公开(公告)号：US07402141B2

公开(公告)日：2008-07-22

申请号：US10927340

申请日：2004-08-25

Applicant: Richard R. Heuser

Inventor： Richard R. Heuser

IPC: A61B5/00 ,  A61M25/00

CPC classification number: A61M25/09041 ,  A61M25/01 ,  A61M25/0105 ,  A61M25/09 ,  A61M2025/0004 ,  A61M2025/0681 ,  A61M2025/09175

Abstract: A catheterization guidewire system provides a first wire for percutaneous insertion in a blood vessel. The first wire may include a lumen running from one end to the other, and a handle adjacent the proximal end for manipulation of the first wire about and along a central axis. A second wire may be inserted in the blood vessel over the first wire, and may have a handle adjacent a proximal end. With the first and second wires coupled together, either of the handles of the first and second wires may be used to manipulate both wires. The wires may be manipulated relative to one another by simultaneous use of both handles. The first wire may have a rigidity selected to allow crossing of a bifurcation in the blood vessel. A third wire, which may also have a handle, may be inserted in the blood vessel over the second wire. A catheter for insertion over at least one of the first, second, and third wires may be provided with a balloon and a stent placement apparatus.

Abstract translation: 导管引导系统提供用于在血管中经皮插入的第一线。 第一线可以包括从一端延伸到另一端的内腔，以及与近端相邻的手柄，用于围绕并沿着中心轴线操纵第一线。 第二线可以在第一线上的血管中插入，并且可以具有邻近近端的手柄。 通过将第一和第二导线耦合在一起，第一和第二导线的手柄中的任一个可用于操纵两条导线。 可以通过同时使用两个把手相对于彼此来操纵电线。 第一线可以具有选择的刚性以允许血管中的分叉交叉。 也可以具有手柄的第三线可以插入第二线上的血管中。 用于插入第一，第二和第三线中的至少一个的导管可以设置有气囊和支架放置装置。

公开(公告)号：US20080161901A1

公开(公告)日：2008-07-03

申请号：US11963460

申请日：2007-12-21

Applicant: Richard R. Heuser ,  James D. Joye

Inventor： Richard R. Heuser ,  James D. Joye

IPC: A61F2/84 ,  A61F2/82

CPC classification number: A61F2/82 ,  A61B17/12045 ,  A61B17/12136 ,  A61B2017/00778 ,  A61B2017/00876 ,  A61B2017/06071 ,  A61B2017/1107 ,  A61B2017/1139 ,  A61B2017/12127 ,  A61B2017/22054 ,  A61B2017/22069 ,  A61F2/2493 ,  A61F2/856 ,  A61F2002/8486 ,  A61F2250/0018 ,  A61F2250/006 ,  A61M25/0905 ,  A61M2025/1052

Abstract: A trifurcated stent apparatus for use by a physician includes a main stent for inserting into a trifurcated blood vessel and two side stents. The main stent includes two openings on the side which are the same diameter as the corresponding side stents. The main stent may be configured to receive a first end of a first side stent and a first end of a second side stent, to create a trifurcated stent. Alternatively, the side stents and the main stent may form a single integrated unit. The main stent and side stents can include one-way valves on one or more of the ends. The one or more one-way valves may be opened or closed, depending on whether the physician desires that fluid pass through. While closed, the valve may be configured to allow passage of various cardiovascular instruments, including but not limited to guidewires, catheters, balloons, or any other device used in blood vessel operations, while not allowing the passage of any fluids.

Abstract translation: 用于医师的三叉支架装置包括用于插入三叉血管和两个侧支架中的主支架。 主支架包括在侧面上具有与相应侧支架相同直径的两个开口。 主支架可以被配置为接收第一侧支架的第一端和第二侧支架的第一端，以产生三叉支架。 或者，侧支架和主支架可以形成单个集成单元。 主支架和侧支架可以包括一个或多个端部上的单向阀。 一个或多个单向阀可以打开或关闭，这取决于医生是否期望流体通过。 在关闭的情况下，阀可以被配置为允许各种心血管器械的通过，包括但不限于导线，导管，球囊或在血管操作中使用的任何其它装置，同时不允许任何流体通过。

公开(公告)号：US06554842B2

公开(公告)日：2003-04-29

申请号：US09803308

申请日：2001-03-09

Applicant: Richard R. Heuser ,  Richard M. DeMello

Inventor： Richard R. Heuser ,  Richard M. DeMello

IPC: A61F1100

CPC classification number: A61B17/32056 ,  A61B17/221 ,  A61B90/39 ,  A61B2017/2212 ,  A61B2090/3954

