公开(公告)号：US11911784B2

公开(公告)日：2024-02-27

申请号：US17514273

申请日：2021-10-29

申请人： CORNELL UNIVERSITY

发明人： Yong Lak Joo ,  Yevgen Zhmayev

IPC分类号： B05B5/03 ,  B05D1/04 ,  C08L101/00 ,  C09D7/61 ,  C09D7/20 ,  C09D7/40 ,  B05D1/06 ,  C09D129/04 ,  B05D5/08 ,  B05D3/04 ,  B82Y30/00

CPC分类号： B05B5/03 ,  B05D1/04 ,  B05D1/06 ,  B05D5/08 ,  C08L101/00 ,  C09D7/20 ,  C09D7/61 ,  C09D7/67 ,  C09D129/04 ,  B05D3/042 ,  B05D2601/20 ,  B82Y30/00 ,  Y10T428/30

摘要： Provided in certain embodiments herein are alternating current electrospray systems and processes for manufacturing depositions, such as thin layer depositions. In some embodiments, processes and systems provided herein are suitable for and configured to manufacture uniform depositions, such as having uniform thickness.

公开(公告)号：US11903976B2

公开(公告)日：2024-02-20

申请号：US16666987

申请日：2019-10-29

申请人： CORNELL UNIVERSITY

发明人： Minglin Ma ,  James A. Flanders ,  Duo An

IPC分类号： A61K35/39 ,  A61K9/00 ,  A61K47/36 ,  A61K35/28 ,  A61K35/12 ,  A61K9/06 ,  A61K9/14

CPC分类号： A61K35/39 ,  A61K9/0024 ,  A61K9/06 ,  A61K9/146 ,  A61K35/28 ,  A61K47/36 ,  A61K2035/128

摘要： Disclosed are an implantable therapeutic delivery system and methods of treatment utilizing the implantable therapeutic delivery system. The implantable therapeutic delivery system includes a nanofibrous core substrate including one or more internal spaces wherein one or more therapeutic agents is positioned in the one or more internal spaces; and an outer biocompatible polymeric coating surrounding said nanofibrous core substrate.

公开(公告)号：US20240050599A1

公开(公告)日：2024-02-15

申请号：US18113206

申请日：2023-02-23

申请人： Cornell University

发明人： John W. Babich ,  James M. Kelly ,  Alejandro Amor-Coarasa ,  Shashikanth Ponnala

IPC分类号： A61K51/04 ,  A61P35/00

CPC分类号： A61K51/0482 ,  A61P35/00 ,  A61K51/0497 ,  A61K51/0402

摘要： The present technology provides compounds, as well as compositions including such compounds, useful for imaging and/or treatment of a glioma, a breast cancer, an adrenal cortical cancer, a cervical carcinoma, a vulvar carcinoma, an endometrial carcinoma, a primary ovarian carcinoma, a metastatic ovarian carcinoma, a non-small cell lung cancer, a small cell lung cancer, a bladder cancer, a colon cancer, a primary, gastric adenocarcinoma, a primary colorectal adenocarcinoma, a renal cell carcinoma, and/or a prostate cancer.

公开(公告)号：US11898992B2

公开(公告)日：2024-02-13

申请号：US17933988

申请日：2022-09-21

申请人： Cornell University

发明人： Amit Lal ,  Mamdouh Abdelmejeed ,  Justin Kuo

IPC分类号： G01N29/07 ,  G01K11/22 ,  G01N29/24 ,  G01N33/24 ,  G10K11/28 ,  H05B1/02

CPC分类号： G01N29/07 ,  G01K11/22 ,  G01N29/2437 ,  G01N33/24 ,  G10K11/28 ,  H05B1/023 ,  G01N2291/011 ,  G01N2291/0231 ,  G01N2291/02881 ,  G01N2291/044 ,  G01N2291/106

摘要： Disclosed are devices, systems and methods for touch, force and/or thermal sensing by an ultrasonic transceiver chip. In some aspects, an ultrasonic transceiver sensor device includes a semiconductor substrate; a CMOS layer attached to the substrate; an array of piezoelectric transducers coupled to the CMOS layer to generate ultrasonic pulses; and a contact layer attached to the substrate on a side opposite the substrate for providing a surface for contact with an object, where an ultrasonic pulse generated by a piezoelectric transducer propagates through the substrate and the contact layer, such that when the object is in contact with the surface of the contact layer, a reflected ultrasonic pulse is produced and propagates through the contact layer and the substrate to be received at the array of piezoelectric transducers, and the CMOS layer receive and process outputs from the piezoelectric transducers produced in response to the received reflected ultrasonic pulses.

公开(公告)号：US20240041327A1

公开(公告)日：2024-02-08

申请号：US18274963

申请日：2022-01-28

申请人： CORNELL UNIVERSITY

发明人： Steven G. ADIE ,  Nichaluk LEARTPRAPUN

IPC分类号： A61B5/00 ,  G06T5/50

CPC分类号： A61B5/0066 ,  A61B5/7203 ,  A61B5/7257 ,  G06T5/50

摘要： Methods, systems, and devices for generating resolution-enhanced space-domain image of a target sample based on optical coherent tomography (OCT) imaging technologies are disclosed. In an aspect, a system includes a processing platform comprising one or more processing devices operatively coupled to one or more memory devices. The processing platform is configured to acquire a plurality of related sets of optical coherence tomography (OCT) image data for a target object volume, reconstruct space-domain OCT images for each of the plurality of sets of OCT image data, coherently average the reconstructed space-domain OCT images to suppress noise or enhance a signal-to-noise ratio, and computationally expand a spatial bandwidth of the coherent-averaged OCT image data via deconvolution.

