公开(公告)号：US4965018A

公开(公告)日：1990-10-23

申请号：US326795

申请日：1989-03-21

申请人： Manabu Uchida ,  Naoyuki Yoshida ,  Masakazu Kaneoya

发明人： Manabu Uchida ,  Naoyuki Yoshida ,  Masakazu Kaneoya

IPC分类号： C07D213/30 ,  C07D213/55 ,  C09K19/34 ,  C09K19/54 ,  G02F1/13

CPC分类号： C07D213/30 ,  C09K19/3444 ,  C09K19/3463

摘要： A novel optically active pyridylethanol derivative having a high twistability and also a superior temperature characteristic is provided, which derivative is expressed by the formula ##STR1## wherein R is an alkyl group of alkoxy group each of 1 to 20 carbon atoms or hydrogen atom, m and n each represent 0 or 1, ##STR2## each independently represent ##STR3## wherein Y is any one of H, halogen atom or CN and ##STR4## is a pyridine ring the N atom of which may be present at an optionally chosen site thereof.

公开(公告)号：US4640796A

公开(公告)日：1987-02-03

申请号：US801877

申请日：1985-11-26

申请人： Naoyuki Yoshida ,  Kisei Kitano ,  Yoshito Furukawa ,  Tetsuya Ogawa ,  Shigeru Sugimori ,  Yasuyuki Goto ,  Toyoshiro Isoyama ,  Kazunori Nigorikawa

发明人： Naoyuki Yoshida ,  Kisei Kitano ,  Yoshito Furukawa ,  Tetsuya Ogawa ,  Shigeru Sugimori ,  Yasuyuki Goto ,  Toyoshiro Isoyama ,  Kazunori Nigorikawa

IPC分类号： G02F1/13 ,  C07D239/26 ,  C07D239/30 ,  C07D239/34 ,  C07D239/38 ,  C09K19/34 ,  C09K19/42 ,  C07D403/00

CPC分类号： C07D239/26 ,  C07D239/34 ,  C07D239/38 ,  C09K19/3466

摘要： A novel 1,4-dipyrimidinylbenzene derivative which is useful as a component constituting a liquid crystal composition which is superior in properties and also physically and chemically stable, as a material for liquid crystal display elements, and a liquid crystal composition containing the same are provided, which derivative is expressed by the formula ##STR1## wherein X represents an alkyl group or an alkoxy group each of 1 to 10 carbon atoms, methylthio group or cyano group and Y represents an alkyl group or an alkoxy group each of 1 to 10 carbon atoms.

摘要翻译： 提供一种新的1,4-二嘧啶基苯衍生物，其可用作构成液晶组合物的特性，物理和化学稳定性的组分，作为液晶显示元件的材料，以及含有该液晶组合物的液晶组合物 该衍生物由式（1）表示，其中X代表1-10个碳原子的烷基或烷氧基，甲硫基或氰基，Y代表1-10个碳原子的烷基或烷氧基 原子

公开(公告)号：US07902173B2

公开(公告)日：2011-03-08

申请号：US11363174

申请日：2006-02-28

申请人： Naoyuki Yoshida ,  Kazushi Ishida ,  Shuji Sasaki ,  Takuo Ikeda ,  Jun Hiraki ,  Shigeyuki Aoyama

发明人： Naoyuki Yoshida ,  Kazushi Ishida ,  Shuji Sasaki ,  Takuo Ikeda ,  Jun Hiraki ,  Shigeyuki Aoyama

IPC分类号： A01N43/04 ,  A61K31/715

CPC分类号： C08B5/14 ,  A61K8/731 ,  A61Q19/00 ,  Y10S514/861 ,  Y10S514/863

摘要： The present invention provides a compound selected from sulfated cellulose and salts thereof which can be used as an active ingredient for a cutaneous external preparation produced intending to prevent, soften, improve or cure atopic cutaneous symptoms and the like and which are excellent in a hydrolytic resistance, and dermatitis therapeutic agents and cosmetics using the same.

