公开(公告)号：US09696304B2

公开(公告)日：2017-07-04

申请号：US15392412

申请日：2016-12-28

Applicant: University of Tennessee Research Foundation

Inventor： Jie Wu ,  Shigetoshi Eda

IPC: G01N27/02 ,  G01N33/543

CPC classification number: G01N33/5438 ,  G01N27/021 ,  G01N27/122 ,  G01N27/125 ,  G01N27/3275

Abstract: Methods are described for detecting pathogens, infectious diseases, and physiological conditions by quantifying change of impedance over time of when a biological sample is applied onto a lab-on-a-chip. The lab-on-a-chip utilizes alternating-current electrokinetic (ACEK) phenomena such that molecules move or are carried in an electric field generated by the application of an electrical signal of predetermined magnitude and frequency to an electrode array of the lab-on-a-chip.

公开(公告)号：US20170067736A1

公开(公告)日：2017-03-09

申请号：US15255800

申请日：2016-09-02

Applicant: BERKELEY SPRINGS INSTRUMENTS LLC

Inventor： Eugene B. SILVERMAN

IPC: G01B17/02 ,  G01N27/02 ,  G01N17/04

CPC classification number: G01B17/02 ,  G01N17/043 ,  G01N27/021 ,  G01N29/07 ,  G01N29/28 ,  G01N2291/011 ,  G01N2291/0258 ,  G01N2291/02854

Abstract: Ultrasonic transducers are imbedded into sacrificial metal coupons which are located in the vicinity of underground or aboveground structures, such as a pipe or tank, which allow for the measurement of the effectiveness of impressed current cathodic protection systems and can be used to determine the corrosion rate of the structure that is being protected. When excited by a pulser-receiver excitation pulse, the ultrasonic transducers can be used to determine the thickness of the coupon and its rate of change over time. The sacrificial metal coupon ultrasonic transducer assembly can be located in the vicinity of underground piping, under or inside of a tank, underground or underwater, or inserted into structures where absolute material loss values or material loss rate of change is being monitored.

Abstract translation: 超声波换能器被嵌入牺牲金属试样，其位于地下或地上结构附近，例如管或罐，其允许测量外加电流阴极保护系统的有效性，并且可用于确定腐蚀速率 的被保护的结构。 当由脉冲发生器接收器激发脉冲激发时，超声换能器可用于确定试样的厚度及其随时间的变化率。 牺牲金属试样超声波换能器组件可以位于地下管线附近，在地下或水下的罐的下面或内部，或插入到正在监测绝对材料损失值或材料损失变化率的结构中。

公开(公告)号：US20160054257A1

公开(公告)日：2016-02-25

申请号：US14888271

申请日：2014-04-10

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Yu ISHIGE ,  Masao KAMAHORI ,  Atsushi KISHIOKA ,  Tetsuyoshi ONO ,  Masafumi MIYAKE

IPC: G01N27/413 ,  G01N27/02 ,  G01N27/333 ,  G01N27/04

CPC classification number: G01N27/413 ,  G01N27/021 ,  G01N27/04 ,  G01N27/333 ,  G01N27/4035 ,  G01N27/4166 ,  G01N33/492

Abstract: An electrolyte concentration measuring apparatus is provided with: a plurality of ion selective electrodes and one reference electrode; a sample introduction unit that introduces a sample solution to the plurality of ion selective electrodes and the reference electrode; a potential measuring unit that measures a voltage between the plurality of ion selective electrodes and the reference electrode; and a resistance measuring unit that measures a direct-current resistance of the plurality of ion selective electrodes.

Abstract translation: 电解质浓度测定装置具备：多个离子选择电极和一个参比电极; 将样品溶液引入到所述多个离子选择电极和所述参考电极的样品引入单元; 电位测量单元，其测量所述多个离子选择电极与所述参考电极之间的电压; 以及测量多个离子选择电极的直流电阻的电阻测量单元。

公开(公告)号：US09213009B2

公开(公告)日：2015-12-15

申请号：US13326923

申请日：2011-12-15

Applicant: Stephen K. Bishop ,  Jacob J. Hart

Inventor： Stephen K. Bishop ,  Jacob J. Hart

IPC: G01B15/00 ,  G01N27/02 ,  G01N33/44

CPC classification number: G01N27/021 ,  G01N33/442

Abstract: The present application relates to a method and system for optimizing a composite system by electrically monitoring the reactive and physiological behavior of the resin binder in a composite system, so as to develop the desired properties of the resin during the cure process. A method of manufacturing a composite part can include assembling a composite preform with a resinous material and an open circuit. Further, the method can include subjecting the composite preform to a curing cycle so that a resin in the resinous material melts and closes the open circuit. Further, the method can include electrically monitoring a current through the resin during the curing cycle. Further, the method can include selectively controlling a manufacturing variable in response to the step of electrically monitoring the current through the resin.

