利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

43 条记录 (耗时 0.021 秒)

    Enhancer for the antianemia effect of erythropoietin and method of augmenting the antianemia effect of erythropoietin
    31.
    发明授权
    Enhancer for the antianemia effect of erythropoietin and method of augmenting the antianemia effect of erythropoietin 失效
    促红细胞生成素抗血症作用的增强剂及促红细胞生成素抗血栓作用的方法

    公开(公告)号：US5399551A

    公开(公告)日：1995-03-21

    申请号：US137789

    申请日：1993-10-19

    申请人： Michihito Ise ,  Hideo Hayashi

    发明人： Michihito Ise ,  Hideo Hayashi

    IPC分类号： A61K9/00 ,  A61K38/18 ,  A61K47/02 ,  A61K37/10 ,  B01J20/02

    CPC分类号： A61K9/0019 ,  A61K38/1816 ,  A61K47/02 ,  Y10S514/814

    摘要： There is disclosed an enhancer for the antianemia effect of erythropoietin using a spherical carbon as an active ingredient in an amount effective for treating anemia in combination with erythropoietin. The enhancer is orally administered. The antianemia effect of erythropoietin can be remarkably enhanced, the dosage of erythropoietin can be remarkably decreased, and side effects from erythropoietin can be remarkably reduced. There is further disclosed a method of augmenting the antianemia effect of erythropoietin by administering to a patient an effective amount of a spherical carbon in combination with a portion of an effective amount of erythropoietin for treating anemia.

    摘要翻译： 公开了使用球形碳作为活性成分的促红细胞生成素的抗血症效果的增强剂，其用量与红细胞生成素联合治疗贫血有效。 口服施用增强剂。 红细胞生成素的抗血症作用显着增强，促红细胞生成素的用量显着降低，促红细胞生成素的副作用明显降低。 还公开了通过与有效量的促红细胞生成素的一部分组合施用有效量的球形碳用于治疗贫血的方法来增加促红细胞生成素的抗血症效果的方法。

    Cellular nucleic acid binding protein and uses thereof in regulating gene expression and in the treatment of aids
    34.
    发明授权
    Cellular nucleic acid binding protein and uses thereof in regulating gene expression and in the treatment of aids 失效
    细胞核酸结合蛋白及其在调节基因表达和辅助治疗中的用途

    公开(公告)号：US5350835A

    公开(公告)日：1994-09-27

    申请号：US788266

    申请日：1991-11-05

    申请人： Richard B. Gaynor ,  Foon K. Wu

    发明人： Richard B. Gaynor ,  Foon K. Wu

    IPC分类号： A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/16 ,  C07K14/47 ,  C07K16/18 ,  C12N15/12 ,  C12N15/48 ,  C12P21/08 ,  G01N33/53 ,  A61K37/10

    CPC分类号： C07K14/005 ,  C07K14/4702 ,  C07K16/18 ,  G01N33/5308 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K2319/00 ,  C12N2740/16322 ,  Y10S435/974 ,  Y10S930/221

    摘要： The invention relates to a cellular protein which is specific and has high affinity for nucleic acid sequences characteristic of an intact TAR RNA loop sequence of the HIV LTR TAR region. The invention also relates to a between 1,000-10,000-fold purified, about 185 kD protein preparation isolated from a mammalian cell nuclear extract preparation, most specifically a HeLa cell extract. The about 185 kD protein is shown to regulate HIV viral gene expression by binding a TAR RNA region of an HIV LTR template, in the presence of a cofactor fraction (including at least a.about.100 kD cofactor), and a tat protein. The TRP-185, having a molecular weight of about 185 kD protein may also provide a research tool in the study of viral and cellular gene expression. A route for the development of immunodiagnostics for AIDS and related disorders may also be provided given the specific and high affinity of TRP-185 for HIV RNA. The 185 kD protein and related encoding amino acid and DNA sequences may also be used in therapeutic agents for AIDS and related disorders and, for the generation of specific antibodies for use in the diagnosis and study of the epidemiology of AIDS.

