公开(公告)号：US20100324645A1

公开(公告)日：2010-12-23

申请号：US12486652

申请日：2009-06-17

申请人： JOHN STANKUS ,  Mikael Trollsas ,  Syed Hossainy ,  Liangxuan Zhang ,  Ed Berger ,  Stephen Pacetti ,  John L. Toner

发明人： JOHN STANKUS ,  Mikael Trollsas ,  Syed Hossainy ,  Liangxuan Zhang ,  Ed Berger ,  Stephen Pacetti ,  John L. Toner

IPC分类号： A61M25/10 ,  A61F2/84

CPC分类号： A61L29/16 ,  A61L29/08 ,  A61L29/085 ,  A61L29/141 ,  A61L2300/416 ,  A61L2300/606

摘要： A drug delivery balloon is provided comprising a balloon having a surface, and a coating disposed on at least a portion of the balloon surface, the coating including an cytostatic therapeutic agent, an excipient, and a plasticizer. In accordance with the present subject matter, at least 30% of the coating transfers from the balloon surface within two minutes after inflation of the balloon. Alternatively, at least 30% of the coating transfers from the balloon surface within one minute after inflation. The coating results in an effective pharmacokinetic profile of an cytostatic therapeutic agent in a vasculature or target tissue.

摘要翻译： 提供了药物递送球囊，其包括具有表面的球囊，以及设置在球囊表面的至少一部分上的涂层，所述涂层包括细胞抑制剂，赋形剂和增塑剂。 根据本主题，至少30％的涂层在气球膨胀后两分钟内从气球表面转移。 或者，至少30％的涂层在充气后一分钟内从气球表面转移。 涂层导致脉管系统或靶组织中细胞抑制治疗剂的有效药代动力学特征。

公开(公告)号：US20110143014A1

公开(公告)日：2011-06-16

申请号：US12636079

申请日：2009-12-11

申请人： John Stankus ,  Mikael Trollsas ,  Syed Hossainy ,  Stephen Pacetti ,  Michael Ngo

发明人： John Stankus ,  Mikael Trollsas ,  Syed Hossainy ,  Stephen Pacetti ,  Michael Ngo

IPC分类号： B05D7/00

CPC分类号： A61L29/085 ,  A61F2/958 ,  A61F2250/0067 ,  A61L29/16 ,  A61L2300/204 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2420/02 ,  A61L2420/06 ,  A61M25/10 ,  A61M25/1029 ,  A61M2025/1031 ,  A61M2025/105

摘要： A drug delivery balloon is provided, the a balloon having an outer surface, and a tunable coating disposed on at least a length of the balloon surface. The tunable coating includes a first therapeutic agent and a first excipient, and can include a second therapeutic agent and a second excipient. The first and second therapeutic agents have different dissolution rates during balloon inflation and therefore provide a coating that is tunable.

摘要翻译： 提供药物递送球囊，具有外表面的气囊和设置在球囊表面的至少一段长度上的可调涂层。 可调涂层包括第一治疗剂和第一赋形剂，并且可以包括第二治疗剂和第二赋形剂。 第一和第二治疗剂在球囊膨胀期间具有不同的溶解速率，因此提供可调谐的涂层。

公开(公告)号：US20110144577A1

公开(公告)日：2011-06-16

申请号：US12636158

申请日：2009-12-11

申请人： John Stankus ,  Stephen Pacetti ,  Mikael Trollsas ,  Syed Hossainy

发明人： John Stankus ,  Stephen Pacetti ,  Mikael Trollsas ,  Syed Hossainy

IPC分类号： A61M29/00 ,  A61K47/32 ,  A61K31/44 ,  A61P9/10

CPC分类号： A61L29/16 ,  A61L29/085 ,  A61L29/141 ,  A61L2300/416

摘要： A tunable coating formulation is described for a drug delivery balloon comprising a therapeutic agent, an excipient and a plasticizer. The tunable coating includes a first therapeutic agent and a first excipient, and can have a second therapeutic agent and a second excipient. The first and second therapeutic agents have different dissolution rates during balloon inflation and therefore provide a coating that is tunable. The plasticizer in the formulation has a weigh ratio of excipient to plasticizer below 1:0.1.

