公开(公告)号：US10238758B2

公开(公告)日：2019-03-26

申请号：US15261890

申请日：2016-09-10

Applicant: STC.UNM

Inventor： Yubin Miao

IPC: A61K51/00 ,  A61M36/14 ,  A61K51/08 ,  C07K7/56 ,  A61K38/17 ,  A61K38/00

Abstract: The present invention is directed to novel non-invasive diagnostic tools/compounds to image cancers, especially, melanoma, including metastatic melanoma in vivo. The present compounds exhibit enhanced uptake in cancerous cells and tissue, suggesting favorable selective activity of compounds according to the present invention, which can be used as effective therapeutic agents against melanoma, including metastatic melanoma. The compounds according to the present invention represent an advance in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention are useful to initiate therapy for melanoma as well as monitor patients' response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma. Compounds according to the present invention may be used as diagnostic and therapeutic tools for a number of conditions and diseases states, especially melanoma.

公开(公告)号：US10216965B2

公开(公告)日：2019-02-26

申请号：US15109747

申请日：2014-12-23

Applicant: STC.UNM ,  Case Western Reserve University

Inventor： James Plusquellic ,  Swarup Bhunia

IPC: G06F21/75 ,  G11C23/00 ,  G06F7/58 ,  H04L9/08 ,  G09C1/00 ,  G06F21/60 ,  G11C13/00 ,  G11C16/10 ,  G11C16/26

Abstract: This disclosure describes techniques for generating physically unclonable functions (PUF) from non-volatile memory cells. The PUFs leverage resistance variations in non-volatile memory cells. Resistance variations in array of non-volatile memory cells may be produce a bitstring during an enrollment process. The bitstring may be stored in the non-volatile memory array. Regeneration may include retrieving the bitstring from the non-volatile memory array.

公开(公告)号：US20190056184A1

公开(公告)日：2019-02-21

申请号：US15768829

申请日：2016-10-17

Applicant: STC.UNM

Inventor： Sang Eon Han ,  Sang M. Han

IPC: F28F13/18 ,  F24S70/20 ,  F25B23/00

CPC classification number: F28F13/185 ,  F24S70/20 ,  F25B23/003 ,  F28F2245/06 ,  F28F2270/00 ,  Y02E10/40 ,  Y10T428/24802 ,  Y10T428/24893 ,  Y10T428/24942

Abstract: The present prevention provides a surface coating for cooling a surface by light scattering comprising a plurality of successive layers, each of the layers may be comprised of a plurality of spheres arranged to form a structure comprised of packed spheres. Each layer may have a different arrangement of packed spheres to create to a different light scattering property in each of the layers. The coating of the structures may also be formed by randomly packed spheres and the spheres may have a uniform diameter.

公开(公告)号：US10184930B2

公开(公告)日：2019-01-22

申请号：US15039825

申请日：2014-11-26

Applicant: STC.UNM

Inventor： Steven R. J. Brueck ,  Jeremy Scott Edwards ,  Alexander Neumann ,  Yuliya Kuznetsova ,  Edgar A. Mendoza

IPC: G01N21/00 ,  G01N33/487 ,  C12Q1/6869 ,  B01L3/00 ,  C23C16/34 ,  C23C16/455 ,  C23C16/50 ,  G01N21/65

Abstract: Methods and apparatus for long read, label-free, optical nanopore long chain molecule sequencing. In general, the present disclosure describes a novel sequencing technology based on the integration of nanochannels to deliver single long-chain molecules with widely spaced (>wavelength), ˜1-nm aperture “tortuous” nanopores that slow translocation sufficiently to provide massively parallel, single base resolution using optical techniques. A novel, directed self-assembly nanofabrication scheme using simple colloidal nanoparticles is used to form the nanopore arrays atop nanochannels that unfold the long chain molecules. At the surface of the nanoparticle array, strongly localized electromagnetic fields in engineered plasmonic/polaritonic structures allow for single base resolution using optical techniques.

公开(公告)号：US10109480B2

公开(公告)日：2018-10-23

申请号：US15599376

申请日：2017-05-18

Applicant: STC.UNM

Inventor： Seung-Chang Lee ,  Steven R. J. Brueck

IPC: H01L21/02 ,  C30B25/04 ,  C30B25/18 ,  C30B29/40 ,  C30B23/02 ,  C30B29/42 ,  H01L29/06 ,  H01L29/267 ,  C30B7/00

Abstract: Exemplary embodiments provide materials and methods of forming high-quality semiconductor devices using lattice-mismatched materials. In one embodiment, a composite film including one or more substantially-single-particle-thick nanoparticle layers can be deposited over a substrate as a nanoscale selective growth mask for epitaxially growing lattice-mismatched materials over the substrate.

公开(公告)号：US10092660B2

公开(公告)日：2018-10-09

申请号：US14113653

申请日：2012-04-25

Applicant: Hugh Smyth ,  Ibrahim M. El-Sherbiny

Inventor： Hugh Smyth ,  Ibrahim M. El-Sherbiny

IPC: A61K9/51 ,  A61K47/48 ,  A61K9/00 ,  A61K31/496

Abstract: The invention relates to solid compositions that may be suitable for administering a therapeutic agent to a subject. The invention also relates to methods of making such solid compositions. The invention further relates to methods of treating a disease, condition, or disorder by administering to a subject such solid compositions.