Abstract: A small-diameter surgical snare device that is capable of fitting through existing balloon or guiding catheters includes metal tubing along a section of a core wire. The distal end of the core wire connects to one or more snare wires that form the snaring loop. The distal end of the snaring loop supports a radiopaque coil or collar that makes the end of the loop visible under fluoroscopy. The snaring loop may consist of one or two wires or an overlap of a tapered end of the core wire. A radiopaque coil is attached to a distal end of the metal tubing, to provide flexibility and visibility to a distal region of the device. Alternatively, a polyimide tube and a short radiopaque marker may be included at a distal end of the metal tubing. The polyimide tube fits inside of the metal tubing, to add strength and torsion control to the distal region of the device, while the radiopaque marker adds visibility. In all embodiments, a shrink tube is fit over the radiopaque coil or marker that is supported by the distal end of the metal tubing, to ensure that the coil does not stretch when the snaring loop is extended during use.

Abstract translation: 能够通过现有气囊或引导导管装配的小口径手术圈套装置包括沿芯线部分的金属管。 芯线的远端连接到形成缠绕环的一个或多个圈套线。 缠绕环的远端支持不透射线圈或环，使得环的末端在荧光透视下可见。 缠绕环可以由一条或两条线或芯线的锥形端的重叠组成。 不透射线圈附接到金属管的远端，以向装置的远侧区域提供灵活性和可见性。 或者，可以在金属管的远端包括聚酰亚胺管和短的不透射线的标记。 聚酰亚胺管装配在金属管道的内部，以增加设备远端区域的强度和扭力控制，而不透射线的标记增加了可视性。 在所有实施例中，收缩管装配在由金属管的远端支撑的不透射线圈或标记上，以确保线圈在使用期间在缠绕环延伸时不拉伸。

公开(公告)号：US06464681B1

公开(公告)日：2002-10-15

申请号：US09705963

申请日：2000-11-03

Applicant: Richard R. Heuser

Inventor： Richard R. Heuser

IPC: A61M3100

CPC classification number: A61M25/1011 ,  A61B17/00491 ,  A61B17/0057 ,  A61B2017/00557 ,  A61B2017/00575 ,  A61M2025/1052

Abstract: Methods for treating bodily tissues and fluid vessels are disclosed. According to a method of repairing a perforation in a bodily fluid vessel, a viscous, moldable substance is inserted into the vessel at the location of the perforation. A path is opened through the moldable substance to permit fluid flow through the vessel. According to a method of introducing a tissue-killing substance into a bodily fluid vessel, a catheter is provided that has a blocking mechanism configured to selectively block and unblock the vessel. The catheter also has a delivery system that is configured to introduce the tissue-killing substance into the vessel. The vessel is substantially blocked upstream of a selected tissue using the blocking mechanism. The tissue-killing substance is introduced into the vessel through the delivery system, and the vessel is unblocked when the tissue-killing substance has substantially traveled toward the selected tissue. According to a method of occluding a bodily fluid vessel, a catheter is provided that has a first passage. The first passage has an occlusion element housed therein. The catheter is positioned in the vessel, and the occlusion element is moved out of the passage and into the vessel to thereby occlude the vessel. A catheter is also disclosed that may be used with the above methods.

Abstract translation: 公开了用于治疗身体组织和流体血管的方法。 根据在体液容器中修复穿孔的方法，在穿孔的位置将粘性可成型物质插入容器中。 通过可模制物质打开通道，以允许流体流过容器。 根据将组织杀伤物质引入体液容器的方法，提供具有阻挡机构的导管，所述阻塞机构构造成选择性地阻断和解除容器的阻塞。 导管还具有配置成将组织杀伤物质引入血管的输送系统。 使用阻塞机构，在所选择的组织的上游基本上阻塞血管。 组织杀伤物质通过输送系统引入血管，并且当组织杀伤物质基本上朝向所选择的组织移动时，血管被解除封闭。 根据封闭体液容器的方法，提供具有第一通道的导管。 第一通道具有容纳在其中的遮挡元件。 导管定位在容器中，并且阻塞元件移出通道并进入容器中，从而封闭容器。 还公开了可以与上述方法一起使用的导管。