Abstract translation: 本申请涉及通过电化学监测复合体系中树脂粘合剂的反应性和生理行为来优化复合体系的方法和系统，以便在固化过程中发展出树脂所需的性能。 制造复合部件的方法可以包括将复合预成型件与树脂材料和开路组装。 此外，该方法可以包括使复合预制件经受固化循环，使得树脂材料中的树脂熔化并闭合开路。 此外，该方法可以包括在固化周期期间电监测通过树脂的电流。 此外，该方法可以包括响应于电监测通过树脂的电流的步骤选择性地控制制造变量。

公开(公告)号：US20150260706A1

公开(公告)日：2015-09-17

申请号：US14434257

申请日：2013-10-09

Applicant: DUBLIN CITY UNIVERSITY

Inventor： Anthony Killard ,  Troy Hibbard ,  Karl Crowley

IPC: G01N33/497 ,  G01N27/02

CPC classification number: G01N33/497 ,  A61B5/082 ,  A61B5/097 ,  G01N27/021 ,  G01N2033/4975 ,  Y10T436/175383 ,  Y10T436/255 ,  Y10T436/25875

Abstract: A system for sensing and measuring ammonia in a breath sample is described. The system comprises a sampling means for capturing and directing a breath sample from a subject to an ammonia sensor, the ammonia sensor comprising a conducting polymer polyaniline sensor. The sampling means comprises a breath sample capture chamber, the chamber having an inlet and outlet, the inlet having a first valve through which a breath is exhaled into the sample capture chamber, the outlet having a second valve through which breath surplus to the volume of the chamber is expelled, to provide capture of a breath sample of predefined volume.

Abstract translation: 描述了用于感测和测量呼吸样品中的氨的系统。 该系统包括用于捕获并将呼吸样本从受试者引导到氨传感器的采样装置，所述氨传感器包括导电聚合物聚苯胺传感器。 所述采样装置包括呼吸样本捕获室，所述腔室具有入口和出口，所述入口具有第一阀，通过所述第一阀将呼吸呼出到所述样品捕获室中，所述出口具有第二阀，通过所述第二阀， 腔室被排出，以提供捕获预定体积的呼气样本。

公开(公告)号：US20150233852A1

公开(公告)日：2015-08-20

申请号：US14429719

申请日：2013-10-02

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： G. Marco Bommarito ,  Myungchan Kang ,  Michael C. Palazzotto ,  Timothy J. Nies ,  Kelvin J. Witcher

IPC: G01N27/02 ,  G01N27/22

CPC classification number: G01N27/023 ,  A47L15/4295 ,  A47L15/46 ,  A61L2/04 ,  A61L2/28 ,  A61L2202/17 ,  D06F39/002 ,  G01N27/021 ,  G01N27/22

Abstract: An electronic indicator includes artificial soil and sensor. An electrical characteristic of the electronic indicator can vary due to a change in the volume of the artificial soil. In some embodiments, the electrical characteristic of the electronic indicator can be measured by an electrical characteristic reader and used to determine efficacy of a cleaning cycle.

Abstract translation: 电子指示器包括人造土壤和传感器。 电子指示器的电气特性可能由于人造土体积的变化而变化。 在一些实施例中，电子指示器的电特性可以由电特性读取器测量并用于确定清洁循环的功效。

公开(公告)号：US20150185206A1

公开(公告)日：2015-07-02

申请号：US14541024

申请日：2014-11-13

Applicant: ACEA Biosciences, Inc.

Inventor： Yama A. Abassi ,  Naichen Yu ,  Josephine Atienza ,  Xiao Xu ,  Xiaobo Wang

IPC: G01N33/50 ,  G01N27/02

CPC classification number: G01N33/5041 ,  C12Q1/002 ,  G01N27/021 ,  G01N33/5014 ,  G01N33/5438 ,  G01N2333/4716 ,  G01N2333/705 ,  G01N2333/91205 ,  G01N2500/04 ,  G01N2500/10

Abstract: Use of cell-substrate impedance based methods for screening for agonists of G-Protein Coupled Receptors (GPCRs) or inhibitors of a Receptor Tyrosine Kinases (RTKs), identifying compounds that affect GPCR or RTK pathways, validating molecular targets involved in a GPCR or RTK signaling pathways, monitoring dose-dependent functional activation of GPCR or RTK; determining desensitization of a GPCR and identifying a compound capable of affecting RTK activity in cancer cell proliferation.

