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    STRUCTURED-LIGHT IMAGING SYSTEMS AND METHODS FOR DETERMINING SUB-DIFFUSE SCATTERING PARAMETERS
    32.
    发明公开
    STRUCTURED-LIGHT IMAGING SYSTEMS AND METHODS FOR DETERMINING SUB-DIFFUSE SCATTERING PARAMETERS 审中-公开

    公开(公告)号：US20230363647A1

    公开(公告)日：2023-11-16

    申请号：US18223466

    申请日：2023-07-18

    Applicant: The Trustees of Dartmouth College

    Inventor： Stephen Chad Kanick ,  Brian William Pogue ,  Keith D. Paulsen ,  Jonathan T. Elliott ,  David M. McClatchy, III ,  Venkataramanan Krishnaswamy

    IPC: A61B5/00

    CPC classification number: A61B5/0075 ,  A61B2576/00

    Abstract: A method for determining sub-diffuse scattering parameters of a material includes illuminating the material with structured light and imaging remission by the material of the structured light. The method further includes determining, from captured remission images, sub-diffuse scattering parameters of the material. A structured-light imaging system for determining sub-diffuse scattering parameters of a material includes a structured-light illuminator, for illuminating the material with structured light of periodic spatial structure, and a camera for capturing images of the remission of the structured light by the material. The structured-light imaging system further includes an analysis module for processing the images to quantitatively determine the sub-diffuse scattering parameters. A software product includes machine-readable instructions for analyzing images of remission of structured light by a material to determine sub-diffuse scattering parameters of the material.

    Systems and methods for guiding tissue resection
    34.
    发明授权
    Systems and methods for guiding tissue resection 有权

    公开(公告)号：US10973589B2

    公开(公告)日：2021-04-13

    申请号：US16859065

    申请日：2020-04-27

    Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

    Inventor： Venkataramanan Krishnaswamy ,  Richard J. Barth, Jr. ,  Keith D. Paulsen

    IPC: G06K9/00 ,  A61B34/20 ,  A61B34/00 ,  A61B90/00 ,  A61B34/10 ,  A61B17/00 ,  A61B17/34

    Abstract: A method for guiding resection of local tissue from a patient includes generating at least one image of the patient, automatically determining a plurality of surgical guidance cues indicating three-dimensional spatial properties associated with the local tissue, and generating a visualization of the surgical guidance cues relative to the surface. A system for generating surgical guidance cues for resection of a local tissue from a patient includes a location module for processing at least one image of the patient to determine three-dimensional spatial properties of the local tissue, and a surgical cue generator for generating the surgical guidance cues based upon the three-dimensional spatial properties. A patient-specific locator form for guiding resection of local tissue from a patient includes a locator form surface matching surface of the patient, and a plurality of features indicating a plurality of surgical guidance cues, respectively.

    METHOD AND APPARATUS FOR QUANTITATIVE HYPERSPECTRAL FLUORESCENCE AND REFLECTANCE IMAGING FOR SURGICAL GUIDANCE
    35.
    发明申请
    METHOD AND APPARATUS FOR QUANTITATIVE HYPERSPECTRAL FLUORESCENCE AND REFLECTANCE IMAGING FOR SURGICAL GUIDANCE 审中-公开

    公开(公告)号：US20190384048A1

    公开(公告)日：2019-12-19

    申请号：US16443760

    申请日：2019-06-17

    Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

    Inventor： Pablo A. Valdes ,  David W. Roberts ,  Keith D. Paulsen ,  Frederic Leblond

    IPC: G02B21/06 ,  G02B21/36 ,  A61B1/06

    Abstract: An imaging system includes an illumination device for illuminating a target. A surgical microscope receives light from the target, the surgical microscope comprising at least one optical output port at which at least a portion of the received light is provided as an output from the surgical microscope. A tunable filter receives the portion of the received light provided as the output from the surgical microscope, the tunable filter being tunable to pass a filtered portion of the received light, the filtered portion of the received light having a plurality of wavelengths selected by the tunable filter and provided as output from the tunable filter. A high-resolution, broad-bandwidth electronic camera receives the light of a plurality of wavelengths selected by the tunable filter, the electronic camera converting the light of a plurality of wavelengths selected by the tunable filter to a plurality of electrical signals. A processor processes the plurality of electrical signals to form an image of the target.

