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31.发明授权Block copolymer comprising at least one polyester block and a poly (ethylene glycol) block 有权包含至少一个聚酯嵌段和聚（乙二醇）嵌段的嵌段共聚物公开(公告)号：US08916188B2
公开(公告)日：2014-12-23
申请号：US12106212
申请日：2008-04-18
Applicant: Mikael O. Trollsas , Michael H. Ngo , Syed Hossainy , David J. Sherman
Inventor： Mikael O. Trollsas , Michael H. Ngo , Syed Hossainy , David J. Sherman
CPC classification number: A61L31/10 , A61L31/047 , A61L31/06 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/606 , C08L71/02 , C08L67/04
Abstract: The present invention provides a block copolymer for a coating on an implantable device for controlling release of drug and methods of making and using the same.
Abstract translation: 本发明提供了用于控制药物释放的可植入装置上的涂层的嵌段共聚物及其制备和使用方法。
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公开(公告)号：US08568471B2
公开(公告)日：2013-10-29
申请号：US13015488
申请日：2011-01-27
Applicant: Mikael Trollsas , Michael H. Ngo , Boris Anukhin , Alexander Nikanorov , Syed Hossainy , John E. Papp , Dudley Jayasinghe , Zella Solter
Inventor： Mikael Trollsas , Michael H. Ngo , Boris Anukhin , Alexander Nikanorov , Syed Hossainy , John E. Papp , Dudley Jayasinghe , Zella Solter
IPC: A61F2/82
CPC classification number: A61F2/958 , A61F2/82 , A61F2/844 , A61F2/86 , A61F2/89 , A61F2/91 , A61F2/915 , A61F2002/825 , A61F2002/91558 , A61F2002/91566 , A61F2002/91575 , A61F2002/9522 , A61F2210/0004 , A61F2210/0014 , A61F2210/0019 , A61F2210/0076 , A61F2230/0006 , A61F2230/0008 , A61F2250/0067 , A61F2250/0096 , A61F2250/0098 , A61L27/00 , A61L31/06 , A61L31/14 , B21D39/046 , B29C35/08 , B29C2035/0838 , B29K2067/046 , B29L2023/00 , B29L2031/7543 , Y10T29/49826 , Y10T29/4987 , Y10T29/49908 , Y10T29/49925 , Y10T29/49927 , C08L67/04 , C08L71/02
Abstract: A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold, after being deployed by the balloon, provides a crush recovery of about 90% after the diameter of the scaffold has been pinched or crushed by 50%. The scaffold has a pattern including an asymmetric closed cell connecting links connecting the closed cells.
Abstract translation: 医疗装置包括压接到具有膨胀气囊的导管的聚合物构架。 支架在被气囊部署之后，在支架的直径被挤压或压碎50％后，提供约90％的压碎回收率。 支架具有图案，其包括连接连接封闭单元的链接的非对称封闭单元。
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公开(公告)号：US08465773B2
公开(公告)日：2013-06-18
申请号：US13472328
申请日：2012-05-15
Applicant: Syed Hossainy , Michael Ngo , Mikael Trollsas , John Stankus , Gene Michal
Inventor： Syed Hossainy , Michael Ngo , Mikael Trollsas , John Stankus , Gene Michal
CPC classification number: A61K47/42 , A61K9/0024 , A61K47/34 , A61L27/3804 , A61L27/3839 , A61L27/3895 , A61L27/48 , A61L27/52 , Y10S530/812 , Y10S530/815 , C08L89/00 , C08L71/02
Abstract: Compositions for forming a self-reinforcing composite biomatrix, methods of manufacture and use therefore are herein disclosed. Kits including delivery devices suitable for delivering the compositions are also disclosed. In some embodiments, the composition can include at least three components. In one embodiment, a first component can include a first functionalized polymer, a second component can include a second functionalized polymer and a third component can include silk protein or constituents thereof. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition can include a biologic encapsulated, suspended, disposed within or loaded into a biodegradable carrier. In some embodiments, the composition(s) of the present invention can be delivered by a dual lumen injection device to a treatment area in situ, in vivo, as well as ex vivo applications.
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公开(公告)号：US20120225040A1
公开(公告)日：2012-09-06
申请号：US13472324
申请日：2012-05-15
Applicant: Syed Hossainy , Michael Ngo , Mikael Trollsas , John Stankus , Gene Michal
Inventor： Syed Hossainy , Michael Ngo , Mikael Trollsas , John Stankus , Gene Michal
CPC classification number: A61K47/42 , A61K9/0024 , A61K47/34 , A61L27/3804 , A61L27/3839 , A61L27/3895 , A61L27/48 , A61L27/52 , Y10S530/812 , Y10S530/815 , C08L89/00 , C08L71/02
Abstract: Compositions for forming a self-reinforcing composite biomatrix, methods of manufacture and use therefore are herein disclosed. Kits including delivery devices suitable for delivering the compositions are also disclosed. In some embodiments, the composition can include at least three components. In one embodiment, a first component can include a first functionalized polymer, a second component can include a second functionalized polymer and a third component can include silk protein or constituents thereof. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition can include a biologic encapsulated, suspended, disposed within or loaded into a biodegradable carrier. In some embodiments, the composition(s) of the present invention can be delivered by a dual lumen injection device to a treatment area in situ, in vivo, as well as ex vivo applications.
