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41.发明申请Compositions for the prevention and treatment of neuroinjury and methods of use thereof 审中-公开用于预防和治疗神经损伤的组合物及其使用方法公开(公告)号：US20090291893A1
公开(公告)日：2009-11-26
申请号：US12453778
申请日：2009-05-21
申请人： Byron D. Ford
发明人： Byron D. Ford
IPC分类号： A61K38/16 , A61K31/7052 , A61P25/00
CPC分类号： A61K38/1883 , A61K9/0019 , A61K31/7052 , A61K31/713 , A61K38/185
摘要： A method for preventing or ameliorating secondary neuronal injury and inflammation following traumatic brain injury (TBI) is disclosed. The method comprises the step of administering into a subject in need of such treatment an effective amount of a pharmaceutical composition containing a neuregulin (NRG), a variant of NRG, or an expression vector encoding a NRG or a variant of NRG.
摘要翻译： 公开了一种在创伤性脑损伤（TBI）后预防或改善继发性神经元损伤和炎症的方法。 该方法包括向需要这种治疗的受试者施用有效量的含有神经调节蛋白（NRG），NRG变体或编码NRG或NRG变体的表达载体的药物组合物的步骤。
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公开(公告)号：US20240325481A1
公开(公告)日：2024-10-03
申请号：US18432324
申请日：2024-02-05
IPC分类号： A61K36/42 , A01N63/50 , A01P1/00 , A61K31/352 , A61K33/30 , A61K38/47 , A61P31/18 , C12N15/10 , C12N15/82 , C12P19/34
CPC分类号： A61K36/42 , A01N63/50 , A01P1/00 , A61K31/352 , A61K33/30 , A61K38/47 , A61P31/18 , C12N15/1096 , C12N15/8283 , C12P19/34 , C07K2319/01
摘要： In one aspect, nutraceutical compositions, methods of preparation and methods of use comprise a nutraceutical composition comprising an antimicrobial hevamine A-related protein from Momordica balsamina alone or in combination with one or more nutraceutical ingredients. In another aspect, a method of preventing or treating a microbial infection in a plant comprises applying an effective amount of a composition containing the hevamine A-related protein to a whole plant, plant part, or media in which the plant is growing. In a further aspect, the present application provides a transgenic plant stably transformed with a polynucleotide encoding the hevamine A-related protein.
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公开(公告)号：US12083159B2
公开(公告)日：2024-09-10
申请号：US16811754
申请日：2020-03-06
IPC分类号： A61K38/16 , A61K38/08 , A61K45/06 , A61K47/60 , A61K47/64 , C07K7/06 , C07K14/005 , C12N7/00
CPC分类号： A61K38/162 , A61K38/08 , A61K45/06 , A61K47/60 , A61K47/6455 , C07K7/06 , C07K14/005 , C12N7/00 , C07K2319/10 , C12N2740/16032 , C12N2740/16322 , Y02A50/30
摘要： Compositions and methods for reducing the growth of and/or preventing the formation of a microbial biofilm are disclosed. The composition comprises an antimicrobial SMR peptide comprising an HIV-1 SMRwt peptide and a cell penetrating peptide (CPP) domain. In some embodiments, the composition further comprises one or more other antimicrobial peptides (AMPs), antibiotics, matrix-inhibiting compounds, matrix-disaggregating compounds, quorum sensing inhibitors, or a combination thereof. In other embodiments, the compositions are used for impregnating or coating an article and/or material surface with the composition to render it less prone to microbial infections.
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公开(公告)号：US12077564B2
公开(公告)日：2024-09-03
申请号：US17305749
申请日：2021-07-14
发明人： Vincent C. Bond , Michael Powell , Ming Bo Huang , Syed Ali
IPC分类号： C07K14/16 , A61K9/127 , A61K38/16 , C07K14/005 , A61K38/00 , A61K39/00 , A61K39/39 , A61K45/06 , C12N15/00 , C12P21/02 , G01N33/543 , G01N33/566
CPC分类号： C07K14/163 , A61K9/127 , A61K38/162 , C07K14/005 , A61K38/00 , A61K39/39 , A61K2039/55555 , A61K45/06 , C07K2319/00 , C07K2319/055 , C07K2319/50 , C07K2319/60 , C12N15/00 , C12N2740/16311 , C12N2740/16322 , C12P21/02 , G01N33/543 , G01N33/566
摘要： The present application relates to methods of producing exosomes. The application also provides a method for preparing a protein composition comprising culturing an exosome-producing cell expressing a Nef-fusion protein comprising a Nef-derived peptide fused to a protein of interest; isolating exosomes from the exosome-producing cell culture; and purifying the protein of interest from the isolated exosomes. The application further discloses compositions that comprise exosomes containing the Nef-fusion protein, as well as methods of using the Nef-fusion protein and exosomes containing the Nef-fusion protein.
