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公开(公告)号：US20140127308A1
公开(公告)日：2014-05-08
申请号：US14002504
申请日：2012-02-21
Applicant: Emmanuel Opara , James J. Yoo , Justin M. Saul , Sittadjody Sivanandane , Anthony Atala
Inventor： Emmanuel Opara , James J. Yoo , Justin M. Saul , Sittadjody Sivanandane , Anthony Atala
CPC classification number: A61K35/54 , A61K9/167 , A61K9/5036 , A61K9/5073 , A61K31/565 , A61K31/57 , A61K2300/00
Abstract: A composition comprising microcapsules, the microcapsules containing both live mammalian ovarian granulosa cells and live mammalian ovarian theca cells, is described. In some embodiments, the granulosa cells and the theca cells are contained in separate microcapsules in the composition; in some embodiments, the granulosa cells and the theca cells are contained together in the same microcapsules in the composition The composition is can be used for estrogen, and optionally also progesterone, delivery, and hence is preferably free or essentially free of oocytes. Methods of using the same and pharmaceutical formulations containing the same are also described.
Abstract translation: 描述了包含微胶囊的组合物，包含活哺乳动物卵巢颗粒细胞和活哺乳动物卵巢细胞的微胶囊。 在一些实施方案中，颗粒细胞和细胞被包含在组合物中的分离的微胶囊中; 在一些实施方案中，颗粒细胞和细胞在组合物中一起包含在相同的微胶囊中。组合物可用于雌激素，并且任选地也可用于孕酮，递送，因此优选是游离的或基本上不含卵母细胞。 还描述了使用它们的方法和含有它们的药物制剂。
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公开(公告)号：US20110172683A1
公开(公告)日：2011-07-14
申请号：US12986771
申请日：2011-01-07
Applicant: James J. Yoo , Anthony Atala , Paul Scarpinato , Sang Jin Lee , Mitchell Ladd
Inventor： James J. Yoo , Anthony Atala , Paul Scarpinato , Sang Jin Lee , Mitchell Ladd
IPC: A61B17/00
CPC classification number: A61B17/322 , A61B90/02 , A61B2017/00969 , A61B2017/3225
Abstract: Provided herein is a tissue stretching device including a tissue clamping member defining an area in a Z plane, wherein the tissue clamping member is configured to hold tissue parallel to the Z plane. Methods of use of the tissue stretching device to stretch a tissue as well as for culturing organized tissues are also provided. Stretched and/or cultured tissues produced by these processes are also provided, as well as methods of treatment making use of the same.
Abstract translation: 本文提供了一种组织拉伸装置，其包括限定Z平面中的区域的组织夹持构件，其中组织夹持构件被构造成保持平行于Z平面的组织。 还提供了使用组织拉伸装置拉伸组织以及培养有组织的组织的方法。 还提供了通过这些方法生产的拉伸和/或培养的组织，以及使用它们的治疗方法。
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公开(公告)号：US07806937B2
公开(公告)日：2010-10-05
申请号：US10298198
申请日：2002-11-15
Applicant: Anthony Atala , James J. Yoo
Inventor： Anthony Atala , James J. Yoo
IPC: C12N5/00
CPC classification number: A61L27/3604 , A61K35/12 , A61L27/18 , A61L27/3679 , A61L27/38 , A61L2430/22 , C12N5/0068 , C12N5/0697 , C12N2500/84 , C12N2501/11 , C12N2502/1347 , C12N2502/243 , C12N2533/40 , C08L67/04
Abstract: The invention is directed to compositions and methods for reconstructing artificial female reproductive organs. The constructs and methods of the invention can be used for ameliorating congenital malformations and disorders of female reproductive tract using tissue engineered female reproductive organs, such as the uterus, vagina, cervix, and fallopian tubes. These tissue engineered female reproductive organs can be generated by perfusing cultured cell populations derived from cells of the female reproductive tissues, such as uterine, vaginal, cervical, fallopian tube epithelial cells as well as smooth muscle cells.
