公开(公告)号：US20180286047A1

公开(公告)日：2018-10-04

申请号：US15997802

申请日：2018-06-05

Applicant: Mauna Kea Technologies

Inventor： Nicolas Linard ,  Barbara Andre ,  Julien Dauguet ,  Tom Vercauteren

IPC: G06T7/00 ,  G06T7/174

Abstract: According to a first aspect, the invention relates to a method to support clinical decision by characterizing images acquired in sequence through a video medical device. The method comprises defining at least one image quantitative criterion, storing sequential images in a buffer, for each image (10) in the buffer, automatically determining, using a first algorithm, at least one output based on said image quantitative criterion and attaching said output to a timeline (11).

公开(公告)号：US09655499B2

公开(公告)日：2017-05-23

申请号：US14394241

申请日：2013-04-08

Applicant: Mauna Kea Technologies ,  EndoControl ,  Université Pierre et Marie Curie ,  Centre National de la Recherche Scientifique—CNRS

Inventor： Mustafa Suphi Erden ,  Benoit Rosa ,  Jérôme Szewczyk ,  Guillaume Morel ,  Clément Vidal ,  Patrick Henri ,  Nicolas Boularot

IPC: A61B1/06 ,  A61B1/00 ,  A61B1/005 ,  A61B5/00 ,  F21V8/00 ,  G02B6/04 ,  G02B6/00

CPC classification number: A61B1/0057 ,  A61B1/00133 ,  A61B1/00165 ,  A61B1/00172 ,  A61B5/0062 ,  A61B5/0068 ,  A61B5/0084 ,  G02B6/0008 ,  G02B6/04 ,  G02B2006/0098

Abstract: A miniaturized scanning system to generate movement of a flexible device positioned at a distal part of a medical tool. The miniaturized scanning system includes an inner shaft with a longitudinal axis, adapted to guide said flexible device along the longitudinal axis, an abutment comprising an external surface and adapted to maintain said device, and a pusher mechanism adapted to engage with said abutment. The miniaturized scanning system includes at least one end portion adapted to contact said external surface of the abutment at a contact point, wherein said end portion is configured to translate along said longitudinal axis of the inner shaft and wherein the translation of said end portion results in a bending of the device in a bending plane defined by the longitudinal axis of the inner shaft and said contact point.

公开(公告)号：US08808171B2

公开(公告)日：2014-08-19

申请号：US12300247

申请日：2007-05-11

Applicant: Francois Lacombe ,  Bertrand Viellerobe ,  Nicolas Boularot ,  Francois Doussoux ,  Aymeric Perchant

Inventor： Francois Lacombe ,  Bertrand Viellerobe ,  Nicolas Boularot ,  Francois Doussoux ,  Aymeric Perchant

IPC: A61B1/06 ,  A61B1/00 ,  A61B1/04 ,  G02B23/26 ,  G02B6/06 ,  A61B5/00 ,  A61B1/313

CPC classification number: G02B23/26 ,  A61B1/00165 ,  A61B1/043 ,  A61B1/313 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  G02B6/06

Abstract: An endoscopy device includes several light guides (1, 2, 3), each light guide having one or more optical fibers. The light guides are coupled with a sweeping system (4) arranged to direct an excitation light beam in alternation in one of the fibers of the guides from the proximal end of the guide including the one of the fibers. In this way, the proximal ends of the guides may make use of the same sweeping system, whereas the distal ends of the guides may be installed simultaneously in different zones of interest of an object or animal (10) under study for an almost simultaneous observation of the zones of interest. The invention also relates to an endoscopy method used in a device according to the invention. A device and a method according to the invention may be applied to quasi-simultaneous reflectance, fluorescence, multi-photon imaging of several areas of interest.

