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151 条记录 (耗时 0.067 秒)

    Tumor Necrosis Factor Receptors 6 Alpha & 6 Beta
    31.
    发明申请
    Tumor Necrosis Factor Receptors 6 Alpha & 6 Beta 审中-公开
    肿瘤坏死因子受体6 Alpha＆6 Beta

    公开(公告)号：US20060234285A1

    公开(公告)日：2006-10-19

    申请号：US11419656

    申请日：2006-05-22

    申请人： Reiner Gentz ,  Guo-Liang Yu ,  Jian Ni ,  Reinhard Ebner ,  Ping Feng ,  Steven Ruben

    发明人： Reiner Gentz ,  Guo-Liang Yu ,  Jian Ni ,  Reinhard Ebner ,  Ping Feng ,  Steven Ruben

    IPC分类号： C12Q1/68 ,  G01N33/574 ,  A61K38/17 ,  C07H21/04 ,  C12P21/06 ,  C07K14/715

    CPC分类号： G01N33/57488 ,  A61K38/00 ,  C07K14/70578 ,  C07K14/7151

    摘要： The present invention relates to novel Tumor Necrosis Factor Receptor proteins. In particular, isolated nucleic acid molecules are provided encoding the human TNFR-6α & -6β proteins. TNFR-6α & -6β polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TNFR-6α & -6β activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

    摘要翻译： 本发明涉及新型肿瘤坏死因子受体蛋白。 特别地，提供编码人TNFR-6α和-6β蛋白的分离的核酸分子。 还提供了TNFR-6α和-6β多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及鉴定TNFR-6α和-6β活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

    Human Ependymin
    33.
    发明申请
    Human Ependymin 失效
    人类ependymin

    公开(公告)号：US20050197491A9

    公开(公告)日：2005-09-08

    申请号：US10733646

    申请日：2003-12-12

    申请人： Reinhard Ebner ,  Steven Ruben

    发明人： Reinhard Ebner ,  Steven Ruben

    IPC分类号： A61K38/00 ,  C07K14/475 ,  C12N1/21 ,  C12N15/12 ,  C07K14/705 ,  C07H21/04 ,  C12Q1/68

    CPC分类号： G01N33/6893 ,  A61K38/00 ,  C07K14/475 ,  G01N2500/00 ,  G01N2800/28 ,  Y10S530/857

    摘要： The present invention relates to a novel human Ependymin protein which is a member of the ependymin family. In particular, isolated nucleic acid molecules are provided encoding the human Ependymin protein. Ependymin polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Ependymin activity. Also provided are diagnostic methods for detecting nervous system-related disorders and therapeutic methods for treating nervous system-related disorders.

    摘要翻译： 本发明涉及一种新型人类ependymin蛋白，其是室温室家族的成员。 特别地，提供编码人类ependymin蛋白的分离的核酸分子。 也可以提供ependymin多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定Ependymin活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测神经系统相关疾病的诊断方法和用于治疗神经系统相关疾病的治疗方法。

    157 human secreted proteins
    36.
    发明申请
    157 human secreted proteins 审中-公开
    157人分泌蛋白

    公开(公告)号：US20060073561A1

    公开(公告)日：2006-04-06

    申请号：US10986405

    申请日：2004-11-12

    申请人： Craig Rosen ,  Steven Ruben ,  Henrik Olsen ,  Kevin Baker ,  Michele Fiscella ,  Ping Wei ,  Charles Birse ,  George Komatsoulis ,  Gil Choi ,  Paul Moore ,  Ram Gupta ,  Yanggu Shi

    发明人： Craig Rosen ,  Steven Ruben ,  Henrik Olsen ,  Kevin Baker ,  Michele Fiscella ,  Ping Wei ,  Charles Birse ,  George Komatsoulis ,  Gil Choi ,  Paul Moore ,  Ram Gupta ,  Yanggu Shi

    IPC分类号： A61K38/17 ,  C07K14/47 ,  C07H21/04 ,  C12P21/06

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating diseases, disorders, and/or conditions related to said human secreted proteins. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

    摘要翻译： 本发明涉及人分泌多肽和编码所述多肽的分离的核酸分子，其可用于诊断和治疗与所述人分泌蛋白相关的疾病，病症和/或病症。 结合这些多肽的抗体也包括在本发明中。 本发明还包括载体，宿主细胞，以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。 本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。