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140 条记录 (耗时 0.037 秒)

    New urea derivatives, their preparation and their application in therapy
    33.
    发明授权
    New urea derivatives, their preparation and their application in therapy 失效
    新型尿素衍生物，其制备及其在治疗中的应用

    公开(公告)号：US5288758A

    公开(公告)日：1994-02-22

    申请号：US918424

    申请日：1992-07-22

    申请人： Jean-Louis Vidaluc ,  Dennis Bigg

    发明人： Jean-Louis Vidaluc ,  Dennis Bigg

    IPC分类号： C07C275/10 ,  C07C275/14 ,  C07C275/24 ,  C07C275/30 ,  C07C275/54 ,  C07C335/04 ,  C07C335/16 ,  C07C335/18 ,  C07D213/75 ,  A01N47/30 ,  C07C275/04

    CPC分类号： C07D213/75 ,  C07C275/24 ,  C07C275/30 ,  C07C275/54 ,  C07C335/16 ,  C07C335/18

    摘要： New urea derivatives corresponding to the general formula 1 ##STR1## in which: R.sup.1 represents a C.sub.1 -C.sub.4 alkyl group;R.sup.2 represents:a C.sub.5 -C.sub.7 cycloalkyl groupa cycloalkylmethyl group in which the cycloalkyl radical contains from 5 to 7 carbon atomsa benzyl groupa benzyl group in which the aromatic ring bears a C.sub.1 -C.sub.4 alkyl group, a C.sub.1 -C.sub.4 alkoxy group, a halogen atom or a nitro group;A represents an oxygen atom or a methylene radical;n represents 1 or 2;X represents an oxygen or sulfur atom;B represents a direct bond, a methylene radical or a carbonyl radical;as well as the therapeutically acceptable salts of these molecules.The invention also relates to the application of the compounds of general formula 1 in therapy, and to the preparation processes.

    摘要翻译： 对应于通式1的新型脲衍生物，其中：R1表示C1-C4烷基; R2表示：C5-C7环烷基环烷基甲基，其中环烷基含有5至7个碳原子，苄基苄基，其中芳环带有C1-C4烷基，C1-C4烷氧基， 卤素原子或硝基; A表示氧原子或亚甲基; n表示1或2; X表示氧或硫原子; B代表直接键，亚甲基或羰基; 以及这些分子的治疗上可接受的盐。 本发明还涉及通式1的化合物在治疗中的应用，以及制备方法。

    Feed supplement for ruminants
    34.
    发明授权
    Feed supplement for ruminants 失效
    反刍动物饲料补充剂

    公开(公告)号：US5072039A

    公开(公告)日：1991-12-10

    申请号：US432613

    申请日：1989-11-06

    申请人： Michael Worsley

    发明人： Michael Worsley

    IPC分类号： A23K50/15 ,  C07C273/18 ,  C07C275/10

    CPC分类号： C07C275/10 ,  A23K50/15 ,  C07C273/1863

    摘要： The invention includes a process wherein a solid, substantially non-polymerized alkyl aldehyde mono urea is produced if methanol or ethanol is used as the solvent for each of urea and an aldehyde in a reaction carried out under basic conditions. The process is useful in connection with making the following novel compounds: isobutyraldehyde mono urea, isovaleraldehyde mono urea, 2-methyl butyraldehyde mono urea and valeraldehyde mono urea. The compounds are useful as feed supplements for ruminants as they produce microbial attack-inducing acids and slowly release ammonia in the rumen.

    摘要翻译： 本发明包括一种方法，其中如果在基本条件下进行的反应中使用甲醇或乙醇作为尿素和醛中的每一种的溶剂，则产生固体，基本上未聚合的醛单脲。 该方法与制备以下新化合物有关：异丁醛单脲，异戊醛单脲，2-甲基丁醛单脲和戊醛单脲。 这些化合物可用作反刍动物的饲料添加剂，因为它们产生微生物侵袭诱导酸，并在瘤胃中缓慢释放氨。