Abstract translation: 内窥镜检查装置包括若干个光导（1,2,3），每个光导具有一根或多根光纤。 光导件与扫掠系统（4）耦合，所述清扫系统（4）被布置成从引导件的近端引导引导光纤中的一个纤维中的激发光束，所述光纤包括所述一个光纤。 以这种方式，引导件的近端可以使用相同的扫掠系统，而引导件的远端可以同时安装在正在研究的几乎同时观察的物体或动物（10）的不同感兴趣的区域中 的感兴趣区域。 本发明还涉及在根据本发明的装置中使用的内窥镜检查方法。 根据本发明的装置和方法可以应用于若干感兴趣区域的准同时反射，荧光，多光子成像。

公开(公告)号：US20140207150A1

公开(公告)日：2014-07-24

申请号：US14123659

申请日：2012-06-25

Applicant: Benoît Rosa ,  Benoît Herman ,  Jérôme Szewczyk ,  Guillaume Morel ,  Clément Vidal ,  Patrick Henri ,  François Lacombe ,  Jérôme Lopez

Inventor： Benoît Rosa ,  Benoît Herman ,  Jérôme Szewczyk ,  Guillaume Morel ,  Clément Vidal ,  Patrick Henri ,  François Lacombe ,  Jérôme Lopez

IPC: A61B17/00 ,  A61B19/00

Abstract: The invention relates to an endoscopic instrument (1) having an elongate body with a distal end (4) designed to be introduced into the body of the patient so as to come into proximity with an internal organ, the distal end carrying a tool (7) for intervention on the internal organ. The endoscopic instrument has a fool (10) rigidly connected to the distal end and designed to bear on the internal organ, and also controllable means (13) for conferring movements on the tool, at least in directions transverse to a longitudinal axis (X) of the distal end of the endoscopic instrument, when the foot is bearing against the internal organ.

Abstract translation: 本发明涉及一种内窥镜器械（1），其具有细长体，其具有设计成被引入患者体内的远端（4），以便与内部器官接近，远端承载工具（7 ）干预内脏。 内窥镜仪器具有刚性地连接到远端并被设计成承载在内部器官上的傻瓜（10），以及用于赋予工具上的运动的可控制装置（13），至少在横向于纵向轴线（X）的方向上， 的内窥镜仪器的远端，当脚抵靠内脏器官时。

公开(公告)号：US20120184842A1

公开(公告)日：2012-07-19

申请号：US13496526

申请日：2010-09-17

Applicant: Nicolas Boularot ,  Magalie Genet ,  France Schwarz

Inventor： Nicolas Boularot ,  Magalie Genet ,  France Schwarz

IPC: A61B1/06 ,  A61B5/055 ,  A61B6/03 ,  A61B8/00

CPC classification number: A61B5/415 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/416 ,  A61B5/418 ,  A61B5/6848

Abstract: A method to inspect a solid organ in a subject includes introducing a needle in a predetermined area of the solid organ, inserting an optical probe through a lumen of the needle, and imaging the predetermined area using the optical probe. An optical probe to inspect a solid organ in a subject, the optical probe being intended to be positioned in the solid organ through a needle, the optical probe includes an optical fiber bundle, a ferule to protect the distal tip of the optical fiber bundle, the ferule comprising a shank and a head, and a sheath wrapping the fiber bundle and the shank, wherein the head of the ferule has a length adapted for the optical probe to image the solid organ while keeping the sheath inside the needle.

Abstract translation: 检查对象中的实体器官的方法包括将针插入实体器官的预定区域，将光学探针插入针的内腔，并使用光学探针对预定区域成像。 一种用于检查被检体内的实体器官的光学探针，所述光学探针旨在通过针位于所述实体器官中，所述光学探针包括光纤束，用于保护所述光纤束的远端的纤丝束， 所述纤维包括柄和头部，以及包裹所述纤维束和所述柄部的鞘，其中，所述纤毛头的长度具有适于光学探针成像固体器官的长度，同时将鞘保持在针内。

公开(公告)号：US07869679B2

公开(公告)日：2011-01-11

申请号：US12249665

申请日：2008-10-10

Applicant: Bertrand Viellerobe ,  Francois Lacombe ,  Nicolas Boularot ,  Francois Doussoux ,  Nicolas Lavillonniere

Inventor： Bertrand Viellerobe ,  Francois Lacombe ,  Nicolas Boularot ,  Francois Doussoux ,  Nicolas Lavillonniere

IPC: G02B6/06

CPC classification number: G01N21/6458 ,  A61B1/00165 ,  A61B1/00186 ,  A61B1/043 ,  A61B1/0638 ,  A61B1/07 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0084 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2201/024 ,  G01N2201/0846 ,  G01N2201/086

Abstract: An imaging device includes an illumination module comprising at least one emitter for emitting at least one excitation beam; a scanning and injection module comprising an image guide, a proximal end and a distal end of which are linked by a plurality of optical fibers; a scanning and injection optical system configured to alternately inject the at least one excitation beam into an optical fiber of the image guide from the proximal end of the image guide; a detection module comprising a detector for detecting a luminous flux collected at the distal end of the image guide, wherein at least one of the illumination module and the detection module is optically conjugated with the scanning and injection module using a conjugating optical fiber.