摘要翻译： 本发明提供一种选自硫酸纤维素及其盐的化合物，其可用作预防，软化，改善或治愈特应性皮肤症状等的皮肤外用制剂的活性成分，并且其耐水解性优异 ，以及使用其的皮炎治疗剂和化妆品。

公开(公告)号：US20080220033A1

公开(公告)日：2008-09-11

申请号：US12073675

申请日：2008-03-07

申请人： Naoyuki Yoshida ,  Kazushi Ishida ,  Akiko Yoda

发明人： Naoyuki Yoshida ,  Kazushi Ishida ,  Akiko Yoda

IPC分类号： A61K9/16 ,  A61Q99/00

CPC分类号： A61K8/731 ,  A61Q1/02 ,  A61Q1/04 ,  A61Q1/10 ,  A61Q1/12

摘要： The invention provides a cosmetic ingredient and cosmetic compositions containing the same that exhibit skin protection/recovery properties and which are suitable for use in various cosmetic forms, such as skin care cosmetics, makeup cosmetics and skin cleansing agents. The cosmetic ingredient and cosmetic compositions containing the same include spherical sulfated cellulose or a salt thereof prepared by sulfate esterification of a part of the hydroxy groups of spherical cellulose.

摘要翻译： 本发明提供含有其具有皮肤保护/恢复性能并且适合用于各种化妆品形式的化妆品成分和化妆品组合物，例如护肤化妆品，化妆化妆品和皮肤清洁剂。 含有它们的化妆品成分和化妆品组合物包括通过一部分球形纤维素的羟基的硫酸酯化制备的球形硫酸纤维素或其盐。

公开(公告)号：US20070049746A1

公开(公告)日：2007-03-01

申请号：US11513110

申请日：2006-08-31

申请人： Naoyuki Yoshida ,  Kazushi Ishida

发明人： Naoyuki Yoshida ,  Kazushi Ishida

IPC分类号： C08B13/00

CPC分类号： B01J20/286 ,  B01D15/3804 ,  B01J20/26 ,  B01J20/262 ,  B01J20/265 ,  B01J20/28019 ,  C08B5/14

摘要： The invention provides spherical sulfated cellulose which has a high sulfur content and which is excellent for adsorbing proteins, a production process for the same, a protein adsorbing agent containing the above spherical sulfated cellulose and a chromatography apparatus using the same for a filler. More specifically, the invention provides a process for producing spherical sulfated cellulose comprising a step in which spherical cellulose is subjected to at least one sulfate esterification treatment with a mixture of N,N-dimethylformamide and sulfuric anhydride.

摘要翻译： 本发明提供了具有高硫含量，对于吸附蛋白质，其制备方法，含有上述球形硫酸化纤维素的蛋白质吸附剂和使用该球形硫酸纤维素的色谱装置的球形硫酸纤维素。 更具体地，本发明提供了一种制备球形硫酸纤维素的方法，其包括使用N，N-二甲基甲酰胺和硫酸酐的混合物对球形纤维素进行至少一种硫酸酯酯化处理的步骤。

公开(公告)号：US06642424B2

公开(公告)日：2003-11-04

申请号：US09849356

申请日：2001-05-07

申请人： Naoyuki Yoshida ,  Kunio Ogasawara

发明人： Naoyuki Yoshida ,  Kunio Ogasawara

IPC分类号： C07C4318

CPC分类号： C07D307/77 ,  C07B2200/07 ,  C07C29/147 ,  C07C35/37 ,  C07C49/643 ,  C07C69/013 ,  C07C69/16 ,  C07C2603/68 ,  C07D303/32 ,  C07D317/70 ,  C07D473/00 ,  C07D493/08 ,  C07F7/1804 ,  C12P7/62 ,  C12P15/00 ,  C12P41/004 ,  C07C35/26

摘要： Intermediate compounds, including 2-(t-butyldimethylsilyloxymethyl)-3,4-[(dimethylmethylene)dioxy]-5-hydroxy-tricyclo[5.2.1.02,6]dec-8-ene, which are useful for the synthesis of neplanocin A having strong antitumor activity. Improved processes for the preparation of neplanocin A, starting from optically active 2-hydroxymethyl-5-hydroxy-tricyclo[5.2.1.02,6]deca-3,8-diene and via a key step comprising a retro-Diels-Alder reaction of the above intermediate.