    Pharmaceutical compositions containing nitroxyalkylamines, novel nitroxyalkylamines and processes for the preparation thereof
    36.
    发明授权
    Pharmaceutical compositions containing nitroxyalkylamines, novel nitroxyalkylamines and processes for the preparation thereof 失效
    含有硝基烷基胺，新型硝基烷基胺的药物组合物及其制备方法

    公开(公告)号：US5037849A

    公开(公告)日：1991-08-06

    申请号：US424452

    申请日：1989-10-20

    申请人： Herbert Simon ,  Helmut Michel ,  Michael Schultz ,  Wolfgang Bartsch

    发明人： Herbert Simon ,  Helmut Michel ,  Michael Schultz ,  Wolfgang Bartsch

    IPC分类号： A61K31/21 ,  A61K31/395 ,  A61K31/40 ,  A61K31/445 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  C07C235/10 ,  C07C235/26 ,  C07C235/40 ,  C07C237/08 ,  C07C237/18 ,  C07C275/10 ,  C07C275/14 ,  C07C275/16 ,  C07C275/26 ,  C07D211/06 ,  C07D295/13 ,  C07D295/14 ,  C07D295/215

    CPC分类号： C07D295/215 ,  A61K31/21 ,  C07C235/10 ,  C07C235/26 ,  C07C235/40 ,  C07C237/08 ,  C07C275/10 ,  C07C275/14 ,  C07C275/16 ,  C07C275/26 ,  C07D295/13 ,  C07C2101/14

    摘要： The present invention provides pharmaceutical compositions effective against angina-like heart and circulatory diseases containing at least one nitroxyalkylamine derivative of the general formula: ##STR1## wherein R.sub.1 is a hydrogen atom, a lower-alkyl radical, a C.sub.3 -C.sub.8 -cycloalkyl or C.sub.3 -C.sub.8 -cycloalkenyl radical, an aminocarbonyl, C.sub.1 -C.sub.6 -mono- or di-alkylaminocarbonyl radical, R.sup.2 is a hydrogen atom, a lower-alkyl radical or a C.sub.3 -C.sub.8 -cycloalkyl or cycloalkenyl radical or R.sup.2, together with R.sup.1 and the nitrogen atom to which they are attached, form a heteroaliphatic ring containing up to 6 carbon atoms, A is a valency bond or a straight-chained or branched lower-alkylene radical, in which a --CH.sub.2 -- group can be replaced by a cycloalkylene radical, B is a lower-alkylene radical, in which a --CH.sub.2 -- group can be replaced by a cycloalkylene radical and X is an --NR.sup.3 --CO-- or --CO--NR.sup.3 -- radical, in which R.sup.3 is a hydrogen atom or a lower-alkyl radical, when X is an --NR.sup.3 --CO-- radical, R.sup.3, together with the nitrogen atom and a carbon atom of the group A, bridge a heterocyclic ring containing 4 to 6 carbon atoms or R.sup.3, together with R.sup.2, A and the two nitrogen atoms, bridge a heterocyclic ring containing 3 to 5 carbon atoms; and the optically-active forms and physiologically acceptable salts thereof.

    摘要翻译： 本发明提供了有效抗心绞痛的心脏和循环系统疾病的药物组合物，其含有至少一种以下通式的硝基烷基胺衍生物：其中R 1是氢原子，低级烷基，C 3 -C 8 - 环烷基或C 3 -C 8 - 环烯基，氨基羰基，C 1 -C 6 - 单 - 或二 - 烷基氨基羰基，R 2是氢原子，低级烷基或C 3 -C 8 - 环烷基或环烯基或R 2，连同 R1和它们所连接的氮原子形成含有至多6个碳原子的杂脂族环，A是价键或直链或支链的低级亚烷基，其中-CH 2 - 基团可以被 亚环烷基，B是低级亚烷基，其中-CH 2 - 基团可被亚环烷基代替，X是-NR 3 -CO-或-CO-NR 3 - 基，其中R 3是氢原子 或低级烷基，当X是-NR 3 -CO-基时，R 3与硝基一起形成 原子和A基团的碳原子，桥接含有4至6个碳原子的杂环或R3与R2，A和两个氮原子一起桥接含有3至5个碳原子的杂环; 和其光学活性形式和生理上可接受的盐。