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公开(公告)号：US08377841B2
公开(公告)日：2013-02-19
申请号：US13243173
申请日：2011-09-23
CPC分类号： C01B3/40 , B01J23/10 , B01J23/42 , B01J23/52 , B01J23/63 , B01J23/66 , B01J35/006 , B01J37/03 , B01J37/06 , C01B3/16 , C01B3/326 , C01B2203/0233 , C01B2203/0283 , C01B2203/1011 , C01B2203/1041 , C01B2203/1064 , C01B2203/107 , C01B2203/1076 , C01B2203/1082 , C01B2203/1223 , Y02P20/52
摘要： The invention contemplates a method of making a catalytic material, and uses of the material. The catalytic material is made by depositing catalytic metals, such as gold or platinum, on substrate materials, such as lanthanum-doped ceria or other oxides. The catalytic metal, which comprises both crystalline and non-crystalline structures, is treated, for example with aqueous basic NaCN solution, to leach away at least some of the crystalline metallic component. The remaining noncrystalline metallic component associated with the substrate exhibits catalytic activity that is substantially similar to the catalyst as prepared. The use of the catalyst in an apparatus such as a reactor or analytic instrument is contemplated, as is the use of the catalyst in efficient, cost-effective reactions, such as removal of carbon monoxide from fuel gases, for example by performing the water gas shift reaction.
摘要翻译： 本发明考虑了制备催化材料的方法和材料的用途。 催化材料通过在诸如金或铂的催化金属上沉积在诸如掺镧掺杂的二氧化铈或其它氧化物的衬底材料上而制成。 包括结晶和非结晶结构的催化金属例如用碱性NaCN水溶液处理以去除至少一些结晶金属组分。 与基材相关的剩余的非结晶金属组分显示出与所制备的催化剂基本相似的催化活性。 预期在诸如反应器或分析仪器的装置中使用催化剂，以及催化剂在有效且成本有效的反应中的使用，例如从燃料气体中除去一氧化碳，例如通过执行水气 转变反应。
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32.发明授权Humanized model of membrane attack complex (MAC) formation on murine retina and compositions, kits and methods for treatment of macular degeneration 有权鼠视网膜上的膜攻击复合物（MAC）形成的人源化模型及其治疗黄斑变性的组合物，试剂盒和方法公开(公告)号：US08324182B2
公开(公告)日：2012-12-04
申请号：US12867566
申请日：2009-02-13
CPC分类号： A61K48/005 , A61K48/0075 , C12N2799/022 , G01N33/564 , G01N2333/70596 , G01N2800/164
摘要： Methods and compositions for treating a subject having age-related macular degeneration (AMD), methods of assaying human macular degeneration (MD), and methods and kits for assaying potential therapeutic agents for treatment of human MD are provided herein.
摘要翻译： 本文提供了用于治疗患有年龄相关性黄斑变性（AMD）的受试者的方法和组合物，测定人黄斑变性（MD）的方法，以及用于测定治疗人MD的潜在治疗剂的方法和试剂盒。
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公开(公告)号：US08278344B2
公开(公告)日：2012-10-02
申请号：US12859997
申请日：2010-08-20
申请人： Gregory D. Cuny , Xin Teng , Junying Yuan , Alexei Degterev
发明人： Gregory D. Cuny , Xin Teng , Junying Yuan , Alexei Degterev
IPC分类号： A61K31/40
CPC分类号： C07D417/12 , C07D207/34 , C07D231/14 , C07D241/24 , C07D263/34 , C07D277/56 , C07D285/06 , C07D307/68 , C07D307/84 , C07D333/38
摘要： The invention features a series of heterocyclic derivatives that inhibit tumor necrosis factor alpha (TNF-α) induced necroptosis. The heterocyclic compounds of the invention are described by Formulas (I) and (Ia)-(Ie) and are shown to inhibit TNF-α induced necroptosis in FADD-deficient variant of human Jurkat T cells. The invention further features pharmaceutical compositions featuring the compounds of the invention. The compounds and compositions of the invention may also be used to treat disorders where necroptosis is likely to play a substantial role.