摘要翻译： 中间体化合物，包括可用于合成的2-（叔丁基二甲基甲硅烷氧基甲基）-3,4 - [（二甲基亚甲基）二氧基] -5-羟基 - 三环[5.2.1.0 2,6]癸-8-烯 的尼泊洛环素A具有很强的抗肿瘤活性。 从光学活性的2-羟甲基-5-羟基 - 三环[5.2.1.0 2,6]癸-3,8-二烯开始制备尼泊洛环素A的改进方法，并通过关键步骤，其包括逆狄氏剂 - 阿尔德反应的上述中间体。

公开(公告)号：US06294555B1

公开(公告)日：2001-09-25

申请号：US09674162

申请日：2000-10-27

申请人： Shiro Kato ,  Yoshihito Toyotomi ,  Hirotake Tateishi ,  Hiroshi Harada ,  Naoyuki Yoshida ,  Kazuo Morikage ,  Yukiko Morikage

发明人： Shiro Kato ,  Yoshihito Toyotomi ,  Hirotake Tateishi ,  Hiroshi Harada ,  Naoyuki Yoshida ,  Kazuo Morikage ,  Yukiko Morikage

IPC分类号： A61K31445

CPC分类号： C07D405/14 ,  C07D211/58

摘要： Compound of the formula (I): wherein Ar is a group of the following formula (Ar-1) or (Ar-2): A is a group of the formula: —Z—N(Q1)(Q2), —CO—R7 or —(CH2)p—CH(R8)—COR9, or a pharmaceutically acceptable acid addition salt thereof, a process for preparing the same, a pharmaceutical composition containing the same, and intermediates therefor. The compounds of the present invention show a potent affinity for 5-HT4 receptors, and they are useful as a gastrointestinal motility enhancer or a gastrointestinal prokinetic agent.

摘要翻译： 式（I）的化合物：其中Ar是下式（Ar-1）或（Ar-2）的基团：A是下式的基团：或其药学上可接受的酸加成盐，其制备方法 含有该组合物的药物组合物及其中间体。 本发明的化合物显示出对5-HT 4受体的有效亲和力，并且它们可用作胃肠蠕动增强剂或胃肠促动力剂。

公开(公告)号：US6093598A

公开(公告)日：2000-07-25

申请号：US206193

申请日：1998-12-04

申请人： Naoyuki Yoshida

发明人： Naoyuki Yoshida

IPC分类号： G03F7/00 ,  G03F7/16 ,  H01L21/027 ,  H01L21/311 ,  H01L21/768 ,  H01L21/822 ,  H01L21/8242 ,  H01L27/04 ,  H01L27/108 ,  H01L21/8234

CPC分类号： H01L27/10852 ,  G03F7/0035 ,  G03F7/16 ,  H01L21/0274 ,  H01L21/31144 ,  H01L21/76802 ,  H01L27/10888

摘要： A semiconductor stacked type dynamic random access memory device has a node contact hole formed in an inter-level insulating layer and a storage electrode held in contact with a source region of an access transistor through the node contact hole, and the node contact hole and the storage electrode are patterned by using a photo-lithography and an etching, wherein a photo-resist mask for the node contact hole is different in thickness from a photo-resist mask for the storage electrode by value equivalent to a half of the period of the periodicity representative of sensitized characteristics of the photo-resist in the presence of an optical standing wave in the photo-resist masks, thereby keeping the nesting tolerance between the two patterns.

