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公开(公告)号:US20070004008A1
公开(公告)日:2007-01-04
申请号:US11459845
申请日:2006-07-25
申请人: Jian Ni , Craig Rosen , Reiner Gentz , Jeffrey Su , Geoffrey Krissansen , Ping Feng
发明人: Jian Ni , Craig Rosen , Reiner Gentz , Jeffrey Su , Geoffrey Krissansen , Ping Feng
CPC分类号: C07K14/70535 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/70503 , C12N9/6421 , C12N9/6475 , C12N9/6489 , C12N9/6491 , C12N2799/026
摘要: The present invention relates to novel human proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells and recombinant methods for producing the proteins of the invention. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译: 本发明涉及包含编码这种蛋白质的基因的编码区的新型人类蛋白质和分离的核酸。 还提供了用于产生本发明的蛋白质的载体,宿主细胞和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。
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公开(公告)号:US20050119457A1
公开(公告)日:2005-06-02
申请号:US10314942
申请日:2002-12-10
申请人: Jian Ni , Craig Rosen , Reiner Gentz , Jeffrey Su , Geoffrey Krissansen , Ping Feng
发明人: Jian Ni , Craig Rosen , Reiner Gentz , Jeffrey Su , Geoffrey Krissansen , Ping Feng
IPC分类号: C12N15/09 , A61K38/00 , A61K45/00 , A61K48/00 , A61P35/00 , C07K14/47 , C07K14/705 , C07K14/735 , C07K16/18 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/64 , C12N15/12 , C12Q1/68 , G01N33/15 , G01N33/50 , C07H21/04
CPC分类号: C07K14/70535 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/70503 , C12N9/6421 , C12N9/6475 , C12N9/6489 , C12N9/6491 , C12N2799/026
摘要: The present invention relates to novel human proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells and recombinant methods for producing the proteins of the invention. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译: 本发明涉及包含编码这种蛋白质的基因的编码区的新型人类蛋白质和分离的核酸。 还提供了用于产生本发明的蛋白质的载体,宿主细胞和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。
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公开(公告)号:US20060188962A1
公开(公告)日:2006-08-24
申请号:US11404843
申请日:2006-04-17
申请人: Kenneth Carter , Ping Feng , Craig Rosen , Steven Ruben , Gregory Endress
发明人: Kenneth Carter , Ping Feng , Craig Rosen , Steven Ruben , Gregory Endress
CPC分类号: C07K14/47 , A61K38/00 , C07K2319/00 , C07K2319/02
摘要: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译: 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体,宿主细胞,抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。
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公开(公告)号:US07199225B2
公开(公告)日:2007-04-03
申请号:US10435392
申请日:2003-05-12
申请人: Jian Ni , Ping Feng , Patrick J. Dillon , Reiner L. Gentz , Joseph Merregaert , Patrick Smits
发明人: Jian Ni , Ping Feng , Patrick J. Dillon , Reiner L. Gentz , Joseph Merregaert , Patrick Smits
IPC分类号: C07K16/28
CPC分类号: C12Q1/6883 , A61K38/00 , A61K48/00 , A61K2039/51 , C07K14/47 , C07K14/51 , C12N2799/026 , C12Q2600/156 , Y10T436/143333
摘要: A human ECM-1 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for stimulating the differentiation in growth of osteoblasts and osteoclasts, which may be used to promote the healing of bone fractures and de novo bone formation, for osteoporosis, for and to promote angiogenesis. Antagonists to the polypeptide of the present invention are also disclosed which may be utilized to treat osteodystrophy, osteohypertrophy, osteoma, osteoblastoma and cancers. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention.
摘要翻译: 公开了编码这种多肽的人ECM-1多肽和DNA(RNA),以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽刺激成骨细胞和破骨细胞生长分化的方法,其可用于促进骨折愈合和从头骨形成,用于骨质疏松症,促进血管生成。 还公开了本发明多肽的拮抗剂,其可用于治疗骨营养不良,骨质肥大,骨瘤,成骨细胞瘤和癌症。 用于鉴定编码本发明多肽的核酸序列中的突变的诊断测定。
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公开(公告)号:US20080200391A1
公开(公告)日:2008-08-21
申请号:US12105768
申请日:2008-04-18
申请人: Jian Ni , Ping Feng , Patrick J. Dillon , Reiner L. Gentz , Joseph Merregaert , Patrick Smits
发明人: Jian Ni , Ping Feng , Patrick J. Dillon , Reiner L. Gentz , Joseph Merregaert , Patrick Smits
IPC分类号: A61K38/16 , C07H21/00 , C12N15/63 , C12N5/00 , C12P21/00 , A61P19/00 , C07K16/00 , G01N33/00 , C07K14/00
CPC分类号: C12Q1/6883 , A61K38/00 , A61K48/00 , A61K2039/51 , C07K14/47 , C07K14/51 , C12N2799/026 , C12Q2600/156 , Y10T436/143333
摘要: A human ECM-1 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for stimulating the differentiation in growth of osteoblasts and osteoclasts, which may be used to promote the healing of bone fractures and de novo bone formation, for osteoporosis, for and to promote angiogenesis. Antagonists to the polypeptide of the present invention are also disclosed which may be utilized to treat osteodystrophy, osteohypertrophy, osteoma, osteoblastoma and cancers. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention.
