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    Hybrid protein C
    33.
    发明授权
    Hybrid protein C 失效
    杂交蛋白C

    公开(公告)号：US5358932A

    公开(公告)日：1994-10-25

    申请号：US126440

    申请日：1993-09-23

    申请人： Donald C. Foster ,  Richard D. Holly

    发明人： Donald C. Foster ,  Richard D. Holly

    IPC分类号： C12N9/60 ,  C12N9/64 ,  C07K15/06

    CPC分类号： C12N9/6464 ,  C12N9/60 ,  C12Y304/21069 ,  C07K2319/00

    摘要： Human protein C molecules are modified to provide increased resistance to inactivation by human plasma factors while retaining substantially the biological activity of human protein C. The modifications are generally to the heavy chain of protein C, which chain may be substituted with a protein C heavy chain of non-human origin, such as bovine, yielding a chimeric protein C molecule. The human protein C heavy chain may also be modified to be human-like, in that at least one amino acid from a non-human sequence may be substituted for the corresponding residue(s) of the human sequence, thereby allowing the molecule to retain substantially human characteristics yet having increased resistance to inactivation. Also included are methods for producing the modified protein C molecules and pharmaceutical compositions thereof. The modified molecules, having an increased half-life in human plasma, are particularly useful for treating coagulation-related disorders, such as protein C deficiency or thrombosis, or for promoting fibrinolysis in a patient.

    摘要翻译： 人蛋白C分子被修饰以提供对人血浆因子的失活增强的抗性，同时保留人蛋白C的生物活性。修饰通常是蛋白C的重链，该链可被C蛋白重链取代 非人源的，如牛，产生嵌合蛋白C分子。 人蛋白C重链也可以被修饰为人样，因为来自非人序列的至少一个氨基酸可以被人序列的相应残基取代，从而允许分子保留 基本上人的特征，但具有增加的失活抗性。 还包括生产修饰的蛋白C分子的方法及其药物组合物。 在人血浆中具有增加的半衰期的改性分子对于治疗凝血相关疾病如蛋白C缺乏或血栓形成或促进患者的纤维蛋白溶解特别有用。

    Making leadframe semiconductor packages with stacked dies and interconnecting interposer
    37.
    发明授权
    Making leadframe semiconductor packages with stacked dies and interconnecting interposer 有权
    制造具有堆叠管芯和互连插件的引线框半导体封装

    公开(公告)号：US06603072B1

    公开(公告)日：2003-08-05

    申请号：US09828046

    申请日：2001-04-06

    申请人： Donald C. Foster ,  David A. Zoba

    发明人： Donald C. Foster ,  David A. Zoba

    IPC分类号： H05K702

    CPC分类号： H01L25/0657 ,  H01L24/73 ,  H01L2224/32145 ,  H01L2224/32225 ,  H01L2224/48091 ,  H01L2224/48227 ,  H01L2224/4824 ,  H01L2224/48247 ,  H01L2224/73265 ,  H01L2924/01004 ,  H01L2924/19107 ,  H01L2924/00014 ,  H01L2924/00012 ,  H01L2924/00

    摘要： In a leadframe type of semiconductor package, the internal electrical interconnectability of and signal routing between multiple dies laminated in a stack with the die paddle of the leadframe is substantially enhanced by laminating an “interposer” in the stack. The interposer comprises a dielectric layer and a metallic layer patterned to include wire bonding pads arrayed around the periphery of a surface thereof, and circuit traces interconnecting selected ones of the wire bonding pads in a single plane across the horizontal span of the interposer. In packages having multiple dies and relatively few leads, the bonding pads and circuit traces can be flexibly arranged on the interposer by the package designer to substantially increase the number and routings of internal electrical interconnections otherwise possible between the dies and between the dies and the leads of the package.