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公开(公告)号：US20110190872A1
公开(公告)日：2011-08-04
申请号：US13015474
申请日：2011-01-27
Applicant: Boris Anukhin , Michael H. Ngo , Mikael Trollsas , Syed Hossainy , John Papp
Inventor： Boris Anukhin , Michael H. Ngo , Mikael Trollsas , Syed Hossainy , John Papp
CPC classification number: A61F2/89 , A61F2/82 , A61F2/915 , A61F2002/91508 , A61F2002/91575 , A61F2240/002 , A61M25/1034 , B23P11/005 , B29C55/24 , B29C69/00 , Y10T29/49908
Abstract: A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold, after being deployed by the balloon, provides a crush recovery of about 90% after the diameter of the scaffold has been pinched or crushed by 50%. The scaffold also has a reduced crimped profile and a modification of the scaffold's ring structure at the crowns that contributes to the reduced crimped profile.
Abstract translation: 医疗装置包括压接到具有膨胀气囊的导管的聚合物构架。 支架在被气囊部署之后，在支架的直径被挤压或压碎50％后，提供约90％的压碎回收率。 支架还具有减小的卷边轮廓和在冠部处的支架环形结构的改进，其有助于减小卷曲轮廓。
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Patent Agency Ranking
36.发明申请公开(公告)号：US20110144577A1
公开(公告)日：2011-06-16
申请号：US12636158
申请日：2009-12-11
Applicant: John Stankus , Stephen Pacetti , Mikael Trollsas , Syed Hossainy
Inventor： John Stankus , Stephen Pacetti , Mikael Trollsas , Syed Hossainy
CPC classification number: A61L29/16 , A61L29/085 , A61L29/141 , A61L2300/416
Abstract: A tunable coating formulation is described for a drug delivery balloon comprising a therapeutic agent, an excipient and a plasticizer. The tunable coating includes a first therapeutic agent and a first excipient, and can have a second therapeutic agent and a second excipient. The first and second therapeutic agents have different dissolution rates during balloon inflation and therefore provide a coating that is tunable. The plasticizer in the formulation has a weigh ratio of excipient to plasticizer below 1:0.1.
Abstract translation: 对于包含治疗剂，赋形剂和增塑剂的药物递送球，描述了可调涂层制剂。 可调涂层包括第一治疗剂和第一赋形剂，并且可以具有第二治疗剂和第二赋形剂。 第一和第二治疗剂在球囊膨胀期间具有不同的溶解速率，因此提供可调谐的涂层。 制剂中的增塑剂具有赋形剂与增塑剂的重量比低于1:0.1。
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公开(公告)号：US20100324645A1
公开(公告)日：2010-12-23
申请号：US12486652
申请日：2009-06-17
Applicant: JOHN STANKUS , Mikael Trollsas , Syed Hossainy , Liangxuan Zhang , Ed Berger , Stephen Pacetti , John L. Toner
Inventor： JOHN STANKUS , Mikael Trollsas , Syed Hossainy , Liangxuan Zhang , Ed Berger , Stephen Pacetti , John L. Toner
CPC classification number: A61L29/16 , A61L29/08 , A61L29/085 , A61L29/141 , A61L2300/416 , A61L2300/606
Abstract: A drug delivery balloon is provided comprising a balloon having a surface, and a coating disposed on at least a portion of the balloon surface, the coating including an cytostatic therapeutic agent, an excipient, and a plasticizer. In accordance with the present subject matter, at least 30% of the coating transfers from the balloon surface within two minutes after inflation of the balloon. Alternatively, at least 30% of the coating transfers from the balloon surface within one minute after inflation. The coating results in an effective pharmacokinetic profile of an cytostatic therapeutic agent in a vasculature or target tissue.
