19 human secreted proteins
    33.
    发明申请
    19 human secreted proteins 审中-公开
    19种人体分泌的蛋白质

    公开(公告)号:US20060188962A1

    公开(公告)日:2006-08-24

    申请号:US11404843

    申请日:2006-04-17

    摘要: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

    摘要翻译: 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体,宿主细胞,抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

    Human extracellular matrix-1
    34.
    发明授权
    Human extracellular matrix-1 失效
    人细胞外基质-1

    公开(公告)号:US07199225B2

    公开(公告)日:2007-04-03

    申请号:US10435392

    申请日:2003-05-12

    IPC分类号: C07K16/28

    摘要: A human ECM-1 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for stimulating the differentiation in growth of osteoblasts and osteoclasts, which may be used to promote the healing of bone fractures and de novo bone formation, for osteoporosis, for and to promote angiogenesis. Antagonists to the polypeptide of the present invention are also disclosed which may be utilized to treat osteodystrophy, osteohypertrophy, osteoma, osteoblastoma and cancers. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention.

    摘要翻译: 公开了编码这种多肽的人ECM-1多肽和DNA(RNA),以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽刺激成骨细胞和破骨细胞生长分化的方法,其可用于促进骨折愈合和从头骨形成,用于骨质疏松症,促进血管生成。 还公开了本发明多肽的拮抗剂,其可用于治疗骨营养不良,骨质肥大,骨瘤,成骨细胞瘤和癌症。 用于鉴定编码本发明多肽的核酸序列中的突变的诊断测定。