    Apparatus for measuring in-vivo mechanical properties of biological tissues
    37.
    发明授权
    Apparatus for measuring in-vivo mechanical properties of biological tissues 有权

    公开(公告)号：US09655545B2

    公开(公告)日：2017-05-23

    申请号：US14345029

    申请日：2012-09-17

    Applicant: The Trustees of Dartmouth College

    Inventor： Songbai Ji ,  David W. Roberts ,  Keith D. Paulsen

    IPC: A61B5/107 ,  A61B5/00 ,  G02B21/00 ,  G02B21/36 ,  A61B90/20 ,  G06T7/33 ,  A61B19/00 ,  G06T7/00 ,  A61B90/00

    CPC classification number: A61B5/1079 ,  A61B5/0053 ,  A61B5/0077 ,  A61B90/20 ,  A61B2090/364 ,  A61B2090/371 ,  G02B21/0012 ,  G02B21/367 ,  G06T7/344 ,  G06T2200/04 ,  G06T2207/10012 ,  G06T2207/10056 ,  G06T2207/30016

    Abstract: An apparatus and method for measuring mechanical properties of tissue has a stereo optical surgical microscope with at least one objective lens and at least two digital cameras such that paired images obtained from the digital cameras form stereo pairs, and a digital image processing system adapted to determine surface topography of tissue from the stereo pairs of images and a resulting surface displacement map as a result from indentation. The apparatus has an one indenter; and mechanical modeling routines stored in memory of the image processing system, the mechanical modeling routines capable of constructing computer models of mechanical properties of tissue, and fitting parameters of the computer model to observed surface displacement maps generated by coregistering surface topography of tissue with and without the indenter positioned on the tissue. In an embodiment, fitted parameters of the computer model are displayed and used to adjust a surgical plan. An apparatus and method for measuring mechanical properties of tissue has a stereo optical surgical microscope with at least one objective lens and at least two digital cameras such that paired images obtained from the digital cameras form stereo pairs, and a digital image processing system adapted to determine surface topography of tissue from the stereo pairs of images and a resulting surface displacement map as a result from indentation. The apparatus has an one indenter; and mechanical modeling routines stored in memory of the image processing system, the mechanical modeling routines capable of constructing computer models of mechanical properties of tissue, and fitting parameters of the computer model to observed surface displacement maps generated by coregistering surface topography of tissue with and without the indenter positioned on the tissue. In an embodiment, fitted parameters of the computer model are displayed and used to adjust a surgical plan.

    STRUCTURED-LIGHT IMAGING SYSTEMS AND METHODS FOR DETERMINING SUB-DIFFUSE SCATTERING PARAMETERS
    38.
    发明申请
    STRUCTURED-LIGHT IMAGING SYSTEMS AND METHODS FOR DETERMINING SUB-DIFFUSE SCATTERING PARAMETERS 审中-公开
    结构光成像系统和确定次差分散射参数的方法

    公开(公告)号：US20160157723A1

    公开(公告)日：2016-06-09

    申请号：US15013623

    申请日：2016-02-02

    Applicant: The Trustees of Dartmouth College

    Inventor： Stephen Chad Kanick ,  Brian William Pogue ,  Keith D. Paulsen ,  Jonathan T. Elliott ,  David M. McClatchy, III ,  Venkataramanan Krishnaswamy

    IPC: A61B5/00

    CPC classification number: A61B5/0075 ,  A61B2576/00

    Abstract: A method for determining sub-diffuse scattering parameters of a material includes illuminating the material with structured light and imaging remission by the material of the structured light. The method further includes determining, from captured remission images, sub-diffuse scattering parameters of the material. A structured-light imaging system for determining sub-diffuse scattering parameters of a material includes a structured-light illuminator, for illuminating the material with structured light of periodic spatial structure, and a camera for capturing images of the remission of the structured light by the material. The structured-light imaging system further includes an analysis module for processing the images to quantitatively determine the sub-diffuse scattering parameters. A software product includes machine-readable instructions for analyzing images of remission of structured light by a material to determine sub-diffuse scattering parameters of the material.