Abstract translation: 提供了药物递送球囊，其包括具有表面的球囊，以及设置在球囊表面的至少一部分上的涂层，所述涂层包括细胞抑制剂，赋形剂和增塑剂。 根据本主题，至少30％的涂层在气球膨胀后两分钟内从气球表面转移。 或者，至少30％的涂层在充气后一分钟内从气球表面转移。 涂层导致脉管系统或靶组织中细胞抑制治疗剂的有效药代动力学特征。
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公开(公告)号：US07674416B2
公开(公告)日：2010-03-09
申请号：US11020826
申请日：2004-12-22
Applicant: James Hong , Rahul Bhagat , Syed Hossainy , Santosh Prabhu , K. T. Venkateswara Rao , Ashok Shah , Srinivasan Sridharan
Inventor： James Hong , Rahul Bhagat , Syed Hossainy , Santosh Prabhu , K. T. Venkateswara Rao , Ashok Shah , Srinivasan Sridharan
IPC: B32B38/08
CPC classification number: A61F2/915 , A61F2/07 , A61F2/91 , A61F2002/072 , A61F2002/91533 , A61F2002/91558 , A61F2002/91575 , A61F2220/0058 , A61F2230/0013 , A61F2230/0054 , A61L31/10 , A61L31/16 , Y10S623/901
Abstract: A hybrid stent is formed which exhibits both high flexibility and high radial strength. The expandable hybrid stent for implantation in a body lumen, such as a coronary artery, consists of radially expandable cylindrical rings generally aligned on a common longitudinal axis and interconnected by one or more links. In one embodiment, a dip-coated covered stent is formed by encapsulating cylindrical rings within a polymer material. In other embodiments, at least some of the rings and links are formed of a polymer material which provides longitudinal and flexural flexibility to the stent. These polymer rings and links are alternated with metallic rings and links in various configurations to attain sufficient column strength along with the requisite flexibility in holding open the target site within the body lumen. Alternatively, a laminated, linkless hybrid stent is formed by encapsulating cylindrical rings within a polymer tube.
Abstract translation: 形成具有高柔性和高径向强度的混合支架。 用于植入体腔（例如冠状动脉）中的可扩张混合支架由径向可扩展的圆柱形环构成，其通常在公共纵向轴线上对齐并且由一个或多个连杆相互连接。 在一个实施例中，通过将圆柱形环封装在聚合物材料内而形成浸涂的覆盖支架。 在其它实施例中，至少一些环和链节由聚合物材料形成，该聚合物材料向支架提供纵向和弯曲的柔性。 这些聚合物环和链环与金属环和各种结构的链接交替，以获得足够的柱强度以及在体腔内保持打开靶部位所需的灵活性。 或者，通过在聚合物管内封装圆柱形环来形成层压的无环式混合支架。
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公开(公告)号：US07416558B2
公开(公告)日：2008-08-26
申请号：US11497706
申请日：2006-08-01
Applicant: Philip S. Yip , James Jacobs , Syed Hossainy , Jon Becker , Timothy A. Limon
Inventor： Philip S. Yip , James Jacobs , Syed Hossainy , Jon Becker , Timothy A. Limon
IPC: A61F2/06
CPC classification number: A61F2/91 , A61F2/90 , A61F2/915 , A61F2002/91508 , A61F2002/91516 , A61F2002/91533 , A61F2002/91575 , A61F2210/0076 , A61F2220/005 , A61F2250/0036 , A61F2250/0067 , A61F2250/0071 , Y10S623/903
Abstract: An intravascular stent includes an eluting sheath fabricated from a mesh for controlled release of therapeutic drugs and for delivery of the therapeutic drugs in localized drug therapy in a blood vessel. The eluting sheath is attached to at least a portion of an outside surface area of the stent structure and is fabricated from a mesh designed to neck down in response to a radially outward directed force resulting in the uniform expansion of the stent. The eluting sheath can be loaded with at least one therapeutic drug for the release thereof at a treatment site to facilitate repair of a damaged vessel. The stent has a high degree of flexibility in the longitudinal direction, yet has adequate vessel wall coverage and radial strength sufficient to hold open an artery or other body lumen.
Abstract translation: 血管内支架包括由用于控制释放治疗药物的网格和用于在血管中局部药物治疗中递送治疗药物的筛网制成的洗脱鞘。 洗脱鞘附着到支架结构的外表面区域的至少一部分上，并且由设计成颈部向下的网眼制成，以适应径向向外的力，导致支架的均匀膨胀。 洗脱鞘可以装载至少一种用于在治疗部位释放的治疗药物，以便于修复受损血管。 支架在纵向具有高度的柔性，但具有足够的容器壁覆盖和径向强度足以保持打开动脉或其他体腔。
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公开(公告)号：US20080113081A1
公开(公告)日：2008-05-15
申请号：US12018122
申请日：2008-01-22
Applicant: Syed Hossainy , Srinivasan Sridharan
Inventor： Syed Hossainy , Srinivasan Sridharan
IPC: B05D5/00
CPC classification number: A61M25/1029 , A61M2025/1031 , A61M2025/105
Abstract: Methods for modifying a balloon of a catheter assembly are disclosed.
Abstract translation: 公开了用于修改导管组件的球囊的方法。
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