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公开(公告)号：US11491478B2
公开(公告)日：2022-11-08
申请号：US16327130
申请日：2017-08-18
发明人： Hideji Tajima , Kazuhiro Nakamura , Yu Sugiyama
摘要： A dispensing cylinder capable of performing a dispensing treatment for both minute and large amounts of liquid includes: a cylinder having a cavity; a nozzle provided at one end of the cylinder, having a through hole in fluid communication with the cavity and extending in an axial direction of the cavity, and a plunger slidable in the cavity in the axial direction. The cavity has a large diameter region having a large inner peripheral surface and a small diameter region having a second inner peripheral surface. The plunger has a thick shaft portion slidable in the large diameter region and a thin shaft portion protruding from a distal end of the thick shaft portion in the axial direction and slidable in the small diameter region.
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32.发明申请公开(公告)号：US20210106985A1
公开(公告)日：2021-04-15
申请号：US16496723
申请日：2018-03-28
发明人： Hideji Tajima , Kazuhiro Nakamura , Yu Sugiyama
摘要： A photometric dispensing nozzle unit, a photometric dispensing apparatus, and a photometric dispensing method are for preventing an increase in apparatus scale and have a simple structure to be easily handled. A nozzle performs suction/discharge of gas through a distal end opening and can have a dispensing tip attached thereto. A light guide end portion is provided in the nozzle and can receive or irradiate light at a distal end of the nozzle. A dispensing cylinder has a cylinder having a cavity therein, a plunger that is slidable in the cavity, and a suction/discharge port that performs suction/discharge of gas. A suction/discharge flow path passes through the nozzle and communicates with the suction/discharge port and the distal end opening of the nozzle. A light guide path is optically connected to the light guide end portion through the nozzle but not through the dispensing cylinder.
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公开(公告)号：US10301064B2
公开(公告)日：2019-05-28
申请号：US14000832
申请日：2011-08-19
申请人： Hideji Tajima
发明人： Hideji Tajima
摘要： The invention relates to a reaction container and a method for producing the reaction container, and provides a low-cost reaction container which is capable of consistently, quickly, and efficiently performing a process that includes a reaction such as extraction or amplification of a nucleic acid, while saving user's trouble without increasing the scale of the device.The reaction container is configured to comprise: one or two or more housing parts for reactions comprising: a narrow-mouthed piping part in which a reaction reagent or a portion thereof is housed or is housable; a wide-mouthed piping part that is communicated with the narrow-mouthed piping part and provided on an upper side of the narrow-mouthed piping part, and has an aperture that is wider than an aperture of the narrow-mouthed piping part; and a punchable film provided such that it partitions an interval between the wide-mouthed piping part and the narrow-mouthed piping part.
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公开(公告)号：US10273533B2
公开(公告)日：2019-04-30
申请号：US15263463
申请日：2016-09-13
发明人： Hideji Tajima
IPC分类号： C12Q1/68 , G01N21/64 , G01N21/13 , G01N21/31 , G01N35/00 , G01N35/10 , C12Q1/686 , C12Q1/6848 , B01L7/00
摘要： The invention relates to an automatic response/light measurement device and a method therefor, and the purpose is to effectively and quickly perform an optical measurement relating to a reaction with high reliability without increasing a device size. The device is configured to have: a container group in which a plurality of reaction containers are arranged; a measurement mount provided with a plurality of coupling ends that are joinable with apertures of the reaction containers, and have light guide portions that optically connect with the interior of the joined reaction containers; a mount transfer mechanism; a measuring device having a measuring end having at least one light guide portion that is optically connectable to the light guide portions of the coupling ends, that is able to receive light based on an optical state within the reaction containers; an on-mount measuring end transfer mechanism; and a measurement control portion.
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37.发明授权Automatic light measurement device with a movable mount for coupling with multiple reaction containers 有权自动光测量装置，带有多个反应容器的可移动支架公开(公告)号：US09481906B2
公开(公告)日：2016-11-01
申请号：US13983508
申请日：2012-02-06
申请人： Hideji Tajima
发明人： Hideji Tajima
CPC分类号： C12Q1/686 , B01L7/52 , B01L7/54 , B01L2300/1805 , C12Q1/6848 , G01N21/13 , G01N21/31 , G01N21/6428 , G01N21/6452 , G01N35/0098 , G01N35/10 , G01N35/1065 , G01N2021/6421 , G01N2021/6439 , G01N2035/00366 , G01N2035/00376 , G01N2035/103 , G01N2035/1076 , G01N2201/08 , G01N2203/0226
摘要： The invention relates to an automatic response/light measurement device and a method therefor, and the purpose is to effectively and quickly perform an optical measurement relating to a reaction with high reliability without increasing a device size. The device is configured to have: a container group in which a plurality of reaction containers are arranged; a measurement mount provided with a plurality of coupling ends that are joinable with apertures of the reaction containers, and have light guide portions that optically connect with the interior of the joined reaction containers; a mount transfer mechanism; a measuring device having a measuring end having at least one light guide portion that is optically connectable to the light guide portions of the coupling ends, that is able to receive light based on an optical state within the reaction containers; an on-mount measuring end transfer mechanism; and a measurement control portion.
