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    Electro-rheological fluid having high dielectric breakdown stength and methods of making and storing the electro-rheological fluid
    31.
    发明授权
    Electro-rheological fluid having high dielectric breakdown stength and methods of making and storing the electro-rheological fluid 失效
    具有高介电击穿长度的电流变流体以及制造和储存电流变流体的方法

    公开(公告)号：US06277306B1

    公开(公告)日：2001-08-21

    申请号：US09200457

    申请日：1998-11-27

    申请人： Shigeki Endo ,  Takayuki Maruyama ,  Hiroaki Wada ,  Tasuku Saito

    发明人： Shigeki Endo ,  Takayuki Maruyama ,  Hiroaki Wada ,  Tasuku Saito

    IPC分类号： H01B320

    CPC分类号： C10M171/001

    摘要： An electro-rheological fluid made from an oil medium and fine particulates by mixing, is highly reliable and in which dielectric breakdown, such as generation of electrical discharge, is very low even when a high voltage is applied. A method of manufacturing the electro-rheological fluid and a method of storing the fluid are also provided. The electro-rheolological fluid includes fine particulates dispersed in an oil medium having an electric insulation property, and has a dielectric breakdown strength of 4 kV/mm or more. When the electro-rheological fluid is placed under a reduced pressure of 10 Pa, foaming does not occur. Alternatively, the electro-reheoleological fluid can contain 20% by volume or more of a gas contained in the oil medium that has a dielectric breakdown strength of 4 kV/mm or more.

    摘要翻译： 由油介质和细粒子通过混合制成的电流变流体是高度可靠的，即使施加高电压，诸如放电产生的介质击穿也非常低。 还提供了制造电流变流体的方法和储存流体的方法。 电流变流体包括分散在具有电绝缘性的油介质中的细小颗粒，并且具有4kV / mm以上的介电击穿强度。 当电流变流体放置在10Pa的减压下时，不会发生起泡。 或者，电致液化流体可以含有介质击穿强度为4kV / mm以上的油介质中所含的20体积％以上的气体。

    Naphthyloxy acetic acid derivatives
    32.
    发明授权
    Naphthyloxy acetic acid derivatives 失效
    萘氧基乙酸衍生物

    公开(公告)号：US6013673A

    公开(公告)日：2000-01-11

    申请号：US12448

    申请日：1998-01-23

    申请人： Yuuki Nagao ,  Kazuhiko Torisu ,  Takayuki Maruyama

    发明人： Yuuki Nagao ,  Kazuhiko Torisu ,  Takayuki Maruyama

    IPC分类号： A61K31/16 ,  A61K31/41 ,  A61K31/44 ,  C07C233/22 ,  C07C235/20 ,  C07C235/34 ,  C07C235/66 ,  C07C243/28 ,  C07C255/16 ,  C07D213/40 ,  C07D257/04

    CPC分类号： C07D213/40 ,  C07C233/22 ,  C07C235/20 ,  C07C235/34 ,  C07C235/66 ,  C07C243/28 ,  C07C255/16 ,  C07D257/04

    摘要： A naphthyloxyacetic acid derivative of the formula (I) ##STR1## wherein R.sup.1 is H, alkyl, alkylene-(--COOR.sup.10, --OH, --CONR.sup.4 R.sup.5, --CONR.sup.6 -alkylene-OH, --NR.sup.4 R.sup.5, -cyano or -tetrazolyl); A is single bond, alkylene, alkenylene, --S-alkylene, --O-alkylene; B is NR.sup.3 CO, CONR.sup.3 ; R.sup.2 is (1) alkyl (2) alkenyl, (3) alkyl or alkenyl substituted by 1-3 of phenyl, cycloalkyl, naphthyl and heterocyclic ring containing nitrogen atom (the said ring may be substituted by 1-3 of alkyl, alkoxy and halogen etc.), (4) NR.sup.7 R.sup.8 or (5) alkylene-NR.sup.7 R.sup.8 ; non-toxic salt thereof, non-toxic acid addition salt thereof and hydrate thereof can bind the PGE.sub.2 receptor and exhibits the activity to antagonize or agonize for PGE.sub.2., therefore, they are useful as PGE.sub.2 antagonist or PGE.sub.2 agonist.

