公开(公告)号：US10703791B2

公开(公告)日：2020-07-07

申请号：US16572038

申请日：2019-09-16

Applicant: UNIVERSITY OF WASHINGTON ,  THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

Inventor： Daniel Adriano Silva Manzano ,  Shawn Yu ,  Umut Ulge ,  David Baker ,  Kenan Christopher Garcia ,  Jamie Spangler ,  Carl Walkey

IPC: C07K14/55 ,  C07K14/54 ,  A61K38/00

Abstract: De novo designed polypeptides that bind to IL-2 receptor βγc heterodimer (IL-2Rβγc), IL-4 receptor αγc heterodimer (IL-4Rαγc), or IL-13 receptor α subunit (IL-13Rα) are disclosed, as are methods for using and designing the polypeptides.

公开(公告)号：US10351603B2

公开(公告)日：2019-07-16

申请号：US15490351

申请日：2017-04-18

Applicant: UNIVERSITY OF WASHINGTON

Inventor： David Baker ,  Jacob B. Bale ,  Neil P. King ,  William H. Sheffler ,  Daniel Ellis

IPC: C07K14/00

Abstract: Synthetic nanostructures, polypeptides that are useful, for example, in making synthetic nanostructures, and methods for using such synthetic nanostructures are disclosed herein.

公开(公告)号：US10149892B2

公开(公告)日：2018-12-11

申请号：US15896536

申请日：2018-02-14

Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

Inventor： Justin Siegel ,  David Baker ,  Sydney Rin Anna Gordon ,  Ingrid Swanson Pultz ,  Elizabeth Joy Stanley ,  Sarah Jane Wolf

IPC: A61K38/48 ,  C12N9/50 ,  C12N9/52

Abstract: Disclosed herein are compositions and methods for treating celiac sprue.

公开(公告)号：US20160369264A1

公开(公告)日：2016-12-22

申请号：US15187599

申请日：2016-06-20

Applicant: Howard Hughes Medical Institute ,  University of Washington

Inventor： Tamir Gonen ,  Shane Gonen ,  Timothee Lionnet ,  David Baker ,  Frank DiMaio ,  Brian English ,  Harve Rouault

IPC: C12N15/10 ,  G06F19/16 ,  G01N33/68

CPC classification number: C12N15/1037 ,  G01N33/542 ,  G01N33/6803 ,  G01N33/6845 ,  G01N2610/00 ,  G16B15/00

Abstract: This document relates to two dimensional (2D) protein arrays can be used in biotechnology applications, as well as methods of making and using 2D protein arrays. In some cases, a 2D protein array can be used to evaluate (e.g., image) a structure (e.g., a three dimensional (3D) structure) of a protein of interest. In some cases, a 2D protein array can be used to evaluate (e.g., characterize) protein-protein interactions (e.g., stable interactions vs. transient interactions). In some cases, a 2D protein array can be used to evaluate a binding domain in a protein of interest. In some cases, a 2D protein array can be used to evaluate (e.g., identify) binding targets and/or partners of a protein of interest.

Abstract translation: 本文件涉及二维（2D）蛋白质阵列，可用于生物技术应用，以及制作和使用2D蛋白质阵列的方法。 在一些情况下，2D蛋白质阵列可用于评价（例如，图像）感兴趣的蛋白质的结构（例如，三维（3D）结构）。 在某些情况下，可以使用2D蛋白质阵列评估（例如，表征）蛋白质 - 蛋白质相互作用（例如，稳定的相互作用与瞬时相互作用）。 在一些情况下，可以使用2D蛋白质阵列来评估感兴趣的蛋白质中的结合结构域。 在一些情况下，可以使用2D蛋白质阵列来评估（例如，鉴定）结合目标和/或目的蛋白质的配偶体。

公开(公告)号：US12275757B2

公开(公告)日：2025-04-15

申请号：US18337881

申请日：2023-06-20

Applicant: University of Washington ,  INSTITUTE FOR RESEARCH IN BIOMEDICINE

Inventor： Neil P. King ,  David Baker ,  Brooke Fiala ,  Lance Joseph Stewart ,  Laurent Perez ,  Antonio Lanzavecchia ,  Jessica Marcandalli ,  Jorge Fallas ,  Yang Hsia

IPC: A61K39/12 ,  A61K39/00 ,  A61K39/155 ,  A61K39/385 ,  A61P31/14 ,  B82Y5/00 ,  C07K14/005 ,  C12N7/00

Abstract: Disclosed herein are nanostructures and their use, where the nanostructures include (a) a plurality of first assemblies, each first assembly comprising a plurality of identical first polypeptides; (b) a plurality of second assemblies, each second assembly comprising a plurality of identical second polypeptides, wherein the second polypeptide differs from the first polypeptide; wherein the plurality of first assemblies non-covalently interact with the plurality of second assemblies to form a nanostructure; and wherein the nanostructure displays multiple copies of one or more paramyxovirus and/or pneumovirus F proteins or antigenic fragments thereof, on an exterior of the nanostructure.