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45.发明授权公开(公告)号：US11826366B2
公开(公告)日：2023-11-28
申请号：US17452995
申请日：2021-10-31
发明人： Zhigang Xiong , Roger P. Simon
IPC分类号： A61K31/4965 , A61K31/55 , C07K14/435 , A61K9/00 , A61K31/155 , A61K31/40
CPC分类号： A61K31/4965 , A61K9/0019 , A61K9/0085 , A61K31/155 , A61K31/40 , A61K31/55 , C07K14/43518 , A61K9/00
摘要： A composition and method for preventing or reducing the incidence of a transient ischemic attack in a subject at risk for developing a stroke comprises orally administering to the subject a prophylactically effective amount of a pharmaceutical composition comprising an ASIC1a inhibitor capable of penetrating the blood-brain barrier. Preferred ASIC1a inhibitors for use in the disclosed methods include amiloride and amiloride analogs.
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公开(公告)号：US11802140B2
公开(公告)日：2023-10-31
申请号：US17669844
申请日：2022-02-11
发明人： Roger P. Simon , Zhigang Xiong
IPC分类号： C07K14/435 , A61K38/17 , A61K31/439 , A61K31/4418 , A61K31/4965 , A61K31/498 , A61K38/16 , A61K45/06
CPC分类号： C07K14/43518 , A61K31/439 , A61K31/4418 , A61K31/498 , A61K31/4965 , A61K38/16 , A61K38/17 , A61K38/1767 , A61K45/06 , A61K38/17 , A61K2300/00
摘要： A system, including methods and compositions, for treatment of ischemia.
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公开(公告)号：US11801285B2
公开(公告)日：2023-10-31
申请号：US17585022
申请日：2022-01-26
IPC分类号： A61K35/76 , A61K38/47 , A61K39/00 , A61K39/15 , A61P31/14 , A61K9/00 , A61K45/06 , A61K36/42 , A61K48/00
CPC分类号： A61K38/47 , A61K9/0053 , A61K35/76 , A61K36/42 , A61K45/06 , A61P31/14 , C12Y302/01014 , A61K48/00 , C12N2750/14143
摘要： The present application relates to a compositions and methods comprising or expressing a HEVAR or MOMO30 protein derived from Momordica balsamina. The HEVAR or MOMO30 protein and/or a nucleic acid encoding the same may be used in methods for treating or preventing viral infections, particularly those caused by coronaviruses, such as SARS-CoV-2.
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公开(公告)号：US11414462B1
公开(公告)日：2022-08-16
申请号：US17380786
申请日：2021-07-20
摘要： The present application relates to methods and compositions and methods for treating viral infections, especially those caused by SARS-CoV-2. In one aspect, a method of treatment comprises administering to a subject in need of such treatment an effective amount of a pharmaceutical composition comprising a multipartite SARS-CoV-2-inhibiting peptide comprising a secretion modulating region (VI-SMR) peptide from HIV-1 Nef in combination with a cell-penetrating peptide (CPP) domain, a Clusterin (Clu)-binding peptide (Clu-BP) domain, a mitochondrial targeting (Mito-T) peptide domain, an anti-fusogenic (AF) peptide domain, a viral attachment inhibitor (VAI) domain or combination thereof, optionally where the SARS-CoV-2-inhibiting peptide is pegylated and/or modified with one or more hydrophobic domains.
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公开(公告)号：US11266723B1
公开(公告)日：2022-03-08
申请号：US17342897
申请日：2021-06-09
IPC分类号： C07K16/10 , A61P31/14 , A61K39/00 , A61K45/06 , A61K39/15 , A61K38/47 , A61K9/00 , A61K35/76 , A61K36/42 , A61K48/00
摘要： The present application relates to a compositions and methods comprising or expressing a HEVAR or MOMO30 protein derived from Momordica balsamina. The HEVAR or MOMO30 protein and/or a nucleic acid encoding the same may be used in methods for treating or preventing viral infections, particularly those caused by coronaviruses, such as SARS-CoV-2.
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公开(公告)号：US20210220354A1
公开(公告)日：2021-07-22
申请号：US17248952
申请日：2021-02-15
发明人： Zhigang XIONG , Roger P. SIMON
IPC分类号： A61K31/4965 , A61K9/00 , A61K31/155 , A61K31/40 , A61K31/55 , C07K14/435
摘要： This application discloses a composition comprising an amiloride and/or an amiloride analog which can be used for reducing nerve injury or nervous system injury in a subject. The formulation of such composition is also disclosed. The application further directs to methods for treating nerve injury or nervous system injury by administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising amiloride, an amiloride analog or a pharmaceutically acceptable salt thereof.
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