摘要翻译： 对于包含治疗剂，赋形剂和增塑剂的药物递送球，描述了可调涂层制剂。 可调涂层包括第一治疗剂和第一赋形剂，并且可以具有第二治疗剂和第二赋形剂。 第一和第二治疗剂在球囊膨胀期间具有不同的溶解速率，因此提供可调谐的涂层。 制剂中的增塑剂具有赋形剂与增塑剂的重量比低于1:0.1。

公开(公告)号：US08951595B2

公开(公告)日：2015-02-10

申请号：US12636079

申请日：2009-12-11

申请人： John Stankus ,  Mikael Trollsas ,  Syed Hossainy ,  Stephen Pacetti ,  Michael Ngo

发明人： John Stankus ,  Mikael Trollsas ,  Syed Hossainy ,  Stephen Pacetti ,  Michael Ngo

IPC分类号： A61L33/00 ,  A61F2/958 ,  A61L29/08 ,  A61L29/16 ,  A61M25/10

CPC分类号： A61L29/085 ,  A61F2/958 ,  A61F2250/0067 ,  A61L29/16 ,  A61L2300/204 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2420/02 ,  A61L2420/06 ,  A61M25/10 ,  A61M25/1029 ,  A61M2025/1031 ,  A61M2025/105

摘要： A drug delivery balloon is provided, the a balloon having an outer surface, and a tunable coating disposed on at least a length of the balloon surface. The tunable coating includes a first therapeutic agent and a first excipient, and can include a second therapeutic agent and a second excipient. The first and second therapeutic agents have different dissolution rates during balloon inflation and therefore provide a coating that is tunable.

摘要翻译： 提供药物递送球囊，具有外表面的气囊和设置在球囊表面的至少一段长度上的可调涂层。 可调涂层包括第一治疗剂和第一赋形剂，并且可以包括第二治疗剂和第二赋形剂。 第一和第二治疗剂在球囊膨胀期间具有不同的溶解速率，因此提供可调谐的涂层。

公开(公告)号：US20120276152A1

公开(公告)日：2012-11-01

申请号：US13366841

申请日：2012-02-06

申请人： Syed Hossainy ,  John Stankus ,  Mikael Trollsas ,  Dariush Davalian

发明人： Syed Hossainy ,  John Stankus ,  Mikael Trollsas ,  Dariush Davalian

IPC分类号： A61K9/00 ,  A61K31/351 ,  A61K31/4412 ,  A61K31/44 ,  A61K38/02 ,  A61K31/734 ,  A61K31/045 ,  A61K33/26 ,  A61K31/04 ,  A61K31/519 ,  A61K31/4985 ,  A61K31/352 ,  A61K38/22 ,  A61K31/198 ,  A61K33/00 ,  A61K31/502 ,  A61K47/30 ,  A61P9/10 ,  A61K31/16

CPC分类号： A61K31/16 ,  A61K31/04 ,  A61K31/045 ,  A61K31/198 ,  A61K31/351 ,  A61K31/352 ,  A61K31/44 ,  A61K31/4412 ,  A61K31/4985 ,  A61K33/30 ,  A61K45/06 ,  A61K2300/00

摘要： Methods and systems for treating an infarct by delivery of zinc chelator to modulate tissue.

摘要翻译： 通过递送锌螯合剂来调节组织来治疗梗死的方法和系统。

公开(公告)号：US09572795B2

公开(公告)日：2017-02-21

申请号：US13572507

申请日：2012-08-10

申请人： Syed Hossainy ,  Dariush Davalian ,  Mikael Trollsas ,  John Stankus ,  Jinping Wan

发明人： Syed Hossainy ,  Dariush Davalian ,  Mikael Trollsas ,  John Stankus ,  Yuet Mei Khong ,  Jinping Wan

