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公开(公告)号：US09861764B2
公开(公告)日：2018-01-09
申请号：US14539538
申请日：2014-11-12
Applicant: Wake Forest University Health Sciences
Inventor： Ryan P. Terlecki
CPC classification number: A61M5/427 , A61M5/28 , A61M5/3287 , A61M2210/167
Abstract: Embodiments of the invention provide needle guides that facilitate direct penile injection of drug therapies.
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公开(公告)号：US09726683B2
公开(公告)日：2017-08-08
申请号：US14948938
申请日：2015-11-23
Applicant: Wake Forest University Health Sciences
Inventor： Lawrence L. Rudel , Chadwick D. Miller , Michael J. Thomas
CPC classification number: G01N33/92 , G01N2405/00 , G01N2560/00 , G01N2800/323 , G01N2800/50 , G01N2800/56 , G06F19/00 , G16H50/30
Abstract: A computer-based method for determining a prediction of risk and/or an indication of extent of coronary stenosis in a human subject, comprises the steps of: (a) inputting the level of at least one cholesteryl ester measured in a blood sample collected from said subject; and then (b) inputting the age and gender of said subject; and then (c) generating in said computer from said cholesteryl ester level input, said age input and said gender input a prediction of risk and/or an indication of extent of coronary stenosis in said subject. Systems and methods are also described.
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公开(公告)号：US09675646B2
公开(公告)日：2017-06-13
申请号：US14375818
申请日：2013-01-31
Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES
Inventor： Khalil Bitar
IPC: A61K35/34 , A61L27/20 , C12N5/00 , C12N5/077 , A61L27/38 , A61L27/50 , C12N5/0797 , A61F2/04 , A61F2/08
CPC classification number: A61K35/34 , A61F2/04 , A61F2/08 , A61F2002/045 , A61L27/20 , A61L27/3826 , A61L27/3873 , A61L27/50 , A61L2430/30 , C12N5/0068 , C12N5/0623 , C12N5/0661 , C12N2501/999 , C12N2533/54 , C12N2533/72 , C08L5/08
Abstract: Methods of generating tubular, bioengineered, smooth muscle structures are disclosed as well as bioengineered tissue for tubular organ repair or replacement. The methods can include the steps of obtaining smooth muscle cells; culturing the muscle cells to form a smooth muscle cell construct of directionally oriented smooth muscle cells; disposing the smooth muscle cell construct around a tubular scaffold; and culturing construct and scaffold in a growth media until a smooth muscle cell structure is achieved. The step of obtain smooth muscle cells can further include obtaining autologous smooth muscle cells from a subject. In one preferred embodiment, the muscle cells can first be on a fibrin substrate to form a muscle construct, which is then disposed around a tubular scaffold, for example, a chitosan scaffold. The methods of the present invention can further include connecting two or more tubular structures together to form an elongate composite structure.
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公开(公告)号：US09671301B2
公开(公告)日：2017-06-06
申请号：US12443249
申请日：2007-09-28
Applicant: David L. Carroll , Faith M. Coldren , Nicole H. Levi , Lawrence X. Webb , William D. Wagner , Thomas L. Smith , Brian Werner , J. Baxter Mcguirt , Manoj Namboothiry
Inventor： David L. Carroll , Faith M. Coldren , Nicole H. Levi , Lawrence X. Webb , William D. Wagner , Thomas L. Smith , Brian Werner , J. Baxter Mcguirt , Manoj Namboothiry
CPC classification number: G01L11/02 , A61B5/03 , A61B5/445 , A61B2562/0247
Abstract: The present invention provides a method of sensing pressure in a region of interest by providing a plurality of metallic particles operatively associated with one another in the region of interest (for example, wherein the metallic particles sustain a plasmon upon excitation), and with the metallic particles configured or positioned in relationship to one another so that a physical property of the particles (for example, the energy of the plasmon) varies in response to pressure; measuring the physical property of the metallic particles that varies in response to pressure; and then determining the pressure in the region of interest from the detected physical property (e.g., resistance, energy of the plasmon). Compositions, articles and formulations for carrying out the method in industrial and biomedical applications are also described.
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公开(公告)号：US09598704B2
公开(公告)日：2017-03-21
申请号：US14697704
申请日：2015-04-28
Applicant: Wake Forest University Health Sciences
Inventor： Tao Xu , James J. Yoo , Anthony Atala
IPC: C12N15/87 , C12N5/00 , C12N15/63 , C12N15/89 , A61K31/713
CPC classification number: C12N15/895 , A61K31/713 , C12N15/63 , C12N15/87 , C12N15/89
Abstract: Provided herein are methods and apparatuses for transfecting a cell with a compound of interest by stressing the cell, e.g. with shear stress. The compound of interest may be nucleic acids, proteins, molecules, nanoparticles, drugs, etc., or any combination thereof. Methods of printing cells with an inkjet printing device are also provided, wherein at least a portion of viable cells (preferably at least 1%) are transfected with a compound of interest. Preferably, at least 25% of the cells are viable after printing. In addition, methods of forming an array of viable cells are provided wherein at least a portion of the viable printed cells (preferably at least 1%) are transfected with at least one compound of interest.
