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98 条记录 (耗时 0.031 秒)

    Age formation inhibitors
    33.
    发明授权
    Age formation inhibitors 失效
    年龄形成抑制剂

    公开(公告)号：US5302608A

    公开(公告)日：1994-04-12

    申请号：US71036

    申请日：1993-06-02

    申请人： Takashi Sohda ,  Hitoshi Ikeda ,  Yu Momose

    发明人： Takashi Sohda ,  Hitoshi Ikeda ,  Yu Momose

    IPC分类号： C07D277/48 ,  C07D417/04 ,  C07D417/12 ,  A61K31/425

    CPC分类号： C07D417/04 ,  C07D277/48 ,  C07D417/12

    摘要： Thiourea compounds represented by the general formula: ##STR1## wherein A is an aromatic ring group which may be substituted; R.sup.1 is a hydrogen atom or a lower alkyl or aryl group which may be substituted, or may combine with A to form a cyclic ring; and --COB is an acyl group of a carboxylic acid or an esterified carboxyl group or salts thereof are provided as agents for inhibiting the formation of AGE (Advanced Glycosidation End Product), which are employable for treating diseases caused by AGE-formation, such as diabetic complications, senile cataract, atherosclerosis etc.

    摘要翻译： 由以下通式表示的硫脲化合物：其中A是可被取代的芳环基团; R1是氢原子或可被取代的低级烷基或芳基，或可以与A结合形成环状环; 提供-COB为羧酸或酯化羧基的酰基或其盐作为用于抑制AGE（Advanced Glycosidation End Product）形成抑制剂的药剂，其可用于治疗由AGE形成引起的疾病，例如 糖尿病并发症，老年性白内障，动脉粥样硬化等。

    Oxazolidinedione derivatives and their use
    38.
    发明授权
    Oxazolidinedione derivatives and their use 失效
    恶唑二酮衍生物及其用途

    公开(公告)号：US06552058B1

    公开(公告)日：2003-04-22

    申请号：US09667247

    申请日：2000-09-22

    申请人： Takashi Sohda ,  Hitoshi Ikeda ,  Yu Momose ,  Sachiko Imai

    发明人： Takashi Sohda ,  Hitoshi Ikeda ,  Yu Momose ,  Sachiko Imai

    IPC分类号： C07D26318

    CPC分类号： C07D263/44 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

    摘要： Novel 2,4-oxazolidinedione compounds of the formula: wherein R is a hydrocarbon residue or a heterocyclic group each of which may be substituted; Y is —CO—, —CH(OH)— or —NR3— (wherein R3 is an alkyl group which may be substituted); m is 0 or 1; n is 0, 1 or 2; X is CH or N; A is bivalent straight or branched hydrocarbon chain residue having 1 to 7 carbon atoms; R1 and R2 each are hydrogen or an alkyl group, or R1 and R2 are combined with each other to form a 5- to 6-membered heterocyclic group optionally containing nitrogen; L and M each are hydrogen, or L and M are combined with each other to form a bond, or pharmaceutically acceptable salts thereof, having excellent hypoglycemic and hypolipidemic activities and are useful as anti-diabetics or hypolipidemic agents.

    摘要翻译： 下式的新型2,4-恶唑烷二酮化合物：其中R是可以被取代的烃残基或杂环基; Y是-CO - ， - CH（OH） - 或-NR 3 - （其中R 3是可被取代的烷基）; m为0或1; n为0,1或2; X是CH或N; A是具有1至7个碳原子的二价直链或支链烃链残基; R 1和R 2各自为氢或烷基，或者R 1和R 2彼此结合形成任选含有氮的5至6元杂环基; L和M各自为氢，或L和M彼此结合以形成具有优异的降血糖和降血脂活性的键或其药学上可接受的盐，并且可用作抗糖尿病药或降血脂药。

    Anticachectic composition
    39.
    发明授权
    Anticachectic composition 失效
    防寒组成

    公开(公告)号：US06365607B1

    公开(公告)日：2002-04-02

    申请号：US09605628

    申请日：2000-06-28

    申请人： Yu Momose ,  Etsuya Matsutani ,  Takashi Sohda

    发明人： Yu Momose ,  Etsuya Matsutani ,  Takashi Sohda

    IPC分类号： A61K3144

    CPC分类号： A61K31/4439 ,  A61K31/422 ,  A61K31/427

    摘要： A medicinal composition for the prophylaxis and treatment of cachexia which comprises a compound of the formula: wherein R represents a hydrocarbon group that may be substituted or a heterocyclic group that may be substituted; Y represents a group of the formula —CO—, —CH(OH)—, or —NR3— (R3 represents an alkyl group that may be substituted); m is 0 or 1; n is 0, 1 or 2; X represents CH or N; A represents a bond or a bivalent aliphatic hydrocarbon group having 1 to 7 carbon atoms; Q represents oxygen or sulfur; R1 represents hydrogen or an alkyl group; ring E may have further 1 to 4 substituents, which may form a ring in combination with R1; L and M respectively represent hydrogen or may be combined with each other to form a bond, provided that when m and n are 0, X represents CH, A represents a bond, Q represents sulfur, R1, L and M respectively represent hydrogen, and ring E does not have further substituents, R does not represent dihydrobenzopyranyl; or a salt thereof.

    摘要翻译： 一种用于预防和治疗恶病质的药物组合物，其包含下式化合物：其中R表示可被取代的烃基或可被取代的杂环基; Y表示式-CO-，-CH（OH） - 或-NR 3 - （R 3表示可被取代的烷基）的基团; m为0或1; n为0,1或2; X表示CH或N; A表示碳原子数1〜7的键或2价脂肪族烃基， Q表示氧或硫; R1表示氢或烷基; 环E可以具有另外1至4个取代基，其可以与R 1组合形成环; L和M分别表示氢或可以彼此结合形成键，条件是当m和n为0时，X表示CH，A表示键，Q表示硫，R 1，L和M表示氢， 环E不具有其它取代基，R不表示二氢苯并吡喃基; 或其盐。

    Optically active 2R, 4S benzothiepin isomer
    40.
    发明授权
    Optically active 2R, 4S benzothiepin isomer 失效
    光学活性的2R，4S苯并硫代异构体

    公开(公告)号：US06346521B1

    公开(公告)日：2002-02-12

    申请号：US08579731

    申请日：1995-12-28

    申请人： Takashi Sohda ,  Shigehisa Taketomi ,  Tsuneo Oda

    发明人： Takashi Sohda ,  Shigehisa Taketomi ,  Tsuneo Oda

    IPC分类号： A61K3167

    CPC分类号： C07D495/04 ,  C07F9/6561 ,  C07F9/657181

    摘要： This invention relates to an optically active benzothiepin derivative represented by the formula: wherein R represents a lower alkyl group; R1 and R2 independently represent a lower alkyl group, or may bind together to form a ring, which exhibits excellent osteogenesis-promoting action and is useful as a prophylactic or therapeutic drug for bone diseases.

    摘要翻译： 本发明涉及由下式表示的光学活性苯并硫代衍生物：其中R代表低级烷基; R1和R2独立地表示低级烷基，或者可以结合在一起形成环，其表现出优异的成骨促进作用，并且可用作骨疾病的预防或治疗药物。