公开(公告)号：US10851059B2

公开(公告)日：2020-12-01

申请号：US16325880

申请日：2017-08-16

Applicant: Novartis AG

Inventor： Florian Karl Kleinbeck-Riniker ,  Ives Mafli ,  Benjamin Martin ,  Gerhard Penn ,  Gottfried Sedelmeier ,  Joerg Sedelmeier ,  Francesco Venturoni

IPC: C07C271/22 ,  C07D213/16 ,  C07C201/12 ,  C07C251/38 ,  C07C201/16 ,  C07C205/53 ,  C07C249/08 ,  C07D213/36 ,  C07C205/51 ,  C07C67/347 ,  C07C231/02 ,  C07C269/00 ,  C07C201/06 ,  C07C227/18 ,  C07C45/49 ,  C07C229/06 ,  C07C249/02 ,  C07D207/267 ,  C07D207/12

Abstract: The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril, inter alia via nitro 5 compounds. It further relates to new intermediate compounds and their use for said new chemical synthesis route, as well as a new catalyst ligand.

公开(公告)号：US09504933B2

公开(公告)日：2016-11-29

申请号：US13973142

申请日：2013-08-22

Applicant: ANGUS Chemical Company

Inventor： Mahesh Sawant ,  Daniel M. Trauth ,  John G. Pendergast, Jr. ,  Ravindra S. Dixit

IPC: B01J19/00 ,  B01J19/24 ,  B01D3/00 ,  C07C201/00 ,  C07C201/06 ,  C07C201/08 ,  C07C205/00 ,  C07C205/01 ,  C07C205/02 ,  C07C205/05

CPC classification number: B01D3/009 ,  B01J2219/00006 ,  C07C201/08 ,  C07C205/02 ,  C07C205/05

Abstract: Disclosed is an apparatus for synthesizing nitroalkanes by reaction of a hydrocarbon feedstock with aqueous nitric acid. The apparatus may be designed such that it can synthesize more than one nitroalkane using the same equipment.

公开(公告)号：US20150073180A1

公开(公告)日：2015-03-12

申请号：US14240058

申请日：2012-08-29

Applicant: Thomas Knauf ,  Michael Merkel

Inventor： Thomas Knauf ,  Michael Merkel

IPC: C07C201/06 ,  C07C205/06

CPC classification number: C07C201/06 ,  C07C201/08 ,  C07C201/16 ,  C07C205/06 ,  C07C209/36 ,  C07C211/46

Abstract: The invention relates to a method for producing nitrobenzene, in which crude nitrobenzene is first produced by nitrating benzene and said crude nitrobenzene is then washed in succession in at least one acid wash, in at least one alkaline wash and in at least one neutral wash, at least one additional wash with an aqueous solution of a potassium salt being interposed between the last alkaline wash and the first neutral wash.

Abstract translation: 本发明涉及生产硝基苯的方法，其中首先通过硝化苯生产粗硝基苯，然后将所述粗硝基苯在至少一种酸洗涤液，至少一种碱性洗涤液和至少一种中性洗涤液中连续洗涤， 在最后的碱性洗涤和第一中性洗涤之间插入钾盐水溶液至少一次另外的洗涤。

公开(公告)号：US20110040092A1

公开(公告)日：2011-02-17

申请号：US12675852

申请日：2008-09-05

Applicant: Christopher Murray ,  Graham Sandford

Inventor： Christopher Murray ,  Graham Sandford

IPC: C07D301/03 ,  C07C201/06 ,  C07D241/18 ,  C07D213/89

CPC classification number: C07B33/00 ,  B01J19/0093 ,  B01J2219/00867 ,  B01J2219/00891

Abstract: The invention relates to a process for making HOF.RCN and using it to oxidise organic substrates in a quick and safe way. The process comprises passing diluted fluorine through a conduit and RCN in water through another conduit into a microreactor to form HOF.RCN and reacting this with an organic substrates.

Abstract translation: 本发明涉及一种制备HOF.RCN的方法，并使用它以快速和安全的方式氧化有机基材。 该方法包括将稀释的氟通过导管和RCN在水中通过另一导管进入微反​​应器以形成HOF.RCN并使其与有机底物反应。

公开(公告)号：US20100174104A1

公开(公告)日：2010-07-08

申请号：US12404435

申请日：2009-03-16

Applicant: X. Peter Zhang ,  Shifa Zhu

Inventor： X. Peter Zhang ,  Shifa Zhu

IPC: C07C255/46 ,  C07C315/00 ,  C07C201/06

CPC classification number: C07C315/04 ,  B01J31/1815 ,  B01J2231/325 ,  B01J2531/025 ,  B01J2531/845 ,  C07B2200/07 ,  C07C2601/02 ,  C07C317/12 ,  C07C317/14 ,  C07C317/20 ,  C07C317/24 ,  C07C317/44

Abstract: Asymmetric cyclopropanation of olefins with diazosulfones.