Abstract translation: 一种成像装置包括：照明模块，包括至少一个用于发射至少一个激发光束的发射器; 扫描和注射模块，包括图像引导件，其近端和远端由多根光纤连接; 扫描和注射光学系统，被配置为从所述图像引导件的近端交替地将所述至少一个激发光束注入到所述图像引导件的光纤中; 检测模块，包括用于检测在图像引导件的远端处收集的光通量的检测器，其中照明模块和检测模块中的至少一个使用共轭光纤与扫描和注射模块光学共轭。

公开(公告)号：US20100234686A1

公开(公告)日：2010-09-16

申请号：US12300247

申请日：2007-05-11

Applicant: Francois Lacombe ,  Bertrand Viellerobe ,  Nicolas Boularot ,  Francois Doussoux ,  Aymeric Perchant

Inventor： Francois Lacombe ,  Bertrand Viellerobe ,  Nicolas Boularot ,  Francois Doussoux ,  Aymeric Perchant

IPC: A61B1/06 ,  G02B6/04

CPC classification number: G02B23/26 ,  A61B1/00165 ,  A61B1/043 ,  A61B1/313 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  G02B6/06

Abstract: An endoscopy device includes several light guides (1, 2, 3), each light guide having one or more optical fibres. The light guides are coupled with a sweeping system (4) arranged to direct an excitation light beam in alternation in one of the fibres of the guides from the proximal end of the guide including the one of the fibres. In this way, the proximal ends of the guides may make use of the same sweeping system, whereas the distal ends of the guides may be installed simultaneously in different zones of interest of an object or animal (10) under study for an almost simultaneous observation of the zones of interest. The invention also relates to an endoscopy method used in a device according to the invention. A device and a method according to the invention may be applied to quasi-simultaneous reflectance, fluorescence, multi-photon imaging of several areas of interest.

Abstract translation: 内窥镜检查装置包括若干个光导（1,2,3），每个光导具有一根或多根光纤。 光导件与扫掠系统（4）耦合，所述清扫系统（4）被布置成从引导件的近端引导引导光纤中的一个纤维中的激发光束，所述光纤包括所述一个光纤。 以这种方式，引导件的近端可以使用相同的扫掠系统，而引导件的远端可以同时安装在正在研究的几乎同时观察的物体或动物（10）的不同感兴趣的区域中 的感兴趣区域。 本发明还涉及在根据本发明的装置中使用的内窥镜检查方法。 根据本发明的装置和方法可以应用于若干感兴趣区域的准同时反射，荧光，多光子成像。

公开(公告)号：US20100168610A1

公开(公告)日：2010-07-01

申请号：US12651238

申请日：2009-12-31

Applicant: Francois Lacombe ,  David Hughett ,  Chris Tihansky ,  Magalie Genet

Inventor： Francois Lacombe ,  David Hughett ,  Chris Tihansky ,  Magalie Genet

IPC: A61B10/04 ,  A61B10/06

CPC classification number: A61B10/04 ,  A61B1/018 ,  A61B10/06

Abstract: A method to perform an endoscopic biopsy includes deploying a mechanical forceps through an accessory channel of an endoscope assembly, deploying an optical probe through the accessory channel to an area of investigation, optically evaluating tissue at the area of investigation, actuating the mechanical forceps to grasp a sample of the tissue, and retrieving the mechanical forceps and the optical probe through the accessory channel of the endoscope assembly. A biopsy apparatus includes a delivery conduit, an optical probe configured to investigate the tissue upon a distal end of an optical conduit extending through the delivery conduit, and a forceps assembly slidably engaged over the optical conduit, the forceps assembly comprising jaws configured to operate between a closed position and at least one open position, wherein the jaws of the forceps are urged into the closed position as the forceps are retracted within the delivery conduit.