IPC分类号： A61M37/00 ,  A61K31/409 ,  A61K9/00 ,  A61K9/127 ,  A61K9/51 ,  A61L29/16 ,  A61K41/00 ,  A61M25/00 ,  A61M25/10

CPC分类号： A61K31/409 ,  A61K9/0009 ,  A61K9/0019 ,  A61K9/1272 ,  A61K9/5146 ,  A61K41/0071 ,  A61L29/16 ,  A61L2300/224 ,  A61L2300/626 ,  A61M25/0045 ,  A61M25/10 ,  A61M2025/105 ,  A61M2025/1086

摘要： This invention relates to photodynamic therapy (PDT) of vulnerable plaque using two pluralities of nanoparticles, one plurality comprising a PDT agent that is sensitive to blue-green light wherein the nanoparticles are capable of penetrating only into the fibrous cap of the vulnerable plaque and one plurality comprising a PDT agent that is sensitive to red light wherein the nanoparticles are capable of penetrating into the core of the vulnerable plaque.

摘要翻译： 本发明涉及使用两种纳米颗粒的易损斑块的光动力疗法（PDT），其一个包括对蓝绿色光敏感的PDT剂，其中纳米颗粒仅能穿透易损斑块的纤维帽和一个 多个包含对红光敏感的PDT剂，其中纳米颗粒能够渗入易损斑块的核心。

公开(公告)号：US08465773B2

公开(公告)日：2013-06-18

申请号：US13472328

申请日：2012-05-15

申请人： Syed Hossainy ,  Michael Ngo ,  Mikael Trollsas ,  John Stankus ,  Gene Michal

发明人： Syed Hossainy ,  Michael Ngo ,  Mikael Trollsas ,  John Stankus ,  Gene Michal

IPC分类号： A61K35/28 ,  A61K47/48 ,  A61K47/42 ,  A61K9/00 ,  A61K9/08 ,  C07K17/08 ,  A61F2/00 ,  C08L89/00

CPC分类号： A61K47/42 ,  A61K9/0024 ,  A61K47/34 ,  A61L27/3804 ,  A61L27/3839 ,  A61L27/3895 ,  A61L27/48 ,  A61L27/52 ,  Y10S530/812 ,  Y10S530/815 ,  C08L89/00 ,  C08L71/02

摘要： Compositions for forming a self-reinforcing composite biomatrix, methods of manufacture and use therefore are herein disclosed. Kits including delivery devices suitable for delivering the compositions are also disclosed. In some embodiments, the composition can include at least three components. In one embodiment, a first component can include a first functionalized polymer, a second component can include a second functionalized polymer and a third component can include silk protein or constituents thereof. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition can include a biologic encapsulated, suspended, disposed within or loaded into a biodegradable carrier. In some embodiments, the composition(s) of the present invention can be delivered by a dual lumen injection device to a treatment area in situ, in vivo, as well as ex vivo applications.

公开(公告)号：US20120225040A1

公开(公告)日：2012-09-06

申请号：US13472324

申请日：2012-05-15

申请人： Syed Hossainy ,  Michael Ngo ,  Mikael Trollsas ,  John Stankus ,  Gene Michal

发明人： Syed Hossainy ,  Michael Ngo ,  Mikael Trollsas ,  John Stankus ,  Gene Michal

IPC分类号： A61K35/12 ,  A61K35/34 ,  A61P9/10 ,  A61K35/44 ,  A61K35/32 ,  A61K35/28 ,  A61K35/54

CPC分类号： A61K47/42 ,  A61K9/0024 ,  A61K47/34 ,  A61L27/3804 ,  A61L27/3839 ,  A61L27/3895 ,  A61L27/48 ,  A61L27/52 ,  Y10S530/812 ,  Y10S530/815 ,  C08L89/00 ,  C08L71/02

摘要： Compositions for forming a self-reinforcing composite biomatrix, methods of manufacture and use therefore are herein disclosed. Kits including delivery devices suitable for delivering the compositions are also disclosed. In some embodiments, the composition can include at least three components. In one embodiment, a first component can include a first functionalized polymer, a second component can include a second functionalized polymer and a third component can include silk protein or constituents thereof. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition can include a biologic encapsulated, suspended, disposed within or loaded into a biodegradable carrier. In some embodiments, the composition(s) of the present invention can be delivered by a dual lumen injection device to a treatment area in situ, in vivo, as well as ex vivo applications.