公开(公告)号：US12194075B2

公开(公告)日：2025-01-14

申请号：US17028377

申请日：2020-09-22

Applicant: University of Washington

Inventor： David Baker ,  Jorge Fallas ,  George Ueda ,  William H. Sheffler ,  Vanessa Nguyen

IPC: C12Q1/68 ,  A61K38/03 ,  C07K14/00 ,  C12P19/34 ,  G16B5/00 ,  G16B15/30

Abstract: Described herein are polypeptides capable of self-assembling to form homo-oligomers, and methods for designing such polypeptides.

公开(公告)号：US11820800B2

公开(公告)日：2023-11-21

申请号：US17285033

申请日：2019-11-04

Applicant: UNIVERSITY OF WASHINGTON

Inventor： Zibo Chen ,  Scott Boyken ,  Sherry Bermeo ,  Robert A. Langan ,  David Baker

IPC: C07K14/00 ,  C07K14/435 ,  G01N33/53 ,  G16B15/00 ,  G16B5/00 ,  B82Y10/00 ,  G06N3/00 ,  H03K19/00 ,  B82Y5/00 ,  C07K19/00 ,  G16B5/10 ,  G16B5/30 ,  G01N33/542

CPC classification number: C07K14/435 ,  B82Y5/00 ,  B82Y10/00 ,  C07K14/00 ,  C07K19/00 ,  G01N33/53 ,  G06N3/002 ,  G16B5/00 ,  G16B15/00 ,  H03K19/00 ,  C07K2319/00 ,  G01N33/542 ,  G16B5/10 ,  G16B5/30 ,  Y10S977/914

Abstract: Disclosed herein are designed heterodimer proteins, monomeric polypeptides capable of forming heterodimer proteins, protein scaffolds including such polypeptides, and methods for using the heterodimer proteins and subunit polypeptides for designing logic gates.

公开(公告)号：US11655278B2

公开(公告)日：2023-05-23

申请号：US17473731

申请日：2021-09-13

Applicant: UNIVERSITY OF WASHINGTON ,  THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

Inventor： Daniel Adriano Silva Manzano ,  Shawn Yu ,  David Baker ,  Kenan Christopher Garcia ,  Jamie Spangler ,  Carl Walkey ,  Umut Ulge

IPC: C07K14/55 ,  C07K14/54 ,  A61K47/62 ,  A61K47/60 ,  A61K38/00

CPC classification number: C07K14/55 ,  A61K47/60 ,  A61K47/62 ,  C07K14/5406 ,  C07K14/5437 ,  C07K14/5443 ,  A61K38/00 ,  C07B2200/13 ,  C07K2319/30 ,  C07K2319/33 ,  C07K2319/74

Abstract: De novo designed polypeptides that bind to IL-2 receptor βc heterodimer (IL-2Rβc), IL-4 receptor αc heterodimer (IL-4Rαc), or IL-13 receptor α subunit (IL-13Rα) are disclosed, as are methods for using and designing the polypeptides.

公开(公告)号：US11524979B2

公开(公告)日：2022-12-13

申请号：US16610574

申请日：2018-06-14

Applicant: UNIVERSITY OF WASHINGTON

Inventor： Parisa Hosseinzadeh ,  David Baker ,  Gaurav Bhardwaj ,  Vikram K. Mulligan

IPC: C07K7/64

Abstract: Disclosed herein are macrocyclic polypeptides having no more than 3 ammo acid substitutions compared to the amino acid sequence of any one of SEQ ID NO: 1-2.37 or a mirror image thereof, wherein the polypeptide includes both L and D amino acids, libraries of such polypeptides, and uses thereof.

公开(公告)号：US11485961B2

公开(公告)日：2022-11-01

申请号：US17019497

申请日：2020-09-14

Applicant: UNIVERSITY OF WASHINGTON ,  The Regents of the University of California

Inventor： Ingrid Swanson Pultz ,  Clancey Wolf ,  Justin Bloomfield Siegel ,  Christine Elaine Tinberg ,  Lance Stewart ,  David Baker

IPC: C12N9/50 ,  C12N9/52 ,  A61P1/14 ,  A61K38/00

Abstract: Polypeptides, and methods for their use, are disclosed that have an amino acid sequence at least 75% identical to the amino acid sequence of SEQ ID NO:1, are provided, wherein (a) the polypeptide degrades a PFQFQLPY (SEQ ID NO: 140) peptide and/or a PFPQPQQPF (SEQ ID NO: 68) at pH 4; (b) residue 467 is Ser, residue 267 is Glu, and residue 271 is Asp; and (c) the polypeptide comprises an amino acid change from SEQ ID NO: 1 at one or more residues selected from the group consisting of 221, 262E, 268, 269, 270, 319A, 320, 354E/Q/R/Y, 358S/Q/T, 368F/Q, 399, 402, 406, 424, 449, 461, 463, 105, 171, 172, 173, 174, and 456.