Abstract translation: 执行内窥镜活检的方法包括通过内窥镜组件的附件通道部署机械镊子，将光学探针通过附件通道展开到调查区域，在调查区域光学评估组织，致动机械镊子以掌握 组织的样品，以及通过内窥镜组件的附件通道取回机械钳和光学探头。 活检装置包括输送导管，配置成调查延伸穿过输送导管的光学导管的远端处的组织的光学探针，以及可滑动地接合在光学导管上的钳子组件，所述镊子组件包括夹爪， 关闭位置和至少一个打开位置，其中当镊子在输送导管内缩回时，镊子的钳口被推入关闭位置。

公开(公告)号：US20090240143A1

公开(公告)日：2009-09-24

申请号：US12396294

申请日：2009-03-02

Applicant: Anne Osdoit ,  Magalie Genet ,  Nicolas Boularlot ,  Alexander Meining ,  Christain Prinz

Inventor： Anne Osdoit ,  Magalie Genet ,  Nicolas Boularlot ,  Alexander Meining ,  Christain Prinz

IPC: A61B1/06 ,  A61B6/00 ,  A61B10/04

CPC classification number: A61B5/415 ,  A61B1/043 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/418

Abstract: A method for observing a mucosa of a biliary or pancreatic system in a subject includes positioning a optical probe in contact with said mucosa, wherein the optical probe accesses the biliary or pancreatic system using a working channel of an endoscope inserted orally in the subject. An optical probe to be used with a fiber optic microscope for in vivo observation includes an optical fiber bundle, a miniaturized objective connected coaxially at a distal tip of the optical fiber bundle, wherein the optical fiber bundle and the miniaturized objective each have a diameter of less than 1.2 mm such that said optical probe can access a biliary or pancreatic system using a working channel of an endoscope inserted orally.

Abstract translation: 用于观察受试者中胆汁或胰脏系统的粘膜的方法包括定位与所述粘膜接触的光学探针，其中所述光学探针使用在受试者中口服插入的内窥镜的工作通道进入胆汁或胰腺系统。 与用于体内观察的光学显微镜一起使用的光学探针包括光纤束，与光纤束的远端同轴地同轴的小型化物镜，其中，光纤束和小型化物镜的直径为 小于1.2mm，使得所述光学探针可以使用经口插入的内窥镜的工作通道进入胆汁或胰腺系统。

公开(公告)号：US20070290145A1

公开(公告)日：2007-12-20

申请号：US11665768

申请日：2005-10-21

Applicant: Bertrand Viellerobe ,  Francois Lacombe ,  Alexandre Loiseau ,  Frederic Louradour ,  Mikael Lelek ,  Alain Barthelemy ,  Domoinique Pagnoux

Inventor： Bertrand Viellerobe ,  Francois Lacombe ,  Alexandre Loiseau ,  Frederic Louradour ,  Mikael Lelek ,  Alain Barthelemy ,  Domoinique Pagnoux

IPC: G21K5/04 ,  F21K2/00 ,  F21V9/16

CPC classification number: G02B23/2484 ,  A61B5/0062 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0086 ,  G01N21/6452 ,  G01N21/6458 ,  G01N2021/6417 ,  G01N2021/6484 ,  G01N2201/08 ,  G01N2201/1053 ,  G02B6/04 ,  G02B21/002 ,  G02B21/16 ,  G02B23/2469

Abstract: A system for carrying out fibered multiphoton microscopic imagery of a sample (10) for use in endoscopy or fluorescence microscopy includes: a femtosecond pulsed laser (1, 2) for generating a multiphoton excitation laser radiation; an image guide (8) having a number of optical fibers and permitting the sample to be illuminated by a point-by-point scanning in a subsurface plane; pre-compensating elements (4) for pre-compensating for dispersion effects of the excitation pulses in the image guide (8), these elements being situated between the pulsed laser and the image guide (8); scanning elements for directing, in succession, the excitation laser beam in a fiber of the image guide, and; in particular, an optical head (9) for focussing the excitation laser beam exiting the image guide in the sample (10).

Abstract translation: 用于进行用于内窥镜检查或荧光显微镜检查的样品（10）的纤维多光子显微镜图像的系统包括：用于产生多光子激发激光辐射的飞秒脉冲激光器（1,2） 具有多个光纤的图像引导件（8），并允许通过在地下平面中的逐点扫描照亮样品; 预补偿元件（4），用于对图像引导件（8）中的激励脉冲的色散效应进行预补偿，这些元件位于脉冲激光器和图像引导件（8）之间; 用于连续地引导图像引导件的光纤中的激发激光束的扫描元件，以及 特别地，用于聚焦离开图像引导件的激发激光束在样品（10）中的光学头（9）。