    摘要翻译： 其中R 1为H，烷基，亚烷基 - （ - COOR 10，-OH，-CONR 4 R 5，-CONR 6 - 亚烷基-OH，-NR 4 R 5 - 氰基或四唑基）的式（I）的萘氧基乙酸衍生物; A是单键，亚烷基，亚烯基，-S-亚烷基，-O-亚烷基; B为NR3CO，CONR3; R2是（1）烷基（2）烯基，（3）被1-3个含氮原子的苯基，环烷基，萘基和杂环取代的烷基或链烯基（所述环可以被1-3个烷基，烷氧基和 卤素等），（4）NR7R8或（5）亚烷基-NR7R8; 其无毒盐，无毒性酸加成盐和其水合物可结合PGE2受体并表现出拮抗或激动PGE2的活性，因此它们可用作PGE2拮抗剂或PGE2激动剂。

    Naphthyloxyacetic acid
    33.
    发明授权
    Naphthyloxyacetic acid 失效
    萘氧基乙酸

    公开(公告)号：US5624959A

    公开(公告)日：1997-04-29

    申请号：US355187

    申请日：1994-12-08

    申请人： Yuuki Nagao ,  Takayuki Maruyama ,  Nobuyuki Hamanaka

    发明人： Yuuki Nagao ,  Takayuki Maruyama ,  Nobuyuki Hamanaka

    IPC分类号： C07C311/08 ,  C07C311/13 ,  C07C311/20 ,  C07C311/27 ,  C07C311/28 ,  C07C311/29 ,  A61K31/195

    CPC分类号： C07C311/13 ,  C07C311/08 ,  C07C311/20 ,  C07C311/27 ,  C07C311/28 ,  C07C311/29

    摘要： (1) Naphthyloxyaetic acid represented by the compound of the formula (I): ##STR1## and non-toxic salts thereof, (2) process for the preparation of the compounds represented by the compound of the formula (I) described hereinbefore,(3) PGE.sub.2 antagonist or agonist containing the compound represented by the compound of the formula (I) as the active ingredient.The compounds represented by the compounds of the formula (I) can be adapted to medicines which possess an inhibitory effect of uterine contraction, an analgesic action, an inhibitory effect of digestive peristalsis, a sleep-inducing effect as PGE.sub.2 antagonists, and an uterine contractile activity, a promoting effect of digestive peristalsis, a suppressive effect of gastric acid secretion, hypotensive activity as PGE.sub.2 agonists. The compounds bind to PGE.sub.2 receptor and have an activity of antagonist or agonist against the action thereof.

    摘要翻译： （1）由式（I）的化合物代表的萘乙酸：其中，（I）化合物及其无毒盐，（2）由上述式（I）的化合物表示的化合物的制备方法， （3）PGE2拮抗剂或含有式（I）化合物所代表的化合物作为活性成分的激动剂。 由式（I）化合物表示的化合物可以适用于具有子宫收缩抑制作用，止痛作用，消化性蠕动抑制作用，睡眠诱导作用PGE2拮抗剂和子宫收缩的药物 活动，消化性蠕动的促进作用，胃酸分泌的抑制作用，作为PGE2激动剂的降血压活性。 该化合物与PGE2受体结合，并具有拮抗剂或激动剂抵抗其作用的活性。

    SILICON CARBIDE SINGLE CRYSTAL WAFER AND PRODUCING METHOD THEREOF
    36.
    发明申请
    SILICON CARBIDE SINGLE CRYSTAL WAFER AND PRODUCING METHOD THEREOF 有权
    硅碳化硅单晶及其生产方法

    公开(公告)号：US20090302326A1

    公开(公告)日：2009-12-10

    申请号：US11912207

    申请日：2006-04-19

    申请人： Takayuki Maruyama

    发明人： Takayuki Maruyama

    IPC分类号： H01L29/24 ,  H01L21/20

    CPC分类号： H01L21/02529 ,  C30B25/00 ,  C30B25/02 ,  C30B25/18 ,  C30B29/36 ,  H01L21/02378 ,  H01L21/02433 ,  H01L21/02609 ,  H01L21/0262 ,  H01L29/045 ,  H01L29/24 ,  H01L29/78

