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公开(公告)号：US10548963B2
公开(公告)日：2020-02-04
申请号：US16046505
申请日：2018-07-26
IPC分类号： A61K39/085 , A61K39/116 , A61K39/00 , C07K16/12 , A61K47/64
摘要： The present application relates to immunogenic compositions comprising a mixture of staphylococcal antigens which combines antigen having different functions, for instance, combinations including a staphylococcal extracellular component binding protein and a staphylococcal transporter protein or a staphylococcal extracellular component binding protein and a staphylococcal regulator of virulence or toxin or a staphylococcal transporter protein and a staphylococcal regulator of virulence or toxin. Vaccines, methods of treatment, uses of and processes to make a staphylococcal vaccine are also described.
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公开(公告)号：US20190298854A1
公开(公告)日：2019-10-03
申请号：US16082674
申请日：2017-03-06
发明人： Abdelatif A ELOUAHABI , Patrick POHLHAUS , Laurent Bernard Jean STRODIOT , Ashley GALLOWAY , Jin Christiane Lee , Michele R. STONE
摘要： The present invention concerns drug delivery particles which can prevent interaction between a biologically-active cargo comprised within the particles and components of an aqueous environment in which said particles are present. The particles are sensitive to pH such that above a threshold pH level the biologically-active cargo becomes accessible to the surrounding environment. Such particles are accordingly useful for stably storing a biologically-active cargo in an aqueous composition containing components which would otherwise interact deleteriously with the cargo, and releasing the cargo to mediate a biological effect in the body of an animal, such as a human, to which the composition is administered. Also provided are compositions comprising such particles, as well as methods for making and using such particles and compositions.
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公开(公告)号：US10376573B2
公开(公告)日：2019-08-13
申请号：US14407987
申请日：2013-06-14
发明人： Mariagrazia Pizza , Peter Dull , Marzia Monica Giuliani , Muhamed-Kheir Taha , Eva Hong , Ala-Eddine Deghmane
IPC分类号： A61K39/095 , A61K39/39 , A61K39/00
摘要： A method for immunizing a subject against serogroup X meningococcus by administering a vaccine comprising one, two or all three of: (i) a meningococcal fHbp antigen; (ii) a meningococcal NHBA antigen; and/or (iii) a meningococcal NadA antigen. The vaccine may also include meningococcal outer membrane vesicles.
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公开(公告)号：US20190151430A1
公开(公告)日：2019-05-23
申请号：US16269370
申请日：2019-02-06
发明人： Mario CONTORNI , Lorenzo TARLI
IPC分类号： A61K39/095 , A61K47/02
CPC分类号： A61K39/095 , A61K47/02 , A61K2039/55505 , A61K2039/55583 , A61K2039/6018 , A61K2039/70
摘要： Factor H binding protein (fHBP) has been proposed for use in immunising against serogroup B meningococcus (‘MenB’). This antigen can be efficiently adsorbed to an aluminium hydroxyphosphate adjuvant by (i) ensuring that adsorption takes place at a pH which is equal to or below the adjuvant's point of zero charge (PZC), and/or (ii) selecting a fHBP and adjuvant with an isoelectric point/PZC within the range of 5.0 to 7, and/or (iii) selecting a fHBP with an isoelectric point above the adjuvant's PZC and using a buffer to bring the pH to within 1.2 pH units of the PZC. The adsorption is particularly useful for compositions which include multiple fHBP variants, and also in situations where an aluminium hydroxide adjuvant should be avoided. Buffered pharmaceutical compositions can include at least two different meningococcal fHBP antigens, both of which are at least 85% adsorbed to aluminium hydroxyphosphate adjuvant.
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公开(公告)号：US10150979B2
公开(公告)日：2018-12-11
申请号：US15309283
申请日：2015-05-05
发明人： Evita Balducci , Francesco Berti , Valdemar Robert Janulczyk , Immaculada Margarit Y Ros , Chiara Toniolo
IPC分类号： C12P19/04 , A61K39/09 , C07K14/315 , C08B37/00
摘要： The invention relates to bacterial mutants, particularly from Streptococcus agalactiae, that secrete capsular polysaccharide and methods of purifying the secreted bacterial capsular polysaccharides from culture medium. The extracted polysaccharides are useful for producing vaccines comprising the polysaccharides alone or conjugated to proteins.