摘要翻译： 半导体堆叠型动态随机存取存储器件具有形成在层间绝缘层中的节点接触孔和通过节点接触孔与存取晶体管的源极区域保持接触的存储电极，并且节点接触孔和 存储电极通过光刻和蚀刻进行图案化，其中用于节点接触孔的光致抗蚀剂掩模的厚度与用于存储电极的光致抗蚀剂掩模的厚度不同，相当于 在光阻掩模中存在光驻波的情况下代表光刻胶的敏化特性的周期性，从而保持两种图案之间的嵌套公差。

公开(公告)号：US06057190A

公开(公告)日：2000-05-02

申请号：US880989

申请日：1997-06-23

申请人： Naoyuki Yoshida

发明人： Naoyuki Yoshida

IPC分类号： H01L27/04 ,  H01L21/822 ,  H01L21/8242 ,  H01L27/108

CPC分类号： H01L27/10852 ,  H01L27/10817

摘要： In a semiconductor device manufacturing method, a first insulating film is formed on a semiconductor substrate. A contact hole is selectively formed in the first insulating film. A first conductive film is formed on the first insulating film to fill the interior of the contact hole. A second insulating film is formed on the first conductive film. A second conductive film is formed on the second insulating film. The second insulating film and the second conductive film are patterned to leave the second insulating film and the second conductive film only immediately above the contact hole. A third conductive film is formed on the surfaces of the first conductive film, the second insulating film, and the second conductive film. The third conductive film on the first and second conductive films is removed to form a cylindrical lower electrode consisting of the third conductive film left only on the side surfaces of the second insulating film and the second conductive film. An exposed portion of the first conductive film and the second conductive film are removed to expose the first and second insulating films. The second insulating film is removed to expose the first conductive film. A third insulating film and a fourth insulating film serving as an upper electrode are formed.

摘要翻译： 在半导体器件制造方法中，在半导体衬底上形成第一绝缘膜。 在第一绝缘膜中选择性地形成接触孔。 在第一绝缘膜上形成第一导电膜以填充接触孔的内部。 在第一导电膜上形成第二绝缘膜。 在第二绝缘膜上形成第二导电膜。 图案化第二绝缘膜和第二导电膜，使第二绝缘膜和第二导电膜仅在接触孔的正上方。 在第一导电膜，第二绝缘膜和第二导电膜的表面上形成第三导电膜。 除去第一导电膜和第二导电膜上的第三导电膜，以形成由仅在第二绝缘膜和第二导电膜的侧表面上留下的第三导电膜构成的圆柱形下电极。 去除第一导电膜和第二导电膜的暴露部分以露出第一和第二绝缘膜。 去除第二绝缘膜以露出第一导电膜。 形成作为上电极的第三绝缘膜和第四绝缘膜。

公开(公告)号：US5760597A

公开(公告)日：1998-06-02

申请号：US659515

申请日：1996-06-06

申请人： Naoyuki Yoshida ,  Hiroyuki Takamatsu ,  Shingo Sumie ,  Yutaka Kawata ,  Hidehisa Hashizume ,  Futoshi Ojima ,  Yuji Hirao

发明人： Naoyuki Yoshida ,  Hiroyuki Takamatsu ,  Shingo Sumie ,  Yutaka Kawata ,  Hidehisa Hashizume ,  Futoshi Ojima ,  Yuji Hirao

IPC分类号： G01N21/88 ,  G01N21/00 ,  G01N21/956 ,  G01R31/265 ,  G01R31/28 ,  H01L21/66 ,  G01R31/26

CPC分类号： G01R31/2656 ,  G01R31/2831 ,  H01L22/14

摘要： In addition to microwave and excitation light, bias light as well is irradiated upon a surface of a semiconductor sample that is passivated using a solution which contains an electrolyte. Irradiation of the bias light increases the quantity of ionic substances that exist in the solution, largely changes a surface potential of the semiconductor sample, and suppresses surface recombination. This makes it possible to measure the lifetime of carriers which exist within the semiconductor sample at a high accuracy, without influenced by surface recombination.

摘要翻译： 除了微波和激发光之外，偏光也照射在使用含有电解质的溶液钝化的半导体样品的表面上。 偏置光的照射增加溶液中存在的离子物质的量，极大地改变了半导体样品的表面电位，并抑制了表面复合。 这使得可以以高精度测量半导体样品内存在的载流子的寿命，而不受表面复合的影响。