Abstract translation: 本发明涉及用于重建人造女性生殖器官的组合物和方法。 本发明的构建和方法可用于使用组织工程化的女性生殖器官如子宫，阴道，子宫颈和输卵管改善先天性畸形和女性生殖道障碍。 这些组织工程化的雌性生殖器官可以通过灌注来自雌性生殖组织的细胞的培养细胞群，如子宫，阴道，子宫颈，输卵管上皮细胞以及平滑肌细胞产生。
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公开(公告)号：US20100160183A1
公开(公告)日：2010-06-24
申请号：US12663020
申请日：2008-06-06
Applicant: Tao Xu , James J. Yoo , Anthony Atala
Inventor： Tao Xu , James J. Yoo , Anthony Atala
CPC classification number: C12N15/895 , A61K31/713 , C12N15/63 , C12N15/87 , C12N15/89
Abstract: Provided herein are methods and apparatuses for transfecting a cell with a compound of interest by stressing the cell, e.g. with shear stress. The compound of interest may be nucleic acids, proteins, molecules, nanoparticles, drugs, etc., or any combination thereof. Methods of printing cells with an inkjet printing device are also provided, wherein at least a portion of viable cells (preferably at least 1%) are transfected with a compound of interest. Preferably, at least 25% of the cells are viable after printing. In addition, methods of forming an array of viable cells are provided wherein at least a portion of the viable printed cells (preferably at least 1%) are transfected with at least one compound of interest.
Abstract translation: 本文提供了用于通过施加细胞来转染具有感兴趣的化合物的细胞的方法和装置，例如， 具有剪切应力。 感兴趣的化合物可以是核酸，蛋白质，分子，纳米颗粒，药物等，或其任何组合。 还提供了用喷墨印刷装置印刷细胞的方法，其中至少一部分活细胞（优选至少1％）用感兴趣的化合物转染。 优选地，至少25％的细胞在印刷后是活的。 此外，提供形成活细胞阵列的方法，其中至少一部分活的印刷细胞（优选至少1％）用至少一种目标化合物转染。
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公开(公告)号：US20100104544A1
公开(公告)日：2010-04-29
申请号：US12618179
申请日：2009-11-13
Applicant: Anthony Atala , James J. Yoo
Inventor： Anthony Atala , James J. Yoo
CPC classification number: C12N5/0686 , A61K35/12 , A61K35/22 , C12N2500/02
Abstract: Provided herein are isolated populations of kidney cells harvested from differentiated cells of the kidney, wherein the cells have been expanded in vitro. The kidney cells preferably produce erythropoietin (EPO). The kidney cells may also be selected based upon EPO production. Methods of producing an isolated population of EPO producing cells are also provided, and methods of treating a kidney disease resulting in decreased EPO production in a patient in need thereof are provided, including administering the population to the patient, whereby the cells express EPO in vivo in an oxygen tension-dependent manner.
Abstract translation: 本文提供了从分化的肾细胞收获的分离的肾细胞群体，其中细胞已经在体外扩增。 肾细胞优选产生促红细胞生成素（EPO）。 也可以基于EPO生产来选择肾细胞。 还提供了产生分离的EPO产生细胞群体的方法，并且提供了治疗有需要的患者中导致EPO产生减少的肾脏疾病的方法，包括向患者施用群体，由此细胞体内表达EPO 以氧依赖于张力的方式。
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Patent Agency Ranking
公开(公告)号：US09283251B2
公开(公告)日：2016-03-15
申请号：US14002504
申请日：2012-02-21
Applicant: Emmanuel Opara , James J. Yoo , Justin M. Saul , Sittadjody Sivanandane , Anthony Atala
Inventor： Emmanuel Opara , James J. Yoo , Justin M. Saul , Sittadjody Sivanandane , Anthony Atala
CPC classification number: A61K35/54 , A61K9/167 , A61K9/5036 , A61K9/5073 , A61K31/565 , A61K31/57 , A61K2300/00
Abstract: A composition comprising microcapsules, the microcapsules containing both live mammalian ovarian granulosa cells and live mammalian ovarian theca cells, is described. In some embodiments, the granulosa cells and the theca cells are contained in separate microcapsules in the composition; in some embodiments, the granulosa cells and the theca cells are contained together in the same microcapsules in the composition The composition is can be used for estrogen, and optionally also progesterone, delivery, and hence is preferably free or essentially free of oocytes. Methods of using the same and pharmaceutical formulations containing the same are also described.
Abstract translation: 描述了包含微胶囊的组合物，包含活哺乳动物卵巢颗粒细胞和活哺乳动物卵巢细胞的微胶囊。 在一些实施方案中，颗粒细胞和细胞被包含在组合物中的分离的微胶囊中; 在一些实施方案中，颗粒细胞和细胞在组合物中一起包含在相同的微胶囊中。组合物可用于雌激素，并且任选地也可用于孕酮，递送，因此优选是游离的或基本上不含卵母细胞。 还描述了使用它们的方法和含有它们的药物制剂。
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公开(公告)号：US08691274B2
公开(公告)日：2014-04-08
申请号：US12370921
申请日：2009-02-13
Applicant: Tao Xu , James J. Yoo , Anthony Atala , Dennis Dice
Inventor： Tao Xu , James J. Yoo , Anthony Atala , Dennis Dice
CPC classification number: A61K9/5089 , A61F2/062 , A61K35/32 , A61K35/34 , A61K35/36 , A61L27/38 , A61L27/50 , A61L27/58 , B33Y80/00 , B41J3/407 , C12N5/0655 , C12N11/04 , C12N11/08 , C12N2533/54 , C12N2533/56 , D01D5/0007 , D01F6/625
Abstract: Provided herein is an apparatus for printing cells which includes an electrospinning device and an inkjet printing device operatively associated therewith. Methods of making a biodegradable scaffold having cells seeded therein are also provided. Methods of forming microparticles containing one or more cells encapsulated by a substrate are also provided, as are methods of forming an array of said microparticles.