公开(公告)号：US06190379B1

公开(公告)日：2001-02-20

申请号：US09115585

申请日：1998-07-14

Applicant: Richard R. Heuser ,  Shinji Hara

Inventor： Richard R. Heuser ,  Shinji Hara

IPC: A61B1804

CPC classification number: A61B18/1492 ,  A61B18/08 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00392 ,  A61B2018/00422 ,  A61B2018/0075 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/00898 ,  A61B2018/1253 ,  A61B2018/144 ,  A61M25/09025 ,  A61M25/104 ,  A61M2025/1093

Abstract: A system and method for treating a stenosis or blockage in a bodily fluid passageway is described. The system includes a catheter and a controller for generating radio frequency energy along a pair of output lines, a monitoring circuit for monitoring the phase of the radio frequency energy along the output lines, and an impedance matching circuit for adjusting the output impedance of the generator so that it equals that of a load, e.g., the patient. The catheter includes a catheter body which is insertable into the bodily passageway and operatively connected to the controller. A lumen in the catheter body defines an opening and a stainless steel, metallic-plated mandril is disposed within the lumen so that a terminal end thereof extends through the opening and into the bodily passageway. An internal electrode is joined to the terminal end of the mandril, with the other end of the mandril operatively connected to one of the output lines for receiving the radio frequency energy produced by the generator and delivering such energy to the terminal end and the internal electrode. An external electrode in the form of a grounding pad is located externally of a patient so that when the radio frequency energy is delivered via the mandril to the internal electrode, the same causes or enables the capacitative heating of a stenosis. The method of the present invention relates to finding the most optimal position for placement of the catheter so that optimal power may be delivered to the stenosis.

Abstract translation: 描述了用于治疗体液通道中的狭窄或阻塞的系统和方法。 该系统包括导管和用于沿着一对输出线产生射频能量的控制器，用于监测沿着输出线的射频能量相位的监视电路，以及用于调节发生器的输出阻抗的阻抗匹配电路 使其等于负载，例如患者。 导管包括可插入身体通道并可操作地连接到控制器的导管主体。 导管主体中的内腔限定开口，并且不锈钢，金属镀金的心轴设置在内腔内，使得其末端延伸穿过开口并进入身体通道。 内部电极连接到心轴的终端，其中心轴的另一端可操作地连接到输出线之一，用于接收由发电机产生的射频能量，并将这种能量传送到终端和内部电极 。 接地垫形式的外部电极位于患者的外部，使得当射频能量经由心轴输送到内部电极时，相同的原因或能够使狭窄的电容加热。 本发明的方法涉及找到用于放置导管的最佳位置，使得可以将最佳功率递送至狭窄。

公开(公告)号：US20150045728A1

公开(公告)日：2015-02-12

申请号：US14509551

申请日：2014-10-08

Applicant: Richard R. Heuser

Inventor： Richard R. Heuser

IPC: A61M25/10 ,  A61B18/14 ,  A61B18/20 ,  A61M5/158

CPC classification number: A61M25/10 ,  A61B18/1492 ,  A61B18/201 ,  A61B2017/00261 ,  A61B2018/0041 ,  A61M5/158 ,  A61M25/0067 ,  A61M25/007 ,  A61M25/0084 ,  A61M2025/0089 ,  A61M2025/105 ,  A61M2025/1052 ,  A61M2025/1063 ,  A61M2205/054 ,  A61M2210/12

Abstract: A catheterization system for treatment of a condition within a blood vessel is provided with a catheter, a balloon immediately adjacent to the distal end of the catheter, an inflation device for expanding the balloon, and a fluid injection device for injecting a treatment fluid through the central lumen of the catheter and out of the aperture at the distal end of the catheter into the treatment area. The system may include an RF wire, a hollow needle wire, a dissection tool, or a laser wire insertable through the central lumen of the catheter and selectively operable adjacent the proximal end of the catheter to apply treatment within the blood vessel.