摘要翻译： 本发明涉及一种自动响应/光测量装置及其方法，其目的是在不增加设备尺寸的情况下有效且快速地执行与高可靠性的反应有关的光学测量。 该装置被配置为具有：多个反应容器布置在其中的容器组; 测量座，其具有可与反应容器的孔连接的多个连接端，并具有与连接的反应容器的内部光学连接的导光部; 安装传送机构; 测量装置，其具有测量端，所述测量端具有至少一个导光部分，所述至少一个导光部分可光学地连接到所述耦合端的导光部分，其能够接收基于所述反应容器内的光学状态的光; 安装测量端传输机构; 和测量控制部分。
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公开(公告)号：US20160201023A1
公开(公告)日：2016-07-14
申请号：US14916764
申请日：2014-09-02
发明人： Hideji TAJIMA
摘要： A culture system comprises: a preparatory culture vessel and a main culture vessel that accommodate cells and a solution; a main stage that holds the preparatory culture vessel and the main culture vessel; a connecting tube that connects the culture vessels; a valve that opens and closes the connecting tube; and a rotating mechanism that rotates the main stage and imparts a height difference between the culture vessels to transfer the cells and solution by dropping between the culture vessels.
摘要翻译： 培养系统包括：准备培养容器和容纳细胞和溶液的主培养容器; 是筹备文化船和主培养容器的主要阶段; 连接培养容器的连接管; 打开和关闭连接管的阀; 以及旋转机构，其旋转主级并赋予培养容器之间的高度差以通过在培养容器之间滴落来转移细胞和溶液。
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39.发明申请METHOD FOR PRETREATING SPECIMEN AND METHOD FOR ASSAYING BIOLOGICAL SUBSTANCE 审中-公开用于预测样本的方法和用于测定生物物质的方法公开(公告)号：US20160025722A1
公开(公告)日：2016-01-28
申请号：US14874154
申请日：2015-10-02
发明人： Hideji TAJIMA
IPC分类号： G01N33/543 , B01L3/00
CPC分类号： G01N33/54386 , B01L3/508 , B01L3/52 , B01L2200/10 , B01L2300/0636 , C12Q1/6804 , G01N33/54326 , G01N33/54393 , G01N35/026 , G01N35/1009 , Y10T436/143333 , Y10T436/25125 , C12Q2563/143
摘要： This invention relates to an assay device and a method for pretreating a specimen containing a biologically-relevant substance and then assaying the biologically-relevant substance. Biologically-relevant substances used in the assay method include microorganisms, cells, viruses, nucleic acids, polysaccharides, proteins (including antigens, antibodies, chromoproteins, and enzymes), peptides, nucleic acids, and small molecules. This pretreatment method removes contaminants from the biologically-relevant substances using supports such as magnetic particles, gels, resins, membranes, and solid-phased reagents. Therefore, in the assay method the following steps are generally carried out (i) a pretreatment step of treating a specimen using one or more first supports and then one or more second supports, and (ii) the assay step carried out after the pretreatment step. In particular, the pretreatment method reduces false positives and false negatives in the assay.
摘要翻译： 本发明涉及一种用于预处理含有生物相关物质并然后测定生物相关物质的试样的测定装置和方法。 用于测定方法的生物相关物质包括微生物，细胞，病毒，核酸，多糖，蛋白质（包括抗原，抗体，色蛋白和酶），肽，核酸和小分子。 这种预处理方法使用诸如磁性颗粒，凝胶，树脂，膜和固相试剂的载体从生物相关物质中除去污染物。 因此，在测定方法中，通常进行以下步骤：（i）使用一种或多种第一载体然后一种或多种第二载体处理样品的预处理步骤，和（ii）在预处理步骤之后进行的测定步骤 。 特别地，预处理方法减少了测定中的假阳性和假阴性。
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40.发明授权Carrier enclosing tip, carrier treating apparatus and method of carrier treatment 有权载体封闭尖端，载体处理装置和载体处理方法公开(公告)号：US09101921B2
公开(公告)日：2015-08-11
申请号：US13968829
申请日：2013-08-16
发明人： Hideji Tajima
CPC分类号： B01L3/00 , B01D15/22 , B01J2220/64 , B01L3/0275 , B01L2200/0631 , B01L2300/0681 , B01L2300/1827 , C07K1/16 , C07K1/22 , G01N1/405 , G01N30/6091
摘要： The invention relates to a carrier enclosing tip, a carrier treating apparatus, and a method of carrier treatment. An object is to perform separation/purification more efficiently and rapidly as compared with treatments using conventional liquid chromatography or filters. There is provided a carrier enclosing tip comprising: a tip-like container having a fitting opening which is fittable to a nozzle for use in gas suction and discharge, or a member to be fitted to a nozzle, and a port through which fluid inflow and outflow can be effected by the gas suction and discharge; and a carrier which is enclosed in the tip-like container, and is capable of adsorbing a biosubstance in the fluid or is capable of reacting with or binding to the biosubstance.
摘要翻译： 本发明涉及一种载体包封尖端，载体处理装置和载体处理方法。 与使用常规液相色谱或过滤器的处理相比，目的是更有效和快速地进行分离/纯化。 提供了一种载体封闭末端，其包括：具有可装配到用于吸气和排出的喷嘴的装配开口的顶端状容器，或将装配到喷嘴的构件，以及流体流入和 流出可以通过吸气和排放来实现; 以及被包封在前端状容器中的载体，能够将生物体吸附在流体中或能够与生物体反应或结合。
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