摘要翻译： 本发明具有一系列抑制肿瘤坏死因子α（TNF-α）诱导的人工坏死的杂环衍生物。 本发明的杂环化合物由式（I）和（Ia） - （Ie）描述，并且显示出抑制人Jurkat T细胞的FADD缺陷型变体中的TNF-α诱导的人工死亡。 本发明还涉及以本发明化合物为特征的药物组合物。 本发明的化合物和组合物也可以用于治疗棘球菌根可能起重要作用的病症。
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公开(公告)号：US08202695B2
公开(公告)日：2012-06-19
申请号：US11710339
申请日：2007-02-23
IPC分类号： A61K31/7076
CPC分类号： A61K31/198 , A61K31/522 , A61K31/7076 , A61K45/06 , A61K47/183 , A61K47/26 , Y02A50/469 , A61K2300/00
摘要： Bacterial virulence is repressed by compositions and methods for activating permanently a repressor of virulence factors. Compositions provided contain at least one non-metabolizable analog of guanine, guanosine, isoleucine and valine.
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公开(公告)号：US20110118125A1
公开(公告)日：2011-05-19
申请号：US12990855
申请日：2009-05-01
申请人： Jill Maron , Diana Bianchi , Kirby Johnson , Donna Slonim
发明人： Jill Maron , Diana Bianchi , Kirby Johnson , Donna Slonim
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： The present invention provides systems for assessing neonatal development and/or conditions by analyzing neonatal saliva RNA. Methods of identifying genes involved in neonatal development and/or conditions affecting neonates, are provided. Methods of determining a diagnosis of a neonate comprising detection of one or more differentially expressed genes are also provided.
摘要翻译： 本发明提供了通过分析新生儿唾液RNA来评估新生儿发育和/或病症的系统。 提供了鉴定涉及新生儿发育和/或影响新生儿的病症的基因的方法。 还提供了确定包括检测一种或多种差异表达基因的新生儿的诊断的方法。
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公开(公告)号：US20110104653A1
公开(公告)日：2011-05-05
申请号：US12673678
申请日：2009-01-07
申请人： Christopher Rogers , Ethan Danahy
发明人： Christopher Rogers , Ethan Danahy
IPC分类号： G09B3/00
CPC分类号： G06F3/0483 , G06F8/34
摘要： A digital workbook program, method, and system include a program interface module configured to communicate with a set of applications and a workbook module configured to generate a digital workbook from a master digital workbook. The digital workbook includes content and mechanisms that enable inputs to and receipt of outputs from the set of applications. Also included are a user interface module configured to generate user interface screens within which the digital workbook is presented and a storage module configured to store the digital workbook with user-entered inputs and outputs from the set of applications. The applications can communicate with a set of devices. Also, the digital workbook program, method, and system can be configured to enable authoring of digital workbooks and presentation in a visual library, as well as analysis of user specific digital workbooks.
摘要翻译： 数字工作簿程序，方法和系统包括被配置为与一组应用通信的程序接口模块和被配置为从主数字工作簿生成数字工作簿的工作簿模块。 数字工作簿包括能够输入和接收来自该组应用程序的输出的内容和机制。 还包括用户界面模块，其被配置为生成显示数字工作簿的用户界面屏幕;以及存储模块，被配置为存储来自该组应用的用户输入的输入和输出的数字工作簿。 应用程序可以与一组设备进行通信。 此外，数字工作簿程序，方法和系统可以被配置为使得能够在视觉库中创建数字工作簿和呈现，以及分析用户特定的数字工作簿。
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37.发明申请humanized model of membrane attack complex (MAC) formation on murine retina and compositions, kits and methods for treatment of macular degeneration 有权鼠视网膜上的膜攻击复合物（MAC）形成的人源化模型和用于治疗黄斑变性的组合物，试剂盒和方法公开(公告)号：US20110015136A1
公开(公告)日：2011-01-20
申请号：US12867566
申请日：2009-02-13
IPC分类号： A61K38/16 , C12Q1/68 , G01N33/53 , G01N33/567 , A61K31/7088 , A61P27/02
CPC分类号： A61K48/005 , A61K48/0075 , C12N2799/022 , G01N33/564 , G01N2333/70596 , G01N2800/164
摘要： Methods and compositions for treating a subject having age-related macular degeneration (AMD), methods of assaying human macular degeneration (MD), and methods and kits for assaying potential therapeutic agents for treatment of human MD are provided herein.
摘要翻译： 本文提供了用于治疗患有年龄相关性黄斑变性（AMD）的受试者的方法和组合物，测定人黄斑变性（MD）的方法，以及用于测定治疗人MD的潜在治疗剂的方法和试剂盒。
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公开(公告)号：US20100211357A1
公开(公告)日：2010-08-19
申请号：US12518333
申请日：2007-12-11
申请人： Ke Betty Li , Linda M. Abriola
发明人： Ke Betty Li , Linda M. Abriola
CPC分类号： G01N1/02 , B09C1/00 , G01N2001/021
摘要： The present invention provides a method for implementing a multi-stage spatial sampling strategy to select optimal sampling locations and determine an optimal sampling density for a quantification of mass discharge uncertainty in a field. The present invention also provides systems and methods for estimating probability of a mass discharge in a control plane.