公开(公告)号：US10092000B2

公开(公告)日：2018-10-09

申请号：US13809573

申请日：2011-07-13

Applicant: David G. Whitten ,  Kirk S. Schanze ,  Eunkyung Ji ,  Thomas S. Corbitt ,  Zhijun Zhou ,  Dimitri Dascier ,  Ying Wang ,  Linnea K. Ista ,  Anand Parthasarathy ,  Eric H. Hill ,  Yanli Tang

Inventor： David G. Whitten ,  Kirk S. Schanze ,  Eunkyung Ji ,  Thomas S. Corbitt ,  Zhijun Zhou ,  Dimitri Dascier ,  Ying Wang ,  Linnea K. Ista ,  Anand Parthasarathy ,  Eric H. Hill ,  Yanli Tang

IPC: A01N43/90 ,  A01N25/08 ,  A01N43/10 ,  A01N33/12 ,  A01N33/10 ,  A01N41/04 ,  A01N25/10 ,  C07D487/08 ,  C07C309/11 ,  C07C217/20 ,  C07D333/16 ,  C07D409/14

Abstract: The present disclosure provides novel oligo phenylene ethynylene (OPE) compounds, methods for synthesizing these compounds, and materials and substances incorporating these compounds. The various OPEs show antibacterial, antiviral and antifungal activity.

公开(公告)号：US10060904B1

公开(公告)日：2018-08-28

申请号：US14868128

申请日：2015-09-28

Applicant: Steven R. J. Brueck ,  Yuliya Kuznetsova ,  Alexander Neumann

Inventor： Steven R. J. Brueck ,  Yuliya Kuznetsova ,  Alexander Neumann

IPC: G01N33/48 ,  G01N33/487 ,  B81C1/00 ,  G01N27/447 ,  C12Q1/68 ,  G03F7/20

CPC classification number: G01N33/48721 ,  B81C1/00071 ,  C12Q1/6869 ,  C12Q2565/631

Abstract: In accordance with the disclosure, a method of forming a nanochannel is provided. The method includes depositing a photosensitive film stack over a substrate; forming a pattern on the film stack using interferometric lithography; depositing a plurality of silica nanoparticles to form a structure over the pattern; removing the pattern while retaining the structure formed by the plurality of silica nanoparticles, wherein the structure comprises one or more enclosed nanochannels, wherein each of the one or more nanochannels comprise one or more sidewalls and a roof; and partially sealing the roof of one or more nanochannels, wherein the roof comprises no more than one unsealed nanochannel per squared micron.

公开(公告)号：US10058099B2

公开(公告)日：2018-08-28

申请号：US15368148

申请日：2016-12-02

Applicant: University of Florida Research Foundation, Inc. ,  STC.UNM

Inventor： David G. Whitten ,  Kirk S. Schanze ,  Eunkyung Ji ,  Dimitri Dascier ,  Anand Parthasarathy ,  Thomas S. Corbitt ,  Kirsten Cicotte ,  Elizabeth LeBleu Dirk ,  Xuzhi Zhu

IPC: A01N43/90 ,  A61L15/46 ,  A01N33/12 ,  A01N43/10 ,  A01N25/34 ,  A01N37/10 ,  A61L15/20 ,  D01H7/00

CPC classification number: A01N43/90 ,  A01N25/34 ,  A01N33/12 ,  A01N37/10 ,  A01N43/10 ,  A61L15/20 ,  A61L15/46 ,  A61L2300/208 ,  A61L2300/404 ,  D01H7/00 ,  A01N59/00 ,  A01N2300/00

Abstract: The invention provides methods and materials for decontamination of surfaces and fabrics, such as non-woven fabrics, that are contaminated with infestations of microorganisms such as bacteria. Biocidal oligomers having conjugated oligo-(aryl/heteroaryl ethynyl) structures and comprising at least one cationic group can be used to decontaminate infested surfaces in the presence of oxygen and, optionally, illumination. Fibers incorporating biocidal oligomers having conjugated oligo-(aryl/heteroaryl ethynyl) structures and comprising at least one cationic group, wherein the oligomer is physically associated with or covalently bonded to, or both, the fiber-forming polymer can be used to form non-woven mats. Biocidal non-woven mats prepared by methods of the invention, incorporating the biocidal oligomers, can be used to suppress bacterial growth in wound and surgical dressings and personal hygiene products.

公开(公告)号：US10048272B2

公开(公告)日：2018-08-14

申请号：US15013102

申请日：2016-02-02

Applicant: STC.UNM ,  TORREY PINES INSTITUTE FOR MOLECULAR STUDIES

Inventor： Bruce S. Edwards ,  Larry A. Sklar ,  Clemencia Pinilla ,  Richard A. Houghten ,  Jon R. Appel ,  Marc A. Giulianotti ,  Jose Medina-Franco

IPC: A61K31/497 ,  A61K31/517 ,  A61K31/17 ,  G01N33/68 ,  C07D403/14 ,  A61K31/496 ,  A61K45/06 ,  C07C275/28 ,  C40B30/02 ,  G01N33/74 ,  A61K38/00 ,  C07D241/08 ,  C07K1/04

Abstract: The present invention provides novel methods and assays for high-throughput screening of combinatorial libraries to identify FPR1 and/or FPR2 ligands (e.g., agonists and/or antagonists), preferably FPR1 agonists and/or FPR2 antagonists, by positional scanning deconvolution.The invention also provides novel FPR1 and FPR2 ligands (e.g, agonists and antagonists), related pharmaceutical compositions and methods of treating FPR1 and FPR2-related disorders.