    摘要翻译： 本发明涉及对HIV LTR TAR区域的完整TAR RNA环序列特征性的核酸序列具有特异性且具有高亲和性的细胞蛋白质。 本发明还涉及从哺乳动物细胞核提取物制剂，特别是HeLa细胞提取物分离的1,000-10,000倍纯化的约185kD蛋白质制剂。 通过结合HIV LTR模板的TAR RNA区域，在辅因子级分（包括至少DIFFERENCE 100kD辅因子）和tat蛋白的存在下，约185kD蛋白质显示出调节HIV病毒基因表达。 具有约185kD蛋白质的分子量的TRP-185也可以在病毒和细胞基因表达的研究中提供研究工具。 鉴于TRP-185对HIV RNA的特异性和高亲和力，也可以提供用于发展艾滋病和相关疾病免疫诊断的途径。 185kD蛋白质和相关编码氨基酸和DNA序列也可用于AIDS和相关疾病的治疗剂，并用于产生用于诊断和研究艾滋病流行病学的特异性抗体。

    Hepatocyte specific receptor mediated endocytosis type magnetic resonance imaging contrast agents
    38.
    发明授权
    Hepatocyte specific receptor mediated endocytosis type magnetic resonance imaging contrast agents 失效
    肝细胞特异性受体介导的内吞型磁共振成像造影剂

    公开(公告)号：US5284646A

    公开(公告)日：1994-02-08

    申请号：US771876

    申请日：1991-10-03

    申请人： Edward T. Menz ,  Jeffrey M. Rothenberg ,  Ernest V. Groman ,  Lee Josephson

    发明人： Edward T. Menz ,  Jeffrey M. Rothenberg ,  Ernest V. Groman ,  Lee Josephson

    IPC分类号： A61K49/18 ,  C08G18/18 ,  C08G18/20 ,  C08G18/24 ,  C08G18/26 ,  C08J9/14 ,  G01R33/28 ,  G01N24/08 ,  A61K37/10

    CPC分类号： A61K49/18 ,  A61K49/1866 ,  A61K49/1869 ,  B82Y5/00 ,  C08G18/1808 ,  C08G18/1816 ,  C08G18/1825 ,  C08G18/2036 ,  C08G18/246 ,  C08G18/26 ,  C08J9/144 ,  G01R33/5601 ,  C08G2101/00 ,  C08J2375/04

    摘要： A new class of magnetic resonance (MR) contrast agents are described whose in vivo biodistribution is based upon the ability of certain cells to recognize and internalize macromolecules, including the MR contrast agents of the present invention, via a process which substantially involves receptor mediated endocytosis. The RME-type MR contrast agents described herein comprised of biodegradable superparamagnetic metal oxides associated with a variety of macromolecular species, including but not limited to, serum proteins, hormones, asialoglycoproteins, galactose-terminal species, polysaccharides, arabinogalactan, or conjugates of these molecules with other polymeric substances such as a poly(organosilane) and dextran. One of the advantages of these MR contrast agents is that they may be selectively directed to those cells which bear receptors for a particular macromolecule or ligand and are capable of undergoing receptor mediated endocytosis. An MR contrast agent prepared from biodegradable superparamagnetic iron oxide and asialofetuin, or more preferably arabinogalactan, for example, is selectively localized in the hepatocytes of the liver with no significant accumulation in the spleen. An MR experiment which can be carried out shortly after administration to the subject of the contrast agents of the invention can thus provide a method for obtaining an enhanced MR image, as well as valuable information regarding the functional or metabolic state of the organ or tissue under examination. Preparative methods, biodistribution data, and time function MR images are further provided.

    摘要翻译： 描述了一类新的磁共振（MR）造影剂，其体内生物分布基于某些细胞通过基本上涉及受体介导的内吞作用的方法识别和内化大分子（包括本发明的MR造影剂）的能力， 。 本文所述的RME型MR造影剂包括与各种大分子物质相关的可生物降解的超顺磁性金属氧化物，包括但不限于血清蛋白，激素，去唾液酸糖蛋白，半乳糖末端物质，多糖，阿拉伯半乳聚糖或这些分子的缀合物 与其他聚合物质如聚（有机硅烷）和葡聚糖。 这些MR造影剂的优点之一是它们可以选择性地定向到承载特定大分子或配体的受体的细胞，并且能够进行受体介导的内吞作用。 由生物降解的超顺磁性氧化铁和脱唾液酸铁蛋白制备的MR造影剂，或更优选阿拉伯半乳聚糖，例如选择性地定位在肝脏的肝细胞中，在脾脏中没有显着的积累。 因此，可以在给予本发明的造影剂的受试者后不久进行的MR实验可以提供获得增强的MR图像的方法，以及关于器官或组织的功能或代谢状态的有价值的信息 检查。 还提供了制备方法，生物分布数据和时间函数MR图像。