摘要翻译： 本发明提供了一种用于实现多级空间采样策略以选择最佳采样位置并确定用于量化场中质量放电不确定度的最佳采样密度的方法。 本发明还提供了用于估计控制平面中的质量放电的概率的系统和方法。
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公开(公告)号：US07595473B2
公开(公告)日：2009-09-29
申请号：US11209432
申请日：2005-08-22
IPC分类号： G01N21/00
CPC分类号： G01J3/2803 , G01J3/02 , G01J3/0213 , G01J3/0229 , G01J3/10 , G01J3/4406 , G01J2001/0276 , G01N21/6428 , G01N21/6458 , G01N2021/6441 , G01N2021/6484 , G01N2201/08 , G01N2201/088
摘要： The present invention relates to a method and system of array imaging that extends or maximizes the longevity of the sensor array by minimizing the effects of photobleaching. The imaging system has a light source, a variable exposure aperture, and a variable filter system. The system extends the longevity of sensors by (1) using the variable exposure aperture to selectively expose sections of the sensor array containing representative numbers of each type of sensor, and/or (2) using the variable filter system to control the intensity of the excitation light, providing only the intensity required to induce the appropriate excitation and increasing that intensity over time as necessary to counteract the effects of photobleaching.
摘要翻译： 本发明涉及阵列成像的方法和系统，该方法和系统通过最小化光漂白的影响来延长或最大化传感器阵列的寿命。 成像系统具有光源，可变曝光孔径和可变过滤器系统。 该系统通过（1）使用可变曝光孔径来延长传感器的寿命，以选择性地暴露包含每种类型的传感器的代表数的传感器阵列的部分，和/或（2）使用可变过滤器系统来控制传感器的强度 激发光，仅提供诱导适当激发所需的强度，并根据需要随时间增加强度以抵消光漂白的影响。
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40.发明申请公开(公告)号：US20090117593A1
公开(公告)日：2009-05-07
申请号：US11982371
申请日：2007-11-01
IPC分类号： C07K14/435 , C07K1/00 , C12N5/06 , G01N33/554
CPC分类号： G01N33/74 , C07K14/44 , G01N2333/71 , G01N2500/10
摘要： The invention relates to T. cruzi trans-sialidase (TS) and to the neurotrophic and IL-6 secretion-inducing activities of the protein. TS, neurotrophic variants and/or neurotrophic peptides based upon the sequence of TS can be administered to a mammal to directly or indirectly provide neurotrophic support for neurons. A mammalian neurotrophic factor (e.g., CNTF, LIF) can be co-administered with the TS, neurotrophic variant and/or neurotrophic peptide. TS, IL-6 secretion-inducing variants and/or IL-6 secretion-inducing peptides based upon the sequence of TS can be administered to a mammal to induce the secretion of IL-6. TS, active variants and/or active peptides can be administered to a mammal having an acquired or congenital condition characterized by neuronal degeneration or to a mammal that has experienced trauma to the brain, spinal cord or peripheral nerves. The invention also relates to neurotrophic and IL-6 secretion-inducing variants of TS and to neurotrophic and IL-6 secretion-inducing peptides. The invention also relates to compositions comprising TS, active variants thereof and/or active peptides and a physiologically acceptable carrier.
摘要翻译： 本发明涉及克氏锥虫唾液酸酶（TS）和蛋白质的神经营养和IL-6分泌诱导活性。 可以将基于TS序列的TS，神经营养变体和/或神经营养肽施用于哺乳动物以直接或间接地为神经元提供神经营养支持。 哺乳动物神经营养因子（例如，CNTF，LIF）可以与TS，神经营养变体和/或神经营养肽共同施用。 基于TS序列的TS，IL-6分泌诱导变体和/或IL-6分泌诱导肽可以给予哺乳动物以诱导IL-6的分泌。 TS，活性变体和/或活性肽可以被给予具有以神经元变性为特征的获得性或先天性病症的哺乳动物或经历对脑，脊髓或周围神经的创伤的哺乳动物。 本发明还涉及TS的神经营养和IL-6分泌诱导变体，以及神经营养和IL-6分泌诱导肽。 本发明还涉及包含TS，其活性变体和/或活性肽和生理上可接受的载体的组合物。
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