公开(公告)号：US11892344B2

公开(公告)日：2024-02-06

申请号：US17721882

申请日：2022-04-15

申请人： Cornell University

发明人： Amit Lal

IPC分类号： G01N29/46 ,  G01H11/08 ,  G06F17/14 ,  H10N30/50 ,  H10N30/85 ,  H04B11/00

CPC分类号： G01H11/08 ,  G01N29/46 ,  G06F17/142 ,  H10N30/50 ,  H10N30/85 ,  G01N2291/0426 ,  H04B11/00

摘要： A device configured for low-energy ultrasonic 2D Fourier transform analysis, comprising: (i) a first layer comprising an array of piezoelectric pixels; (ii) a second layer comprising an array of piezoelectric pixels; (iii) a third layer, positioned between the first and second layers, comprising a bulk ultrasonic transmission medium; wherein the second layer of array of piezoelectric pixels is in the Fourier plane of an input signal of the first layer array of piezoelectric pixels.

公开(公告)号：US11884685B2

公开(公告)日：2024-01-30

申请号：US17267687

申请日：2019-08-16

申请人： CORNELL UNIVERSITY

发明人： Arthur Paden King ,  Sierra C. Marker ,  Robert Swanda ,  Shu-Bing Qian ,  Justin J. Wilson

IPC分类号： C07F13/00 ,  A61P35/00

CPC分类号： C07F13/00 ,  A61P35/00

摘要： A composition comprising the following structure: (1) wherein Re represents a rhenium ion having a +1 charge; (I) represents an uncharged bidentate ligand containing at least one ring containing a ring nitrogen atom bound to the rhenium (Re), and the bidentate ligand containing another nitrogen atom, either in a ring or not in a ring, bound to the rhenium (Re); and L1, L2, L3, and L4 are neutral ligands with at least one neutral ligand being an isonitrile ligand of the formula —CN—R, wherein R is an aliphatic or aromatic hydrocarbon group containing 1-20 carbon atoms; and X− represents a non-coordinating monovalent anion; wherein the bidentate ligand and R are optionally substituted by one or more groups selected from (i)-(xi) as further discussed above. Methods for treating a condition that benefits from ER stress induction, such as cancer, by administering the above rhenium complex are also disclosed.

公开(公告)号：US20240026456A1

公开(公告)日：2024-01-25

申请号：US18458199

申请日：2023-08-30

申请人： CORNELL UNIVERSITY

发明人： Iwijn DE VLAMINCK ,  John Richard LEE ,  Philip Smith BURNHAM ,  Alexandre Pellan CHENG ,  Manikkam SUTHANTHRIAN ,  Darshana M. DADHANIA

IPC分类号： C12Q1/6883 ,  C12Q1/689 ,  C12Q1/70 ,  C40B30/06

CPC分类号： C12Q1/6883 ,  C12Q1/689 ,  C12Q1/701 ,  C40B30/06 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/158

摘要： The present disclosure is directed to methods of detecting cell-free DNA (cfDNA) in biological samples and using it to quantify organ damage and identify pathogens. In some aspects, the biological samples are from patients who have undergone solid-organ transplantation. The disclosure is also directed to methods of detecting and analyzing methylation patterns in cell-free DNA from organ transplant patients to identify the presence of pathogens as well as quantify contributing tissue proportions as a measurement of the host response.

公开(公告)号：US20240018276A1

公开(公告)日：2024-01-18

申请号：US18122416

申请日：2023-03-16

申请人： Cornell University

发明人： Minglin MA ,  Qingsheng LIU

IPC分类号： C08B37/00 ,  A61K9/00 ,  A61K9/06 ,  A61K9/48 ,  A61K47/34 ,  C08F116/06

CPC分类号： C08B37/0084 ,  A61K9/0024 ,  A61K9/06 ,  A61K9/4866 ,  A61K47/34 ,  C08F116/06

摘要： The present invention is directed to a polymer of Formula (IV):




wherein A, X, Q, Y, Z, m1, m2, m3, k1, and k2 are as described herein and wherein the monomer units of the polymer are the same or different. The present invention also relates to a monomer of Formula (III):




wherein R″, X1, Y1, Z1, m4, m5, and m6 are as described herein, and a polymeric network comprising two or more monomers of Formula (III). The present invention also relates to a hydrogel comprising any of the polymers and monomers described herein, a capsule comprising the hydrogel, and a method of delivering a therapeutic agent to a subject using the capsule.

公开(公告)号：US11866440B2

公开(公告)日：2024-01-09

申请号：US17160948

申请日：2021-01-28

申请人： NOVITA PHARMACEUTICALS, INC. ,  CORNELL UNIVERSITY

发明人： Xin-Yun Huang ,  Christy Young Shue

IPC分类号： C07D487/04 ,  C07D405/12 ,  C07D277/82 ,  C07D285/08 ,  C07D249/12 ,  A61K31/428 ,  A61K31/433 ,  A61K31/522

CPC分类号： C07D487/04 ,  A61K31/428 ,  A61K31/433 ,  A61K31/522 ,  C07D249/12 ,  C07D277/82 ,  C07D285/08 ,  C07D405/12

摘要： Provided are compositions and methods for treating a condition or disorder mediated by fascin activity in a subject in need thereof which method comprises administering to the subject a therapeutically effective amount of at least one compound of any one of Formula I-a to I-n, II, II-a, II-b or III or a pharmaceutically acceptable salt thereof.