Abstract translation: 用于治疗血管内的病症的导管系统设置有导管，紧邻导管远端的气囊，用于扩张气囊的充气装置，以及用于通过 导管的中央腔，并将导管远端的孔插入治疗区域。 该系统可以包括RF导线，中空针线，解剖工具或可插入通过导管的中心腔的激光线，并且可选择性地可操作地邻近导管的近端操作以在血管内进行治疗。

公开(公告)号：US20130053732A1

公开(公告)日：2013-02-28

申请号：US13217233

申请日：2011-08-24

Applicant: Richard R. Heuser

Inventor： Richard R. Heuser

IPC: A61B18/02 ,  A61N7/00 ,  A61B18/18

CPC classification number: A61N7/022 ,  A61B18/1492 ,  A61B2018/00267 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/0212 ,  A61B2018/1861 ,  A61N1/0551 ,  A61N1/36117

Abstract: Embodiments herein provide systems and methods for the treatment of hypertension. In various embodiments, methods and devices are provided that may be used to treat hypertension in a subject by applying energy, such as radio frequency (RF), microwave, ultrasound, or cryo energy, to one or more renal sympathetic and/or parasympathetic nerves, thereby selectively denervating the renal sympathetic and/or parasympathetic nerves. An exemplary system in accordance with the present disclosure may include a plurality of wires or one or more flexible mesh elements that are extendable from a catheter to expand and contact the inner wall of a conduit at a plurality of points. Additionally, in various embodiments the disclosed methods and devices may be used not only in the renal arteries, but also in the renal veins and/or in the renal pelvis and/or ureter.

Abstract translation: 本文的实施方案提供了用于治疗高血压的系统和方法。 在各种实施方案中，提供了可用于通过向一种或多种肾交感神经和/或副交感神经施加能量（例如射频（RF）），微波，超声波或低温能量来治疗受试者的高血压的方法和装置。 从而选择性地去神经肾交感神经和/或副交感神经。 根据本公开的示例性系统可以包括多个线或一个或多个柔性网状元件，其可以从导管延伸以在多个点处扩展和接触导管的内壁。 另外，在各种实施方案中，所公开的方法和装置不仅可用于肾动脉，还可用于肾静脉和/或肾盂和/或输尿管。

公开(公告)号：US20120239137A1

公开(公告)日：2012-09-20

申请号：US13422594

申请日：2012-03-16

Applicant: Richard R. Heuser ,  Kumar G. Jambunathan

Inventor： Richard R. Heuser ,  Kumar G. Jambunathan

IPC: A61F2/90

CPC classification number: A61F2/07 ,  A61F2/88 ,  A61F2/89 ,  A61F2002/072 ,  A61F2250/0018 ,  A61F2250/0039

Abstract: Embodiments herein provide differential dilation stents for use in percutaneous interventions, such as transluminal bypass procedures. In some embodiments, the stents may be used in the process of creating an arteriovenous (AV) fistula during a percutaneous bypass procedure, and such stents may have two or more specialized regions that are configured to adopt a predetermined diameter, shape, and/or tensile strength upon insertion in order to suit the needs of the vessel or procedure. The disclosed stents may be used for creating and/or maintaining an arterial/venous fistula for bypass of an occlusion in a cardiac artery using a cardiac vein, or the femoral artery, for example using the tibial or popliteal vein.

Abstract translation: 本文的实施方案提供用于经皮干预的差异扩张支架，例如经腔旁路手术。 在一些实施例中，支架可用于在经皮旁路手术期间产生动静脉（AV）瘘的过程中，并且这种支架可具有被配置为采用预定直径，形状和/或形状的两个或更多个专门区域 插入时的拉伸强度，以适应船只或程序的需要。 所公开的支架可用于创建和/或维持动脉/静脉瘘，以使用心静脉或股动脉绕过心脏动脉闭塞，例如使用胫骨或al静脉。

公开(公告)号：US08066674B2

公开(公告)日：2011-11-29

申请号：US12646901

申请日：2009-12-23

Applicant: Richard R. Heuser

Inventor： Richard R. Heuser

IPC: A61M5/178

CPC classification number: A61M25/0662 ,  A61B17/3415 ,  A61B17/3417 ,  A61B17/3462 ,  A61B17/3498 ,  A61B2017/3441 ,  A61M29/00 ,  A61M39/0613 ,  A61M2025/0004 ,  A61M2025/0681 ,  A61M2025/0687 ,  A61M2039/062 ,  A61M2039/0626 ,  A61M2039/0633

