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    Antibodies that specifically bind Cytostatin III
    2.
    发明授权
    Antibodies that specifically bind Cytostatin III 失效
    特异性结合细胞抑素III的抗体

    公开(公告)号：US06413726B1

    公开(公告)日：2002-07-02

    申请号：US09734036

    申请日：2000-12-12

    申请人： Jian Ni ,  Guo-Liang Yu ,  Reiner Gentz ,  Patrick J. Dillon

    发明人： Jian Ni ,  Guo-Liang Yu ,  Reiner Gentz ,  Patrick J. Dillon

    IPC分类号： G01N3350

    CPC分类号： C07K14/475 ,  C07K2319/00

    摘要： The invention relates to Cytostatin III polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.

    摘要翻译： 本发明涉及细胞抑制素III多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。 本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。

    DNA encoding the chemotactic cytokine III
    3.
    发明授权
    DNA encoding the chemotactic cytokine III 失效
    编码趋化性细胞因子III的DNA

    公开(公告)号：US5952197A

    公开(公告)日：1999-09-14

    申请号：US812003

    申请日：1997-03-05

    申请人： Jian Ni ,  Reiner Gentz ,  Guo-Liang Yu ,  Jeffrey Su ,  Patrick J. Dillon

    发明人： Jian Ni ,  Reiner Gentz ,  Guo-Liang Yu ,  Jeffrey Su ,  Patrick J. Dillon

    IPC分类号： A61K38/00 ,  C07K14/52 ,  C12N15/19 ,  C12N15/00 ,  C12N15/63

    CPC分类号： C07K14/52 ,  C07K14/521 ,  A61K38/00

    摘要： Human chemotactic cytokine III polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, auto-immune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever, cerebral ischemia, glomerulonephritis, HTLV-1 related diseases and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding chemotactic cytokine III and for detecting altered levels of the polypeptide in a host.

    摘要翻译： 公开了人类趋化性细胞因子III多肽和编码这种趋化性细胞因子的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种趋化性细胞因子治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 针对这种趋化性细胞因子的拮抗剂及其作为治疗类风湿性关节炎，自身免疫和慢性和急性炎症和感染性疾病，过敏反应，前列腺素不依赖性发烧，脑缺血，肾小球肾炎，HTLV-1相关疾病和骨髓衰竭的治疗用途 也被披露。 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码趋化性细胞因子III的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定。

    Cytostatin III
    5.
    发明授权
    Cytostatin III 有权
    细胞抑素III

    公开(公告)号：US06232291B1

    公开(公告)日：2001-05-15

    申请号：US09307817

    申请日：1999-05-10

    申请人： Jian Ni ,  Guo-Liang Yu ,  Reiner Gentz ,  Patrick J. Dillon

    发明人： Jian Ni ,  Guo-Liang Yu ,  Reiner Gentz ,  Patrick J. Dillon

    IPC分类号： C07K14435

    CPC分类号： C07K14/475 ,  C07K2319/00

    摘要： The invention relates to Cytostatin III polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.

    摘要翻译： 本发明涉及细胞抑制素III多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。 本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。

    Polynucleotides encoding human tumor necrosis factor delta
    6.
    发明授权
    Polynucleotides encoding human tumor necrosis factor delta 失效
    编码人肿瘤坏死因子δ的多核苷酸

    公开(公告)号：US06509170B1

    公开(公告)日：2003-01-21

    申请号：US08815783

    申请日：1997-03-12

    申请人： Guo-Liang Yu ,  Jian Ni ,  Reiner Gentz ,  Patrick J. Dillon

    发明人： Guo-Liang Yu ,  Jian Ni ,  Reiner Gentz ,  Patrick J. Dillon

    IPC分类号： C12P2106

    CPC分类号： G01N33/6863 ,  C07K16/2875 ,  G01N2333/525

    摘要： The invention relates to human TNF delta and TNF epsilon polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.

    摘要翻译： 本发明涉及人TNFδ和TNFε多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。 本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。

    Antibodies that bind tumor necrosis factor delta
    7.
    发明授权
    Antibodies that bind tumor necrosis factor delta 有权
    结合肿瘤坏死因子δ的抗体

    公开(公告)号：US06506882B2

    公开(公告)日：2003-01-14

    申请号：US10082260

    申请日：2002-02-26

    申请人： Guo-Liang Yu ,  Jian Ni ,  Reiner Gentz ,  Patrick J. Dillon

    发明人： Guo-Liang Yu ,  Jian Ni ,  Reiner Gentz ,  Patrick J. Dillon

    IPC分类号： C07K1600

    CPC分类号： G01N33/6863 ,  C07K16/2875 ,  G01N2333/525

    摘要： The invention relates to human TNF delta and TNF epsilon polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.

    摘要翻译： 本发明涉及人TNFδ和TNFε多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。 本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。

    Cytostatin III nucleic acids encoding
    8.
    发明授权
    Cytostatin III nucleic acids encoding 失效
    细胞抑素III核酸编码

    公开(公告)号：US5945309A

    公开(公告)日：1999-08-31

    申请号：US820825

    申请日：1997-03-19

    申请人： Jian Ni ,  Guo-Liang Yu ,  Reiner Gentz ,  Patrick J. Dillon

    发明人： Jian Ni ,  Guo-Liang Yu ,  Reiner Gentz ,  Patrick J. Dillon

    IPC分类号： C07K14/475 ,  C12N1/21 ,  C07K14/435 ,  C12N5/10

    CPC分类号： C07K14/475 ,  C07K2319/00

    摘要： The invention relates to Cytostatin III polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.

    摘要翻译： 本发明涉及细胞抑制素III多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。 本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。

    Human extracellular matrix-1
    9.
    发明授权
    Human extracellular matrix-1 失效
    人细胞外基质-1

    公开(公告)号：US07199225B2

    公开(公告)日：2007-04-03

    申请号：US10435392

    申请日：2003-05-12

    申请人： Jian Ni ,  Ping Feng ,  Patrick J. Dillon ,  Reiner L. Gentz ,  Joseph Merregaert ,  Patrick Smits

    发明人： Jian Ni ,  Ping Feng ,  Patrick J. Dillon ,  Reiner L. Gentz ,  Joseph Merregaert ,  Patrick Smits

    IPC分类号： C07K16/28

    CPC分类号： C12Q1/6883 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/51 ,  C07K14/47 ,  C07K14/51 ,  C12N2799/026 ,  C12Q2600/156 ,  Y10T436/143333

    摘要： A human ECM-1 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for stimulating the differentiation in growth of osteoblasts and osteoclasts, which may be used to promote the healing of bone fractures and de novo bone formation, for osteoporosis, for and to promote angiogenesis. Antagonists to the polypeptide of the present invention are also disclosed which may be utilized to treat osteodystrophy, osteohypertrophy, osteoma, osteoblastoma and cancers. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention.

    摘要翻译： 公开了编码这种多肽的人ECM-1多肽和DNA（RNA），以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽刺激成骨细胞和破骨细胞生长分化的方法，其可用于促进骨折愈合和从头骨形成，用于骨质疏松症，促进血管生成。 还公开了本发明多肽的拮抗剂，其可用于治疗骨营养不良，骨质肥大，骨瘤，成骨细胞瘤和癌症。 用于鉴定编码本发明多肽的核酸序列中的突变的诊断测定。