摘要:
A vaccine delivered by transcutaneous immunization provides an effective treatment against infections by pathogens such as, for example, enterotoxigenic Escherichia coli (ETEC) and/or for symptoms of diarrheal disease caused thereby. For example, one, two, three, four, five or more antigens derived from ETEC and capable of inducing an antigen-specific immune response (e.g., toxins, colonization or virulence factors) and one or more optional adjuvant (e.g., whole bacterial ADP-ribosylating exotoxins, B subunits or toxoids thereof, detoxified mutants and derivatives thereof) are used to manufacture vaccines or to induce systemic and/or mucosal immunity.
摘要:
A transcutaneous immunization system delivers antigen to immune cells without perforation of the skin, and induces an immune response in an animal or human. The system uses an adjuvant, preferably an ADP-ribosylating exotoxin, to induce an antigen-specific immune response (e.g., humoral and/or cellular effectors) after transcutaneous application of a formulation containing antigen and adjuvant to intact skin of the animal or human. The efficiency of immunization may be enhanced by adding hydrating agents (e.g., liposomes), penetration enhancers, or occlusive dressings to the transcutaneous delivery system. This system may allow activation of Langerhans cells in the skin, migration of the Langerhans cells to lymph nodes, and antigen presentation.
摘要:
A transcutaneous immunization system delivers antigen to immune cells without perforation of the skin, and induces an immune response in an animal or human. The system uses an adjuvant, preferably an ADP-ribosylating exotoxin, to induce an antigen-specific immune response (e.g., humoral and/or cellular effectors) after transcutaneous application of a formulation containing antigen and adjuvant to intact skin of the animal or human. The efficiency of immunization may be enhanced by adding hydrating agents (e.g., liposomes), penetration enhancers, or occlusive dressings to the transcutaneous delivery system. This system may allow activation of Langerhans cells in the skin, migration of the Langerhans cells to lymph nodes, and antigen presentation.
摘要:
The present invention is directed to concrete compositions prepared using firm aqueous gels (aquagels) as all or part of the aggregate in a concrete mix. The concrete sets around the aquagels in the initial set stage. Because the aquagels maintain the pore structure of the concrete while it sets, a concrete product can be obtained that has substantially uniform density regardless of depth. During the curing and/or drying stages, the moisture migrates out of the concrete and the aquagels, and the aquagels dry to a fraction of the size of the original aquagel in the cell or pore in the concrete. This results in cellular, lightweight concrete having reduced density, reduced weight, reduced thermal conductivity, and reduced sound transmission compared to concrete prepared without using aquagels.
摘要:
The charcoal-foam heating material is formed by combining a charcoal mixture with an aqueous surfactant and water to create a semi-homogenous charcoal-foam slurry. The slurry is poured into shaping molds so that the slurry dries into the charcoal-foam heating material. In the preferred embodiment, a concrete surfactant is used during the mixing process and the charcoal-foam slurry is formed into briquettes and used as a cooking fuel.
摘要:
A charcoal heating material, such as charcoal briquettes, includes a porous structure that facilitates the flow of oxygen about the charcoal, and thereby, enables the briquettes to ignite easily and quickly. In particular the lightweighted charcoal briquettes have a density from about 0.50 grams per cubic centimeter to about 0.80 grams per cubic centimeter. Methods of forming charcoal heating materials include mixing a rheology modifying agent and a moisture phase with a charcoal mixture to facilitate absorption of additional water into the solid matrix, providing increased porosity and lightweighting of the finished briquette after drying.
摘要:
This present invention provides C-TAB.G5 and C-TAB.G5.1 isolated polypeptides comprising the receptor binding domains of C. difficile toxin A and toxin B as set forth in the amino acid sequences of SEQ ID NO: 2 and SEQ ID NO: 4. The C-TAB.G5 and C-TAB.G5.1 isolated polypeptides may be used to neutralize toxic effects of C. difficile toxin A and/or toxin B.
摘要翻译:本发明提供了包含艰巨梭菌毒素A和毒素B的受体结合结构域的C-TAB.G5和C-TAB.G5.1分离的多肽,如SEQ ID NO:2和SEQ ID NO:2的氨基酸序列所示 NO:4.C-TAB.G5和C-TAB.G5.1分离的多肽可用于中和艰难梭菌毒素A和/或毒素B的毒性作用。
摘要:
A server system for remote monitoring includes a wireless communication interface, a processor, and a storage device. The wireless communication interface receives at least one data packet over wireless communications from a remote monitoring system. The processor processes the data packet including sensor information from a sensor coupled to the remote monitoring system. The storage device stores the sensor information.
摘要:
The present invention relates to starch foam microparticles having a porous structure, and which typically have a diameter of less than or equal to about 50 microns. The present invention also relates to novel uses for the starch foam microparticles in beekeeping and in the pharmaceutical, plastics and fragrance industries.
摘要:
A fiber-reinforced and starch-based composition can be prepared by combining two fractions. The first fraction can include a gelatinized starch, water, and fibers, wherein the fibers are substantially homogenously mixed with the starch in an amount sufficient to structurally reinforce the mechanical characteristics of the starch-based composition. The second fraction is then combined with the first fraction, wherein the second fraction can include non-gelatinized starch, non-volatile plasticizer, and a water-resistant polymer. The composition is mixed so as to form a thermoplastic composition being capable of expanding when rapidly heated to above the boiling point of water and the softening point of the plasticized starch. Additionally, fiber-reinforced articles can be prepared from a method of processing the starch-based compositions. Such a method includes introducing the fiber-reinforced starch-based composition into a mold, and molding the composition into a fiber-reinforced article.