公开(公告)号：US20100166769A1

公开(公告)日：2010-07-01

申请号：US12704928

申请日：2010-02-12

Applicant: Pei-Wen Hsiao ,  Chia- Ying Wu ,  Yi-Chun Yeh

Inventor： Pei-Wen Hsiao ,  Chia- Ying Wu ,  Yi-Chun Yeh

IPC: A61K39/42 ,  C12P21/00 ,  C12N9/26 ,  A61K39/145 ,  G01N33/53 ,  C07K16/08 ,  C12N5/07 ,  C12N15/00 ,  A61P31/16

CPC classification number: A61K39/145 ,  A61K39/12 ,  A61K39/215 ,  A61K2039/5258 ,  C07K14/005 ,  C07K16/1018 ,  C12N2760/16034 ,  C12N2760/16122 ,  C12N2760/16123 ,  C12N2760/16134 ,  C12N2770/20022 ,  C12N2770/20023 ,  C12N2770/20034 ,  C12N2830/006 ,  G01N33/56983 ,  G01N2333/11 ,  G01N2469/10 ,  G01N2469/20

Abstract: Virus-like particles (VLPs) of mammalian-hosted viruses, such as SARS-CoV and influenza viruses, have been recombinantly produced from Vero cells. The VLPs closely emulate the exterior of authentic virus particles and are highly immunogenic. They can elicit not only humoral but also cellular immune responses in a mammal. Compositions and methods related to the VLPs are also described.

Abstract translation: 从Vero细胞重组产生哺乳动物宿主病毒（如SARS-CoV和流感病毒）的病毒样颗粒（VLP）。 VLP密切模仿真实病毒颗粒的外观，具有高度的免疫原性。 它们可以引起哺乳动物体液，但也可引起细胞免疫反应。 还描述了与VLP相关的组合物和方法。

公开(公告)号：US07691624B2

公开(公告)日：2010-04-06

申请号：US11582867

申请日：2006-10-18

Applicant: Ta-Chau Chang ,  Cheng-Chung Chang ,  Chi-Chih Kang ,  Ji-Yen Cheng

Inventor： Ta-Chau Chang ,  Cheng-Chung Chang ,  Chi-Chih Kang ,  Ji-Yen Cheng

IPC: C12M1/34 ,  C12M3/00

CPC classification number: G01N21/6428

Abstract: This invention relates to a device for detecting cancer cells. The device includes a light source for generating light (e.g., a light emitting diode), a first optical filter selected from the group consisting of a band pass filter and a long pass filter, a second optical filter (i.e., a band pass filter) disposed between the light source and the first optical filter, and a sample receiver for receiving a sample. The sample receiver is disposed between the first and second optical filters. The first optical filter, the sample receiver, and the second optical filter are aligned so that light emitted from the light source passes sequentially through the second optical filter, the sample receiver, and the first optical filter.

Abstract translation: 本发明涉及一种用于检测癌细胞的装置。 该装置包括用于产生光的光源（例如，发光二极管），从由带通滤波器和长通滤波器组成的组中选择的第一滤光器，第二滤光器（即，带通滤光器） 设置在光源和第一滤光器之间，以及用于接收样品的样品接收器。 样品接收器设置在第一和第二滤光器之间。 对准第一滤光器，样品接收器和第二滤光器，使得从光源发射的光顺序地通过第二滤光器，样品接收器和第一滤光器。

公开(公告)号：US07670820B2

公开(公告)日：2010-03-02

申请号：US12013518

申请日：2008-01-14

Applicant: Jei-Fu Shaw ,  Yu-Ting Chen ,  Lien-Hua Hsu

Inventor： Jei-Fu Shaw ,  Yu-Ting Chen ,  Lien-Hua Hsu

IPC: C12N9/26 ,  C12N9/00 ,  C12N1/20 ,  C12N15/00 ,  C07H21/04

CPC classification number: C12N15/8281 ,  A61K8/64 ,  A61K38/00 ,  A61Q17/005 ,  C12N9/2442 ,  C12N15/8282 ,  C12Y302/01014

Abstract: Disclosed herein are novel chitinase polypeptides and nucleic acids encoding the polypeptides. Also disclosed are related vectors, host cells, compositions, and uses.

