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    Cyanine compounds and their application as quenching compounds
    32.
    发明申请
    Cyanine compounds and their application as quenching compounds 有权
    花青化合物及其作为淬灭化合物的应用

    公开(公告)号：US20050191643A1

    公开(公告)日：2005-09-01

    申请号：US10916822

    申请日：2004-08-11

    Applicant: Rosaria Haugland ,  Ching-Ying Cheung ,  Stephen Yue

    Inventor： Rosaria Haugland ,  Ching-Ying Cheung ,  Stephen Yue

    IPC: C07D209/12 ,  C07D209/24 ,  C07D401/04 ,  C07D471/02 ,  C07D491/02 ,  C07D498/02 ,  C12Q1/68

    CPC classification number: C12Q1/6876 ,  C07D209/12 ,  C07D209/14 ,  C07D209/24 ,  C07D401/04 ,  C09B23/12

    Abstract: The present invention provides methods and non-fluorescent carbocyanine quencher compounds having the general formula: Wherein the A moiety is a substituted pyridinium, unsubstituted pyridinium, substituted quinolinium, unsubstituted quinolinium, substituted benzazolium, unsubstituted benzazolium, substituted indolinium, or substituted indolinium. The invention further provides luminescent donor molecule-quencher pairs and luminescent donor molecule-quencher-luminescent acceptor molecule conjugates wherein the quencher is a cyanine compound of the present invention. The energy transfer pairs are used to detect an analyte of interest in a sample.

    Abstract translation: 本发明提供了具有以下通式的方法和非荧光碳花青猝灭剂：其中A部分是取代的吡啶鎓，未取代的吡啶鎓，取代的喹啉鎓，未取代的喹啉鎓，取代的苯并唑鎓，未取代的苯并咪唑鎓，取代的吲哚鎓或取代的吲哚啉鎓。 本发明还提供了发光供体分子猝灭剂对和发光供体分子 - 猝灭剂 - 发光受体分子缀合物，其中猝灭剂是本发明的花青化合物。 能量转移对用于检测样品中感兴趣的分析物。

    Apparatus and methods for self-biasing differential signaling circuitry having multimode output configurations for low voltage applications
    37.
    发明授权
    Apparatus and methods for self-biasing differential signaling circuitry having multimode output configurations for low voltage applications 有权
    具有用于低电压应用的多模输出配置的用于自偏压差动信号电路的装置和方法

    公开(公告)号：US07724037B2

    公开(公告)日：2010-05-25

    申请号：US12352916

    申请日：2009-01-13

    Applicant: Junho Cho ,  Nancy Chan ,  Ramesh Senthinathan ,  Stephen Yue ,  Richard W. Fung

    Inventor： Junho Cho ,  Nancy Chan ,  Ramesh Senthinathan ,  Stephen Yue ,  Richard W. Fung

    IPC: H03K19/094

    CPC classification number: H03K17/302 ,  H03K17/04106

    Abstract: The present disclosure relates to a differential signaling circuit including differential signaling circuitry having at least one output and one input, that can operate in multiple mode of operations while using a single, low voltage supply source. Two or more switches are included and configured to selectively couple a supply voltage to the output dependent on a mode of operation of the differential signaling circuitry. The circuit also includes a switch control biasing circuit operatively coupled to at least one of the switches and to the output of the differential signaling circuitry. The switch control biasing circuit provides a switch control biasing voltage to control a state of the switch based on a voltage level of the output. Further, a bulk biasing circuit is included and operatively coupled to the switch. The bulk biasing circuit selectively provides a bulk biasing voltage to the switch based on the voltage level of the output.

    Abstract translation: 本公开涉及一种差分信号电路，其包括具有至少一个输出和一个输入的差分信号电路，其可以在使用单个低电压电源时在多种操作模式下操作。 两个或更多个开关被包括并配置成根据差分信号电路的操作模式选择性地将电源电压耦合到输出。 电路还包括可操作地耦合到至少一个开关和差分信号电路的输出的开关控制偏置电路。 开关控制偏置电路提供开关控制偏置电压，以基于输出的电压电平来控制开关的状态。 此外，体积偏置电路被包括并且可操作地耦合到开关。 体积偏置电路基于输出的电压电平选择性地向开关提供体积偏置电压。

    Modified actinomycin-based nucleic acid stains and methods of their use
    39.
    发明授权
    Modified actinomycin-based nucleic acid stains and methods of their use 有权
    改良的基于放线菌素的核酸污渍及其使用方法

    公开(公告)号：US08653261B2

    公开(公告)日：2014-02-18

    申请号：US13126150

    申请日：2009-10-26

    Applicant: Stephen Yue ,  Jixiang Liu ,  Jolene Bradford

    Inventor： Stephen Yue ,  Jixiang Liu ,  Jolene Bradford

    IPC: C07D265/38

    CPC classification number: C07D265/38

    Abstract: Actinomysin-based near IR emitting compounds and methods of their use as nucleic acid stains are provided. The actinomysin-based near IR emitting compounds have the structure: wherein R is H or NH2; R1, R2, R3, and R4 are independently a moiety comprising 1-30 atoms selected from H, O, C, and N, wherein the atoms are in a linear, branched, or cyclic configuration; R3 and/or R4 comprise a quaternary nitrogen atom; and R5 is H, F, or Cl.

    Abstract translation: 提供了基于放射性肌动蛋白的近红外发射化合物及其用作核酸污渍的方法。 基于放电肌注蛋白的近红外发射化合物具有以下结构：其中R是H或NH 2; R1，R2，R3和R4独立地是包含1-30个选自H，O，C和N的原子的部分，其中原子是直链，支链或环状构型; R3和/或R4包含季氮原子; R5为H，F或Cl。

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