Abstract translation: 烯烃与重氮砜的不对称环丙烷化反应。

公开(公告)号：US20060178526A1

公开(公告)日：2006-08-10

申请号：US11400007

申请日：2006-04-07

Applicant: Joachim Zechlin ,  Kai Verkerk ,  Dietmar Wastian ,  Katrin Joschek ,  Tim Loddenkemper ,  Wilfried Pinke ,  Michael Schelhaas ,  Georg Ronge

Inventor： Joachim Zechlin ,  Kai Verkerk ,  Dietmar Wastian ,  Katrin Joschek ,  Tim Loddenkemper ,  Wilfried Pinke ,  Michael Schelhaas ,  Georg Ronge

IPC: C07C263/04 ,  C07C201/06 ,  C07C209/36

CPC classification number: C07C209/68 ,  C07C201/12 ,  C07C211/58 ,  C07C263/10 ,  C07C265/14 ,  C07C205/56 ,  C07C205/45

Abstract: The present invention relates to a process for producing 5-nitro-3,4-dihydro-1(2H)-naphthalinone, 1,5-naphthalenediamine and 1,5-naphthalene diisocyanate, in which 4-(2-nitrophenyl)-n-butyronitrile is converted to 4-(2-nitrophenyl)-n-butyric acid.

Abstract translation: 本发明涉及5-硝基-3,4-二氢-1（2H） - 萘酮，1,5-萘二胺和1,5-萘二异氰酸酯的制备方法，其中4-（2-硝基苯基）-n - 丁腈转化为4-（2-硝基苯基） - 正丁酸。

公开(公告)号：US06936741B2

公开(公告)日：2005-08-30

申请号：US10878211

申请日：2004-06-28

Applicant: Jürgen Münnig ,  Dietmar Wastian ,  Wolfgang Lorenz ,  Berthold Keggenhoff

Inventor： Jürgen Münnig ,  Dietmar Wastian ,  Wolfgang Lorenz ,  Berthold Keggenhoff

IPC: B01D19/00 ,  B01D11/04 ,  C02F1/20 ,  C02F1/26 ,  C02F1/52 ,  C02F9/00 ,  C07C201/06 ,  C07C201/16 ,  C07C205/00

CPC classification number: C02F1/26 ,  C02F1/66 ,  C02F9/00 ,  C02F2103/36 ,  C07C201/16 ,  C07C205/06 ,  C07C205/22 ,  C07C205/24 ,  C07C205/57

Abstract: The present invention relates to a process for working up or treating aqueous waste waters which are formed during the nitration of toluene to dinitrotoluene with nitrating acid. These aqueous waste waters containing acidic wash water and alkaline wash water from the dinitrotoluene washing step, and distillate from the sulfuric acid concentration step. The process comprises, a) combining the acidic and alkaline waste waters from the washing step and the aqueous distillate from the sulfuric acid concentration step such that the resulting mixture has a pH below 5, b) separating the aqueous and organic phases which are formed by phase separation, c) subjecting the aqueous phase from b) to an extraction step, wherein d) the organic components contained in the aqueous phase from c) are extracted with toluene, and e) introducing the toluene phase enriched with the organic components into the toluene nitration.

Abstract translation: 本发明涉及一种处理或处理在用硝酸将甲苯硝化成二硝基甲苯期间形成的废水的处理方法。 这些含有来自二硝基甲苯洗涤步骤的酸性洗涤水和碱性洗涤水的含水废水，以及来自硫酸浓缩步骤的馏出物。 该方法包括：a）将来自洗涤步骤的酸性和碱性废水与来自硫酸浓缩步骤的含水馏出物混合，使得所得混合物的pH值低于5，b）将由下式形成的水相和有机相分离： 相分离，c）使来自b）的水相进行萃取步骤，其中d）来自c）的水相中含有的有机组分用甲苯萃取，e）将富含有机组分的甲苯相引入 甲苯硝化。