Abstract translation: 本文公开了新型几丁质酶多肽和编码多肽的核酸。 还公开了相关载体，宿主细胞，组合物和用途。

公开(公告)号：US07649170B2

公开(公告)日：2010-01-19

申请号：US11542568

申请日：2006-10-03

Applicant: Yi-Sheng Wang ,  Chung-Hsuan Chen ,  Shang-Ting Tsai ,  Chiu Wen Chen

Inventor： Yi-Sheng Wang ,  Chung-Hsuan Chen ,  Shang-Ting Tsai ,  Chiu Wen Chen

IPC: H01J49/10

CPC classification number: H01J49/40 ,  H01J49/0095

Abstract: A dual-polarity mass spectrometer includes an ion source, a negative ion mass analyzer, and a positive ion mass analyzer to measure both the negative and positive ion spectra of a sample material simultaneously. The ion source includes a sample surface on which the sample material is positioned, the sample material providing positive ions and negative ions when excited by a laser beam or an energetic particle stream. A first extraction electrode is connected to a voltage higher than the sample surface to attract the negative ions from the sample electrode. A second extraction electrode is connected to a voltage lower than the sample surface to attract the positive ions from the sample electrode. The negative and positive ions are analyzed simultaneously by the negative ion mass analyzer and the positive ion mass analyzer, respectively.

Abstract translation: 双极性质谱仪包括离子源，负离子质量分析仪和正离子质量分析仪，以同时测量样品材料的负离子和正离子光谱。 离子源包括其上放置样品材料的样品表面，当由激光束或能量粒子流激发时，样品材料提供正离子和负离子。 第一引出电极连接到高于样品表面的电压以吸引来自样品电极的负离子。 第二提取电极连接到低于样品表面的电压，以吸引来自样品电极的正离子。 负离子和正离子分别通过负离子质量分析仪和正离子质量分析仪同时分析。

公开(公告)号：US20090317411A1

公开(公告)日：2009-12-24

申请号：US12485546

申请日：2009-06-16

Applicant: Chi-Huey Wong ,  Alice L. Yu ,  John. Yu

Inventor： Chi-Huey Wong ,  Alice L. Yu ,  John. Yu

IPC: A61K39/00 ,  A61K31/7105 ,  A61P35/00

CPC classification number: A61K39/0011 ,  A61K2039/55511 ,  A61K2039/6037 ,  A61K2039/6081 ,  A61K2039/627 ,  C12N15/1137 ,  C12N2310/14

Abstract: An immune composition containing Globo H or its fragment (e.g., SSEA3) and an adjuvant, e.g., α-GalCer, for eliciting immune responses against Globo H or its fragment and uses thereof in cancer treatment. Also disclosed is a method of treating cancer by inhibiting the activity of one of FUT1 and FUT2, both of which involve in Globo H biosynthesis.

Abstract translation: 包含Globo H或其片段（例如SSEA3）和佐剂（例如α-GalCer）的免疫组合物，用于引发针对Globo H或其片段的免疫应答及其在癌症治疗中的用途。 还公开了通过抑制FUT1和FUT2之一的活性来治疗癌症的方法，两者都涉及Globo H生物合成。

公开(公告)号：US20090317366A1

公开(公告)日：2009-12-24

申请号：US12510387

申请日：2009-07-28

Applicant: Che-Kun James Shen ,  Kuen-jer Tsai

Inventor： Che-Kun James Shen ,  Kuen-jer Tsai

IPC: A61K35/12

CPC classification number: A61K38/193 ,  A01K2207/10 ,  A01K2267/0312 ,  A61K35/28

Abstract: A method for treating a progressive neurodegenerative disorder with bone marrow stem cells and a G-CSF receptor agonist.

Abstract translation: 用骨髓干细胞和G-CSF受体激动剂治疗进行性神经变性障碍的方法。

公开(公告)号：US20090298945A1

公开(公告)日：2009-12-03

申请号：US12428551

申请日：2009-04-23

Applicant: Shui-Tein Chen ,  Shih-Hsiung Wu ,  Jung-Feng Hsieh

Inventor： Shui-Tein Chen ,  Shih-Hsiung Wu ,  Jung-Feng Hsieh

IPC: A61K31/194 ,  A61P9/12

CPC classification number: A61K31/194

Abstract: Method of treating hypertension with a trans-aconitic acid containing composition (e.g., a water extract derived from a monocotyledon plant).