Abstract translation: 使用基于细胞底物阻抗的方法筛选G-蛋白偶联受体（GPCR）的激动剂或受体酪氨酸激酶（RTK）的抑制剂，鉴定影响GPCR或RTK途径的化合物，验证参与GPCR或RTK的分子靶标 信号通路，监测GPCR或RTK的剂量依赖性功能活化; 测定GPCR的脱敏作用并鉴定能够影响癌细胞增殖中的RTK活性的化合物。

公开(公告)号：US20130295556A1

公开(公告)日：2013-11-07

申请号：US13936631

申请日：2013-07-08

Applicant: Gabor Schmera ,  Laszlo Kish

Inventor： Gabor Schmera ,  Laszlo Kish

IPC: G01N27/02

CPC classification number: G01N27/021 ,  G01N33/48735 ,  G01N33/56911

Abstract: Methods for detection and identification of bacteria within a sample include the step of inserting a pair of electrodes into the sample. A first impedance across the electrodes is established with a first AC voltage source having a first frequency. A phage is introduced into the sample, and impedance fluctuations that are caused by ion release by the bacteria due to the phage introduction are measured. The use of impedance fluctuations instead of voltage fluctuations to detect and identify bacteria minimizes 1/f noise effects and increases system sensitivity. To further increase system sensitivity by eliminating thermal noise, a second impedance across the electrodes can be established using a second AC voltage source at a second frequency. Second impedance fluctuations are cross-correlated to the first impedance fluctuations, and the cross-correlation results are analyzed to determine whether or not bacteria are present in the sample based on phage electrical activity.

Abstract translation: 用于检测和鉴定样品中的细菌的方法包括将一对电极插入样品中的步骤。 利用具有第一频率的第一AC电压源建立电极两端的第一阻抗。 样品中引入了噬菌体，测量了由于引入噬菌体而导致细菌离子释放引起的阻抗波动。 使用阻抗波动代替电压波动来检测和识别细菌可以最大限度地降低1 / f噪声影响并提高系统灵敏度。 为了通过消除热噪声来进一步提高系统灵敏度，可以使用第二频率的第二AC电压源来建立电极两端的第二阻抗。 第二阻抗波动与第一阻抗波动相互关联，并且分析互相关结果以基于噬菌体电活动来确定样品中是否存在细菌。

公开(公告)号：US08573030B2

公开(公告)日：2013-11-05

申请号：US13031430

申请日：2011-02-21

Applicant: James L. Gole

Inventor： James L. Gole

IPC: G01N9/00 ,  G01R27/28 ,  H01L21/02 ,  G01N27/02

CPC classification number: G01N27/021 ,  G01N27/127

Abstract: Embodiments of the present disclosure provide for methods of selecting a nanostructured deposit for a conductometric gas sensor, methods of detecting a gas based on the acidic or basic characteristic of the gas using a conductometric gas sensor, devices including conductometric gas sensors, arrays of conductometric gas sensors, methods of determining the acidic or basic characteristic of a gas, methods of treating a sensor, and the like.

Abstract translation: 本公开的实施例提供了选择用于电导率气体传感器的纳米结构沉积物的方法，使用电导率气体传感器基于气体的酸性或碱性特征检测气体的方法，包括电导气体传感器的装置，电导率气体阵列 传感器，确定气体的酸性或碱性特性的方法，处理传感器的方法等。

公开(公告)号：US20130009647A1

公开(公告)日：2013-01-10

申请号：US13525695

申请日：2012-06-18

Applicant: Takao MIYAZAWA ,  Juri KATO

Inventor： Takao MIYAZAWA ,  Juri KATO

IPC: G01R29/12

CPC classification number: G01R29/12 ,  G01N17/04 ,  G01N27/021 ,  G01R27/08

Abstract: A sensor device includes a first electrode, a second electrode, a gap forming member and a functional element. The first electrode is composed of a first metallic material. The second electrode is spaced apart from the first electrode, and composed of a second metallic material. The gap forming member is arranged with a gap being formed between the gap forming member and a portion of a surface of the first electrode. The functional element is configured and arranged to measure a difference in electric potential between the first electrode and the second electrode so that a state of a measurement site to be measured is measured based on the difference in electric potential as measured by the functional element.