公开(公告)号：US5414148A

公开(公告)日：1995-05-09

申请号：US249200

申请日：1994-05-26

Applicant: Pascal Metivier ,  Laurent Bernard

Inventor： Pascal Metivier ,  Laurent Bernard

IPC: C07C201/06 ,  C07C201/10 ,  C07C205/22 ,  C07C207/04 ,  C07C205/20 ,  C07C205/21 ,  C07C205/26

CPC classification number: C07C201/00 ,  C07C201/08

Abstract: p-Nitrophenolic compounds, e.g., p-nitrophenol itself, are selectively prepared by (a) reacting a phenolic compound with a nitrosating agent in the presence of sulfuric acid, the concentration of which H.sub.2 SO.sub.4 being at least 60%, (b) oxidizing the p-nitrosophenolic compound thus formed with nitric acid, the concentration of sulfuric acid in the medium of reaction, upon completion of oxidation, being no greater than 80%, and (c) separating the p-nitrophenolic compound which thus precipitates.

Abstract translation: 通过（a）在硫酸存在下使酚类化合物与亚硝化剂反应，其中H 2 SO 4的浓度为至少60％，（b）将硝基酚类化合物氧化为 由硝酸形成的对亚硝基苯酚化合物，氧化后的反应介质中的硫酸浓度不大于80％，（c）分离因此析出的对硝基酚化合物。

公开(公告)号：US5364989A

公开(公告)日：1994-11-15

申请号：US908725

申请日：1992-07-06

Applicant: Isao Aoki ,  Takanori Tabuchi ,  Isao Minamida

Inventor： Isao Aoki ,  Takanori Tabuchi ,  Isao Minamida

IPC: A01N35/08 ,  A01N37/52 ,  A01N43/40 ,  A01N43/42 ,  A01N43/78 ,  C07C205/08 ,  C07C205/09 ,  C07C211/27 ,  C07D213/38 ,  C07D213/61 ,  C07D213/64 ,  C07D213/70 ,  C07D213/74 ,  C07D215/12 ,  C07D239/26 ,  C07D277/28 ,  C07D277/32 ,  C07D277/42 ,  C07C205/02 ,  C07C201/06

CPC classification number: C07D213/64 ,  A01N35/08 ,  A01N37/52 ,  A01N43/40 ,  A01N43/42 ,  A01N43/78 ,  C07C201/12 ,  C07C201/14 ,  C07C211/27 ,  C07D213/38 ,  C07D213/61 ,  C07D213/70 ,  C07D213/74 ,  C07D215/12 ,  C07D239/26 ,  C07D277/28 ,  C07D277/32 ,  C07D277/42

Abstract: Methods for the production of 1,1,1-trihalogeno-2-nitroethanes from 1,1-dihalogenoethylene by using nitric acid or its salt and hydrogen chloride or hydrogen bromide or its salt, and for the production of .alpha.-unsaturated amines from the 1,1,1-trihalogeno-2-nitroethanes which are useful as insecticides.

Abstract translation: 通过使用硝酸或其盐和氯化氢或溴化氢或其盐从1,1-二卤代乙烯生产1,1,1-三卤代-2-硝基乙烷的方法，以及用于从 可用作杀虫剂的1,1,1-三卤代-2-硝基乙基铵。

公开(公告)号：US5082976A

公开(公告)日：1992-01-21

申请号：US603110

申请日：1990-10-25

Applicant: Heinz U. Blank ,  Helmut Kraus

Inventor： Heinz U. Blank ,  Helmut Kraus

IPC: B01J27/122 ,  C07B41/06 ,  C07B61/00 ,  C07C201/06 ,  C07C201/12 ,  C07C205/44 ,  C07C253/30 ,  C07C255/56 ,  C07C303/30 ,  C07C309/73 ,  C07C309/86 ,  C07C315/04 ,  C07C317/24

CPC classification number: C07C255/56 ,  C07C201/12 ,  C07C253/30

Abstract: Benzaldehydes of the formula ##STR1## can be obtained by reaction of substituted .beta.-amino-styrenes of the formula ##STR2## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.8, R.sup.9, R.sup.10, m, n and o have the scope of meaning indicated in the description, with oxygen in the presence of a Cu compound in the solution of an aprotic polar solvent at 0.degree.-120.degree. C.

Abstract translation: 式（I）的苯甲醛可以通过其中R1，R2，R3，R4，R5，R8，R9，R10，m的取代的β-氨基苯乙烯与式 ，n和o具有说明书所示含义的范围，在0〜120℃下，在非质子极性溶剂的溶液中存在Cu化合物的氧。