Abstract translation: 用含有乌头酸的组合物（例如来自单子叶植物的水提取物）治疗高血压的方法。

公开(公告)号：US20090275484A1

公开(公告)日：2009-11-05

申请号：US12423733

申请日：2009-04-14

Applicant: Chi-Huey Wong ,  Pi-Hui Liang

Inventor： Chi-Huey Wong ,  Pi-Hui Liang

IPC: C40B30/04 ,  C40B60/12

CPC classification number: G01N33/5308 ,  B01J19/0046 ,  C40B30/04 ,  C40B40/12 ,  G01N2400/00 ,  G01N2400/10

Abstract: A method, system and device to identify, study and/or mimic carbohydrate-protein interactions on cell surfaces and in solution measured by a glycan microarray. In some instances the method, system and device uses very small quantities of carbohydrate as low as attomol. In some instances the system, method and device is high-throughput. The small quantity sensitivity may allow for close placement of carbohydrate array members wherein due to close proximity multivalent interactions with proteins may be identified.

Abstract translation: 鉴定，研究和/或模拟细胞表面和聚糖微阵列测量溶液中碳水化合物 - 蛋​​白质相互作用的方法，系统和装置。 在某些情况下，该方法，系统和装置使用非常少量的碳水化合物，与阿托莫尔一样低。 在某些情况下，系统，方法和设备是高吞吐量的。 小量的灵敏度可以允许碳水化合物阵列成员的紧密放置，其中由于与蛋白质的近似多价相互作用可以被鉴定。

公开(公告)号：US20090246887A1

公开(公告)日：2009-10-01

申请号：US12411241

申请日：2009-03-25

Applicant: Huan-cheng Chang ,  Chau-chung Han

Inventor： Huan-cheng Chang ,  Chau-chung Han

IPC: G01N33/566

CPC classification number: G01N33/551

Abstract: A diamond-based composition that contains (1) a diamond crystallite having chemically derivatized surface groups, and (2) a polymer having functional groups, in which a portion of the functional groups bind to the chemically derivatized surface groups non-covalently. Also disclosed are methods of using such composition for analyzing a biological sample by determining the identity of biomolecules bound to the composition.

Abstract translation: 一种基于金刚石的组合物，其包含（1）具有化学衍生的表面基团的金刚石微晶，和（2）具有官能团的聚合物，其中一部分官能团非共价结合化学衍生的表面基团。 还公开了通过确定与组合物结合的生物分子的身份来使用这种组合物来分析生物样品的方法。

公开(公告)号：US07582737B2

公开(公告)日：2009-09-01

申请号：US11185664

申请日：2005-07-20

Applicant: Shang-Cheng Hung ,  Jing-Chyi Lee ,  Xin-An Lu

Inventor： Shang-Cheng Hung ,  Jing-Chyi Lee ,  Xin-An Lu

IPC: C08B37/10 ,  C13K5/00 ,  C13K7/00 ,  C07H5/04 ,  C07H5/06 ,  C08B37/00

CPC classification number: A61K31/727 ,  C07H3/06 ,  C07H15/04 ,  C07H15/203 ,  C08B37/0078 ,  C08L5/10 ,  Y02P20/55

Abstract: Orthogonally protected disaccharide building blocks for synthesis of heparin oligosaccharide. The disaccharide building block has a formula (I), in which L is a leaving group, P1, P2, P3 and are different, and of them P1 is an ester-type protecting group, P2 is a hydroxyl protecting group that could be oxidized to a carboxylic acid, P3 is a hydroxyl protecting group, and P4 is a hydroxyl protecting group which allows chemoslective deprotection with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ). Acting as an elongation unit, the disaccharide building block of formula (I) may react with a starting unit of formula (II) to synthesize a heparin oligosaccharide.

Abstract translation: 用于合成肝素寡糖的正交保护的二糖结构单元。 二糖结构单元具有式（I），其中L是离去基团，P1，P2，P3并不同，其中P1是酯型保护基，P2是可被氧化的羟基保护基 对于羧酸，P3是羟基保护基，P4是允许用2,3-二氯-5,6-二氰基-1,4-苯醌（DDQ）进行化学选择性去保护的羟基保护基。 作为延伸单元，式（I）的二糖结构单元可与式（II）的起始单元反应以合成肝素寡糖。