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公开(公告)号：US20180318415A1
公开(公告)日：2018-11-08
申请号：US15781351
申请日：2016-12-06
IPC分类号： A61K39/39 , A61K39/145
CPC分类号： A61K39/39 , A61K9/5123 , A61K9/5161 , A61K31/7008 , A61K31/722 , A61K39/145 , A61K45/06 , A61K2039/541 , A61K2039/55555 , A61K2039/55572 , C12N2760/16134 , A61K2300/00
摘要： The invention relates to a composition comprising solid lipid nanoparticles (SLNs), wherein the SLNs comprise an aminoalkyl glucosaminide phosphate (AGP).
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公开(公告)号：US20180303923A1
公开(公告)日：2018-10-25
申请号：US15769542
申请日：2016-10-19
发明人： Elisabeth Marie Monique BERTAUD , Ralph Leon BIEMANS , Nicolas Jean Benoit MONIOTTE , Laurent Bernard Jean STRODIOT
CPC分类号： A61K39/092 , A61K47/6415 , A61K47/646 , A61K2039/6087 , A61K2039/62 , A61K2039/70
摘要： The present invention is in the field of pneumococcal capsular saccharide conjugate vaccines. Specifically, the present invention relates to sized Streptococcus pneumoniae serotype 6A capsular polysaccharides, in particular Streptococcus pneumoniae serotype 6A capsular polysaccharides having the average size (e.g. Mw) of the Streptococcus pneumoniae serotype 6A capsular polysaccharide is between 100-1000 kDa, suitably conjugated to a carrier protein.
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公开(公告)号：US20180265551A1
公开(公告)日：2018-09-20
申请号：US15533483
申请日：2015-12-07
IPC分类号： C07K14/005
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/245 , C12N2710/16122 , C12N2710/16134
摘要： The invention generally relates to recombinant human cytomegalovirus (CMV) gB proteins and immunogenic fragments thereof, which do not comprise a transmembrane (TM) domain; and comprise one or more mutations that reduce the aggregation between the monomeric trimers of gB, and/or adhesion of the monomeric trimer of gB to the host cell.
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公开(公告)号：US10040832B2
公开(公告)日：2018-08-07
申请号：US15119220
申请日：2015-02-20
IPC分类号： A61K39/00 , C07K14/21 , C07K16/12 , A61K39/102 , A61K39/104
摘要： The present invention relates to compositions comprising Moraxella catarrhalis (M. catarrhalis) Ubiquitous surface protein A2 (UspA2). More particularly, the present application relates to UspA2 protein constructs and immunogenic compositions comprising the constructs, vaccines comprising such immunogenic compositions and therapeutic uses of the same. The invention further relates to compositions comprising UspA2 in combination with at least one antigen from Haemophilus influenzae, immunogenic compositions comprising the antigens, vaccines comprising such immunogenic compositions and therapeutic uses of the same.
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公开(公告)号：US20180169210A1
公开(公告)日：2018-06-21
申请号：US15802347
申请日：2017-11-02
发明人： Mariagrazia PIZZA
IPC分类号： A61K39/095 , A61K39/39
CPC分类号： A61K39/095 , A61K39/00 , A61K39/39 , A61K2039/53 , A61K2039/55505 , C07K14/22 , Y02A50/464 , Y02A50/466
摘要： Two or more Neisserial proteins are joined such that they are translated as a single polypeptide chain. Hybrid proteins are represented by the formula NH2-A-[—X-L-]n—B—COOH where X is an amino acid sequence, L is an optional linker amino acid sequence, A is an optional N-terminal amino acid sequence, B is an optional C-terminal amino acid sequence, and n is an integer greater than 1. Proteins where each of the n —X— moieties shares sequence identity to each other —X— moiety, the protein is a ‘tandem protein’.
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