公开(公告)号：US20100331819A1

公开(公告)日：2010-12-30

申请号：US12491063

申请日：2009-06-24

申请人： Syed Hossainy ,  Dariush Davalian ,  Mikael Trollsas ,  John Stankus ,  Yuet Mei Khong ,  Jinping Wan

发明人： Syed Hossainy ,  Dariush Davalian ,  Mikael Trollsas ,  John Stankus ,  Yuet Mei Khong ,  Jinping Wan

IPC分类号： A61M25/00 ,  A61K9/127 ,  A61K9/14 ,  A61K31/409 ,  A61K31/555 ,  A61K31/197 ,  A61K31/22 ,  A61P35/00

CPC分类号： A61K31/409 ,  A61K9/0009 ,  A61K9/0019 ,  A61K9/1272 ,  A61K9/5146 ,  A61K41/0071 ,  A61L29/16 ,  A61L2300/224 ,  A61L2300/626 ,  A61M25/0045 ,  A61M25/10 ,  A61M2025/105 ,  A61M2025/1086

摘要： This invention relates to photodynamic therapy (PDT), more specifically PDT for atherosclerotic plaque via delivering PDT-loaded nanoparticles such as liposomes, polymersomes, micelles and polymeric nanoparticles into the diseased vascular tissue. This invention provides method and formulations for delivering multiple drugs and delivering drugs to specific targeted site.

摘要翻译： 本发明涉及光动力治疗（PDT），更具体地涉及通过将负载PDT的纳米颗粒（例如脂质体，聚合物囊泡，胶束和聚合物纳米颗粒）递送到患病血管组织中的动脉粥样硬化斑块的PDT。 本发明提供用于递送多种药物并将药物递送至特定目标部位的方法和制剂。

公开(公告)号：US08465772B2

公开(公告)日：2013-06-18

申请号：US13472324

申请日：2012-05-15

申请人： Syed Hossainy ,  Michael Ngo ,  Mikael Trollsas ,  John Stankus ,  Gene Michal

发明人： Syed Hossainy ,  Michael Ngo ,  Mikael Trollsas ,  John Stankus ,  Gene Michal

IPC分类号： A61K35/28 ,  A61K47/48 ,  A61K47/42 ,  A61K9/00 ,  A61K9/08 ,  C07K17/08 ,  A61F2/00 ,  C08L89/00

CPC分类号： A61K47/42 ,  A61K9/0024 ,  A61K47/34 ,  A61L27/3804 ,  A61L27/3839 ,  A61L27/3895 ,  A61L27/48 ,  A61L27/52 ,  Y10S530/812 ,  Y10S530/815 ,  C08L89/00 ,  C08L71/02

摘要： Compositions for forming a self-reinforcing composite biomatrix, methods of manufacture and use therefore are herein disclosed. Kits including delivery devices suitable for delivering the compositions are also disclosed. In some embodiments, the composition can include at least three components. In one embodiment, a first component can include a first functionalized polymer, a second component can include a second functionalized polymer and a third component can include silk protein or constituents thereof. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition can include a biologic encapsulated, suspended, disposed within or loaded into a biodegradable carrier. In some embodiments, the composition(s) of the present invention can be delivered by a dual lumen injection device to a treatment area in situ, in vivo, as well as ex vivo applications.

摘要翻译： 本文公开了用于形成自增强复合生物基质的组合物，因此制造和使用方法。 还公开了包括适合递送组合物的递送装置的试剂盒。 在一些实施方案中，组合物可以包括至少三种组分。 在一个实施方案中，第一组分可以包括第一官能化聚合物，第二组分可以包括第二官能化聚合物，第三组分可以包括丝蛋白或其组分。 在一些实施方案中，组合物可以包括至少一种细胞类型和/或至少一种生长因子。 在一些实施方案中，组合物可以包括生物封装的，悬浮的，置于生物降解载体内或加载到可生物降解的载体中。 在一些实施方案中，本发明的组合物可以通过双腔注射装置原位，体内和离体应用递送至治疗区域。