Abstract translation: 本文提供了一种用于印刷电池的装置，其包括静电纺丝装置和与其可操作地相关联的喷墨打印装置。 还提供了制备具有种子细胞的可生物降解的支架的方法。 还提供了形成包含一个或多个由基底包封的细胞的微粒的方法，以及形成所述微粒阵列的方法。
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公开(公告)号：US20130281400A1
公开(公告)日：2013-10-24
申请号：US13882433
申请日：2011-11-10
Applicant: James J. Yoo , Sang Jin Lee , Jaehyun Kim , Anthony Atala
Inventor： James J. Yoo , Sang Jin Lee , Jaehyun Kim , Anthony Atala
IPC: C12N5/071
CPC classification number: C12N5/0658 , C12N2500/02
Abstract: The present provides a system and method of maintaining and/or increasing cell viability by downregulating cellular metabolic rate under hypoxic conditions. The present invention also relates to a system and method of prolonging the survival of implanted cells that are under hypoxic condition until host neovascularization is achieved.
Abstract translation: 本发明提供通过在低氧条件下下调细胞代谢速率来维持和/或增加细胞存活力的系统和方法。 本发明还涉及延长在缺氧条件下进行宿主新生血管形成的植入细胞的存活的系统和方法。
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9.发明申请OXYGEN-GENERATING COMPOSITIONS FOR ENHANCING CELL AND TISSUE SURVIVAL IN VIVO 审中-公开用于增强体内细胞和组织存活的氧气产生组合物公开(公告)号：US20100112087A1
公开(公告)日：2010-05-06
申请号：US12532520
申请日：2008-04-08
Applicant: Benjamin S. Harrison , James J. Yoo , Anthony Atala
Inventor： Benjamin S. Harrison , James J. Yoo , Anthony Atala
CPC classification number: A61K9/7007 , A61K31/77 , A61K38/00 , A61L15/18 , A61L15/26 , A61L15/64 , A61L26/0076 , A61L26/009 , A61L27/446 , A61L27/58 , C08L67/04
Abstract: A method of treating hypoxic tissue such as wound tissue comprises contacting a composition to the hypoxic tissue in a hypoxia-treatment effective amount, the composition comprising a biodegradable polymer and an inorganic peroxide incorporated into the polymer.
Abstract translation: 治疗缺氧组织如伤口组织的方法包括以低氧治疗有效量将组合物接触缺氧组织，所述组合物包含掺入聚合物中的生物可降解聚合物和无机过氧化物。
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公开(公告)号：US20080305146A1
公开(公告)日：2008-12-11
申请号：US12134813
申请日：2008-06-06
Applicant: Anthony Atala , James J. Yoo
Inventor： Anthony Atala , James J. Yoo
CPC classification number: C12N5/0686 , A61K9/0024 , A61K35/12 , A61K35/22 , C12N2500/02 , C12N2502/256 , G01N15/1031 , G01N33/56966 , G01N2015/0065 , G01N2015/1081
Abstract: Provided herein are isolated populations of kidney cells harvested from differentiated cells of the kidney, wherein cells have been expanded in vitro. The kidney cells may include peritubular interstitial cells of the kidney, and preferably produce erythropoietin (EPO). The kidney cells may also be selected based upon EPO production. Methods of producing an isolated population of EPO producing cells are also provided, and methods of treating a kidney disease resulting in decreased EPO production in a patient in need thereof are provided, including administering the population to the patient, whereby the cells produce EPO in vivo.
Abstract translation: 本文提供从肾分化细胞收获的分离的肾细胞群体，其中细胞已经在体外扩增。 肾细胞可以包括肾的肾周间质细胞，并且优选产生促红细胞生成素（EPO）。 也可以基于EPO生产来选择肾细胞。 还提供了产生分离的EPO产生细胞群体的方法，并且提供了在有需要的患者中治疗导致EPO产生减少的肾脏疾病的方法，包括向患者施用群体，由此细胞在体内产生EPO 。
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