Abstract: A catheter introducer system is provided with a catheter sheath having a valve providing for a friction fit around a catheter. The friction fit is selectively adjustable to vary between a first configuration for longitudinal movement of the catheter through the valve and a second configuration for holding the catheter longitudinally in place. The valve may include a chuck to grip the catheter radially. The chuck may include an annular base and an opposed annular clamp, and a washer disposed between the base and the clamp. At least one of the base and the clamp may include a beveled surface that forces the washer radially inwardly as the base and the clamp are drawn together. The system also includes one or more dilators layered within the sheath. One or more of the dilators may include a preformed arcuate portion configured to access a targeted branched vessel. The layered dilators and sheaths are typically softer and more hydrophilic proceeding from the innermost dilator out to the sheath. The dilator may be reinforced by a wire embedded in the body of the dilator. The distal tip of the sheath may be stiffened by a ring affixed adjacent the distal end. The sheath may include in the innermost dilator a trocar formed of a flexible, hollow outer wire and an inner stiff needle, which can extend beyond the wire for piercing and be withdrawn to relax the wire for advancement of the dilator.

Abstract translation: 导管导引器系统设置有导管鞘，其具有提供围绕导管的摩擦配合的阀。 摩擦配合可选择性地可调节，以在导管通过阀的纵向移动的第一构型和用于将导管纵向保持在适当位置的第二构型之间变化。 阀可以包括卡盘以径向地夹持导管。 卡盘可以包括环形基座和相对的环形夹具，以及设置在基座和夹具之间的垫圈。 基座和夹具中的至少一个可以包括斜面，当基部和夹具被拉在一起时迫使垫圈径向向内。 该系统还包括在鞘内分层的一个或多个扩张器。 一个或多个扩张器可以包括构造成进入目标分支血管的预成形弓形部分。 层状扩张器和护套通常比最内侧的扩张器向护套更软和更亲水。 扩张器可以通过嵌入在扩张器的体内的线来加强。 护套的远端可以通过邻近远端固定的环来加固。 护套可以在最内侧的扩张器中包括由柔性的中空的外部线和内部刚性针形成的套针针，该针可以延伸超过线以刺穿并被撤回以松弛线来推进扩张器。

公开(公告)号：US07914492B2

公开(公告)日：2011-03-29

申请号：US11656898

申请日：2007-01-22

Applicant: Richard R. Heuser

Inventor： Richard R. Heuser

IPC: A61M5/178

CPC classification number: A61M29/00 ,  A61B17/3415 ,  A61B17/3462 ,  A61B17/3498 ,  A61B2017/3441 ,  A61M25/0662 ,  A61M39/0613 ,  A61M2025/0004 ,  A61M2025/0681 ,  A61M2025/0687 ,  A61M2039/0633

Abstract: A catheter introducer system is provided with a catheter sheath having a valve providing for a friction fit around a catheter. The friction fit is selectively adjustable to vary between a first configuration for longitudinal movement of the catheter through the valve and a second configuration for holding the catheter longitudinally in place. The valve may includes a chuck to grip the catheter radially. The chuck may include an annular base and an opposed annular clamp, and a washer disposed between the base and the clamp. At least one of the base and the clamp may include a beveled surface that forces the washer radially inwardly as the base and the clamp are drawn together. The system also includes one or more dilators layered within the sheath. The layered dilators and sheaths are typically softer and more hydrophilic proceeding from the innermost dilator out to the sheath. The dilator may be reinforced by a wire embedded in the body of the dilator. The distal tip of the sheath may be stiffened by a ring affixed adjacent the distal end. The sheath may include in the innermost dilator a trocar formed of a flexible, hollow outer wire and an inner stiff needle, which can extend beyond the wire for piercing and be withdrawn to relax the wire for advancement of the dilator.

Abstract translation: 导管导引器系统设置有导管鞘，其具有提供围绕导管的摩擦配合的阀。 摩擦配合可选择性地可调节，以在导管通过阀的纵向移动的第一构型和用于将导管纵向保持在适当位置的第二构型之间变化。 阀可以包括卡盘以径向地夹持导管。 卡盘可以包括环形基座和相对的环形夹具，以及设置在基座和夹具之间的垫圈。 基座和夹具中的至少一个可以包括斜面，当基部和夹具被拉在一起时迫使垫圈径向向内。 该系统还包括在鞘内分层的一个或多个扩张器。 层状扩张器和护套通常比最内侧的扩张器向护套更软和更亲水。 扩张器可以通过嵌入在扩张器的体内的线来加强。 护套的远端可以通过邻近远端固定的环来加固。 护套可以在最内侧的扩张器中包括由柔性的中空的外部线和内部刚性针形成的套针针，该针可以延伸超过线以刺穿并被撤回以松弛线来推进扩张器。