    Abstract translation: 用于确定材料的次漫散射参数的方法包括用结构化光照射材料并通过结构化光的材料进行成像缓解。 该方法还包括从捕获的缓解图像中确定材料的次漫散射参数。 用于确定材料的次散射散射参数的结构光成像系统包括用于用周期性空间结构的结构光照射材料的结构光照明器，以及用于通过所述结构光照明器 材料。 结构光成像系统还包括分析模块，用于处理图像以定量地确定亚漫射散射参数。 软件产品包括用于通过材料分析结构光的缓解图像以确定材料的次漫散射参数的机器可读指令。

    Systems And Methods for Guiding Tissue Resection
    39.
    发明申请
    Systems And Methods for Guiding Tissue Resection 审中-公开
    引导组织切除术的系统与方法

    公开(公告)号：US20160038252A1

    公开(公告)日：2016-02-11

    申请号：US14919411

    申请日：2015-10-21

    Applicant: The Trustees of Dartmouth College

    Inventor： Richard J. Barth, JR. ,  Keith D. Paulsen ,  Venkataramanan Krishnaswamy

    IPC: A61B19/00

    CPC classification number: A61B34/10 ,  A61B34/25 ,  A61B2017/008 ,  A61B2017/3405 ,  A61B2034/105 ,  A61B2034/107 ,  A61B2034/2055 ,  A61B2090/363 ,  A61B2090/371 ,  A61B2090/3908 ,  A61B2090/395

    Abstract: A method for guiding resection of local tissue from a patient includes generating at least one image of the patient, automatically determining a plurality of surgical guidance cues indicating three-dimensional spatial properties associated with the local tissue, and generating a visualization of the surgical guidance cues relative to the surface. A system for generating surgical guidance cues for resection of a local tissue from a patient includes a location module for processing at least one image of the patient to determine three-dimensional spatial properties of the local tissue, and a surgical cue generator for generating the surgical guidance cues based upon the three-dimensional spatial properties. A patient-specific locator form for guiding resection of local tissue from a patient includes a locator form surface matching surface of the patient, and a plurality of features indicating a plurality of surgical guidance cues, respectively.

    Abstract translation: 用于引导患者的局部组织的切除的方法包括产生患者的至少一个图像，自动确定指示与局部组织相关联的三维空间特性的多个手术指导提示，以及产生手术指导线索的可视化 相对于表面。 用于产生用于从患者切除局部组织的外科手术引导线索的系统包括用于处理患者的至少一个图像以确定局部组织的三维空间属性的位置模块，以及用于产生外科手术的外科提示发生器 基于三维空间属性的指导线索。 用于引导患者局部组织切除的患者特异性定位器形式分别包括患者的定位器形式的表面匹配表面以及指示多个手术指导线索的多个特征。

    Method And Apparatus For Medical Imaging Using Differencing Of Multiple Fluorophores
    40.
    发明申请
    Method And Apparatus For Medical Imaging Using Differencing Of Multiple Fluorophores 审中-公开
    使用多个荧光团差异的医学成像方法和装置

    公开(公告)号：US20150374308A1

    公开(公告)日：2015-12-31

    申请号：US14767836

    申请日：2014-02-13

    Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

    Inventor： Kenneth Tichauer ,  Robert W. Holt ,  Frederic Leblond ,  Pablo Valdes ,  Brian W. Pogue ,  Keith D. Paulsen ,  David W. Roberts

    IPC: A61B5/00 ,  A61K49/00

    Abstract: A method of generating corrected fluorescence data of concentrations of a targeted fluorophore in tissue of a subject includes administering first and second fluorescent contrast agents to the subject, the first contrast agent targeted to tissue of interest, the second agent untargeted. The tissue is illuminated with light of a first stimulus wavelength and first data is acquired at an appropriate emissions wavelength; the tissue is illuminated at a second stimulus wavelength and second data is acquired at a second emissions wavelength associated with the second agent, the first and second emissions wavelength differ. Difference data is generated by subtracting the second data from the first data. A system provides for stimulus and capture at multiple wavelengths, with image storage memory and subtraction code, to perform the method. Corrected data may form an fluorescence image, or is used to generate fluorescence tomographic images.

    Abstract translation: 产生受试者组织中靶向荧光团浓度的校正荧光数据的方法包括向受试者施用第一和第二荧光造影剂，靶向目的组织的第一造影剂，第二剂未被靶向。 用第一刺激波长的光照射组织，并以适当的发射波长获取第一数据; 在第二刺激波长照射组织，并且以与第二试剂相关联的第二发射波长获取第二数据，第一和第二发射波长不同。 通过从第一数据中减去第二数据来产生差分数据。 系统提供多个波长的刺激和捕获，具有图像存储和减法代码，以执行该方法。 校正的数据可以形成荧光图像，或用于产生荧光断层图像。

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