AMYLASES AND GLUCOAMYLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM
    42.
    发明申请
    AMYLASES AND GLUCOAMYLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 审中-公开
    琥珀酸和谷氨酰胺,编码它们的核酸及其制备和使用它们的方法

    公开(公告)号:US20130143295A1

    公开(公告)日:2013-06-06

    申请号:US13674199

    申请日:2012-11-12

    IPC分类号: C12N9/26 C12N9/96

    摘要: In one aspect, the invention is directed to polypeptides having an amylase and/or glucoamylase activity, polynucleotides encoding the polypeptides, and methods for making and using these polynucleotides and polypeptides. In one aspect, the polypeptides of the invention can be used as amylases, for example, alpha amylases, to catalyze the hydrolysis of polysaccharide, oligosaccharide or starch into sugars. In one aspect, the invention provides delayed release compositions comprising an desired ingredient coated by a latex polymer coating. In alternative embodiments, enzymes are used to make biofuels, e.g., ethanol, butanol, propanol, or a gasoline-ethanol mix, including a bioethanol, biopropanol, biobutanol, or a biodiesel, or for any form of fuel or biomass processing.

    摘要翻译: 一方面,本发明涉及具有淀粉酶和/或葡糖淀粉酶活性的多肽,编码多肽的多核苷酸,以及制备和使用这些多核苷酸和多肽的方法。 一方面,本发明的多肽可用作淀粉酶,例如α-淀粉酶,以催化多糖,寡糖或淀粉水解成糖。 一方面,本发明提供包含通过胶乳聚合物涂层涂覆的所需成分的延迟释放组合物。 在替代实施方案中,酶用于制备生物燃料,例如乙醇,丁醇,丙醇或汽油 - 乙醇混合物,包括生物乙醇,生物丙醇,生物丁醇或生物柴油,或用于任何形式的燃料或生物质处理。

    Cellulases, nucleic acids encoding them and methods for making and using them
    45.
    发明授权
    Cellulases, nucleic acids encoding them and methods for making and using them 有权
    纤维素酶,编码它们的核酸和制备和使用它们的方法

    公开(公告)号:US08426184B2

    公开(公告)日:2013-04-23

    申请号:US11908672

    申请日:2006-01-13

    摘要: This invention relates to molecular and cellular biology and biochemistry. In one aspect, the invention provides polypeptides having cellulase activity, e.g., endoglucanase, cellobiohydrolase, mannanase and/or β-glucosidase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides cellulase activity, e.g., endoglucanase, cellobiohydrolase, mannanase and/or β-glucosidase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural, food and feed processing and industrial contexts.

    摘要翻译: 本发明涉及分子和细胞生物学和生物化学。 一方面,本发明提供了具有纤维素酶活性的多肽,例如内切葡聚糖酶,纤维二糖水解酶,甘露聚糖酶和/或β-葡糖苷酶活性,编码这些多肽的多核苷酸,以及制备和使用这些多核苷酸和多肽的方法。 一方面,本发明涉及多肽纤维素酶活性,例如内切葡聚糖酶,纤维二糖水解酶,甘露聚糖酶和/或β-葡糖苷酶活性,包括耐热和耐热活性,以及​​编码这些酶的多核苷酸,以及制备和使用这些多核苷酸和多肽。 本发明的多肽可用于各种药物,农业,食品和饲料加工以及工业环境中。

    Chemoenzymatic methods for the synthesis of statins and statin intermediates
    48.
    发明授权
    Chemoenzymatic methods for the synthesis of statins and statin intermediates 有权
    用于合成他汀类药物和他汀类药物中间体的化疗酶法

    公开(公告)号:US08148324B2

    公开(公告)日:2012-04-03

    申请号:US12032337

    申请日:2008-02-15

    IPC分类号: C07K14/00 C12P21/00

    摘要: The invention provides aldolases, nucleic acids encoding them and methods for making and using them, including chemoenzymatic processes for making β,δ-dihydroxyheptanoic acid side chains and compositions comprising these side chains, e.g., [R—(R*,R*)]-2-(4-fluorophenyl)-b,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-(phenylamino)-carbonyl]-1H-pyrrole-1-heptanoic acid (atorvastatin, LIPITOR™), rosuvastatin (CRESTOR™), fluvastatin (LESCOL™), related compounds and their intermediates.

    摘要翻译: 本发明提供醛缩酶,编码它们的核酸和制备和使用它们的方法,包括制备和/或制备δ-二羟基庚酸侧链的化学方法和包含这些侧链的组合物,例如[R-(R *,R *) ] -2-(4-氟苯基)-b,d-二羟基-5-(1-甲基乙基)-3-苯基-4-(苯基氨基) - 羰基] -1H-吡咯-1-庚酸(阿托伐他汀,LIPITOR TM ),瑞舒伐他汀(CRESTOR TM),氟伐他汀(LESCOL TM),相关化合物及其中间体。