公开(公告)号：US11193078B2

公开(公告)日：2021-12-07

申请号：US16389690

申请日：2019-04-19

Applicant: Amyris, Inc.

Inventor： Nicholas Ohler ,  Karl Fisher ,  Jin Ki Hong

IPC: C10L1/04 ,  C10M105/02 ,  C10M105/04 ,  C10M107/14 ,  C07C5/05 ,  C07C5/03

Abstract: Provided herein are olefinic feedstocks derived from conjugated hydrocarbon terpenes (e.g., C10-C30 terpenes), methods for making the same, and methods for their use.

公开(公告)号：US11103808B2

公开(公告)日：2021-08-31

申请号：US16637059

申请日：2018-08-01

Applicant: TOTAL RAFFINAGE CHIMIE ,  AMYRIS, INC.

Inventor： Maha Bahi ,  Anthony Hutin ,  Fernando Leal-Calderon

IPC: C12P1/02 ,  B01D17/04 ,  C12P5/00

Abstract: The present invention is a process for recovering an isoprenoid compound produced by fermentation from a fermentation medium comprising: (a) demulsifying the fermentation medium or a fraction thereof in presence of a salt and a surfactant, thereby generating a stream having an organic phase containing the isoprenoid compound and a phase heavier than the organic phase, and (b) separating the stream obtained in step (a) into the organic phase containing the isoprenoid compound, the phase heavier than the organic phase, and optionally a solid phase containing host cell debris and cells.

公开(公告)号：US11085046B2

公开(公告)日：2021-08-10

申请号：US15771888

申请日：2016-10-28

Applicant: AMYRIS, INC.

Inventor： Andrew Main ,  Grzegorz Wojciechowski ,  Yue Yang ,  Lishan Zhao

IPC: C12N1/14 ,  C12N1/16 ,  C12N1/20 ,  C12N15/52 ,  C12P5/00

Abstract: Provided herein are compositions and methods for producing myrcene by culturing genetically modified microbial host cells that express a myrcene synthase and optionally a geranyl pyrophosphate synthase. Also provided herein are isolated nucleic acid molecules that encode myrcene synthase variants derived from the Ocimum species myrcene synthase, which comprise one or more amino acid substitutions that improve in vivo performance of myrcene synthase in genetically modified microbial host cells. Also provided herein are isolated myrcene synthase variants that exhibit an improved activity for converting geranyl diphosphate into myrcene.

公开(公告)号：US20210017378A1

公开(公告)日：2021-01-21

申请号：US17040829

申请日：2019-03-28

Applicant: KURARAY CO., LTD. ,  AMYRIS, INC.

Inventor： Daisuke KODA

IPC: C08L53/02 ,  C08F212/08 ,  C08F236/06 ,  C08F236/22 ,  C08K3/04 ,  C08K3/36 ,  C08K5/5419 ,  B60C1/00

Abstract: The present invention relates to a block copolymer that contains a polymer block A containing a farnesene-derived monomer unit (a1) and a random copolymer block B containing a C12 or lower conjugated diene-derived monomer unit (b1) and an aromatic vinyl compound-derived monomer unit (b2), the block copolymer having a ratio by mass of the polymer block A to the random copolymer block B (A/B) of 30/70 to 0.5/99.5, a content of the aromatic vinyl compound-derived monomer unit (b2) in the random copolymer block B of 1 to 50% by mass, and a weight average molecular weight (Mw) of 100,000 to 5,000,000.

公开(公告)号：US10894754B2

公开(公告)日：2021-01-19

申请号：US16228567

申请日：2018-12-20

Applicant: AMYRIS, INC.

Inventor： Nicholas L. Ohler ,  Roberto Vazquez

IPC: C07C5/03 ,  C07C7/20 ,  C07C11/21 ,  C10G45/00 ,  C10G53/04 ,  C10G53/08 ,  C10G67/04 ,  C10G67/06 ,  C10L1/04 ,  C10L1/16 ,  C10L1/183

Abstract: Processes and systems for stabilization and subsequent hydrogenation of an immiscible olefin are described. In certain embodiments, the hydrogenation is conducted in a fixed bed reactor in presence of a hydrogenation catalyst.

公开(公告)号：US20200179824A1

公开(公告)日：2020-06-11

申请号：US16637059

申请日：2018-08-01

Applicant: TOTAL RAFFINAGE CHIMIE ,  AMYRIS, INC.

Inventor： Maha Bahi ,  Anthony Hutin ,  Fernando Leal-Calderon

IPC: B01D17/04 ,  C12P5/00

Abstract: The present invention is a process for recovering an isoprenoid compound produced by fermentation from a fermentation medium comprising: (a) demulsifying the fermentation medium or a fraction thereof in presence of a salt and a surfactant, thereby generating a stream having an organic phase containing the isoprenoid compound and a phase heavier than the organic phase, and (b) separating the stream obtained in step (a) into the organic phase containing the isoprenoid compound, the phase heavier than the organic phase, and optionally a solid phase containing host cell debris and cells.

