61K38/20 , A61K38/363 , A61K38/4833 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K47/34 , C12Y304/21005 , G01N33/6869 , G01N2333/54
摘要: The present invention relates to injecting a high specificity cytokine antagonist into a diseased intervertebral disc.
摘要翻译: 本发明涉及将高特异性细胞因子拮抗剂注射到患病的椎间盘中。
-
公开(公告)号:US20070083205A1
公开(公告)日:2007-04-12
申请号:US11235020
申请日:2005-09-26
申请人: Mohamed Attawia , Michael O'Neil
发明人: Mohamed Attawia , Michael O'Neil
IPC分类号: A61B17/58
CPC分类号: A61B17/68 , A61B17/3472 , A61B17/70 , A61B17/7074 , A61B17/7095 , A61B17/8863 , A61B17/8872 , A61B17/92 , A61B2017/3488 , A61L27/3821 , A61L27/3847 , A61L27/54 , A61L2300/414 , A61L2400/16 , A61L2430/38
摘要: A method of treating a fractured vertebral body by using a) a plurality of reinforcement rods combined with the b) a bone growth agent, wherein the reinforcement rods act to mechanically join disparate bone fragments across the fracture planes, thereby stabilizing the fracture site, and the bone growth agent promotes the growth of new bone across the fracture planes, thereby permanently replacing the fracture site with new bone.
摘要翻译: 一种通过使用a)与b)骨生长剂组合的多个加强杆来治疗骨折的椎体的方法,其中所述加强杆用于将不同的骨碎片机械地连接在断裂面上,从而稳定骨折部位,以及 骨生长剂促进新骨穿过骨折面的生长,从而用新骨永久性替代骨折部位。
-
公开(公告)号:US20070073363A1
公开(公告)日:2007-03-29
申请号:US11235664
申请日:2005-09-26
申请人: Thomas DiMauro , Mohamed Attawia , Jeffrey Sutton
发明人: Thomas DiMauro , Mohamed Attawia , Jeffrey Sutton
IPC分类号: A61N5/06
CPC分类号: A61N5/0601 , A61N2005/063 , A61N2005/0651 , A61N2005/0659 , A61N2005/0663
摘要: Red light-emitting implants for treating degenerative disc disease
摘要翻译: 用于治疗退行性椎间盘疾病的红色发光植入物
-
公开(公告)号:US20070073300A1
公开(公告)日:2007-03-29
申请号:US11235674
申请日:2005-09-26
申请人: Mohamed Attawia , Thomas DiMauro , Jeffrey Sutton
发明人: Mohamed Attawia , Thomas DiMauro , Jeffrey Sutton
CPC分类号: A61N5/0613 , A61B17/7001 , A61B17/7032 , A61B17/86 , A61B17/8805 , A61B2017/564 , A61F2/44 , A61N5/0601 , A61N2005/0612 , A61N2005/0643 , A61N2005/0651 , A61N2005/0659 , A61N2005/0663
摘要: Red light implants for delivering red light to spinal implants to enhance osteointegration.
摘要翻译: 用于将红光输送到脊髓植入物以增强骨整合的红光植入物。
-
-
-
-
-
-
-
-
-