    摘要： A silicon carbide single crystal wafer wherein a substrate is cut out at an OFF angle from a (0001) c plane of an α-type silicon carbide single crystal of less than 2° and in an OFF direction in which a deviation from a (11-20) direction is less than 10°, the number of substantially triangular lamination defects exposed from a surface of a wafer which is epitaxial grown on the substrate is less than 4/cm2 over the entire surface of the wafer. The invention provides a producing method of a silicon carbide single crystal wafer capable of enhancing the utility ratio of the bulk silicon carbide single crystal, the element characteristics and the cleavage, as well as a silicon carbide single crystal wafer obtained by such a producing method.

    摘要翻译： 一种碳化硅单晶晶片，其中从与α（α）的α型碳化硅单晶的（0001）c面成OFF角切割基板，在偏离方向偏离（11 -20）方向小于10°时，从在晶片外延生长的晶片的表面露出的基本上三角形层叠缺陷的数量在晶片的整个表面上小于4 / cm 2。 本发明提供了一种能够提高体积碳化硅单晶的利用率，元素特性和切割的碳化硅单晶晶片的制造方法以及通过这种制造方法获得的碳化硅单晶晶片。

    Preventive And/Or Remedy For Lower Urinary Tract Diseases Containing Ep4 Agonist
    39.
    发明申请
    Preventive And/Or Remedy For Lower Urinary Tract Diseases Containing Ep4 Agonist 有权
    预防和/或补救含有Ep4激动剂的下尿路疾病

    公开(公告)号：US20080021021A1

    公开(公告)日：2008-01-24

    申请号：US11660043

    申请日：2005-08-09

    申请人： Hiroki Okada ,  Takayuki Maruyama

    发明人： Hiroki Okada ,  Takayuki Maruyama

    IPC分类号： A61K31/535 ,  A61K31/4164 ,  A61K31/4196 ,  A61K31/421 ,  A61K31/4245 ,  A61K31/5375 ,  A61P13/02 ,  A61K31/54 ,  A61K31/426 ,  A61K31/433 ,  A61K31/495 ,  A61K31/505

    CPC分类号： A61K9/2054 ,  A61K31/5575 ,  A61K31/559 ,  A61K45/06 ,  A61K2300/00

    摘要： (1) A preventive and/or a remedy for lower urinary tract diseases such as inflammation in the lower urinary tract, cystitis (interstitial cystitis, etc.) and urethritis; (2) an agent for improving bladder compliance and/or bladder capacity; and (3) an agent for protecting bladder mucosa and/or bladder epithelial cells and/or promoting the regeneration thereof; each containing an EP4 agonist. An EP4 agonist is useful in ameliorating symptoms of lower urinary tract diseases such as (1) frequent urination, (2) urgency of urination, (3) pain in the reproductive organs and/or lower urinary tract (for example, bladder pain, urinary tract pain, vulvar pain, vaginal pain, scrotal pain, perineal pain, pelvic pain, etc.) and/or (4) discomfort in the reproductive organs and/or lower urinary tract. Among all, a selective EP4 agonist is useful as a preventive and/or remedy for lower urinary tract diseases having no side effect.

    摘要翻译： （1）下泌尿道疾病如下泌尿道炎症，膀胱炎（间质性膀胱炎等）和尿道炎的预防和/或补救措施; （2）改善膀胱依从性和/或膀胱容量的药剂; 和（3）用于保护膀胱粘膜和/或膀胱上皮细胞和/或促进其再生的药剂; 每个含有EP 4激动剂。 EP 4激动剂可用于改善下尿路疾病的症状，例如（1）尿频，（2）排尿紧急，（3）生殖器官和/或下泌尿道疼痛 （例如，膀胱疼痛，尿路疼痛，外阴疼痛，阴道疼痛，阴囊疼痛，会阴疼痛，骨盆疼痛等）和/或（4）生殖器官和/或下尿路中的不适。 其中，选择性EP 4激动剂可用作不具有副作用的下尿路疾病的预防和/或补救措施。