公开(公告)号：US20190119184A1

公开(公告)日：2019-04-25

申请号：US16228567

申请日：2018-12-20

Applicant: AMYRIS, INC.

Inventor： Nicholas L. Ohler ,  Roberto Vazquez

IPC: C07C5/03 ,  C10G67/06 ,  C10L1/04 ,  C07C7/20 ,  C07C11/21 ,  C10G45/00 ,  C10G53/04 ,  C10G53/08 ,  C10G67/04

Abstract: Processes and systems for stabilization and subsequent hydrogenation of an immiscible olefin are described. In certain embodiments, the hydrogenation is conducted in a fixed bed reactor in presence of a hydrogenation catalyst.

公开(公告)号：US09914941B2

公开(公告)日：2018-03-13

申请号：US14474976

申请日：2014-09-02

Applicant: Amyris, Inc.

Inventor： Timothy Stevens Gardner ,  Kristy Michelle Hawkins ,  Adam Leon Meadows ,  Annie Ening Tsong ,  Yoseph Tsegaye

IPC: C12P5/00 ,  C12P23/00 ,  C12N15/52 ,  C12N9/04 ,  C12N9/02 ,  C12N9/12 ,  C12N15/81 ,  C12P7/42

CPC classification number: C12P5/007 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/1288 ,  C12N15/52 ,  C12N15/81 ,  C12P7/42 ,  C12P23/00 ,  C12Y101/01034 ,  C12Y102/0101 ,  C12Y207/08

Abstract: Provided herein are compositions and methods for the heterologous production of acetyl-CoA-derived isoprenoids in a host cell. In some embodiments, the host cell is genetically modified to comprise a heterologous nucleotide sequence encoding an acetaldehyde dehydrogenase, acetylating (ADA, E.C. 1.2.1.10) and an MEV pathway comprising an NADH-using HMG-CoA reductase. In some embodiments, the host cell is genetically modified to comprise a heterologous nucleotide sequence encoding an ADA and an MEV pathway comprising an acetoacetyl-CoA synthase. In some embodiments, the genetically modified host cell further comprises one or more heterologous nucleotide sequences encoding a phosphoketolase and a phosphotransacetylase. In some embodiments, the genetically modified host cell further comprises a functional disruption of the native PDH-bypass. The compositions and methods described herein provide an energy-efficient yet redox balanced route for the heterologous production of acetyl-CoA-derived isoprenoids.

公开(公告)号：US09884803B2

公开(公告)日：2018-02-06

申请号：US15031132

申请日：2014-10-24

Applicant: Givaudan, S.A. ,  Amyris, Inc.

Inventor： Fridtjof Schroeder

IPC: C07C67/00 ,  C07C253/30 ,  C07C17/08 ,  C07C29/09 ,  C07C29/124 ,  C07C29/00 ,  C07C29/147 ,  C07C17/04 ,  C12P17/04

CPC classification number: C07C67/00 ,  C07B2200/09 ,  C07C17/08 ,  C07C29/00 ,  C07C29/095 ,  C07C29/124 ,  C07C29/147 ,  C07C253/30 ,  C12P17/04 ,  C07C69/07 ,  C07C69/145 ,  C07C69/24 ,  C07C69/63 ,  C07C33/02 ,  C07C21/215 ,  C07C255/18 ,  C07C33/035 ,  C07C69/007

Abstract: A method of forming homoallylic compounds 2 from cyclopropylvinyl precursors 1 in the presence of a Bronsted acid HQ

公开(公告)号：US09850336B2

公开(公告)日：2017-12-26

申请号：US14390581

申请日：2013-04-02

Applicant: KURARAY CO., LTD. ,  AMYRIS, INC.

Inventor： Daisuke Koda ,  Kei Hirata

IPC: C08F236/22 ,  C08F236/04 ,  C08F236/06 ,  C08L7/00 ,  C08K3/04 ,  C08K3/36 ,  B60C1/00 ,  C08L21/00 ,  C08L47/00 ,  C08L9/06

CPC classification number: C08F236/22 ,  B60C1/00 ,  C08F236/04 ,  C08F236/06 ,  C08K3/013 ,  C08K3/04 ,  C08K3/36 ,  C08L7/00 ,  C08L9/06 ,  C08L21/00 ,  C08L47/00 ,  C08L2205/02 ,  C08L2205/03 ,  Y02T10/862 ,  C08F4/48 ,  C08K3/0033

Abstract: The present invention relates to a copolymer including a monomer unit (a) derived from a conjugated diene having not more than 12 carbon atoms and a monomer unit (b) derived from farnesene; a process for producing the copolymer including at least the step of copolymerizing a conjugated diene having not more than 12 carbon atoms with farnesene; a rubber composition including (A) the copolymer, (B) a rubber component and (C) carbon black; a rubber composition including (A) the copolymer, (B) a rubber component and (D) silica; a rubber composition including (A) the copolymer, (B) a rubber component, (C) carbon black and (D) silica; and a tire using the rubber composition at least as a part thereof.