    摘要翻译： 在引线框类型的半导体封装中，通过在堆叠中层叠“插入件”，基本上增强了与引线框的管芯焊盘层叠在堆叠中的多个管芯之间的内部电互连性和信号路由。 插入器包括电介质层和金属层，其被图案化以包括围绕其表面的周边排列的引线接合焊盘，以及在穿过插入器的水平跨度的单个平面中将选定引线接合焊盘互连的电路迹线。 在具有多个管芯和相对较少的引线的封装中，接合焊盘和电路迹线可以通过封装设计者灵活地布置在插入器上，以显着地增加在管芯之间和管芯与引线之间可能的内部电互连的数量和布线 的包装。

    Human amyloid protein precursor homolog and kunitz-type inhibitor
    39.
    发明授权
    Human amyloid protein precursor homolog and kunitz-type inhibitor 失效
    人类淀粉样蛋白前体同源物和昆尼兹型抑制剂

    公开(公告)号：US5935854A

    公开(公告)日：1999-08-10

    申请号：US424017

    申请日：1995-04-18

    申请人： Cindy A. Sprecher ,  Donald C. Foster ,  Kjeld E. Norris

    发明人： Cindy A. Sprecher ,  Donald C. Foster ,  Kjeld E. Norris

    IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K14/81 ,  C12N1/21 ,  C12N15/15 ,  C12N5/00

    CPC分类号： C07K14/4711 ,  C07K14/81 ,  A61K38/00

    摘要： The present invention provides isolated DNA molecules comprising a DNA segment encoding a novel human amyloid protein precursor homologue and novel Kunitz-type inhibitors. Also provided are DNA constructs comprising a first DNA segment encoding a novel human amyloid protein precursor homologue or a novel Kunitz-type inhibitor wherein said first DNA segment is operably linked to additional DNA segments required for the expression for the first DNA segment, as well as host cells containing such DNA constructs and methods for producing proteins from the host cells.

    摘要翻译： 本发明提供了分离的DNA分子，其包含编码新型人淀粉样蛋白前体同系物的DNA片段和新型的Kunitz型抑制剂。 还提供了包含编码新型人淀粉样蛋白前体同系物的第一DNA区段或新型Kunitz型抑制剂的DNA构建体，其中所述第一DNA区段与第一DNA区段的表达所需的另外的DNA区段可操作地连接，以及 含有这种DNA构建体的宿主细胞和从宿主细胞产生蛋白质的方法。

    Human amyloid protein precursor homolog and kunitz-type inhibitor
    40.
    发明授权
    Human amyloid protein precursor homolog and kunitz-type inhibitor 失效
    人类淀粉样蛋白前体同源物和昆尼兹型抑制剂

    公开(公告)号：US5677146A

    公开(公告)日：1997-10-14

    申请号：US424022

    申请日：1995-04-18

    申请人： Cindy A. Sprecher ,  Donald C. Foster ,  Kjeld E. Norris

    发明人： Cindy A. Sprecher ,  Donald C. Foster ,  Kjeld E. Norris

    IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K14/81 ,  C12N1/21 ,  C12N15/15 ,  C12N15/09 ,  C12N15/70 ,  C12N15/79

    CPC分类号： C07K14/4711 ,  C07K14/81 ,  A61K38/00

    摘要： The present invention provides isolated DNA molecules comprising a DNA segment encoding a novel human amyloid protein precursor homologue and novel Kunitz-type inhibitors. Also provided are DNA constructs comprising a first DNA segment encoding a novel human amyloid protein precursor homologue or a novel Kunitz-type inhibitor wherein said first DNA segment is operably linked to additional DNA segments required for the expression for the first DNA segment, as well as host cells containing such DNA constructs and methods for producing proteins from the host cells.

    摘要翻译： 本发明提供了分离的DNA分子，其包含编码新型人淀粉样蛋白前体同系物的DNA片段和新型的Kunitz型抑制剂。 还提供了包含编码新型人淀粉样蛋白前体同系物的第一DNA区段或新型Kunitz型抑制剂的DNA构建体，其中所述第一DNA区段与第一DNA区段的表达所需的另外的DNA区段可操作地连接，以及 含有这种DNA构建体的宿主细胞和从宿主细胞产生蛋白质的方法。