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Patent Agency Ranking
公开(公告)号：US09585688B2
公开(公告)日：2017-03-07
申请号：US12986771
申请日：2011-01-07
Applicant: James J. Yoo , Anthony Atala , Paul Scarpinato , Sang Jin Lee , Mitchell Ladd
Inventor： James J. Yoo , Anthony Atala , Paul Scarpinato , Sang Jin Lee , Mitchell Ladd
IPC: A61B17/322 , A61B17/00
CPC classification number: A61B17/322 , A61B90/02 , A61B2017/00969 , A61B2017/3225
Abstract: Provided herein is a tissue stretching device including a tissue clamping member defining an area in a Z plane, wherein the tissue clamping member is configured to hold tissue parallel to the Z plane. Methods of use of the tissue stretching device to stretch a tissue as well as for culturing organized tissues are also provided. Stretched and/or cultured tissues produced by these processes are also provided, as well as methods of treatment making use of the same.
Abstract translation: 本文提供了一种组织拉伸装置，其包括限定Z平面中的区域的组织夹持构件，其中组织夹持构件被构造成保持平行于Z平面的组织。 还提供了使用组织拉伸装置拉伸组织以及培养有组织的组织的方法。 还提供了通过这些方法生产的拉伸和/或培养的组织，以及使用它们的治疗方法。
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公开(公告)号：US09580688B2
公开(公告)日：2017-02-28
申请号：US12618338
申请日：2009-11-13
Applicant: Anthony Atala , James J. Yoo
Inventor： Anthony Atala , James J. Yoo
CPC classification number: C12N5/0686 , A61K35/12 , A61K35/22 , C12N2500/02
Abstract: Provided herein are isolated populations of kidney cells harvested from differentiated cells of the kidney, wherein cells have been expanded in vitro, and methods of use thereof. The cells may be provided in a three dimensional matrix for culturing in vitro and/or implanting in vivo. Methods of seeding cells onto the matrix are also provided.
Abstract translation: 本文提供了从分化的肾细胞收获的分离的肾细胞群，其中细胞已经在体外扩增，以及其使用方法。 细胞可以提供在三维基质中，用于体内和/或体内植入。 还提供了将细胞接种到基质上的方法。
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公开(公告)号：US09562265B2
公开(公告)日：2017-02-07
申请号：US14463723
申请日：2014-08-20
Applicant: Wake Forest University Health Sciences
Inventor： Jan Rohozinski
CPC classification number: C12Q1/686 , C12Q1/6881 , C12Q2600/156
Abstract: Provided herein are primers comprising a nucleotide sequence complementary to a portion of a RhD gene. Also provided herein are methods of determining a RhD zygosity in a subject. Also provided are methods of detecting a weak D allele in a subject. Further provided are kits for determining an RhD zygosity.
Abstract translation: 本文提供的引物包含与RhD基因的一部分互补的核苷酸序列。 本文还提供了确定受试者的RhD接合性的方法。 还提供了检测受试者中弱D等位基因的方法。 还提供了用于确定RhD接合性的试剂盒。
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49.发明申请ENCAPSULATED CELLS FOR TREATING LOW TESTOSTERONE IN MALE SUBJECTS 审中-公开用于治疗男性受试者的低TESTOSTERONE的包封细胞公开(公告)号：US20160354413A1
公开(公告)日：2016-12-08
申请号：US15103962
申请日：2014-12-15
Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES
Inventor： Emmanuel C. Opara
CPC classification number: A61K35/54 , A61K9/5031 , A61K9/5036 , A61K9/5073 , A61K35/48 , A61K35/52 , A61K2300/00
Abstract: A pharmaceutical composition for treating low testosterone comprises microcapsules the microcapsules containing live mammalian ovary cells. The ovary cells comprise ovarian theca cells in a treatment-effective amount, but not granulosa cells or without granulosa cells in amounts detrimental to the administration of testosterone. Methods of treating male subjects afflicted with low testosterone by administration of such ovary cell-containing microcapsules are also described.
Abstract translation: 用于治疗低睾酮的药物组合物包括含有活哺乳动物卵巢细胞的微胶囊的微胶囊。 卵巢细胞以治疗有效量包含卵巢神经细胞，但不包括颗粒细胞或不含有睾丸激素给药量的颗粒细胞。 还描述了通过施用这种含有卵母细胞的微胶囊治疗患有低睾酮的男性受试者的方法。
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50.发明授权Bordetella outer-membrane protein antigens and methods of making and using the same 有权博德特氏菌外膜蛋白抗原及其制备和使用方法公开(公告)号：US09486514B2
公开(公告)日：2016-11-08
申请号：US15014665
申请日：2016-02-03
Applicant: Wake Forest University Health Sciences
Inventor： Rajendar K. Deora , Meenu Mishra , Neelima Sukumar
IPC: C07K14/235 , A61K39/02 , C07K16/12 , G01N33/569 , A61K39/00
CPC classification number: A61K39/099 , A61K2039/505 , A61K2039/55505 , A61K2039/575 , C07K14/235 , C07K16/1225 , G01N33/56911 , G01N2333/235
Abstract: An isolated protein or peptide selected from the group consisting of Bordetella colonization factor A (BcfA) protein and antigenic fragments thereof is described, along with an isolated nucleic acid encoding the same, antibodies that bind to the same, methods of producing an immune response in a mammalian subject in need thereof by administering the proteins, peptides or antibodies, and pharmaceutical compositions comprising the same.
Abstract translation: 描述了选自博德特氏杆菌定植因子A（BcfA）蛋白及其抗原性片段的分离的蛋白质或肽，以及与其编码的分离的核酸，与其结合的抗体，产生免疫应答的方法 通过施用蛋白质，肽或抗体以及包含其的药物组合物，需要其的哺乳动物受试者。
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