摘要翻译: 公开了编码这种多肽的人ECM-1多肽和DNA(RNA),以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽刺激成骨细胞和破骨细胞生长分化的方法,其可用于促进骨折愈合和从头骨形成,用于骨质疏松症,促进血管生成。 还公开了本发明多肽的拮抗剂,其可用于治疗骨营养不良,骨质肥大,骨瘤,成骨细胞瘤和癌症。 用于鉴定编码本发明多肽的核酸序列中的突变的诊断测定。
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公开(公告)号:US07071312B2
公开(公告)日:2006-07-04
申请号:US10915596
申请日:2004-08-11
申请人: Jian Ni , Ping Feng , Patrick J. Dillon , Reiner L. Gentz , Joseph Merregaert , Patrick Smits
发明人: Jian Ni , Ping Feng , Patrick J. Dillon , Reiner L. Gentz , Joseph Merregaert , Patrick Smits
IPC分类号: C07K14/475
CPC分类号: C07K14/47 , A61K38/00 , A61K48/00 , C12N2799/026
摘要: A human epidermal differentiation factor polypeptide and DNA (RNA) encoding such polypeptide and procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for treating and/or preventing skin diseases. Diagnostic assays for detecting mutations in a nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
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公开(公告)号:US20060063922A1
公开(公告)日:2006-03-23
申请号:US11268629
申请日:2005-11-08
申请人: Jian Ni , Ping Feng , Patrick Dillon , Reiner Gentz , Joseph Merregaert , Patrick Smits
发明人: Jian Ni , Ping Feng , Patrick Dillon , Reiner Gentz , Joseph Merregaert , Patrick Smits
IPC分类号: C07H21/04 , C07K14/475 , A61K38/18 , C12P21/06
CPC分类号: C07K14/47 , A61K38/00 , A61K48/00 , C12N2799/026
摘要: A human epidermal differentiation factor polypeptide and DNA (RNA) encoding such polypeptide and procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for treating and/or preventing skin diseases. Diagnostic assays for detecting mutations in a nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
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公开(公告)号:US20050227282A1
公开(公告)日:2005-10-13
申请号:US11142735
申请日:2005-06-02
申请人: Jian Ni , Ping Feng , Patrick Dillon , Reiner Gentz , Joseph Merregaert , Patrick Smits
发明人: Jian Ni , Ping Feng , Patrick Dillon , Reiner Gentz , Joseph Merregaert , Patrick Smits
IPC分类号: G01N33/50 , A61K38/00 , A61K45/00 , A61K48/00 , A61P9/00 , A61P19/10 , A61P35/00 , A61P43/00 , C07H21/04 , C07K14/47 , C07K14/51 , C07K14/785 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , G01N33/15
CPC分类号: C12Q1/6883 , A61K38/00 , A61K48/00 , A61K2039/51 , C07K14/47 , C07K14/51 , C12N2799/026 , C12Q2600/156 , Y10T436/143333
摘要: A human ECM-1 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for stimulating the differentiation in growth of osteoblasts and osteoclasts, which may be used to promote the healing of bone fractures and de novo bone formation, for osteoporosis, for and to promote angiogenesis. Antagonists to the polypeptide of the present invention are also disclosed which may be utilized to treat osteodystrophy, osteohypertrophy, osteoma, osteoblastoma and cancers. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention.
摘要翻译: 公开了编码这种多肽的人ECM-1多肽和DNA(RNA),以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽刺激成骨细胞和破骨细胞生长分化的方法,其可用于促进骨折愈合和从头骨形成,用于骨质疏松症,促进血管生成。 还公开了本发明多肽的拮抗剂,其可用于治疗骨营养不良,骨质肥大,骨瘤,成骨细胞瘤和癌症。 用于鉴定编码本发明多肽的核酸序列中的突变的诊断测定。
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公开(公告)号:US06653445B1
公开(公告)日:2003-11-25
申请号:US09010147
申请日:1998-01-21
申请人: Jian Ni , Craig A. Rosen , Reiner Gentz , Jeffrey Y. Su , Geoffrey W. Krissansen , Ping Feng
发明人: Jian Ni , Craig A. Rosen , Reiner Gentz , Jeffrey Y. Su , Geoffrey W. Krissansen , Ping Feng
IPC分类号: C07K1400
CPC分类号: C07K14/70535 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/70503 , C12N9/6421 , C12N9/6475 , C12N9/6489 , C12N9/6491 , C12N2799/026
摘要: The present invention relates to novel human proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells and recombinant methods for producing the proteins of the invention. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译: 本发明涉及包含编码这种蛋白质的基因的编码区的新型人类蛋白质和分离的核酸。 还提供了用于产生本发明的蛋白质的载体,宿主细胞和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。
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公开(公告)号:US5981220A
公开(公告)日:1999-11-09
申请号:US815718
申请日:1997-03-12
申请人: Jian Ni , Ping Feng , Patrick J. Dillon , Reiner Gentz
发明人: Jian Ni , Ping Feng , Patrick J. Dillon , Reiner Gentz
IPC分类号: G01N33/50 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P43/00 , C07K14/47 , C07K14/485 , C07K16/22 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/02 , C12Q1/68 , C12R1/91 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/577 , C12N15/00
CPC分类号: C07K14/47 , A61K38/00 , A61K48/00 , C12N2799/026
摘要: A human epidermal differentiation factor polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for treating and/or preventing skin diseases. Diagnostic assays for detecting mutations in a nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
摘要翻译: 公开了人表皮分化因子多肽和编码这种多肽的DNA(RNA)以及通过重组技术产生这种多肽的方法。 还公开了利用这种多肽治疗和/或预防皮肤疾病的方法。 还公开了用于检测编码本发明多肽的核酸序列中的突变并用于检测本发明多肽的改变水平的诊断测定。
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